Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
International Journal of Oncology
Join Editorial Board Propose a Special Issue
Print ISSN: 1019-6439 Online ISSN: 1791-2423
Journal Cover
April-2016 Volume 48 Issue 4

Full Size Image

Cover Legend PDF

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
April-2016 Volume 48 Issue 4

Full Size Image

Cover Legend PDF

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Upregulation of metastasis-associated PRL-3 initiates chordoma in zebrafish

  • Authors:
    • Li Li
    • Hongshun Shi
    • Mingming Zhang
    • Xiaoling Guo
    • Fang Tong
    • Wenliang Zhang
    • Junyi Zhou
    • Haihe Wang
    • Shulan Yang
  • View Affiliations / Copyright

    Affiliations: Translational Medicine Centre, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong CPZN 510080, P.R. China, Department of Biochemistry, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, Guangdong CPZN 510080, P.R. China
  • Pages: 1541-1552
    |
    Published online on: January 29, 2016
       https://doi.org/10.3892/ijo.2016.3363
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The metastasis-associated phosphatase of regenerating liver-3 (PRL-3) plays multiple roles in progression of various human cancers; however, significance of its role during development has not been addressed. Here we cloned and characterized the expression pattern of zebrafish prl-3 transcript and showed that it is ubiquitiously expressed in the first 24 h of development with both maternal and zygotic expressions. The transcripts become progressively restricted to the notochord, vessels and the intestine by 96 h post-fertilization. Notably, overexpression of zebrafish Prl-3 (zPrl-3) and human PRL-3 induces notochord malformation in zebrafish. This phenotype resembles chordoma and is confirmed by associated misexpression of notochord-specific markers. Clinical significance of the PRL-3 in chordoma is strongly suggested by detection of PRL-3 antigen in clinical chordoma specimens. Collectively, our results uncovered that aberrant overexpression of PRL-3 could initiate chordoma in early development and suggest the use of PRL-3 could be used as a predictor and a therapeutic target for chordoma.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

Figure 7

Figure 8

View References

1 

Stephens BJ, Han H, Gokhale V and Von Hoff DD: PRL phosphatases as potential molecular targets in cancer. Mol Cancer Ther. 4:1653–1661. 2005. View Article : Google Scholar : PubMed/NCBI

2 

Saha S, Bardelli A, Buckhaults P, Velculescu VE, Rago C, St Croix B, Romans KE, Choti MA, Lengauer C, Kinzler KW, et al: A phosphatase associated with metastasis of colorectal cancer. Science. 294:1343–1346. 2001. View Article : Google Scholar : PubMed/NCBI

3 

Radke I, Götte M, Kersting C, Mattsson B, Kiesel L and Wülfing P: Expression and prognostic impact of the protein tyrosine phosphatases PRL-1, PRL-2, and PRL-3 in breast cancer. Br J Cancer. 95:347–354. 2006. View Article : Google Scholar : PubMed/NCBI

4 

Polato F, Codegoni A, Fruscio R, Perego P, Mangioni C, Saha S, Bardelli A and Broggini M: PRL-3 phosphatase is implicated in ovarian cancer growth. Clin Cancer Res. 11:6835–6839. 2005. View Article : Google Scholar : PubMed/NCBI

5 

Ren T, Jiang B, Xing X, Dong B, Peng L, Meng L, Xu H and Shou C: Prognostic significance of phosphatase of regenerating liver-3 expression in ovarian cancer. Pathol Oncol Res. 15:555–560. 2009. View Article : Google Scholar : PubMed/NCBI

6 

Zhao WB, Li Y, Liu X, Zhang LY and Wang X: Evaluation of PRL-3 expression, and its correlation with angiogenesis and invasion in hepatocellular carcinoma. Int J Mol Med. 22:187–192. 2008.PubMed/NCBI

7 

Ooki A, Yamashita K, Kikuchi S, Sakuramoto S, Katada N, Waraya M, Kawamata H, Nishimiya H, Nakamura K and Watanabe M: Therapeutic potential of PRL-3 targeting and clinical significance of PRL-3 genomic amplification in gastric cancer. BMC Cancer. 11:1222011. View Article : Google Scholar : PubMed/NCBI

8 

Al-Aidaroos AQ and Zeng Q: PRL-3 phosphatase and cancer metastasis. J Cell Biochem. 111:1087–1098. 2010. View Article : Google Scholar : PubMed/NCBI

9 

Guo K, Li J, Wang H, Osato M, Tang JP, Quah SY, Gan BQ and Zeng Q: PRL-3 initiates tumor angiogenesis by recruiting endothelial cells in vitro and in vivo. Cancer Res. 66:9625–9635. 2006. View Article : Google Scholar : PubMed/NCBI

10 

Wu X, Zeng H, Zhang X, Zhao Y, Sha H, Ge X, Zhang M, Gao X and Xu Q: Phosphatase of regenerating liver-3 promotes motility and metastasis of mouse melanoma cells. Am J Pathol. 164:2039–2054. 2004. View Article : Google Scholar : PubMed/NCBI

