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Article

Constitutive activation of casein kinase 2 in glioblastomas: Absence of class restriction and broad therapeutic potential

  • Authors:
    • Nadege Dubois
    • Marie Willems
    • Minh-Tuan Nguyen-Khac
    • Jerome Kroonen
    • Nicolas Goffart
    • Manuel Deprez
    • Vincent Bours
    • Pierre A. Robe
  • View Affiliations / Copyright

    Affiliations: Department of Human Genetics and GIGA Research Center, University of Liège, B-4000 Liège, Belgium, Department of Neuropathology, CHU Liège, University of Liège, B-4000 Liège, Belgium
  • Pages: 2445-2452
    |
    Published online on: April 18, 2016
       https://doi.org/10.3892/ijo.2016.3490
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Abstract

Casein kinase II contributes to the growth and survival of malignant gliomas and attracts increasing attention as a therapeutic target in these tumors. Several reports have suggested that this strategy might be most relevant for specific subgroups of patients, namely Verhaak's classical and TP53 wild-type tumors. Using kinase assays and microarray genetic profiling in a series of 27 proprietary fresh frozen surgical glioma samples, we showed that constitutive CK2 kinase activation is not restricted to tumors that present increased copy numbers or mRNA expression of its catalytic or regulatory subunits, and can result from a functional activation by various cytokines from the glioma microenvironment. Using corresponding primary tumor and human astrocyte cell cultures as well as glioma cell lines, we confirmed that CK2 inhibition is selectively toxic to malignant glial tumors, without any restriction to tumor class or to TP53 status. We finally showed that while the contribution of CK2 to the constitutive NF-κB hyperactivation in malignant gliomas is at best moderate, a delayed activation of NF-κB may associate with the therapeutic resistance of glioma cells to CK2 inhibition.
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1 

Stupp R, Taillibert S, Kanner AA, Kesari S, Steinberg DM, Toms SA, Taylor LP, Lieberman F, Silvani A, Fink KL, et al: Maintenance therapy with tumor-treating fields plus temozolomide vs temozolomide alone for glioblastoma: A randomized clinical trial. JAMA. 314:2535–2543. 2015. View Article : Google Scholar : PubMed/NCBI

2 

Liu R, Wang X, Chen GY, Dalerba P, Gurney A, Hoey T, Sherlock G, Lewicki J, Shedden K and Clarke MF: The prognostic role of a gene signature from tumorigenic breast-cancer cells. N Engl J Med. 356:217–226. 2007. View Article : Google Scholar : PubMed/NCBI

3 

Duncan JS and Litchfield DW: Too much of a good thing: The role of protein kinase CK2 in tumorigenesis and prospects for therapeutic inhibition of CK2. Biochim Biophys Acta. 1784:33–47. 2008. View Article : Google Scholar

4 

Kroonen J, Artesi M, Capraro V, Nguyen-Khac MT, Willems M, Chakravarti A, Bours V and Robe PA: Casein kinase 2 inhibition modulates the DNA damage response but fails to radiosensitize malignant glioma cells. Int J Oncol. 41:776–782. 2012.PubMed/NCBI

5 

Mandal T, Bhowmik A, Chatterjee A, Chatterjee U, Chatterjee S and Ghosh MK: Reduced phosphorylation of Stat3 at Ser-727 mediated by casein kinase 2 - protein phosphatase 2A enhances Stat3 Tyr-705 induced tumorigenic potential of glioma cells. Cell Signal. 26:1725–1734. 2014. View Article : Google Scholar : PubMed/NCBI

6 

Romieu-Mourez R, Landesman-Bollag E, Seldin DC, Traish AM, Mercurio F and Sonenshein GE: Roles of IKK kinases and CK2 in activation of NFκB in breast cancer. Cancer Res. 61:3810–3818. 2001.PubMed/NCBI

7 

Turowec JP, Vilk G, Gabriel M and Litchfield DW: Characterizing the convergence of protein kinase CK2 and caspase-3 reveals isoform-specific phosphorylation of caspase-3 by CK2α': Implications for pathological roles of CK2 in promoting cancer cell survival. Oncotarget. 4:560–571. 2013. View Article : Google Scholar : PubMed/NCBI

8 

Nitta RT, Gholamin S, Feroze AH, Agarwal M, Cheshier SH, Mitra SS and Li G: Casein kinase 2α regulates glioblastoma brain tumor-initiating cell growth through the β-catenin pathway. Oncogene. 34:3688–3699. 2015. View Article : Google Scholar :

