|
1
|
Siegel R, Naishadham D and Jemal A: Cancer
statistics, 2013. CA Cancer J Clin. 63:11–30. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
2
|
Sui X, Kong N, Zhu M, Wang X, Lou F, Han W
and Pan H: Cotargeting EGFR and autophagy signaling: A novel
therapeutic strategy for non-small-cell lung cancer. Mol Clin
Oncol. 2:8–12. 2014.PubMed/NCBI
|
|
3
|
Camidge DR, Pao W and Sequist LV: Acquired
resistance to TKIs in solid tumours: Learning from lung cancer. Nat
Rev Clin Oncol. 11:473–481. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
4
|
Lee JY, Lim SH, Kim M, Kim S, Jung HA,
Chang WJ, Choi MK, Hong JY, Lee SJ, Sun JM, et al: Is there any
predictor for clinical outcome in EGFR mutant NSCLC patients
treated with EGFR TKIs? Cancer Chemother Pharmacol. 73:1063–1070.
2014. View Article : Google Scholar : PubMed/NCBI
|
|
5
|
Park S, Langley E, Sun JM, Lockton S, Ahn
JS, Jain A, Park K, Singh S, Kim P and Ahn MJ: Low EGFR/MET ratio
is associated with resistance to EGFR inhibitors in non-small cell
lung cancer. Oncotarget. 6:30929–30938. 2015.PubMed/NCBI
|
|
6
|
Presutti D, Santini S, Cardinali B, Papoff
G, Lalli C, Samperna S, Fustaino V, Giannini G and Ruberti G: MET
gene amplification and MET receptor activation are not sufficient
to predict efficacy of combined MET and EGFR inhibitors in EGFR
TKI-resistant NSCLC cells. PLoS One. 10:e01433332015. View Article : Google Scholar : PubMed/NCBI
|
|
7
|
Ricciuti B, Mecca C, Cenci M, Leonardi GC,
Perrone L, Mencaroni C, Crinò L, Grignani F, Baglivo S, Chiari R,
et al: miRNAs and resistance to EGFR-TKIs in EGFR-mutant non-small
cell lung cancer: Beyond ‘traditional mechanisms’ of resistance. E
Cancer Med Sci. 9:5692015.
|
|
8
|
Chong CR and Jänne PA: The quest to
overcome resistance to EGFR-targeted therapies in cancer. Nat Med.
19:1389–1400. 2013. View
Article : Google Scholar : PubMed/NCBI
|
|
9
|
Amaravadi RK, Lippincott-Schwartz J, Yin
XM, Weiss WA, Takebe N, Timmer W, DiPaola RS, Lotze MT and White E:
Principles and current strategies for targeting autophagy for
cancer treatment. Clin Cancer Res. 17:654–666. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
10
|
Yang ZJ, Chee CE, Huang S and Sinicrope F:
Autophagy modulation for cancer therapy. Cancer Biol Ther.
11:169–176. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
11
|
Paglin S, Hollister T, Delohery T, Hackett
N, McMahill M, Sphicas E, Domingo D and Yahalom J: A novel response
of cancer cells to radiation involves autophagy and formation of
acidic vesicles. Cancer Res. 61:439–444. 2001.PubMed/NCBI
|
|
12
|
Ertmer A, Huber V, Gilch S, Yoshimori T,
Erfle V, Duyster J, Elsässer HP and Schätzl HM: The anticancer drug
imatinib induces cellular autophagy. Leukemia. 21:936–942.
2007.PubMed/NCBI
|
|
13
|
Li X and Fan Z: The epidermal growth
factor receptor antibody cetuximab induces autophagy in cancer
cells by downregulating HIF-1alpha and Bcl-2 and activating the
beclin 1/hVps34 complex. Cancer Res. 70:5942–5952. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
14
|
Han W, Pan H, Chen Y, Sun J, Wang Y, Li J,
Ge W, Feng L, Lin X, Wang X, et al: EGFR tyrosine kinase inhibitors
activate autophagy as a cytoprotective response in human lung
cancer cells. PLoS One. 6:e186912011. View Article : Google Scholar : PubMed/NCBI
|
|
15
|
Suh DH, Kim MK, Kim HS, Chung HH and Song
YS: Unfolded protein response to autophagy as a promising druggable
target for anticancer therapy. Ann NY Acad Sci. 1271:20–32. 2012.
