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Clonal expansion of antitumor T cells in breast cancer correlates with response to neoadjuvant chemotherapy

  • Authors:
    • Jae-Hyun Park
    • Miran Jang
    • Yunus Emre Tarhan
    • Toyomasa Katagiri
    • Mitsunori Sasa
    • Yasuo Miyoshi
    • Krishna R. Kalari
    • Vera J. Suman
    • Richard Weinshilboum
    • Liewei Wang
    • Judy C. Boughey
    • Matthew P. Goetz
    • Yusuke Nakamura
  • View Affiliations / Copyright

    Affiliations: Department of Medicine, The University of Chicago, Chicago, IL 60637, USA, Division of Genome Medicine, Institute for Genome Research, The University of Tokushima, Tokushima 770-8503, Japan, Department of Surgery, Tokushima Breast Care Clinic, Tokushima 770-0052, Japan, Division of Breast and Endocrine Surgery, Department of Surgery, Hyogo College of Medicine, Hyogo 663-8501, Japan, Department of Health Sciences Research, Mayo Clinic, Rochester, MN 55905, USA, Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN 55905, USA, Department of Surgery, Mayo Clinic, Rochester, MN 55905, USA
    Copyright: © Park et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 471-478
    |
    Published online on: May 27, 2016
       https://doi.org/10.3892/ijo.2016.3540
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Abstract

The immune microenvironment of tumor plays a critical role in therapeutic responses to chemotherapy. Cancer tissues are composed of a complex network between antitumor and pro-tumor immune cells and molecules; therefore a comprehensive analysis of the tumor immune condition is imperative for better understanding of the roles of the immune microenvironment in anticancer treatment response. In this study, we performed T cell receptor (TCR) repertoire analysis of tumor infiltrating T cells (TILs) in cancer tissues of pre- and post-neoadjuvant chemotherapy (NAC) from 19 breast cancer patients; five cases showed CR (complete response), ten showed PR (partial response), and four showed SD/PD (stable disease/progressive disease) to the treatment. From the TCR sequencing results, we calculated the diversity index of the TCRβ chain and found that clonal expansion of TILs could be detected in patients who showed CR or PR to NAC. Noteworthy, the diversity of TCR was further reduced in the post-NAC tumors of CR patients. Our quantitative RT-PCR also showed that expression ratio of CD8/Foxp3 was significantly elevated in the post-NAC tumors of CR cases (p=0.0032), indicating that antitumor T cells were activated and enriched in these tumors. Collectively, our findings suggest that the clonal expansion of antitumor T cells may be a critical factor associated with response to chemotherapy and that their TCR sequences might be applicable for the development of TCR-engineered T cells treatment for individual breast cancer patients when their tumors relapse.
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View References

1 

Siegel RL, Miller KD and Jemal A: Cancer statistics, 2015. CA Cancer J Clin. 65:5–29. 2015. View Article : Google Scholar : PubMed/NCBI

2 

Early Breast Cancer Trialists' Collaborative Group (EBCTCG). Effects of chemotherapy and hormonal therapy for early breast cancer on recurrence and 15-year survival: An overview of the randomised trials. Lancet. 365:1687–1717. 2005. View Article : Google Scholar : PubMed/NCBI

3 

Kaufmann M, Hortobagyi GN, Goldhirsch A, Scholl S, Makris A, Valagussa P, Blohmer JU, Eiermann W, Jackesz R, Jonat W, et al: Recommendations from an international expert panel on the use of neoadjuvant (primary) systemic treatment of operable breast cancer: An update. J Clin Oncol. 24:1940–1949. 2006. View Article : Google Scholar : PubMed/NCBI

4 

von Minckwitz G, Untch M, Blohmer JU, Costa SD, Eidtmann H, Fasching PA, Gerber B, Eiermann W, Hilfrich J, Huober J, et al: Definition and impact of pathologic complete response on prognosis after neoadjuvant chemotherapy in various intrinsic breast cancer subtypes. J Clin Oncol. 30:1796–1804. 2012. View Article : Google Scholar : PubMed/NCBI

5 

Printz C: I-SPY 2 may change how clinical trials are conducted: Researchers aim to accelerate approvals of cancer drugs. Cancer. 119:1925–1927. 2013. View Article : Google Scholar : PubMed/NCBI

