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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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Review

The ‘SPARC’ of life: Analysis of the role of osteonectin/SPARC in pancreatic cancer (Review)

  • Authors:
    • Monica K. Rossi
    • Manu Gnanamony
    • Christopher S. Gondi
  • View Affiliations / Copyright

    Affiliations: Department of Internal Medicine, University of Illinois College of Medicine at Peoria, Peoria, IL 61605, USA
  • Pages: 1765-1771
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    Published online on: March 4, 2016
       https://doi.org/10.3892/ijo.2016.3417
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Abstract

Pancreatic ductal adenocarcinoma (PDAC) is one of the most clinically challenging cancers to manage. An estimated 48,960 people will be diagnosed with pancreatic cancer in 2015, of that population, 94% are projected to perish within 5 years. These dismal survival rates can be attributed, in part, to an advanced diagnosis occurring in 80% of cases. The heterogeneous and dynamic microenvironment of pancreatic cancer, and the lack of both specific risk factors and efficacious screening tools contribute to the challenge of diagnosing pancreatic cancer in its early stages. These clinical challenges have directed research into the unique characteristics that define PDAC. Recently, there has been an increased focus on the interaction of tumor cells with their microenvironment in the hope of identifying new therapeutic targets. One of the most promising avenues in this new vein of research is targeting protein communication between the cancer cells and the extracellular matrix. The secreted protein acidic and rich in cysteine (SPARC) is one such extracellular matrix protein that has shown potential as a therapeutic target due to its influence on PDAC invasion and metastasis. In this review, we discuss the complex interaction of SPARC with PDAC cells and its potential to guide treatment and eventually improve the survival of patients diagnosed with this devastating disease.
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1 

Rahib L, Smith BD, Aizenberg R, Rosenzweig AB, Fleshman JM and Matrisian LM: Projecting cancer incidence and deaths to 2030: The unexpected burden of thyroid, liver, and pancreas cancers in the United States. Cancer Res. 74:2913–2921. 2014. View Article : Google Scholar : PubMed/NCBI

2 

Hariharan D, Saied A and Kocher HM: Analysis of mortality rates for pancreatic cancer across the world. HPB Oxf. 10:58–62. 2008. View Article : Google Scholar

3 

Sener SF, Fremgen A, Menck HR and Winchester DP: Pancreatic cancer: A report of treatment and survival trends for 100,313 patients diagnosed from 1985–1995, using the National Cancer Database. J Am Coll Surg. 189:1–7. 1999. View Article : Google Scholar : PubMed/NCBI

4 

Simard EP, Ward EM, Siegel R and Jemal A: Cancers with increasing incidence trends in the United States: 1999 through 2008. CA Cancer J Clin. 62:118–128. 2012. View Article : Google Scholar : PubMed/NCBI

5 

Siegel R, Naishadham D and Jemal A: Cancer statistics, 2012. CA Cancer J Clin. 62:10–29. 2012. View Article : Google Scholar : PubMed/NCBI

6 

Petersen GM, de Andrade M, Goggins M, Hruban RH, Bondy M, Korczak JF, Gallinger S, Lynch HT, Syngal S, Rabe KG, et al: Pancreatic cancer genetic epidemiology consortium. Cancer Epidemiol Biomarkers Prev. 15:704–710. 2006. View Article : Google Scholar : PubMed/NCBI

7 

Blackford A, Parmigiani G, Kensler TW, Wolfgang C, Jones S, Zhang X, Parsons DW, Lin JC, Leary RJ, Eshleman JR, et al: Genetic mutations associated with cigarette smoking in pancreatic cancer. Cancer Res. 69:3681–3688. 2009. View Article : Google Scholar : PubMed/NCBI

8 

Shi C, Hruban RH and Klein AP: Familial pancreatic cancer. Arch Pathol Lab Med. 133:365–374. 2009.PubMed/NCBI

9 

American Cancer Society. American cancer society. Cancer Facts & Figures. 2013, http://www.cancer.org/research/cancer-factsstatistics/cancerfactsfigures2013/. Access date: June 23rd, 2015

