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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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International Journal of Oncology

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Journal Cover
June-2016 Volume 48 Issue 6

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Journal Metrics

Impact Factor: 4.9

CiteScore: 8.9

CiteScore Rank: Q1: #66/415 Oncology

Source Normalized Impact per Paper (SNIP): 0.955

SCImago Journal Rank (SJR): 1226.0

Review

Hormone signaling pathways as treatment targets in renal cell cancer (Review)

Anna M. Czarnecka, Magdalena Niedzwiedzka, Camillo Porta, Cezary Szczylik
Pages: 2221-2235
Published online on: 28 March 2016

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Review

Interaction between Wnt/β-catenin pathway and microRNAs regulates epithelial-mesenchymal transition in gastric cancer (Review)

Cunen Wu, Yuwen Zhuang, Shan Jiang, Shenlin Liu, Jinyong Zhou, Jian Wu, Yuhao Teng, Baomei Xia, Ruiping Wang, Xi Zou
Pages: 2236-2246
Published online on: 08 April 2016

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Review

αβ T-cell receptor bias in disease and therapy (Review)

Chun-Yan Wang, Pei-Fa Yu, Xiao-Bing He, Yong-Xiang Fang, Wen-Yu Cheng, Zhi-Zhong Jing
Pages: 2247-2256
Published online on: 18 April 2016

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Article Open Access

Potential screening and early diagnosis method for cancer: Tongue diagnosis

Shuwen Han, Xi Yang, Quan Qi, Yuefen Pan, Yongchao Chen, Junjun Shen, Haihong Liao, Zhaoning Ji
Pages: 2257-2264
Published online on: 31 March 2016

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Article Open Access

Chemosensitizing effect of podophyllotoxin acetate on topoisomerase inhibitors leads to synergistic enhancement of lung cancer cell apoptosis

Wan Gi Hong, Jeong Hyun Cho, Sang-Gu Hwang, Eunah Lee, Jaeseok Lee, Jong-Il Kim, Hong-Duck Um, Jong Kuk Park
Pages: 2265-2276
Published online on: 01 April 2016

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Article Open Access

In vivo monitoring of CD44+ cancer stem-like cells by γ-irradiation in breast cancer

Mi Hyun Kim, Min Hwan Kim, Kwang Seok Kim, Myung-Jin Park, Jae-Hoon Jeong, Seung Woo Park, Young Hoon Ji, Kwang Il Kim, Tae Sup Lee, Phil Youl Ryu, Joo Hyun Kang, Yong Jin Lee
Pages: 2277-2286
Published online on: 18 April 2016

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Article Open Access

Tetramethylpyrazine induces differentiation of human umbilical cord-derived mesenchymal stem cells into neuron-like cells in vitro

Chengrui Nan, Li Guo, Zongmao Zhao, Shucheng Ma, Jixiang Liu, Dongdong Yan, Guoqiang Song, Hanjie Liu
Pages: 2287-2294
Published online on: 23 March 2016

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Article Open Access

Impact of multicellular tumor spheroids as an in vivo‑like tumor model on anticancer drug response

Bianca Galateanu, Ariana Hudita, Carolina Negrei, Rodica‑Mariana Ion, Marieta Costache, Miriana Stan, Dragana Nikitovic, A. Wallace Hayes, Demetrios A. Spandidos, Aristidis M. Tsatsakis, Octav Ginghina
Pages: 2295-2302
Published online on: 01 April 2016

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Article Open Access

The hepatocyte growth factor antagonist NK4 inhibits indoleamine-2,3-dioxygenase expression via the c-Met-phosphatidylinositol 3-kinase-AKT signaling pathway

Dongdong Wang, Yasushi Saga, Naoto Sato, Toshikazu Nakamura, Osamu Takikawa, Hiroaki Mizukami, Shigeki Matsubara, Hiroyuki Fujiwara
Pages: 2303-2309
Published online on: 14 April 2016

