Antiproliferative and apoptosis induction of α-mangostin in T47D breast cancer cells

  • Authors:
    • Somchai Kritsanawong
    • Sukanda Innajak
    • Masaya Imoto
    • Ramida Watanapokasin
  • View Affiliations

  • Published online on: February 18, 2016     https://doi.org/10.3892/ijo.2016.3399
  • Pages: 2155-2165
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Abstract

α-Mangostin extracted from mangosteen, Garcinia mangostana Linn. is known as ‘queen of fruits’. The anticancer activity of α-mangostin through apoptosis induction and related signaling pathways in human breast cancer T47D cells was investigated. Human epidermal growth factor receptor 2 (HER2) and mitogen-activated protein kinase (MAPK) signaling have been shown to play important roles in apoptosis. The results showed that α-mangostin induced cell proliferation inhibition, DNA fragmentation, nuclear condensation, increased cleaved caspase-3 and cleaved caspase-9, but decreased Bcl-2 and Mcl-1 expression. Mitochondrial dysfunction and cytochrome c release were also detected. In addition, phosphorylation of ERα, HER2, PI3K, Akt and ERK1/2 were downregulated whereas p-JNK1/2 and p-p38 were upregulated. These results indicated that α-mangostin induced apoptosis associated with HER2/PI3K/Akt and MAPK signaling pathways suggesting that α-mangostin may be used as food supplement or a potential therapeutic compound for breast cancer.
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May-2016
Volume 48 Issue 5

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Kritsanawong S, Innajak S, Imoto M and Watanapokasin R: Antiproliferative and apoptosis induction of α-mangostin in T47D breast cancer cells. Int J Oncol 48: 2155-2165, 2016
APA
Kritsanawong, S., Innajak, S., Imoto, M., & Watanapokasin, R. (2016). Antiproliferative and apoptosis induction of α-mangostin in T47D breast cancer cells. International Journal of Oncology, 48, 2155-2165. https://doi.org/10.3892/ijo.2016.3399
MLA
Kritsanawong, S., Innajak, S., Imoto, M., Watanapokasin, R."Antiproliferative and apoptosis induction of α-mangostin in T47D breast cancer cells". International Journal of Oncology 48.5 (2016): 2155-2165.
Chicago
Kritsanawong, S., Innajak, S., Imoto, M., Watanapokasin, R."Antiproliferative and apoptosis induction of α-mangostin in T47D breast cancer cells". International Journal of Oncology 48, no. 5 (2016): 2155-2165. https://doi.org/10.3892/ijo.2016.3399