6 

Cortazar P, Zhang L, Untch M, Mehta K, Costantino JP, Wolmark N, Bonnefoi H, Cameron D, Gianni L, Valagussa P, et al: Pathological complete response and long-term clinical benefit in breast cancer: The CTNeoBC pooled analysis. Lancet. 384:164–172. 2014. View Article : Google Scholar : PubMed/NCBI

7 

Denkert C, Loibl S, Noske A, Roller M, Müller BM, Komor M, Budczies J, Darb-Esfahani S, Kronenwett R, Hanusch C, et al: Tumor-associated lymphocytes as an independent predictor of response to neoadjuvant chemotherapy in breast cancer. J Clin Oncol. 28:105–113. 2010. View Article : Google Scholar

8 

Jochems C and Schlom J: Tumor-infiltrating immune cells and prognosis: The potential link between conventional cancer therapy and immunity. Exp Biol Med (Maywood). 236:567–579. 2011. View Article : Google Scholar

9 

Mao Y, Qu Q, Zhang Y, Liu J, Chen X and Shen K: The value of tumor infiltrating lymphocytes (TILs) for predicting response to neoadjuvant chemotherapy in breast cancer: A systematic review and meta-analysis. PLoS One. 9:e1151032014. View Article : Google Scholar : PubMed/NCBI

10 

Tumeh PC, Harview CL, Yearley JH, Shintaku IP, Taylor EJ, Robert L, Chmielowski B, Spasic M, Henry G, Ciobanu V, et al: PD-1 blockade induces responses by inhibiting adaptive immune resistance. Nature. 515:568–571. 2014. View Article : Google Scholar : PubMed/NCBI

11 

Qi Q, Liu Y, Cheng Y, Glanville J, Zhang D, Lee JY, Olshen RA, Weyand CM, Boyd SD and Goronzy JJ: Diversity and clonal selection in the human T-cell repertoire. Proc Natl Acad Sci USA. 111:13139–13144. 2014. View Article : Google Scholar : PubMed/NCBI

12 

Scaviner D and Lefranc MP: The human T cell receptor alpha variable (TRAV) genes. Exp Clin Immunogenet. 17:83–96. 2000. View Article : Google Scholar : PubMed/NCBI

13 

Folch G and Lefranc MP: The human T cell receptor beta variable (TRBV) genes. Exp Clin Immunogenet. 17:42–54. 2000. View Article : Google Scholar : PubMed/NCBI

14 

Clambey ET, Davenport B, Kappler JW, Marrack P and Homann D: Molecules in medicine mini review: The αβ T cell receptor. J Mol Med Berl. 92:735–741. 2014. View Article : Google Scholar

15 

Fang H, Yamaguchi R, Liu X, Daigo Y, Yew PY, Tanikawa C, Matsuda K, Imoto S, Miyano S and Nakamura Y: Quantitative T cell repertoire analysis by deep cDNA sequencing of T cell receptor α and β chains using next-generation sequencing (NGS). Oncoimmunology. 3:e9684672015. View Article : Google Scholar

16 

Liu X, Venkataraman G, Lin J, Kiyotani K, Smith S, Montoya M, Nakamura Y and Kline J: Highly clonal regulatory T-cell population in follicular lymphoma - inverse correlation with the diversity of CD8(+) T cells. Oncoimmunology. 4:e10027282015. View Article : Google Scholar

17 

Jang M, Yew PY, Hasegawa K, Ikeda Y, Fujiwara K, Fleming GF, Nakamura Y and Park JH: Characterization of T cell repertoire of blood, tumor, and ascites in ovarian cancer patients using next generation sequencing. Oncoimmunology. 4:e10305612015. View Article : Google Scholar : PubMed/NCBI

18 

Yew PY, Alachkar H, Yamaguchi R, Kiyotani K, Fang H, Yap KL, Liu HT, Wickrema A, Artz A, van Besien K, et al: Quantitative characterization of T-cell repertoire in allogeneic hematopoietic stem cell transplant recipients. Bone Marrow Transplant. 50:1227–1234. 2015. View Article : Google Scholar : PubMed/NCBI

19 

Tamura K, Hazama S, Yamaguchi R, Imoto S, Takenouchi H, Inoue Y, et al: Characterization of T cell repertoire in tumor tissues and blood in advanced colorectal cancers through deep T cell receptor sequencing. Oncol Lett. (In press).