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Article Open Access

Podoplanin-mediated TGF-β-induced epithelial-mesenchymal transition and its correlation with bHLH transcription factor DEC in TE-11 cells Expression of Concern in /10.3892/ijo.2025.5805

Yunyan Wu, Qiang Liu, Xu Yan, Yukio Kato, Makiko Tanaka, Sadaki Inokuchi, Tadashi Yoshizawa, Satoko Morohashi, Hiroshi Kijima
Pages: 2310-2320
Published online on: 18 March 2016

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Article Open Access

Expression and function of CXCL12/CXCR4/CXCR7 in thyroid cancer

Xiaoli Zhu, Qianming Bai, Yongming Lu, Yiqiong Lu, Linlin Zhu, Xiaoyan Zhou, Lijing Wu
Pages: 2321-2329
Published online on: 12 April 2016

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Article Open Access

Docetaxel induces Bcl-2- and pro-apoptotic caspase-independent death of human prostate cancer DU145 cells

Takeharu Ogura, Yoshiyuki Tanaka, Hiroki Tamaki, Mamoru Harada
Pages: 2330-2338
Published online on: 08 April 2016

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Article

Unusual roles of caspase-8 in triple-negative breast cancer cell line MDA-MB-231

Anna De Blasio, Riccardo Di Fiore, Marco Morreale, Daniela Carlisi, Rosa Drago-Ferrante, Mauro Montalbano, Christian Scerri, Giovanni Tesoriere, Renza Vento
Pages: 2339-2348
Published online on: 06 April 2016

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Article

Blockade of Notch3 inhibits the stem-like property and is associated with ALDH1A1 and CD44 via autophagy in non-small lung cancer

Yuanyuan Ma, Mingzhen Li, Jiahui Si, Ying Xiong, Fangliang Lu, Jianzhi Zhang, Liyi Zhang, Panpan Zhang, Yue Yang
Pages: 2349-2358
Published online on: 30 March 2016

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Article

Knockdown of ROS1 gene sensitizes breast tumor growth to doxorubicin in a syngeneic mouse model

Snigdha Tiash, Ming Jang Chua, Ezharul Hoque Chowdhury
Pages: 2359-2366
Published online on: 23 March 2016

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Article

Molecular dysfunctions in acute myeloid leukemia revealed by integrated analysis of microRNA and transcription factor

Xiao-Cong Lin, Yong Xu, Guo-Ping Sun, Jin-Li Wen, Ning Li, Yu-Ming Zhang, Zhi-Gang Yang, Hai-Tao Zhang, Yong Dai
Pages: 2367-2380
Published online on: 15 April 2016

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Article

Mouse interleukin-12/FasTI: A novel bi-functional fusion protein for cancer immuno/gene therapy

Xi Yang, Ashlee H. Tietje, Xianzhong Yu, Yanzhang Wei
Pages: 2381-2386
Published online on: 07 April 2016

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Article

Receptor-interacting protein-1 promotes the growth and invasion in gastric cancer

Guangwei Zhu, Jianxin Ye, Yongjian Huang, Wei Zheng, Jin Hua, Shugang Yang, Jinfu Zhuang, Jinzhou Wang
Pages: 2387-2398
Published online on: 24 March 2016

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Article

Long-term exposure of MCF-12A normal human breast epithelial cells to ethanol induces epithelial mesenchymal transition and oncogenic features

Robert Gelfand, Dolores Vernet, Kevin Bruhn, Jaydutt Vadgama, Nestor F. Gonzalez-Cadavid
Pages: 2399-2414
Published online on: 29 March 2016

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Article

Regulation of myo-inositol biosynthesis by p53-ISYNA1 pathway

Tomoyuki Koguchi, Chizu Tanikawa, Jinichi Mori, Yoshiyuki Kojima, Koichi Matsuda
Pages: 2415-2424
Published online on: 24 March 2016