11 

Guzińska-Ustymowicz K and Pryczynicz A: PRL-3, an emerging marker of carcinogenesis, is strongly associated with poor prognosis. Anticancer Agents Med Chem. 11:99–108. 2011. View Article : Google Scholar

12 

Fiordalisi JJ, Keller PJ and Cox AD: PRL tyrosine phosphatases regulate rho family GTPases to promote invasion and motility. Cancer Res. 66:3153–3161. 2006. View Article : Google Scholar : PubMed/NCBI

13 

Liang F, Liang J, Wang WQ, Sun JP, Udho E and Zhang ZY: PRL3 promotes cell invasion and proliferation by down-regulation of Csk leading to Src activation. J Biol Chem. 282:5413–5419. 2007. View Article : Google Scholar

14 

Wang H, Quah SY, Dong JM, Manser E, Tang JP and Zeng Q: PRL-3 down-regulates PTEN expression and signals through PI3K to promote epithelial-mesenchymal transition. Cancer Res. 67:2922–2926. 2007. View Article : Google Scholar : PubMed/NCBI

15 

Matter WF, Estridge T, Zhang C, Belagaje R, Stancato L, Dixon J, Johnson B, Bloem L, Pickard T, Donaghue M, et al: Role of PRL-3, a human muscle-specific tyrosine phosphatase, in angiotensin-II signaling. Biochem Biophys Res Commun. 283:1061–1068. 2001. View Article : Google Scholar : PubMed/NCBI

16 

Zeng Q, Hong W and Tan YH: Mouse PRL-2 and PRL-3, two potentially prenylated protein tyrosine phosphatases homologous to PRL-1. Biochem Biophys Res Commun. 244:421–427. 1998. View Article : Google Scholar : PubMed/NCBI

17 

Zeng Q, Si X, Horstmann H, Xu Y, Hong W and Pallen CJ: Prenylation-dependent association of protein-tyrosine phosphatases PRL-1, -2, and -3 with the plasma membrane and the early endosome. J Biol Chem. 275:21444–21452. 2000. View Article : Google Scholar : PubMed/NCBI

18 

Yang SL, Aw SS, Chang C, Korzh S, Korzh V and Peng J: Depletion of Bhmt elevates sonic hedgehog transcript level and increases β-cell number in zebrafish. Endocrinology. 152:4706–4717. 2011. View Article : Google Scholar : PubMed/NCBI

19 

Zeng Q, Dong JM, Guo K, Li J, Tan HX, Koh V, Pallen CJ, Manser E and Hong W: PRL-3 and PRL-1 promote cell migration, invasion, and metastasis. Cancer Res. 63:2716–2722. 2003.PubMed/NCBI

20 

Burger A, Vasilyev A, Tomar R, Selig MK, Nielsen GP, Peterson RT, Drummond IA and Haber DA: A zebrafish model of chordoma initiated by notochord-driven expression of HRASV12. Dis Model Mech. 7:907–913. 2014. View Article : Google Scholar :

21 

Stemple DL: Structure and function of the notochord: An essential organ for chordate development. Development. 132:2503–2512. 2005. View Article : Google Scholar : PubMed/NCBI

22 

Krauss S, Concordet JP and Ingham PW: A functionally conserved homolog of the Drosophila segment polarity gene hh is expressed in tissues with polarizing activity in zebrafish embryos. Cell. 75:1431–1444. 1993. View Article : Google Scholar : PubMed/NCBI

23 

Roelink H, Augsburger A, Heemskerk J, Korzh V, Norlin S, Ruiz i Altaba A, Tanabe Y, Placzek M, Edlund T, Jessell TM, et al: Floor plate and motor neuron induction by vhh-1, a vertebrate homolog of hedgehog expressed by the notochord. Cell. 76:761–775. 1994. View Article : Google Scholar : PubMed/NCBI

24 

Yan YL, Hatta K, Riggleman B and Postlethwait JH: Expression of a type II collagen gene in the zebrafish embryonic axis. Dev Dyn. 203:363–376. 1995. View Article : Google Scholar : PubMed/NCBI

25 

Corallo D, Trapani V and Bonaldo P: The notochord: Structure and functions. Cell Mol Life Sci. 72:2989–3008. 2015. View Article : Google Scholar : PubMed/NCBI

26 

Halpern ME, Ho RK, Walker C and Kimmel CB: Induction of muscle pioneers and floor plate is distinguished by the zebrafish no tail mutation. Cell. 75:99–111. 1993. View Article : Google Scholar : PubMed/NCBI

27 

Kispert A and Hermann BG: The Brachyury gene encodes a novel DNA binding protein. EMBO J. 12:4898–4899. 1993.PubMed/NCBI

28 

Schulte-Merker S, Ho RK, Herrmann BG and Nüsslein-Volhard C: The protein product of the zebrafish homologue of the mouse T gene is expressed in nuclei of the germ ring and the notochord of the early embryo. Development. 116:1021–1032. 1992.PubMed/NCBI

