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Article

MicroRNA-205 directly targets Krüppel-like factor 12 and is involved in invasion and apoptosis in basal-like breast carcinoma

  • Authors:
    • Bing Guan
    • Qing Li
    • Li Shen
    • Qiu Rao
    • Yan Wang
    • Yun Zhu
    • Xiao-Jun Zhou
    • Xiao-Hong Li
  • View Affiliations / Copyright

    Affiliations: Department of Pathology, Shanghai 6th People's Hospital Jinshan Branch, Shanghai 201599, P.R. China, Department of Pathology, Shanghai Pudong New Area People's Hospital, Shanghai 201299, P.R. China, Department of Cardiothoracic Surgery, Shanghai Children's Hospital, Shanghai 201040, P.R. China, Department of Pathology, Nanjing Jinling Hospital, Nanjing, Jiangsu 210002, P.R. China, Department of Pathology, The Second Affiliated Hospital with Nanjing Medical University, Nanjing, Jiangsu 210000, P.R. China, Department of Pathology, Jiangsu Province People's Hospital, Nanjing, Jiangsu 210029, P.R. China
  • Pages: 720-734
    |
    Published online on: June 8, 2016
       https://doi.org/10.3892/ijo.2016.3573
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Abstract

We investigated microRNAs (miRs) specific to its target gene and exerting distinct biological functions for basal-like breast carcinoma (BLBC). Total RNA was extracted and subjected to miR microarray and bioinformatics analysis. Based on the comprehensive analysis, expression of miRs including its target was analyzed by quantitative reverse transcription-polymerase chain reaction (qRT-PCR), western blot analysis and immunohistochemistry (IHC). Further functional analyses were conducted including proliferation, invasion and apoptosis. miR-205 was identified as downregulated (less than 0.5-fold) in BLBC relatively to normal control (NC). Gene ontology (GO) analysis suggested miR-205 may directly targeted Krüppel-like factor 12 (KLF12; degree=4). Luciferase assay revealed miR-205 directly targeted KLF12 through binding its 3'-untranslated region (3'-UTR; p=0.0016). qRT-PCR and western blot analysis showed miR-205 expression was low in cells (p=0.007) and tumor tissues (n=6; p=0.0074), and KLF12 RNA/protein was observed at high levels in cells (p=0.0026; p=0.0079) and tumor tissues (n=9; p=0.0083); knock-up of miR-205 increased its expression (p=0.0021) but reduced KLF12 RNA/protein levels (p=0.0038; p=0.009) in cells. Modulation of miR-205 expression by transfecting its mimics in cells, was involved in invasion (p=0.00175) and apoptosis (p=0.006). In conclusion, our results supported that miR-205 was a miR specific to BLBC which functioned as tumor suppressor gene through directly targeting and negatively regulating proto-oncogene KLF12. miR-205 dysregulation was involved in invasion and apoptosis. miR-205 and KLF12 provided a potential diagnosis biomarker and therapeutic approach for BLBC.
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1 

Torre LA, Bray F, Siegel RL, Ferlay J, Lortet-Tieulent J and Jemal A: Global cancer statistics, 2012. CA Cancer J Clin. 65:87–108. 2015. View Article : Google Scholar : PubMed/NCBI

2 

Badve S, Dabbs DJ, Schnitt SJ, Baehner FL, Decker T, Eusebi V, Fox SB, Ichihara S, Jacquemier J, Lakhani SR, et al: Basal-like and triple-negative breast cancers: A critical review with an emphasis on the implications for pathologists and oncologists. Mod Pathol. 24:157–167. 2011. View Article : Google Scholar

3 

Haupt B, Ro JY and Schwartz MR: Basal-like breast carcinoma: A phenotypically distinct entity. Arch Pathol Lab Med. 134:130–133. 2010.PubMed/NCBI

4 

Rakha E and Reis-Filho JS: Basal-like breast carcinoma: From expression profiling to routine practice. Arch Pathol Lab Med. 133:860–868. 2009.PubMed/NCBI

5 

Silva F, Carvalho S, Milanezi F and Schmitt FC: Basal-like carcinoma of the breast. Acta Med Port. 21:373–378. 2008.(In Portuguese). PubMed/NCBI

6 

Su CM, Wang MY, Hong CC, et al: miR-520h is crucial for DAPK2 regulation and breast cancer progression. Oncogene. 2015.