View Article : Google Scholar : PubMed/NCBI
|
|
16
|
Ron D and Walter P: Signal integration in
the endoplasmic reticulum unfolded protein response. Nat Rev Mol
Cell Biol. 8:519–529. 2007. View
Article : Google Scholar : PubMed/NCBI
|
|
17
|
Harding HP, Zhang Y, Bertolotti A, Zeng H
and Ron D: Perk is essential for translational regulation and cell
survival during the unfolded protein response. Mol Cell. 5:897–904.
2000. View Article : Google Scholar : PubMed/NCBI
|
|
18
|
Zou Y, Ling YH, Sironi J, Schwartz EL,
Perez-Soler R and Piperdi B: The autophagy inhibitor chloroquine
overcomes the innate resistance of wild-type EGFR non-small-cell
lung cancer cells to erlotinib. J Thorac Oncol. 8:693–702. 2013.
View Article : Google Scholar : PubMed/NCBI
|
|
19
|
Hu YL, Jahangiri A, Delay M and Aghi MK:
Tumor cell autophagy as an adaptive response mediating resistance
to treatments such as antiangiogenic therapy. Cancer Res.
72:4294–4299. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
20
|
Jo GH, Bogler O, Chwae YJ, Yoo H, Lee SH,
Park JB, Kim YJ, Kim JH and Gwak HS: Radiation-induced autophagy
contributes to cell death and induces apoptosis partly in malignant
glioma cells. Cancer Res Treat. 47:221–241. 2015. View Article : Google Scholar :
|
|
21
|
Sui X, Chen R, Wang Z, Huang Z, Kong N,
Zhang M, Han W, Lou F, Yang J, Zhang Q, et al: Autophagy and
chemotherapy resistance: A promising therapeutic target for cancer
treatment. Cell Death Dis. 4:e8382013. View Article : Google Scholar : PubMed/NCBI
|
|
22
|
Sugita S, Ito K, Yamashiro Y, Moriya S,
Che XF, Yokoyama T, Hiramoto M and Miyazawa K: EGFR-independent
autophagy induction with gefitinib and enhancement of its cytotoxic
effect by targeting autophagy with clarithromycin in non-small cell
lung cancer cells. Biochem Biophys Res Commun. 461:28–34. 2015.
View Article : Google Scholar : PubMed/NCBI
|
|
23
|
Li YY, Lam SK, Mak JC, Zheng CY and Ho JC:
Erlotinib-induced autophagy in epidermal growth factor receptor
mutated non-small cell lung cancer. Lung Cancer. 81:354–361. 2013.
View Article : Google Scholar : PubMed/NCBI
|
|
24
|
Gupta A, Roy S, Lazar AJ, Wang WL,
McAuliffe JC, Reynoso D, McMahon J, Taguchi T, Floris G,
Debiec-Rychter M, et al: Autophagy inhibition and antimalarials
promote cell death in gastrointestinal stromal tumor (GIST). Proc
Natl Acad Sci USA. 107:14333–14338. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
25
|
Milano V, Piao Y, LaFortune T and de Groot
J: Dasatinib-induced autophagy is enhanced in combination with
temozolomide in glioma. Mol Cancer Ther. 8:394–406. 2009.
View Article : Google Scholar : PubMed/NCBI
|
|
26
|
Martin AP, Park MA, Mitchell C, Walker T,
Rahmani M, Thorburn A, Häussinger D, Reinehr R, Grant S and Dent P:
BCL-2 family inhibitors enhance histone deacetylase inhibitor and
sorafenib lethality via autophagy and overcome blockade of the
extrinsic pathway to facilitate killing. Mol Pharmacol. 76:327–341.
2009. View Article : Google Scholar : PubMed/NCBI
|
|
27
|
Guo GF, Jiang WQ, Zhang B, Cai YC, Xu RH,
Chen XX, Wang F and Xia LP: Autophagy-related proteins Beclin-1 and
LC3 predict cetuximab efficacy in advanced colorectal cancer. World
J Gastroenterol. 17:4779–4786. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
28
|
Moreira-Leite FF, Harrison LR, Mironov A,
Roberts RA and Dive C: Inducible EGFR T790M-mediated gefitinib
resistance in non-small cell lung cancer cells does not modulate
sensitivity to PI103 provoked autophagy. J Thorac Oncol. 5:765–777.