9 

Zheng Y, McFarland BC, Drygin D, Yu H, Bellis SL, Kim H, Bredel M and Benveniste EN: Targeting protein kinase CK2 suppresses prosurvival signaling pathways and growth of glioblastoma. Clin Cancer Res. 19:6484–6494. 2013. View Article : Google Scholar : PubMed/NCBI

10 

Verhaak RGW, Hoadley KA, Purdom E, Wang V, Qi Y, Wilkerson MD, Miller CR, Ding L, Golub T, Mesirov JP, et al; Cancer Genome Atlas Research Network. Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1. Cancer Cell. 17:98–110. 2010. View Article : Google Scholar : PubMed/NCBI

11 

Romieu-Mourez R, Landesman-Bollag E, Seldin DC and Sonenshein GE: Protein kinase CK2 promotes aberrant activation of nuclear factor-kappaB, transformed phenotype, and survival of breast cancer cells. Cancer Res. 62:6770–6778. 2002.PubMed/NCBI

12 

Guerra B, Iwabuchi K and Issinger O-G: Protein kinase CK2 is required for the recruitment of 53BP1 to sites of DNA double-strand break induced by radiomimetic drugs. Cancer Lett. 345:115–123. 2014. View Article : Google Scholar

13 

Olsen BB, Fritz G and Issinger O-G: Characterization of ATM and DNA-PK wild-type and mutant cell lines upon DSB induction in the presence and absence of CK2 inhibitors. Int J Oncol. 40:592–598. 2012.

14 

Dixit D, Sharma V, Ghosh S, Mehta VS and Sen E: Inhibition of Casein kinase-2 induces p53-dependent cell cycle arrest and sensitizes glioblastoma cells to tumor necrosis factor (TNFα)-induced apoptosis through SIRT1 inhibition. Cell Death Dis. 3:e2712012. View Article : Google Scholar

15 

Berendsen S, Varkila M, Kroonen J, Seute T, Snijders TJ, Kauw F, Spliet WG, Willems M, Poulet C, Broekman ML, et al: Prognostic relevance of epilepsy at presentation in glioblastoma patients. Neuro Oncol. Sep 29–2015.(Epub ahead of print]). PubMed/NCBI

16 

Robe PA, Bentires-Alj M, Bonif M, Rogister B, Deprez M, Haddada H, Khac MT, Jolois O, Erkmen K, Merville MP, et al: In vitro and in vivo activity of the nuclear factor-kappaB inhibitor sulfasalazine in human glioblastomas. Clin Cancer Res. 10:5595–5603. 2004. View Article : Google Scholar : PubMed/NCBI

17 

Shen J, Channavajhala P, Seldin DC and Sonenshein GE: Phosphorylation by the protein kinase CK2 promotes calpain-mediated degradation of IkappaBalpha. J Immunol. 167:4919–4925. 2001. View Article : Google Scholar : PubMed/NCBI

18 

Robe PA, Nguyen-Khac M-T, Lambert F, Lechanteur C, Jolois O, Ernst-Gengoux P, Rogister B and Bours V: Sulfasalazine unveils a contact-independent HSV-TK/ganciclovir gene therapy bystander effect in malignant gliomas. Int J Oncol. 30:283–290. 2007.

19 

Bredel M, Bredel C, Juric D, Duran GE, Yu RX, Harsh GR, Vogel H, Recht LD, Scheck AC and Sikic BI: Tumor necrosis factor-alpha-induced protein 3 as a putative regulator of nuclear factor-kappaB-mediated resistance to O6-alkylating agents in human glioblastomas. J Clin Oncol. 24:274–287. 2006. View Article : Google Scholar

20 

Artesi M, Kroonen J, Bredel M, Nguyen-Khac M, Deprez M, Schoysman L, Poulet C, Chakravarti A, Kim H, Scholtens D, et al: Connexin 30 expression inhibits growth of human malignant gliomas but protects them against radiation therapy. Neuro-oncol. 17:392–406. 2015.

