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Article

Peripheral ENO1-specific T cells mirror the intratumoral immune response and their presence is a potential prognostic factor for pancreatic adenocarcinoma

  • Authors:
    • Elena Niccolai
    • Paola Cappello
    • Antonio Taddei
    • Federica Ricci
    • Mario Milco D'Elios
    • Marisa Benagiano
    • Paolo Bechi
    • Lapo Bencini
    • Maria Novella Ringressi
    • Andrea Coratti
    • Fabio Cianchi
    • Lisa Bonello
    • Paola Francia Di Celle
    • Domenico Prisco
    • Francesco Novelli
    • Amedeo Amedei
  • View Affiliations / Copyright

    Affiliations: Department of Experimental and Clinical Medicine, University of Florence, and Department of Biomedicine, Azienda Ospedaliera Universitaria Careggi (AOUC), I-50134 Florence, Italy, Centre for Experimental Research and Medical Studies (CERMS), AOU City of Health and Science of Turin, and Department of Molecular Biotechnology and Health Sciences, University of Turin, I-10126 Turin, Italy, Department of Surgery and Translational Medicine, University of Florence, and Department of Biomedicine, Azienda Ospedaliera Universitaria Careggi (AOUC), I-50134 Florence, Italy, Division of General and Oncologic Surgery, Department of Oncology, Azienda Ospedaliera Universitaria Careggi (AOUC), I-50134 Florence, Italy, General Anatomopathology and Molecular Oncogenetics – AOU City of Health and Science of Turin, I-10126 Turin, Italy
  • Pages: 393-401
    |
    Published online on: May 16, 2016
       https://doi.org/10.3892/ijo.2016.3524
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Abstract

Pancreatic ductal adenocarcinoma (PDAC) is an aggressive disease with an average survival of 4-6 months following diagnosis. Surgical resection is the only treatment with curative intent, but resectable PDAC patients are in the minority. Also, unlike other neoplasms, PDAC is resistant to conventional and targeted chemotherapy. Innovative treatments, such as immunotherapy, can be very important and the study of the immune response is fundamental. We previously demonstrated that PDAC patients show tumor-infiltrating T cells specific to α-enolase (ENO1), a glycolytic enzyme over-expressed by pancreatic tumor cells, which plays an important role in promoting cell migration and cancer metastasis. In the present study, we evaluate the functional anticancer proprieties of ENO1-specific T cells isolated from the peripheral blood of PDAC patients. Furthermore, comparing the T cell receptor repertoire of ENO1-specific peripheral and infiltrating tumor T cells from the same patient suggests that ENO1-specific T cells, despite having a different functional profile, can recirculate from the tumor to the periphery. Finally, of clinical relevance, the presence of peripheral ENO1-specific T cells has a prognostic value and significantly correlates with a longer survival.
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Copy and paste a formatted citation
Spandidos Publications style
Niccolai E, Cappello P, Taddei A, Ricci F, D'Elios MM, Benagiano M, Bechi P, Bencini L, Ringressi MN, Coratti A, Coratti A, et al: Peripheral ENO1-specific T cells mirror the intratumoral immune response and their presence is a potential prognostic factor for pancreatic adenocarcinoma. Int J Oncol 49: 393-401, 2016.
APA
Niccolai, E., Cappello, P., Taddei, A., Ricci, F., D'Elios, M.M., Benagiano, M. ... Amedei, A. (2016). Peripheral ENO1-specific T cells mirror the intratumoral immune response and their presence is a potential prognostic factor for pancreatic adenocarcinoma. International Journal of Oncology, 49, 393-401. https://doi.org/10.3892/ijo.2016.3524
MLA
Niccolai, E., Cappello, P., Taddei, A., Ricci, F., D'Elios, M. M., Benagiano, M., Bechi, P., Bencini, L., Ringressi, M. N., Coratti, A., Cianchi, F., Bonello, L., Di Celle, P. F., Prisco, D., Novelli, F., Amedei, A."Peripheral ENO1-specific T cells mirror the intratumoral immune response and their presence is a potential prognostic factor for pancreatic adenocarcinoma". International Journal of Oncology 49.1 (2016): 393-401.
Chicago
Niccolai, E., Cappello, P., Taddei, A., Ricci, F., D'Elios, M. M., Benagiano, M., Bechi, P., Bencini, L., Ringressi, M. N., Coratti, A., Cianchi, F., Bonello, L., Di Celle, P. F., Prisco, D., Novelli, F., Amedei, A."Peripheral ENO1-specific T cells mirror the intratumoral immune response and their presence is a potential prognostic factor for pancreatic adenocarcinoma". International Journal of Oncology 49, no. 1 (2016): 393-401. https://doi.org/10.3892/ijo.2016.3524
Copy and paste a formatted citation
x
Spandidos Publications style
Niccolai E, Cappello P, Taddei A, Ricci F, D'Elios MM, Benagiano M, Bechi P, Bencini L, Ringressi MN, Coratti A, Coratti A, et al: Peripheral ENO1-specific T cells mirror the intratumoral immune response and their presence is a potential prognostic factor for pancreatic adenocarcinoma. Int J Oncol 49: 393-401, 2016.
APA
Niccolai, E., Cappello, P., Taddei, A., Ricci, F., D'Elios, M.M., Benagiano, M. ... Amedei, A. (2016). Peripheral ENO1-specific T cells mirror the intratumoral immune response and their presence is a potential prognostic factor for pancreatic adenocarcinoma. International Journal of Oncology, 49, 393-401. https://doi.org/10.3892/ijo.2016.3524
MLA
Niccolai, E., Cappello, P., Taddei, A., Ricci, F., D'Elios, M. M., Benagiano, M., Bechi, P., Bencini, L., Ringressi, M. N., Coratti, A., Cianchi, F., Bonello, L., Di Celle, P. F., Prisco, D., Novelli, F., Amedei, A."Peripheral ENO1-specific T cells mirror the intratumoral immune response and their presence is a potential prognostic factor for pancreatic adenocarcinoma". International Journal of Oncology 49.1 (2016): 393-401.
Chicago
Niccolai, E., Cappello, P., Taddei, A., Ricci, F., D'Elios, M. M., Benagiano, M., Bechi, P., Bencini, L., Ringressi, M. N., Coratti, A., Cianchi, F., Bonello, L., Di Celle, P. F., Prisco, D., Novelli, F., Amedei, A."Peripheral ENO1-specific T cells mirror the intratumoral immune response and their presence is a potential prognostic factor for pancreatic adenocarcinoma". International Journal of Oncology 49, no. 1 (2016): 393-401. https://doi.org/10.3892/ijo.2016.3524
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