2010. View Article : Google Scholar : PubMed/NCBI
|
|
29
|
Tang MC, Wu MY, Hwang MH, Chang YT, Huang
HJ, Lin AM and Yang JC: Chloroquine enhances gefitinib cytotoxicity
in gefitinib-resistant nonsmall cell lung cancer cells. PLoS One.
10:e01191352015. View Article : Google Scholar : PubMed/NCBI
|
|
30
|
Klionsky DJ, Abeliovich H, Agostinis P,
Agrawal DK, Aliev G, Askew DS, Baba M, Baehrecke EH, Bahr BA,
Ballabio A, et al: Guidelines for the use and interpretation of
assays for monitoring autophagy in higher eukaryotes. Autophagy.
4:151–175. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
31
|
Morgan MJ, Gamez G, Menke C, Hernandez A,
Thorburn J, Gidan F, Staskiewicz L, Morgan S, Cummings C, Maycotte
P, et al: Regulation of autophagy and chloroquine sensitivity by
oncogenic RAS in vitro is context-dependent. Autophagy.
10:1814–1826. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
32
|
Kimura T, Takabatake Y, Takahashi A and
Isaka Y: Chloroquine in cancer therapy: A double-edged sword of
autophagy. Cancer Res. 73:3–7. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
33
|
Hu T, Li P, Luo Z, Chen X, Zhang J, Wang
C, Chen P and Dong Z: Chloroquine inhibits hepatocellular carcinoma
cell growth in vitro and in vivo. Oncol Rep. 35:43–49. 2016.
|
|
34
|
Fan C, Wang W, Zhao B, Zhang S and Miao J:
Chloroquine inhibits cell growth and induces cell death in A549
lung cancer cells. Bioorg Med Chem. 14:3218–3222. 2006. View Article : Google Scholar : PubMed/NCBI
|
|
35
|
Zheng Y, Zhao YL, Deng X, Yang S, Mao Y,
Li Z, Jiang P, Zhao X and Wei Y: Chloroquine inhibits colon cancer
cell growth in vitro and tumor growth in vivo via induction of
apoptosis. Cancer Invest. 27:286–292. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
36
|
Yang A, Rajeshkumar NV, Wang X, Yabuuchi
S, Alexander BM, Chu GC, Von Hoff DD, Maitra A and Kimmelman AC:
Autophagy is critical for pancreatic tumor growth and progression
in tumors with p53 alterations. Cancer Discov. 4:905–913. 2014.
View Article : Google Scholar : PubMed/NCBI
|
|
37
|
Oyadomari S and Mori M: Roles of
CHOP/GADD153 in endoplasmic reticulum stress. Cell Death Differ.
11:381–389. 2004. View Article : Google Scholar
|
|
38
|
Wolff S, Weissman JS and Dillin A:
Differential scales of protein quality control. Cell. 157:52–64.
2014. View Article : Google Scholar : PubMed/NCBI
|
|
39
|
Buchberger A, Bukau B and Sommer T:
Protein quality control in the cytosol and the endoplasmic
reticulum: Brothers in arms. Mol Cell. 40:238–252. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
40
|
Oyadomari S, Koizumi A, Takeda K, Gotoh T,
Akira S, Araki E and Mori M: Targeted disruption of the Chop gene
delays endoplasmic reticulum stress-mediated diabetes. J Clin
Invest. 109:525–532. 2002. View Article : Google Scholar : PubMed/NCBI
|
|
41
|
B'chir W, Maurin AC, Carraro V, Averous J,
Jousse C, Muranishi Y, Parry L, Stepien G, Fafournoux P and Bruhat
A: The eIF2α/ATF4 pathway is essential for stress-induced autophagy
gene expression. Nucleic Acids Res. 41:7683–7699. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
42
|
Senft D and Ronai ZA: UPR, autophagy, and
mitochondria crosstalk underlies the ER stress response. Trends
Biochem Sci. 40:141–148. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
43
|
Deegan S, Saveljeva S, Gorman AM and
Samali A: Stress-induced self-cannibalism: On the regulation of
autophagy by endoplasmic reticulum stress. Cell Mol Life Sci.
70:2425–2441. 2013. View Article : Google Scholar
|
|
44
|
Adolph TE, Tomczak MF, Niederreiter L, Ko
HJ, Böck J, Martinez-Naves E, Glickman JN, Tschurtschenthaler M,
Hartwig J, Hosomi S, et al: Paneth cells as a site of origin for
intestinal inflammation. Nature. 503:272–276. 2013.PubMed/NCBI
|