7 

Baek D, Villén J, Shin C, Camargo FD, Gygi SP and Bartel DP: The impact of microRNAs on protein output. Nature. 455:64–71. 2008. View Article : Google Scholar : PubMed/NCBI

8 

Schmittgen TD: Regulation of microRNA processing in development, differentiation and cancer. J Cell Mol Med. 12:1811–1819. 2008. View Article : Google Scholar : PubMed/NCBI

9 

Croce CM: Causes and consequences of microRNA dysregulation in cancer. Nat Rev Genet. 10:704–714. 2009. View Article : Google Scholar : PubMed/NCBI

10 

Vilquin P, Donini CF, Villedieu M, Grisard E, Corbo L, Bachelot T, Vendrell JA and Cohen PA: MicroRNA-125b upregulation confers aromatase inhibitor resistance and is a novel marker of poor prognosis in breast cancer. Breast Cancer Res. 17:132015. View Article : Google Scholar : PubMed/NCBI

11 

Hu Y, Xu K and Yagüe E: miR-218 targets survivin and regulates resistance to chemotherapeutics in breast cancer. Breast Cancer Res Treat. 151:269–280. 2015. View Article : Google Scholar : PubMed/NCBI

12 

Liu R, Liu C, Chen D, Yang WH, Liu X, Liu CG, Dugas CM, Tang F, Zheng P, Liu Y, et al: FOXP3 controls a miR-146/NF-κB negative feedback loop that inhibits apoptosis in breast cancer cells. Cancer Res. 75:1703–1713. 2015. View Article : Google Scholar : PubMed/NCBI

13 

Zhang G, Hou X, Li Y and Zhao M: MiR-205 inhibits cell apoptosis by targeting phosphatase and tensin homolog deleted on chromosome ten in endometrial cancer Ishikawa cells. BMC Cancer. 14:4402014. View Article : Google Scholar : PubMed/NCBI

14 

Iorio MV, Casalini P, Piovan C, Di Leva G, Merlo A, Triulzi T, Ménard S, Croce CM and Tagliabue E: microRNA-205 regulates HER3 in human breast cancer. Cancer Res. 69:2195–2200. 2009. View Article : Google Scholar : PubMed/NCBI

15 

Verdoodt B, Neid M, Vogt M, Kuhn V, Liffers ST, Palisaar RJ, Noldus J, Tannapfel A and Mirmohammadsadegh A: MicroRNA-205, a novel regulator of the anti-apoptotic protein Bcl2, is downregulated in prostate cancer. Int J Oncol. 43:307–314. 2013.PubMed/NCBI

16 

Matsushima K, Isomoto H, Yamaguchi N, Inoue N, Machida H, Nakayama T, Hayashi T, Kunizaki M, Hidaka S, Nagayasu T, et al: MiRNA-205 modulates cellular invasion and migration via regulating zinc finger E-box binding homeobox 2 expression in esophageal squamous cell carcinoma cells. J Transl Med. 9:302011. View Article : Google Scholar : PubMed/NCBI

17 

Yue X, Wang P, Xu J, Zhu Y, Sun G, Pang Q and Tao R: MicroRNA-205 functions as a tumor suppressor in human glioblastoma cells by targeting VEGF-A. Oncol Rep. 27:1200–1206. 2012.

18 

Chen Z, Tang ZY, He Y, Liu LF, Li DJ and Chen X: miRNA-205 is a candidate tumor suppressor that targets ZEB2 in renal cell carcinoma. Oncol Res Treat. 37:658–664. 2014. View Article : Google Scholar : PubMed/NCBI

19 

Qin AY, Zhang XW, Liu L, Yu JP, Li H, Wang SZ, Ren XB and Cao S: MiR-205 in cancer: An angel or a devil? Eur J Cell Biol. 92:54–60. 2013. View Article : Google Scholar : PubMed/NCBI

20 

Bureau C, Hanoun N, Torrisani J, Vinel JP, Buscail L and Cordelier P: Expression and function of Kruppel like-factors (KLF) in carcinogenesis. Curr Genomics. 10:353–360. 2009. View Article : Google Scholar :