10 

Stathis A and Moore MJ: Advanced pancreatic carcinoma: Current treatment and future challenges. Nat Rev Clin Oncol. 7:163–172. 2010. View Article : Google Scholar : PubMed/NCBI

11 

Sheridan MB, Ward J, Guthrie JA, Spencer JA, Craven CM, Wilson D, Guillou PJ and Robinson PJ: Dynamic contrast-enhanced MR imaging and dual-phase helical CT in the preoperative assessment of suspected pancreatic cancer: A comparative study with receiver operating characteristic analysis. AJR Am J Roentgenol. 173:583–590. 1999. View Article : Google Scholar : PubMed/NCBI

12 

Horton KM and Fishman EK: Adenocarcinoma of the pancreas: CT imaging. Radiol Clin North Am. 40:1263–1272. 2002. View Article : Google Scholar : PubMed/NCBI

13 

Faria SC, Tamm EP, Loyer EM, Szklaruk J, Choi H and Charnsangavej C: Diagnosis and staging of pancreatic tumors. Semin Roentgenol. 39:397–411. 2004. View Article : Google Scholar : PubMed/NCBI

14 

House MG, Yeo CJ, Cameron JL, Campbell KA, Schulick RD, Leach SD, Hruban RH, Horton KM, Fishman EK and Lillemoe KD: Predicting resectability of periampullary cancer with three-dimensional computed tomography. J Gastrointest Surg. 8:280–288. 2004. View Article : Google Scholar : PubMed/NCBI

15 

Vachiranubhap B, Kim YH, Balci NC and Semelka RC: Magnetic resonance imaging of adenocarcinoma of the pancreas. Top Magn Reson Imaging. 20:3–9. 2009. View Article : Google Scholar : PubMed/NCBI

16 

Tellez-Avila FI, Chavez-Tapia NC, López-Arce G, Franco-Guzmán AM, Sosa-Lozano LA, Alfaro-Lara R, Chan-Nuñez C, Giovannini M, Elizondo-Rivera J and Ramírez-Luna MA: Vascular invasion in pancreatic cancer: Predictive values for endoscopic ultrasound and computed tomography imaging. Pancreas. 41:636–638. 2012. View Article : Google Scholar : PubMed/NCBI

17 

Warshaw AL, Tepper JE and Shipley WU: Laparoscopy in the staging and planning of therapy for pancreatic cancer. Am J Surg. 151:76–80. 1986. View Article : Google Scholar : PubMed/NCBI

18 

Sperti C, Pasquali C, Bissoli S, Chierichetti F, Liessi G and Pedrazzoli S: Tumor relapse after pancreatic cancer resection is detected earlier by 18-FDG PET than by CT. J Gastrointest Surg. 14:131–140. 2010. View Article : Google Scholar

19 

Rubin P and Carter SK: Combination radiation therapy and chemotherapy: A logical basis for their clinical use. CA Cancer J Clin. 26:274–292. 1976. View Article : Google Scholar : PubMed/NCBI

20 

Garrido-Laguna I and Hidalgo M: Pancreatic cancer: From state-of-the-art treatments to promising novel therapies. Nat Rev Clin Oncol. 12:319–334. 2015. View Article : Google Scholar : PubMed/NCBI

21 

Bilimoria KY, Bentrem DJ, Ko CY, Ritchey J, Stewart AK, Winchester DP and Talamonti MS: Validation of the 6th edition AJCC Pancreatic Cancer Staging System: Report from the National Cancer Database. Cancer. 110:738–744. 2007. View Article : Google Scholar : PubMed/NCBI

22 

Liotta LA and Kohn EC: The microenvironment of the tumour-host interface. Nature. 411:375–379. 2001. View Article : Google Scholar : PubMed/NCBI

23 

Fidler IJ: The organ microenvironment and cancer metastasis. Differentiation. 70:498–505. 2002. View Article : Google Scholar : PubMed/NCBI

