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Article

E2F1 promotes tumor cell invasion and migration through regulating CD147 in prostate cancer

  • Authors:
    • Yu-Xiang Liang
    • Jian-Ming Lu
    • Ru-Jun Mo
    • Hui-Chan He
    • Jian Xie
    • Fu-Neng Jiang
    • Zhuo-Yuan Lin
    • Yan-Ru Chen
    • Yong-Ding Wu
    • Hong-Wei Luo
    • Zheng Luo
    • Wei-De Zhong
  • View Affiliations / Copyright

    Affiliations: Department of Urology, Guangdong Key Laboratory of Clinical Molecular Medicine and Diagnostics, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou, Guangdong 510180, P.R. China, School of Marine Sciences, Sun Yat-sen University, Guangzhou, Guangdong 510275, P.R. China
  • Pages: 1650-1658
    |
    Published online on: January 29, 2016
       https://doi.org/10.3892/ijo.2016.3364
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Abstract

Increased expression of E2F1 has been reported to be associated with tumor growth and cell survival of prostate cancer (PCa). However, its roles and mechanisms on PCa have not been fully elucidated. The present study found that E2F1 overexpression in PCa tissues was significantly associated with high Gleason score (P=0.01) and advanced pathological stage (P=0.02). In addition, PCa patients with high E2F1 expression more frequently had shorter biochemical recurrence-free survival (P=0.047) than those with low E2F1 expression. Then, we confirmed that the knock-down of E2F1 expression was able to inhibit cell cycle progression, invasion and migration of PCa cell lines in vitro, along with tumor xenograft growth and epithelial-to-mesenchymal transition (EMT) in vivo. Moreover, we identified CD147 as a novel interaction partner for E2F1 through bio-informatic binding site prediction, combined with chromatin immunoprecipitation-PCR (ChIP-PCR) and western blot analysis. Taken together, our data delineate an as yet unrecognized function of E2F1 as enhancer of tumor invasion and migration of PCa via regulating the expression of CD147 in PCa. Importantly, E2F1 may function as a biomarker that can differentiate patients with biochemical recurrent and non-biochemical recurrent disease following radical prostatectomy, highlighting its potential as a therapeutic target.
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Copy and paste a formatted citation
Spandidos Publications style
Liang Y, Lu J, Mo R, He H, Xie J, Jiang F, Lin Z, Chen Y, Wu Y, Luo H, Luo H, et al: E2F1 promotes tumor cell invasion and migration through regulating CD147 in prostate cancer. Int J Oncol 48: 1650-1658, 2016.
APA
Liang, Y., Lu, J., Mo, R., He, H., Xie, J., Jiang, F. ... Zhong, W. (2016). E2F1 promotes tumor cell invasion and migration through regulating CD147 in prostate cancer. International Journal of Oncology, 48, 1650-1658. https://doi.org/10.3892/ijo.2016.3364
MLA
Liang, Y., Lu, J., Mo, R., He, H., Xie, J., Jiang, F., Lin, Z., Chen, Y., Wu, Y., Luo, H., Luo, Z., Zhong, W."E2F1 promotes tumor cell invasion and migration through regulating CD147 in prostate cancer". International Journal of Oncology 48.4 (2016): 1650-1658.
Chicago
Liang, Y., Lu, J., Mo, R., He, H., Xie, J., Jiang, F., Lin, Z., Chen, Y., Wu, Y., Luo, H., Luo, Z., Zhong, W."E2F1 promotes tumor cell invasion and migration through regulating CD147 in prostate cancer". International Journal of Oncology 48, no. 4 (2016): 1650-1658. https://doi.org/10.3892/ijo.2016.3364
Copy and paste a formatted citation
x
Spandidos Publications style
Liang Y, Lu J, Mo R, He H, Xie J, Jiang F, Lin Z, Chen Y, Wu Y, Luo H, Luo H, et al: E2F1 promotes tumor cell invasion and migration through regulating CD147 in prostate cancer. Int J Oncol 48: 1650-1658, 2016.
APA
Liang, Y., Lu, J., Mo, R., He, H., Xie, J., Jiang, F. ... Zhong, W. (2016). E2F1 promotes tumor cell invasion and migration through regulating CD147 in prostate cancer. International Journal of Oncology, 48, 1650-1658. https://doi.org/10.3892/ijo.2016.3364
MLA
Liang, Y., Lu, J., Mo, R., He, H., Xie, J., Jiang, F., Lin, Z., Chen, Y., Wu, Y., Luo, H., Luo, Z., Zhong, W."E2F1 promotes tumor cell invasion and migration through regulating CD147 in prostate cancer". International Journal of Oncology 48.4 (2016): 1650-1658.
Chicago
Liang, Y., Lu, J., Mo, R., He, H., Xie, J., Jiang, F., Lin, Z., Chen, Y., Wu, Y., Luo, H., Luo, Z., Zhong, W."E2F1 promotes tumor cell invasion and migration through regulating CD147 in prostate cancer". International Journal of Oncology 48, no. 4 (2016): 1650-1658. https://doi.org/10.3892/ijo.2016.3364
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