20 

Choudhury NJ, Kiyotani K, Yap KL, Campanile A, Antic T, Yew PY, Steinberg G, Park JH, Nakamura Y and O'Donnell PH: Low T cell receptor diversity, high somatic mutation burden, and high neoantigen load as predictors of clinical outcome in muscle-invasive bladder cancer. Eur Urol Focus. Oct 8–2015. View Article : Google Scholar

21 

Ellingson MS, Hart SN, Kalari KR, Suman V, Schahl KA, Dockter TJ, Felten SJ, Sinnwell JP, Thompson KJ, Tang X, et al: Exome sequencing reveals frequent deleterious germline variants in cancer susceptibility genes in women with invasive breast cancer undergoing neoadjuvant chemotherapy. Breast Cancer Res Treat. 153:435–443. 2015. View Article : Google Scholar : PubMed/NCBI

22 

Giudicelli V, Chaume D and Lefranc MP: IMGT/GENE-DB: A comprehensive database for human and mouse immunoglobulin and T cell receptor genes. Nucleic Acids Res. 33:D256–D261. 2005. View Article : Google Scholar :

23 

Langmead B and Salzberg SL: Fast gapped-read alignment with Bowtie 2. Nat Methods. 9:357–359. 2012. View Article : Google Scholar : PubMed/NCBI

24 

Bolotin DA, Shugay M, Mamedov IZ, Putintseva EV, Turchaninova MA, Zvyagin IV, Britanova OV and Chudakov DM: MiTCR: Software for T-cell receptor sequencing data analysis. Nat Methods. 10:813–814. 2013. View Article : Google Scholar : PubMed/NCBI

25 

Turley SJ, Cremasco V and Astarita JL: Immunological hallmarks of stromal cells in the tumour microenvironment. Nat Rev Immunol. 15:669–682. 2015. View Article : Google Scholar : PubMed/NCBI

26 

Park JH: Immune microenvironment to predict response of cancer chemotherapy and radiotherapy. Immunopharmacogenomics. Nakamura Y: Springer; Tokyo: pp. 143–155. 2015, View Article : Google Scholar

27 

Gebremeskel S and Johnston B: Concepts and mechanisms underlying chemotherapy induced immunogenic cell death: Impact on clinical studies and considerations for combined therapies. Oncotarget. 6:41600–41619. 2015.PubMed/NCBI

28 

Hong M, Puaux A-L, Huang C, Loumagne L, Tow C, Mackay C, Kato M, Prévost-Blondel A, Avril MF, Nardin A, et al: Chemotherapy induces intratumoral expression of chemokines in cutaneous melanoma, favoring T-cell infiltration and tumor control. Cancer Res. 71:6997–7009. 2011. View Article : Google Scholar : PubMed/NCBI

29 

Oda N, Shimazu K, Naoi Y, Morimoto K, Shimomura A, Shimoda M, Kagara N, Maruyama N, Kim SJ and Noguchi S: Intratumoral regulatory T cells as an independent predictive factor for pathological complete response to neoadjuvant paclitaxel followed by 5-FU/epirubicin/cyclophosphamide in breast cancer patients. Breast Cancer Res Treat. 136:107–116. 2012. View Article : Google Scholar : PubMed/NCBI

30 

Matsushita N, Pilon-Thomas SA, Martin LM and Riker AI: Comparative methodologies of regulatory T cell depletion in a murine melanoma model. J Immunol Methods. 333:167–179. 2008. View Article : Google Scholar : PubMed/NCBI

31 

Ladoire S, Arnould L, Apetoh L, Coudert B, Martin F, Chauffert B, Fumoleau P and Ghiringhelli F: Pathologic complete response to neoadjuvant chemotherapy of breast carcinoma is associated with the disappearance of tumor-infiltrating foxp3+ regulatory T cells. Clin Cancer Res. 14:2413–2420. 2008. View Article : Google Scholar : PubMed/NCBI

