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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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April-2016 Volume 48 Issue 4

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

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Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

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Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

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Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

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Article

Tripartite motif 16 inhibits hepatocellular carcinoma cell migration and invasion

Retraction in: /10.3892/ijo.2023.5473
  • Authors:
    • Linlin Li
    • Lei Dong
    • Xiaotong Qu
    • Shi Jin
    • Xiupeng Lv
    • Guang Tan
  • View Affiliations / Copyright

    Affiliations: The 4th Medical Department of Liaoning Cancer Hospital and Institute, Dadong District, Shenyang, Liaoning 110042, P.R. China, Department of Laparoscopic Surgery, First Affiliated Hospital of Dalian Medical University, Shahekou District, Dalian, Liaoning 116001, P.R. China, Department of Second Neurology, The First Affiliated Hospital of Dalian Medical University, Xigang District, Dalian, Liaoning 116000, P.R. China, Department of Radiation Oncology, First Affiliated Hospital of Dalian Medical University, Shahekou District, Dalian, Liaoning 116001, P.R. China, Department of Hepatology, First Affiliated Hospital of Dalian Medical University, Shahekou District, Dalian, Liaoning 116001, P.R. China
  • Pages: 1639-1649
    |
    Published online on: February 17, 2016
       https://doi.org/10.3892/ijo.2016.3398
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Abstract

Tripartite motif 16 (TRIM16), a member of the RING B-box coiled-coil (RBCC)/tripartite totif (TRIM) protein family, has been demonstrated to have significant effects on tumor migration by previous studies, but its specific contribution to hepatocellular carcinoma (HCC) is currently unknown. The aim of this study was to evaluate the prognostic value of TRIM16 and investigate its functional roles in HCC. The expression of TRIM16 in HCC patient samples were examined using qRT-PCR and western blotting. HCC cell lines with either TRIM16 overexpression or knockdown were established. The effect of TRIM16 on HCC cell migration and invasion was investigated using these cells. Compared with paired normal liver tissues in clinical cancer samples, we found that the expression of TRIM16 was significantly downregulated in HCC lesions. We also found knockdown of TRIM16 promoted epithelial-mesenchymal transition (EMT) in a manner associated with HCC metastasis in vitro and in vivo. Mechanistically, TRIM16 inhibited ZEB2 expression, which in turn inhibited transcription of the pivotal ZEB2 target gene E-cadherin. RNA interference-mediated silencing of ZEB2 attenuated shTRIM16-enhanced cell migration and invasion. In conclusion, our findings define TRIM16 as an inhibitor of EMT and metastasis in HCC that predicts poor clinical outcomes.
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Copy and paste a formatted citation
Spandidos Publications style
Li L, Dong L, Qu X, Jin S, Lv X and Tan G: Tripartite motif 16 inhibits hepatocellular carcinoma cell migration and invasion Retraction in /10.3892/ijo.2023.5473. Int J Oncol 48: 1639-1649, 2016.
APA
Li, L., Dong, L., Qu, X., Jin, S., Lv, X., & Tan, G. (2016). Tripartite motif 16 inhibits hepatocellular carcinoma cell migration and invasion Retraction in /10.3892/ijo.2023.5473. International Journal of Oncology, 48, 1639-1649. https://doi.org/10.3892/ijo.2016.3398
MLA
Li, L., Dong, L., Qu, X., Jin, S., Lv, X., Tan, G."Tripartite motif 16 inhibits hepatocellular carcinoma cell migration and invasion Retraction in /10.3892/ijo.2023.5473". International Journal of Oncology 48.4 (2016): 1639-1649.
Chicago
Li, L., Dong, L., Qu, X., Jin, S., Lv, X., Tan, G."Tripartite motif 16 inhibits hepatocellular carcinoma cell migration and invasion Retraction in /10.3892/ijo.2023.5473". International Journal of Oncology 48, no. 4 (2016): 1639-1649. https://doi.org/10.3892/ijo.2016.3398
Copy and paste a formatted citation
x
Spandidos Publications style
Li L, Dong L, Qu X, Jin S, Lv X and Tan G: Tripartite motif 16 inhibits hepatocellular carcinoma cell migration and invasion Retraction in /10.3892/ijo.2023.5473. Int J Oncol 48: 1639-1649, 2016.
APA
Li, L., Dong, L., Qu, X., Jin, S., Lv, X., & Tan, G. (2016). Tripartite motif 16 inhibits hepatocellular carcinoma cell migration and invasion Retraction in /10.3892/ijo.2023.5473. International Journal of Oncology, 48, 1639-1649. https://doi.org/10.3892/ijo.2016.3398
MLA
Li, L., Dong, L., Qu, X., Jin, S., Lv, X., Tan, G."Tripartite motif 16 inhibits hepatocellular carcinoma cell migration and invasion Retraction in /10.3892/ijo.2023.5473". International Journal of Oncology 48.4 (2016): 1639-1649.
Chicago
Li, L., Dong, L., Qu, X., Jin, S., Lv, X., Tan, G."Tripartite motif 16 inhibits hepatocellular carcinoma cell migration and invasion Retraction in /10.3892/ijo.2023.5473". International Journal of Oncology 48, no. 4 (2016): 1639-1649. https://doi.org/10.3892/ijo.2016.3398
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