24 

Sato N, Maehara N and Goggins M: Gene expression profiling of tumor-stromal interactions between pancreatic cancer cells and stromal fibroblasts. Cancer Res. 64:6950–6956. 2004. View Article : Google Scholar : PubMed/NCBI

25 

Sato N, Fukushima N, Maehara N, Matsubayashi H, Koopmann J, Su GH, Hruban RH and Goggins M: SPARC/osteonectin is a frequent target for aberrant methylation in pancreatic adenocarcinoma and a mediator of tumor-stromal interactions. Oncogene. 22:5021–5030. 2003. View Article : Google Scholar : PubMed/NCBI

26 

Li C, Heidt DG, Dalerba P, Burant CF, Zhang L, Adsay V, Wicha M, Clarke MF and Simeone DM: Identification of pancreatic cancer stem cells. Cancer Res. 67:1030–1037. 2007. View Article : Google Scholar : PubMed/NCBI

27 

Hwang RF, Moore T, Arumugam T, Ramachandran V, Amos KD, Rivera A, Ji B, Evans DB and Logsdon CD: Cancer-associated stromal fibroblasts promote pancreatic tumor progression. Cancer Res. 68:918–926. 2008. View Article : Google Scholar : PubMed/NCBI

28 

Hansel DE, Kern SE and Hruban RH: Molecular pathogenesis of pancreatic cancer. Annu Rev Genomics Hum Genet. 4:237–256. 2003. View Article : Google Scholar : PubMed/NCBI

29 

Hruban RH, Maitra A and Goggins M: Update on pancreatic intraepithelial neoplasia. Int J Clin Exp Pathol. 1:306–316. 2008.PubMed/NCBI

30 

Pellegata NS, Sessa F, Renault B, Bonato M, Leone BE, Solcia E and Ranzani GN: K-ras and p53 gene mutations in pancreatic cancer: Ductal and nonductal tumors progress through different genetic lesions. Cancer Res. 54:1556–1560. 1994.PubMed/NCBI

31 

Hezel AF, Kimmelman AC, Stanger BZ, Bardeesy N and Depinho RA: Genetics and biology of pancreatic ductal adenocarcinoma. Genes Dev. 20:1218–1249. 2006. View Article : Google Scholar : PubMed/NCBI

32 

Maitra A and Hruban RH: Pancreatic cancer. Annu Rev Pathol. 3:157–188. 2008. View Article : Google Scholar

33 

Caldas C, Hahn SA, da Costa LT, Redston MS, Schutte M, Seymour AB, Weinstein CL, Hruban RH, Yeo CJ and Kern SE: Frequent somatic mutations and homozygous deletions of the p16 (MTS1) gene in pancreatic adenocarcinoma. Nat Genet. 8:27–32. 1994. View Article : Google Scholar : PubMed/NCBI

34 

Schutte M, Hruban RH, Geradts J, Maynard R, Hilgers W, Rabindran SK, Moskaluk CA, Hahn SA, Schwarte-Waldhoff I, Schmiegel W, et al: Abrogation of the Rb/p16 tumor-suppressive pathway in virtually all pancreatic carcinomas. Cancer Res. 57:3126–3130. 1997.PubMed/NCBI

35 

Hahn SA, Hoque AT, Moskaluk CA, da Costa LT, Schutte M, Rozenblum E, Seymour AB, Weinstein CL, Yeo CJ, Hruban RH, et al: Homozygous deletion map at 18q21.1 in pancreatic cancer. Cancer Res. 56:490–494. 1996.PubMed/NCBI

36 

Yachida S, White CM, Naito Y, Zhong Y, Brosnan JA, Macgregor-Das AM, Morgan RA, Saunders T, Laheru DA, Herman JM, et al: Clinical significance of the genetic landscape of pancreatic cancer and implications for identification of potential long-term survivors. Clin Cancer Res. 18:6339–6347. 2012. View Article : Google Scholar : PubMed/NCBI