32 

Han A, Glanville J, Hansmann L and Davis MM: Linking T-cell receptor sequence to functional phenotype at the single-cell level. Nat Biotechnol. 32:684–692. 2014. View Article : Google Scholar : PubMed/NCBI

33 

Nakamura Y: Challenges and future directions of immunopharmacogenomics. Immunopharmacogenomics. Nakamura Y: Springer; Tokyo: pp. 159–162. 2015, View Article : Google Scholar

34 

Rapoport AP, Stadtmauer EA, Binder-Scholl GK, Goloubeva O, Vogl DT, Lacey SF, Badros AZ, Garfall A, Weiss B, Finklestein J, et al: NY-ESO-1-specific TCR-engineered T cells mediate sustained antigen-specific antitumor effects in myeloma. Nat Med. 21:914–921. 2015. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Park J, Jang M, Tarhan YE, Katagiri T, Sasa M, Miyoshi Y, Kalari KR, Suman VJ, Weinshilboum R, Wang L, Wang L, et al: Clonal expansion of antitumor T cells in breast cancer correlates with response to neoadjuvant chemotherapy. Int J Oncol 49: 471-478, 2016.
APA
Park, J., Jang, M., Tarhan, Y.E., Katagiri, T., Sasa, M., Miyoshi, Y. ... Nakamura, Y. (2016). Clonal expansion of antitumor T cells in breast cancer correlates with response to neoadjuvant chemotherapy. International Journal of Oncology, 49, 471-478. https://doi.org/10.3892/ijo.2016.3540
MLA
Park, J., Jang, M., Tarhan, Y. E., Katagiri, T., Sasa, M., Miyoshi, Y., Kalari, K. R., Suman, V. J., Weinshilboum, R., Wang, L., Boughey, J. C., Goetz, M. P., Nakamura, Y."Clonal expansion of antitumor T cells in breast cancer correlates with response to neoadjuvant chemotherapy". International Journal of Oncology 49.2 (2016): 471-478.
Chicago
Park, J., Jang, M., Tarhan, Y. E., Katagiri, T., Sasa, M., Miyoshi, Y., Kalari, K. R., Suman, V. J., Weinshilboum, R., Wang, L., Boughey, J. C., Goetz, M. P., Nakamura, Y."Clonal expansion of antitumor T cells in breast cancer correlates with response to neoadjuvant chemotherapy". International Journal of Oncology 49, no. 2 (2016): 471-478. https://doi.org/10.3892/ijo.2016.3540
Copy and paste a formatted citation
x
Spandidos Publications style
Park J, Jang M, Tarhan YE, Katagiri T, Sasa M, Miyoshi Y, Kalari KR, Suman VJ, Weinshilboum R, Wang L, Wang L, et al: Clonal expansion of antitumor T cells in breast cancer correlates with response to neoadjuvant chemotherapy. Int J Oncol 49: 471-478, 2016.
APA
Park, J., Jang, M., Tarhan, Y.E., Katagiri, T., Sasa, M., Miyoshi, Y. ... Nakamura, Y. (2016). Clonal expansion of antitumor T cells in breast cancer correlates with response to neoadjuvant chemotherapy. International Journal of Oncology, 49, 471-478. https://doi.org/10.3892/ijo.2016.3540
MLA
Park, J., Jang, M., Tarhan, Y. E., Katagiri, T., Sasa, M., Miyoshi, Y., Kalari, K. R., Suman, V. J., Weinshilboum, R., Wang, L., Boughey, J. C., Goetz, M. P., Nakamura, Y."Clonal expansion of antitumor T cells in breast cancer correlates with response to neoadjuvant chemotherapy". International Journal of Oncology 49.2 (2016): 471-478.
Chicago
Park, J., Jang, M., Tarhan, Y. E., Katagiri, T., Sasa, M., Miyoshi, Y., Kalari, K. R., Suman, V. J., Weinshilboum, R., Wang, L., Boughey, J. C., Goetz, M. P., Nakamura, Y."Clonal expansion of antitumor T cells in breast cancer correlates with response to neoadjuvant chemotherapy". International Journal of Oncology 49, no. 2 (2016): 471-478. https://doi.org/10.3892/ijo.2016.3540
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