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Article

MicroRNA-155 promotes tumor growth of human hepatocellular carcinoma by targeting ARID2

Li Zhang, Wei Wang, Xiaobin Li, Sai He, Jianfeng Yao, Xiaolong Wang, Di Zhang, Xuejun Sun
Pages: 2425-2434
Published online on: 30 March 2016

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Article

CLDN6-induced apoptosis via regulating ASK1-p38/JNK signaling in breast cancer MCF-7 cells

Yaxiong Guo, Dongjing Lin, Mingzi Zhang, Xiaowei Zhang, Yanru Li, Ruan Yang, Yan Lu, Xiangshu Jin, Minlan Yang, Miaomiao Wang, Shuai Zhao, Chengshi Quan
Pages: 2435-2444
Published online on: 01 April 2016

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Article

Constitutive activation of casein kinase 2 in glioblastomas: Absence of class restriction and broad therapeutic potential

Nadege Dubois, Marie Willems, Minh-Tuan Nguyen-Khac, Jerome Kroonen, Nicolas Goffart, Manuel Deprez, Vincent Bours, Pierre A. Robe
Pages: 2445-2452
Published online on: 18 April 2016

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Article

Oridonin induces apoptosis through the mitochondrial pathway in human gastric cancer SGC-7901 cells

Shiyong Gao, Huixin Tan, Nan Zhu, Haiyu Gao, Chunyu Lv, Jian Gang, Yubin Ji
Pages: 2453-2460
Published online on: 07 April 2016

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Article

An asymmetrically dimethylarginated nuclear 90 kDa protein (p90aDMA) induced by interleukin (IL)-2, IL-4 or IL-6 in the tumor microenvironment is selectively degraded by autophagy

Lei Sun, Wu-Yan Xia, Shao-Hua Zhao, Ning Liu, Shan-Shan Liu, Peng Xiu, Lin-Feng Li, Xue-Lei Cao, Jian-Xin Gao
Pages: 2461-2471
Published online on: 23 March 2016

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Article

Optimal sequence of antisense DNA to silence YB-1 in lung cancer by use of a novel polysaccharide drug delivery system

Hiroto Izumi, Shohei Nagao, Shinichi Mochizuki, Nobuaki Fujiwara, Kazuo Sakurai, Yasuo Morimoto
Pages: 2472-2478
Published online on: 23 March 2016

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Article

Leptin promotes breast cancer cell migration and invasion via IL-18 expression and secretion Expression of Concern in /10.3892/ijo.2025.5816

Kuangfa Li, Lan Wei, Yunxiu Huang, Yang Wu, Min Su, Xueli Pang, Nian Wang, Feihu Ji, Changli Zhong, Tingmei Chen
Pages: 2479-2487
Published online on: 12 April 2016

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Article

Epithelial protein lost in neoplasm-α (EPLIN-α) is a potential prognostic marker for the progression of epithelial ovarian cancer

Rong Liu, Tracey A. Martin, Nicola J. Jordan, Fiona Ruge, Lin Ye, Wen G. Jiang
Pages: 2488-2496
Published online on: 29 March 2016

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Article

Specific expression and methylation of SLIT1, SLIT2, SLIT3, and miR-218 in gastric cancer subtypes

Mirang Kim, Jong-Hwan Kim, Su-Jin Baek, Seon-Young Kim, Yong Sung Kim
Pages: 2497-2507
Published online on: 06 April 2016

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Article

Downregulation of RSK2 influences the biological activities of human osteosarcoma cells through inactivating AKT/mTOR signaling pathways

Quanhe Qiu, Jing Jiang, Liangbo Lin, Si Cheng, Daqi Xin, Wei Jiang, Jieliang Shen, Zhenming Hu
Pages: 2508-2520
Published online on: 08 April 2016

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Article

The effect of sulforaphane on the cell cycle, apoptosis and expression of cyclin D1 and p21 in the A549 non-small cell lung cancer cell line