37 

Vonlaufen A, Phillips PA, Xu Z, Goldstein D, Pirola RC, Wilson JS and Apte MV: Pancreatic stellate cells and pancreatic cancer cells: An unholy alliance. Cancer Res. 68:7707–7710. 2008. View Article : Google Scholar : PubMed/NCBI

38 

Bissell MJ and Radisky D: Putting tumours in context. Nat Rev Cancer. 1:46–54. 2001. View Article : Google Scholar

39 

Heldin CH, Rubin K, Pietras K and Ostman A: High interstitial fluid pressure - an obstacle in cancer therapy. Nat Rev Cancer. 4:806–813. 2004. View Article : Google Scholar : PubMed/NCBI

40 

Neesse A, Michl P, Frese KK, Feig C, Cook N, Jacobetz MA, Lolkema MP, Buchholz M, Olive KP, Gress TM, et al: Stromal biology and therapy in pancreatic cancer. Gut. 60:861–868. 2011. View Article : Google Scholar

41 

Lunevicius R, Nakanishi H, Ito S, Kozaki K, Kato T, Tatematsu M and Yasui K: Clinicopathological significance of fibrotic capsule formation around liver metastasis from colorectal cancer. J Cancer Res Clin Oncol. 127:193–199. 2001. View Article : Google Scholar : PubMed/NCBI

42 

Moir JA, Mann J and White SA: The role of pancreatic stellate cells in pancreatic cancer. Surg Oncol. 24:232–238. 2015. View Article : Google Scholar : PubMed/NCBI

43 

Moinfar F, Man YG, Arnould L, Bratthauer GL, Ratschek M and Tavassoli FA: Concurrent and independent genetic alterations in the stromal and epithelial cells of mammary carcinoma: Implications for tumorigenesis. Cancer Res. 60:2562–2566. 2000.PubMed/NCBI

44 

Bachem MG, Schneider E, Gross H, Weidenbach H, Schmid RM, Menke A, Siech M, Beger H, Grünert A and Adler G: Identification, culture, and characterization of pancreatic stellate cells in rats and humans. Gastroenterology. 115:421–432. 1998. View Article : Google Scholar : PubMed/NCBI

45 

Geerts A: History, heterogeneity, developmental biology, and functions of quiescent hepatic stellate cells. Semin Liver Dis. 21:311–335. 2001. View Article : Google Scholar : PubMed/NCBI

46 

Kanno A, Satoh K, Masamune A, Hirota M, Kimura K, Umino J, Hamada S, Satoh A, Egawa S, Motoi F, et al: Periostin, secreted from stromal cells, has biphasic effect on cell migration and correlates with the epithelial to mesenchymal transition of human pancreatic cancer cells. Int J Cancer. 122:2707–2718. 2008. View Article : Google Scholar : PubMed/NCBI

47 

Guweidhi A, Kleeff J, Adwan H, Giese NA, Wente MN, Giese T, Büchler MW, Berger MR and Friess H: Osteonectin influences growth and invasion of pancreatic cancer cells. Ann Surg. 242:224–234. 2005. View Article : Google Scholar : PubMed/NCBI

48 

Arnold SA and Brekken RA: SPARC: A matricellular regulator of tumorigenesis. J Cell Commun Signal. 3:255–273. 2009. View Article : Google Scholar : PubMed/NCBI

49 

Chlenski A, Liu S, Crawford SE, Volpert OV, DeVries GH, Evangelista A, Yang Q, Salwen HR, Farrer R, Bray J, et al: SPARC is a key Schwannian-derived inhibitor controlling neuroblastoma tumor angiogenesis. Cancer Res. 62:7357–7363. 2002.PubMed/NCBI

50 

Podhajcer OL, Benedetti LG, Girotti MR, Prada F, Salvatierra E and Llera AS: The role of the matricellular protein SPARC in the dynamic interaction between the tumor and the host. Cancer Metastasis Rev. 27:691–705. 2008. View Article : Google Scholar : PubMed/NCBI

