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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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May-2016 Volume 48 Issue 5

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

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International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

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International Journal of Epigenetics

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Article

Expression, clinical significance and mechanism of Slit2 in papillary thyroid cancer

  • Authors:
    • Rong-Liang Shi
    • Ning Qu
    • Tian Liao
    • Yu-Long Wang
    • Yu Wang
    • Guo-Hua Sun
    • Qing-Hai Ji
  • View Affiliations / Copyright

    Affiliations: Department of Head and Neck Surgery, Fudan University Shanghai Cancer Center; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, P.R. China
  • Pages: 2055-2062
    |
    Published online on: March 2, 2016
       https://doi.org/10.3892/ijo.2016.3412
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Abstract

Thyroid cancer is a common endocrine malignancy. The last decade has seen exciting progress in understanding thyroid cancer molecular pathogenesis. Several major signaling pathways and related molecular derangements have been elucidated, which represent novel diagnostic and prognostic molecular markers for thyroid cancer. Based on the molecular biology of thyroid cancer, a series of therapeutic targets have been developed, which provide unprecedented opportunities. Thus, histological characterization of subgroups of patients and the correct molecular characterization of patients are thought to be key aspects for future clinical management of these patients. In the present study, we identified Slit2 as a prognostic marker for thyroid cancer oncogenesis and recurrence. Mechanistically, Slit2 regulated Warburg effect in thyroid cancer cells through regulation of HIF1α and HIF1α transcriptional activity. Taken together, our present data uncovered Slit2 as a novel predictive marker for thyroid cancer. The mechanism study indicated that Slit2 regulated the Warburg effect. Additional study on the function of Slit2 in thyroid cancer is required to provide new insights into the potential mechanisms of oncogenesis and recurrence potential of thyroid cancer.
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Copy and paste a formatted citation
Spandidos Publications style
Shi R, Qu N, Liao T, Wang Y, Wang Y, Sun G and Ji Q: Expression, clinical significance and mechanism of Slit2 in papillary thyroid cancer. Int J Oncol 48: 2055-2062, 2016.
APA
Shi, R., Qu, N., Liao, T., Wang, Y., Wang, Y., Sun, G., & Ji, Q. (2016). Expression, clinical significance and mechanism of Slit2 in papillary thyroid cancer. International Journal of Oncology, 48, 2055-2062. https://doi.org/10.3892/ijo.2016.3412
MLA
Shi, R., Qu, N., Liao, T., Wang, Y., Wang, Y., Sun, G., Ji, Q."Expression, clinical significance and mechanism of Slit2 in papillary thyroid cancer". International Journal of Oncology 48.5 (2016): 2055-2062.
Chicago
Shi, R., Qu, N., Liao, T., Wang, Y., Wang, Y., Sun, G., Ji, Q."Expression, clinical significance and mechanism of Slit2 in papillary thyroid cancer". International Journal of Oncology 48, no. 5 (2016): 2055-2062. https://doi.org/10.3892/ijo.2016.3412
Copy and paste a formatted citation
x
Spandidos Publications style
Shi R, Qu N, Liao T, Wang Y, Wang Y, Sun G and Ji Q: Expression, clinical significance and mechanism of Slit2 in papillary thyroid cancer. Int J Oncol 48: 2055-2062, 2016.
APA
Shi, R., Qu, N., Liao, T., Wang, Y., Wang, Y., Sun, G., & Ji, Q. (2016). Expression, clinical significance and mechanism of Slit2 in papillary thyroid cancer. International Journal of Oncology, 48, 2055-2062. https://doi.org/10.3892/ijo.2016.3412
MLA
Shi, R., Qu, N., Liao, T., Wang, Y., Wang, Y., Sun, G., Ji, Q."Expression, clinical significance and mechanism of Slit2 in papillary thyroid cancer". International Journal of Oncology 48.5 (2016): 2055-2062.
Chicago
Shi, R., Qu, N., Liao, T., Wang, Y., Wang, Y., Sun, G., Ji, Q."Expression, clinical significance and mechanism of Slit2 in papillary thyroid cancer". International Journal of Oncology 48, no. 5 (2016): 2055-2062. https://doi.org/10.3892/ijo.2016.3412
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