Agnieszka Żuryń, Anna Litwiniec, Barbara Safiejko-Mroczka, Anna Klimaszewska-Wiśniewska, Maciej Gagat, Adrian Krajewski, Lidia Gackowska, Dariusz Grzanka
Pages: 2521-2533
Published online on: 18 March 2016

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Article

Curcumin and epithelial-mesenchymal transition in breast cancer cells transformed by low doses of radiation and estrogen

Marcela Gallardo, Gloria M. Calaf
Pages: 2534-2542
Published online on: 07 April 2016

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Article

Microarray expression profile analysis of aberrant long non-coding RNAs in esophageal squamous cell carcinoma

Juan Yao, Jun-Xing Huang, Mei Lin, Zheng-Dong Wu, Hong Yu, Peng-Cheng Wang, Jun Ye, Ping Chen, Jing Wu, Guo-Jun Zhao
Pages: 2543-2557
Published online on: 24 March 2016

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Article

Autophagy inhibition facilitates erlotinib cytotoxicity in lung cancer cells through modulation of endoplasmic reticulum stress

Zhongliang Wang, Tingting Du, Xiaorong Dong, Zhenyu Li, Gang Wu, Ruiguang Zhang
Pages: 2558-2566
Published online on: 01 April 2016

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Article

Exosome-shuttling microRNA-21 promotes cell migration and invasion-targeting PDCD4 in esophageal cancer

Juan Liao, Ran Liu, Ya-Juan Shi, Li-Hong Yin, Yue-Pu Pu
Pages: 2567-2579
Published online on: 24 March 2016

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Article

EIF3D silencing suppresses renal cell carcinoma tumorigenesis via inducing G2/M arrest through downregulation of Cyclin B1/CDK1 signaling

Xiu-Wu Pan, Lu Chen, Yi Hong, Dan-Feng Xu, Xi Liu, Lin Li, Yi Huang, Li-Ming Cui, Si-Shun Gan, Qi-Wei Yang, Hai Huang, Fa-Jun Qu, Jian-Qing Ye, Lin-Hui Wang, Xin-Gang Cui
Pages: 2580-2590
Published online on: 28 March 2016

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Article

Histone deacetylase inhibitor-induced cell death in bladder cancer is associated with chromatin modification and modifying protein expression: A proteomic approach

Qingdi Quentin Li, Jian-Jiang Hao, Zheng Zhang, Iawen Hsu, Yi Liu, Zhen Tao, Keidren Lewi, Adam R. Metwalli, Piyush K. Agarwal
Pages: 2591-2607
Published online on: 07 April 2016

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Article

Oridonin inhibits gefitinib-resistant lung cancer cells by suppressing EGFR/ERK/MMP-12 and CIP2A/Akt signaling pathways

Xiangling Xiao, Zhongwei He, Wei Cao, Fen Cai, Liang Zhang, Qiuyue Huang, Chunsheng Fan, Chao Duan, Xiaobo Wang, Jiu Wang, Ying Liu
Pages: 2608-2618
Published online on: 15 April 2016

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Article

Interaction between angiotensin II and relaxin 2 in the progress of growth and spread of prostate cancer cells

Kamila Domińska, Tomasz Ochędalski, Karolina Kowalska, Zuzanna Elżbieta Matysiak‑Burzyńska, Elżbieta Płuciennik, Agnieszka Wanda Piastowska-Ciesielska
Pages: 2619-2628
Published online on: 24 March 2016

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Article

Antiproliferative effects on colon adenocarcinoma cells induced by co-administration of vitamin K1 and Lactobacillus rhamnosus GG

Antonella Orlando, Michele Linsalata, Francesco Russo
Pages: 2629-2638
Published online on: 29 March 2016

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Article

Inhibitory role of TRIP-Br1 oncoprotein in hypoxia-induced apoptosis in breast cancer cell lines