51 

Gundewar C, Sasor A, Hilmersson KS, Andersson R and Ansari D: The role of SPARC expression in pancreatic cancer progression and patient survival. Scand J Gastroenterol. 50:1170–1174. 2015. View Article : Google Scholar : PubMed/NCBI

52 

Gao J, Song J, Huang H, Li Z, Du Y, Cao J, Li M, Lv S, Lin H and Gong Y: Methylation of the SPARC gene promoter and its clinical implication in pancreatic cancer. J Exp Clin Cancer Res. Mar 26–2010.29:28Epub ahead of print. View Article : Google Scholar : PubMed/NCBI

53 

Lunardi S, Muschel RJ and Brunner TB: The stromal compartments in pancreatic cancer: Are there any therapeutic targets? Cancer Lett. 343:147–155. 2014. View Article : Google Scholar

54 

Gorantla B, Bhoopathi P, Chetty C, Gogineni VR, Sailaja GS, Gondi CS and Rao JS: Notch signaling regulates tumor-induced angiogenesis in SPARC-overexpressed neuroblastoma. Angiogenesis. 16:85–100. 2013. View Article : Google Scholar

55 

Komar G, Kauhanen S, Liukko K, Seppänen M, Kajander S, Ovaska J, Nuutila P and Minn H: Decreased blood flow with increased metabolic activity: A novel sign of pancreatic tumor aggressiveness. Clin Cancer Res. 15:5511–5517. 2009. View Article : Google Scholar : PubMed/NCBI

56 

Kindler HL, Niedzwiecki D, Hollis D, Sutherland S, Schrag D, Hurwitz H, Innocenti F, Mulcahy MF, O'Reilly E, Wozniak TF, et al: Gemcitabine plus bevacizumab compared with gemcitabine plus placebo in patients with advanced pancreatic cancer: Phase III trial of the Cancer and Leukemia Group B (CALGB 80303). J Clin Oncol. 28:3617–3622. 2010. View Article : Google Scholar : PubMed/NCBI

57 

Mantoni TS, Schendel RR, Rödel F, Niedobitek G, Al-Assar O, Masamune A and Brunner TB: Stromal SPARC expression and patient survival after chemoradiation for non-resectable pancreatic adenocarcinoma. Cancer Biol Ther. 7:1806–1815. 2008. View Article : Google Scholar : PubMed/NCBI

58 

Ting DT, Wittner BS, Ligorio M, Vincent Jordan N, Shah AM, Miyamoto DT, Aceto N, Bersani F, Brannigan BW, Xega K, et al: Single-cell RNA sequencing identifies extracellular matrix gene expression by pancreatic circulating tumor cells. Cell Rep. 8:1905–1918. 2014. View Article : Google Scholar : PubMed/NCBI

59 

Von Hoff DD, Ramanathan RK, Borad MJ, Laheru DA, Smith LS, Wood TE, Korn RL, Desai N, Trieu V, Iglesias JL, et al: Gemcitabine plus nab-paclitaxel is an active regimen in patients with advanced pancreatic cancer: A phase I/II trial. J Clin Oncol. 29:4548–4554. 2011. View Article : Google Scholar : PubMed/NCBI

60 

Von Hoff DD, Ervin T, Arena FP, Chiorean EG, Infante J, Moore M, Seay T, Tjulandin SA, Ma WW, Saleh MN, et al: Increased survival in pancreatic cancer with nab-paclitaxel plus gemcitabine. N Engl J Med. 369:1691–1703. 2013. View Article : Google Scholar : PubMed/NCBI

61 

Hidalgo M, Cascinu S, Kleeff J, Labianca R, Löhr JM, Neoptolemos J, Real FX, Van Laethem JL and Heinemann V: Addressing the challenges of pancreatic cancer: Future directions for improving outcomes. Pancreatology. 15:8–18. 2015. View Article : Google Scholar