29 

Barresi V, Ieni A, Branca G and Tuccari G: Brachyury: A diagnostic marker for the differential diagnosis of chordoma and hemangioblastoma versus neoplastic histological mimickers. Dis Markers. 2014:5147532014. View Article : Google Scholar : PubMed/NCBI

30 

Nibu Y, José-Edwards DS and Di Gregorio A: From notochord formation to hereditary chordoma: The many roles of Brachyury. BioMed Res Int. 2013:8264352013. View Article : Google Scholar : PubMed/NCBI

31 

Schulte-Merker S, van Eeden FJ, Halpern ME, Kimmel CB and Nüsslein-Volhard C: no tail (ntl) is the zebrafish homologue of the mouse T (Brachyury) gene. Development. 120:1009–1015. 1994.PubMed/NCBI

32 

Kispert A and Herrmann BG: Immunohistochemical analysis of the Brachyury protein in wild-type and mutant mouse embryos. Dev Biol. 161:179–193. 1994. View Article : Google Scholar : PubMed/NCBI

33 

Dumaual CM, Sandusky GE, Crowell PL and Randall SK: Cellular localization of PRL-1 and PRL-2 gene expression in normal adult human tissues. J Histochem Cytochem. 54:1401–1412. 2006. View Article : Google Scholar : PubMed/NCBI

34 

Lin MD, Lee HT, Wang SC, Li HR, Hsien HL, Cheng KW, Chang YD, Huang ML, Yu JK and Chen YH: Expression of phosphatase of regenerating liver family genes during embryogenesis: An evolutionary developmental analysis among Drosophila, amphioxus, and zebrafish. BMC Dev Biol. 13:182013. View Article : Google Scholar : PubMed/NCBI

35 

Ferrari L, Pistocchi A, Libera L, Boari N, Mortini P, Bellipanni G, Giordano A, Cotelli F and Riva P: FAS/FASL are dysregulated in chordoma and their loss-of-function impairs zebrafish notochord formation. Oncotarget. 5:5712–5724. 2014. View Article : Google Scholar : PubMed/NCBI

36 

Peng L, Ning J, Meng L and Shou C: The association of the expression level of protein tyrosine phosphatase PRL-3 protein with liver metastasis and prognosis of patients with colorectal cancer. J Cancer Res Clin Oncol. 130:521–526. 2004. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Li L, Shi H, Zhang M, Guo X, Tong F, Zhang W, Zhou J, Wang H and Yang S: Upregulation of metastasis-associated PRL-3 initiates chordoma in zebrafish. Int J Oncol 48: 1541-1552, 2016.
APA
Li, L., Shi, H., Zhang, M., Guo, X., Tong, F., Zhang, W. ... Yang, S. (2016). Upregulation of metastasis-associated PRL-3 initiates chordoma in zebrafish. International Journal of Oncology, 48, 1541-1552. https://doi.org/10.3892/ijo.2016.3363
MLA
Li, L., Shi, H., Zhang, M., Guo, X., Tong, F., Zhang, W., Zhou, J., Wang, H., Yang, S."Upregulation of metastasis-associated PRL-3 initiates chordoma in zebrafish". International Journal of Oncology 48.4 (2016): 1541-1552.
Chicago
Li, L., Shi, H., Zhang, M., Guo, X., Tong, F., Zhang, W., Zhou, J., Wang, H., Yang, S."Upregulation of metastasis-associated PRL-3 initiates chordoma in zebrafish". International Journal of Oncology 48, no. 4 (2016): 1541-1552. https://doi.org/10.3892/ijo.2016.3363
Copy and paste a formatted citation
x
Spandidos Publications style
Li L, Shi H, Zhang M, Guo X, Tong F, Zhang W, Zhou J, Wang H and Yang S: Upregulation of metastasis-associated PRL-3 initiates chordoma in zebrafish. Int J Oncol 48: 1541-1552, 2016.
APA
Li, L., Shi, H., Zhang, M., Guo, X., Tong, F., Zhang, W. ... Yang, S. (2016). Upregulation of metastasis-associated PRL-3 initiates chordoma in zebrafish. International Journal of Oncology, 48, 1541-1552. https://doi.org/10.3892/ijo.2016.3363
MLA
Li, L., Shi, H., Zhang, M., Guo, X., Tong, F., Zhang, W., Zhou, J., Wang, H., Yang, S."Upregulation of metastasis-associated PRL-3 initiates chordoma in zebrafish". International Journal of Oncology 48.4 (2016): 1541-1552.
Chicago
Li, L., Shi, H., Zhang, M., Guo, X., Tong, F., Zhang, W., Zhou, J., Wang, H., Yang, S."Upregulation of metastasis-associated PRL-3 initiates chordoma in zebrafish". International Journal of Oncology 48, no. 4 (2016): 1541-1552. https://doi.org/10.3892/ijo.2016.3363
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team