Chengping Li, Samil Jung, Young Yang, Keun-Il Kim, Jong-Seok Lim, Chung-Il Cheon, Myeong-Sok Lee
Pages: 2639-2646
Published online on: 24 March 2016

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Article

Knockdown of WAVE1 enhances apoptosis of leukemia cells by downregulating autophagy

Zhaoxia Zhang, Benqing Wu, Wenwen Chai, Lizhi Cao, Yangping Wang, Yan Yu, Liangchun Yang
Pages: 2647-2656
Published online on: 18 March 2016

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Article

Theaflavin-3, 3'-digallate induces apoptosis and G2 cell cycle arrest through the Akt/MDM2/p53 pathway in cisplatin-resistant ovarian cancer A2780/CP70 cells

Youying Tu, Eunhye Kim, Ying Gao, Gary O. Rankin, Bo Li, Yi Charlie Chen
Pages: 2657-2665
Published online on: 06 April 2016

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Article

Apoptotic effect of noscapine in breast cancer cell lines

Edwin O. Quisbert-Valenzuela, Gloria M. Calaf
Pages: 2666-2674
Published online on: 07 April 2016

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Article

Overexpression of long non-coding RNA-CTD903 inhibits colorectal cancer invasion and migration by repressing Wnt/β-catenin signaling and predicts favorable prognosis

Zixu Yuan, Xihu Yu, Beibei Ni, Daici Chen, Zihuan Yang, Jintuan Huang, Jianping Wang, Dianke Chen, Lei Wang
Pages: 2675-2685
Published online on: 21 March 2016

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Article

Salinomycin causes migration and invasion of human fibrosarcoma cells by inducing MMP-2 expression via PI3-kinase, ERK-1/2 and p38 kinase pathways

Seon-Mi Yu, Song Ja Kim
Pages: 2686-2692
Published online on: 22 March 2016

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Article

Tissue microRNAs as predictive markers for gastric cancer patients undergoing palliative chemotherapy

David Smid, Vlastimil Kulda, Kristyna Srbecka, Dasa Kubackova, Jan Dolezal, Ondrej Daum, Radek Kucera, Ondrej Topolcan, Vladislav Treska, Tomas Skalicky, Martin Pesta
Pages: 2693-2703
Published online on: 12 April 2016

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Article

Mangiferin enhances the sensitivity of human multiple myeloma cells to anticancer drugs through suppression of the nuclear factor κB pathway

Tomoya Takeda, Masanobu Tsubaki, Toshiki Kino, Ayako Kawamura, Shota Isoyama, Tatsuki Itoh, Motohiro Imano, Genzoh Tanabe, Osamu Muraoka, Hideaki Matsuda, Takao Satou, Shozo Nishida
Pages: 2704-2712
Published online on: 01 April 2016

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Article

Invasion and increased expression of S100A4 and CYR61 in mesenchymal transformed breast cancer cells is downregulated by GnRH

Carsten Gründker, Gerd Bauerschmitz, Antje Schubert, Günter Emons
Pages: 2713-2721
Published online on: 18 April 2016

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Correction Open Access

[Corrigendum] Constitutive activation of MAPK/ERK inhibits prostate cancer cell proliferation through upregulation of BRCA2

Loredana Moro, Arnaldo A. Arbini, Ersilia Marra, Margherita Greco
Pages: 2722-2722
Published online on: 14 April 2016

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Journal Cover
March-2026 Volume 68 Issue 3

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Journal Metrics

Impact Factor: 4.9

CiteScore: 8.9

CiteScore Rank: Q1: #66/415 Oncology

Source Normalized Impact per Paper (SNIP): 0.955

SCImago Journal Rank (SJR): 1226.0

Article Open Access

Circ72309 modulates gemcitabine metabolism and gemcitabine sensitivity in pancreatic cancer: Serum Circ72309 levels as a potential predictor of treatment response