62 

Gao YY, Han RB, Wang X, Ge SH, Li HL, Deng T, Liu R, Bai M, Zhou LK, Zhang XY, et al: Change of SPARC expression after chemotherapy in gastric cancer. Cancer Biol Med. 12:33–40. 2015.PubMed/NCBI

63 

Neuzillet C, Tijeras-Raballand A, Cros J, Faivre S, Hammel P and Raymond E: Stromal expression of SPARC in pancreatic adenocarcinoma. Cancer Metastasis Rev. 32:585–602. 2013. View Article : Google Scholar : PubMed/NCBI

64 

Seno T, Harada H, Kohno S, Teraoka M, Inoue A and Ohnishi T: Downregulation of SPARC expression inhibits cell migration and invasion in malignant gliomas. Int J Oncol. 34:707–715. 2009. View Article : Google Scholar : PubMed/NCBI

65 

Zhu XC, Dong QZ, Zhang XF, Deng B, Jia HL, Ye QH, Qin LX and Wu XZ: microRNA-29a suppresses cell proliferation by targeting SPARC in hepatocellular carcinoma. Int J Mol Med. 30:1321–1326. 2012.PubMed/NCBI

66 

Zhou X, Tan FK, Guo X and Arnett FC: Attenuation of collagen production with small interfering RNA of SPARC in cultured fibroblasts from the skin of patients with scleroderma. Arthritis Rheum. 54:2626–2631. 2006. View Article : Google Scholar : PubMed/NCBI

67 

Camino AM, Atorrasagasti C, Maccio D, Prada F, Salvatierra E, Rizzo M, Alaniz L, Aquino JB, Podhajcer OL, Silva M, et al: Adenovirus-mediated inhibition of SPARC attenuates liver fibrosis in rats. J Gene Med. 10:993–1004. 2008. View Article : Google Scholar : PubMed/NCBI

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Spandidos Publications style
Rossi MK, Gnanamony M and Gondi CS: The ‘SPARC’ of life: Analysis of the role of osteonectin/SPARC in pancreatic cancer (Review). Int J Oncol 48: 1765-1771, 2016.
APA
Rossi, M.K., Gnanamony, M., & Gondi, C.S. (2016). The ‘SPARC’ of life: Analysis of the role of osteonectin/SPARC in pancreatic cancer (Review). International Journal of Oncology, 48, 1765-1771. https://doi.org/10.3892/ijo.2016.3417
MLA
Rossi, M. K., Gnanamony, M., Gondi, C. S."The ‘SPARC’ of life: Analysis of the role of osteonectin/SPARC in pancreatic cancer (Review)". International Journal of Oncology 48.5 (2016): 1765-1771.
Chicago
Rossi, M. K., Gnanamony, M., Gondi, C. S."The ‘SPARC’ of life: Analysis of the role of osteonectin/SPARC in pancreatic cancer (Review)". International Journal of Oncology 48, no. 5 (2016): 1765-1771. https://doi.org/10.3892/ijo.2016.3417
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Spandidos Publications style
Rossi MK, Gnanamony M and Gondi CS: The ‘SPARC’ of life: Analysis of the role of osteonectin/SPARC in pancreatic cancer (Review). Int J Oncol 48: 1765-1771, 2016.
APA
Rossi, M.K., Gnanamony, M., & Gondi, C.S. (2016). The ‘SPARC’ of life: Analysis of the role of osteonectin/SPARC in pancreatic cancer (Review). International Journal of Oncology, 48, 1765-1771. https://doi.org/10.3892/ijo.2016.3417
MLA
Rossi, M. K., Gnanamony, M., Gondi, C. S."The ‘SPARC’ of life: Analysis of the role of osteonectin/SPARC in pancreatic cancer (Review)". International Journal of Oncology 48.5 (2016): 1765-1771.
Chicago
Rossi, M. K., Gnanamony, M., Gondi, C. S."The ‘SPARC’ of life: Analysis of the role of osteonectin/SPARC in pancreatic cancer (Review)". International Journal of Oncology 48, no. 5 (2016): 1765-1771. https://doi.org/10.3892/ijo.2016.3417
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