21 

Robe PA, Rogister B, Merville M-P and Bours V: Growth regulation of astrocytes and C6 cells by TGFbeta1: Correlation with gap junctions. Neuroreport. 11:2837–2841. 2000. View Article : Google Scholar : PubMed/NCBI

22 

Goffart N, Kroonen J and Rogister B: Glioblastoma-initiating cells: Relationship with neural stem cells and the micro-environment. Cancers (Basel). 5:1049–1071. 2013. View Article : Google Scholar

23 

Kore RA and Abraham EC: Inflammatory cytokines, interleukin-1 beta and tumor necrosis factor-alpha, upregulated in glioblastoma multiforme, raise the levels of CRYAB in exosomes secreted by U373 glioma cells. Biochem Biophys Res Commun. 453:326–331. 2014. View Article : Google Scholar : PubMed/NCBI

24 

Bredel M, Scholtens DM, Yadav AK, Alvarez AA, Renfrow JJ, Chandler JP, Yu IL, Carro MS, Dai F, Tagge MJ, et al: NFKBIA deletion in glioblastomas. N Engl J Med. 364:627–637. 2011. View Article : Google Scholar

25 

Yu M, Yeh J and Van Waes C: Protein kinase casein kinase 2 mediates inhibitor-kappaB kinase and aberrant nuclear factor-kappaB activation by serum factor(s) in head and neck squamous carcinoma cells. Cancer Res. 66:6722–6731. 2006. View Article : Google Scholar : PubMed/NCBI

26 

Guo S, Demicco EG, Romieu-Mourez R, Landesman-Bollag E, Seldin DC and Sonenshein GE: Inducible IκB kinase/IκB kinase ɛ expression is induced by CK2 and promotes aberrant nuclear factor-κB activation in breast cancer cells. Cancer Res. 65:11375–11383. 2005. View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Dubois N, Willems M, Nguyen-Khac M, Kroonen J, Goffart N, Deprez M, Bours V and Robe PA: Constitutive activation of casein kinase 2 in glioblastomas: Absence of class restriction and broad therapeutic potential. Int J Oncol 48: 2445-2452, 2016.
APA
Dubois, N., Willems, M., Nguyen-Khac, M., Kroonen, J., Goffart, N., Deprez, M. ... Robe, P.A. (2016). Constitutive activation of casein kinase 2 in glioblastomas: Absence of class restriction and broad therapeutic potential. International Journal of Oncology, 48, 2445-2452. https://doi.org/10.3892/ijo.2016.3490
MLA
Dubois, N., Willems, M., Nguyen-Khac, M., Kroonen, J., Goffart, N., Deprez, M., Bours, V., Robe, P. A."Constitutive activation of casein kinase 2 in glioblastomas: Absence of class restriction and broad therapeutic potential". International Journal of Oncology 48.6 (2016): 2445-2452.
Chicago
Dubois, N., Willems, M., Nguyen-Khac, M., Kroonen, J., Goffart, N., Deprez, M., Bours, V., Robe, P. A."Constitutive activation of casein kinase 2 in glioblastomas: Absence of class restriction and broad therapeutic potential". International Journal of Oncology 48, no. 6 (2016): 2445-2452. https://doi.org/10.3892/ijo.2016.3490
Copy and paste a formatted citation
x
Spandidos Publications style
Dubois N, Willems M, Nguyen-Khac M, Kroonen J, Goffart N, Deprez M, Bours V and Robe PA: Constitutive activation of casein kinase 2 in glioblastomas: Absence of class restriction and broad therapeutic potential. Int J Oncol 48: 2445-2452, 2016.
APA
Dubois, N., Willems, M., Nguyen-Khac, M., Kroonen, J., Goffart, N., Deprez, M. ... Robe, P.A. (2016). Constitutive activation of casein kinase 2 in glioblastomas: Absence of class restriction and broad therapeutic potential. International Journal of Oncology, 48, 2445-2452. https://doi.org/10.3892/ijo.2016.3490
MLA
Dubois, N., Willems, M., Nguyen-Khac, M., Kroonen, J., Goffart, N., Deprez, M., Bours, V., Robe, P. A."Constitutive activation of casein kinase 2 in glioblastomas: Absence of class restriction and broad therapeutic potential". International Journal of Oncology 48.6 (2016): 2445-2452.
Chicago
Dubois, N., Willems, M., Nguyen-Khac, M., Kroonen, J., Goffart, N., Deprez, M., Bours, V., Robe, P. A."Constitutive activation of casein kinase 2 in glioblastomas: Absence of class restriction and broad therapeutic potential". International Journal of Oncology 48, no. 6 (2016): 2445-2452. https://doi.org/10.3892/ijo.2016.3490
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