Naoko Sekiguchi, Hidenori Takahashi, Shogo Kobayashi, Kazuki Sasaki, Shinichiro Hasegawa, Yoshifumi Iwagami, Daisaku Yamada, Yoshito Tomimaru, Hirofumi Akita, Tadafumi Asaoka, Takehiro Noda, Junzo Shimizu, Koji Tanaka, Ryota Chijimatsu, Yuichiro Doki, Hidetoshi Eguchi
Article Number: 36
Published online on: 16 January 2026

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Review Open Access

Unveiling sex differences in pancreatic ductal adenocarcinoma: Current evidence and future directions (Review)

Sophie Rauschenberg, Elisabeth Orgler‑Gasche, Didem Karakas Zeybek, Ivonne Regel, J.-Matthias Löhr, Daniel Öhlund, Michael Günther, Lina Aguilera Munoz
Article Number: 35
Published online on: 15 January 2026

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Retraction Open Access

[Retracted] LTBP2 promotes the migration and invasion of gastric cancer cells and predicts poor outcome of patients with gastric cancer

Jun Wang, Wen-Jia Liang, Guang-Tao Min, Hong-Peng Wang, Wei Chen, Nan Yao
Article Number: 34
Published online on: 13 January 2026

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Article Open Access

KMO downregulation promotes hepatocellular carcinoma growth via 3‑HAA‑mediated mitochondrial mass and function imbalances

Ming Liu, Xintong Zhang, Yanfen Hu, Li Niu, Linzhi Guo, Guoqing Zhao, Fan Lu, Fengfeng Jia, Li Li, Hao Wu, Jianjun Zhu
Article Number: 33
Published online on: 13 January 2026

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Review Open Access

Regulatory networks of HIFs in tumor‑infiltrating immune cells: From molecular mechanisms to therapeutic implications (Review)

Chaoqun Li, Chenge Qin, Xingchen Li, Jinzhu Wang, Yang Li, Qin Sun
Article Number: 32
Published online on: 12 January 2026

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Retraction Open Access

[Retracted] uPAR and cathepsin B knockdown inhibits radiation‑induced PKC integrated integrin signaling to the cytoskeleton of glioma‑initiating cells

Kiranmai Alapati, Sreelatha Gopinath, Rama Rao Malla, Venkata Ramesh Dasari, Jasti S. Rao
Article Number: 31
Published online on: 05 January 2026

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Article Open Access

PTPN18 functions as a tumor suppressor in breast cancer by negatively regulating cyclin E

Na Zhang, Tao Wang, Bin Bai, Xiaonan Zhang, Wenying Xu, Weilu Chen, Yang Yu, Bing Wang
Article Number: 30
Published online on: 30 December 2025

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Retraction Open Access

[Retracted] Suppression of the death gene BIK is a critical factor for resistance to tamoxifen in MCF‑7 breast cancer cells

Rubí Viedma-Rodriguez, Luis Arturo Baiza-Gutman, Alejandro García-Carrancá, Leticia Moreno-Fierros, Fabio Salamanca-Gómez, Diego Arenas-Aranda
Article Number: 29
Published online on: 23 December 2025

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Journal Cover
April-2026 Volume 68 Issue 4

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Journal Metrics

Impact Factor: 4.9

CiteScore: 8.9

CiteScore Rank: Q1: #66/415 Oncology

Source Normalized Impact per Paper (SNIP): 0.955

SCImago Journal Rank (SJR): 1226.0

Review Open Access

Advances in the study of the breast carcinoma exosomal microRNAs: From basic mechanisms to clinical applications (Review)

Zhi-Min Chen, Peng Huang, Dun-Yang Yang, Shu Lin, Si-Qing Cai
Article Number: 38
Published online on: 30 January 2026

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Retraction Open Access

[Retracted] Matrix metalloproteinase‑1 promotes prostate tumor growth and metastasis

Sai Murali Krishna Pulukuri, Jasti S. Rao
Article Number: 37
Published online on: 19 January 2026

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