21 

Schuierer M, Hilger-Eversheim K, Dobner T, Bosserhoff AK, Moser M, Turner J, Crossley M and Buettner R: Induction of AP-2alpha expression by adenoviral infection involves inactivation of the AP-2rep transcriptional corepressor CtBP1. J Biol Chem. 276:27944–27949. 2001. View Article : Google Scholar : PubMed/NCBI

22 

Nakamura Y, Migita T, Hosoda F, Okada N, Gotoh M, Arai Y, Fukushima M, Ohki M, Miyata S, Takeuchi K, et al: Kruppel-like factor 12 plays a significant role in poorly differentiated gastric cancer progression. Int J Cancer. 125:1859–1867. 2009. View Article : Google Scholar : PubMed/NCBI

23 

Shen X, Hu Y, Jiang Y, Liu H, Zhu L, Jin X, Shan H, Zhen X, Sun L, Yan G, et al: Krüppel-like factor 12 negatively regulates human endometrial stromal cell decidualization. Biochem Biophys Res Commun. 433:11–17. 2013. View Article : Google Scholar : PubMed/NCBI

24 

Bloom HJ: Complications following radiotherapy of the thorax and abdomen. Proc R Soc Med. 52:495–500. 1959.PubMed/NCBI

25 

Elston CW and Ellis IO: Pathological prognostic factors in breast cancer. I The value of histological grade in breast cancer: Experience from a large study with long-term follow-up. Histopathology. 19:403–410. 1991. View Article : Google Scholar : PubMed/NCBI

26 

Finn RS, Dering J, Ginther C, Wilson CA, Glaspy P, Tchekmedyian N and Slamon DJ: Dasatinib, an orally active small molecule inhibitor of both the src and abl kinases, selectively inhibits growth of basal-type/'triple-negative' breast cancer cell lines growing in vitro. Breast Cancer Res Treat. 105:319–326. 2007. View Article : Google Scholar : PubMed/NCBI

27 

Nielsen TO, Hsu FD, Jensen K, Cheang M, Karaca G, Hu Z, Hernandez-Boussard T, Livasy C, Cowan D, Dressler L, et al: Immunohistochemical and clinical characterization of the basal-like subtype of invasive breast carcinoma. Clin Cancer Res. 10:5367–5374. 2004. View Article : Google Scholar : PubMed/NCBI

28 

Gene Ontology Consortium. The Gene Ontology (GO) project in 2006. Nucleic Acids Res. 34:D322–D326. 2006. View Article : Google Scholar :

29 

Blake JA and Harris MA: The Gene Ontology (GO) project: structured vocabularies for molecular biology and their application to genome and expression analysis. Curr Protoc Bioinformatics. Chapter 7(Unit 7): 22008.PubMed/NCBI

30 

Camon E, Magrane M, Barrell D, Binns D, Fleischmann W, Kersey P, Mulder N, Oinn T, Maslen J, Cox A, et al: The Gene Ontology Annotation (GOA) project: Implementation of GO in SWISS-PROT, TrEMBL, and InterPro. Genome Res. 13:662–672. 2003. View Article : Google Scholar : PubMed/NCBI

31 

Guo CJ, Pan Q, Li DG, Sun H and Liu BW: miR-15b and miR-16 are implicated in activation of the rat hepatic stellate cell: An essential role for apoptosis. J Hepatol. 50:766–778. 2009. View Article : Google Scholar : PubMed/NCBI

32 

Rajewsky N: microRNA target predictions in animals. Nat Genet. 38(Suppl): S8–S13. 2006. View Article : Google Scholar : PubMed/NCBI

33 

Storey JD and Tibshirani R: Statistical significance for genomewide studies. Proc Natl Acad Sci USA. 100:9440–9445. 2003. View Article : Google Scholar : PubMed/NCBI

34 

Lewis BP, Burge CB and Bartel DP: Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets. Cell. 120:15–20. 2005. View Article : Google Scholar : PubMed/NCBI

35 

Lewis BP, Shih IH, Jones-Rhoades MW, Bartel DP and Burge CB: Prediction of mammalian microRNA targets. Cell. 115:787–798. 2003. View Article : Google Scholar : PubMed/NCBI

36 

Krek A, Grün D, Poy MN, Wolf R, Rosenberg L, Epstein EJ, MacMenamin P, da Piedade I, Gunsalus KC, Stoffel M, et al: Combinatorial microRNA target predictions. Nat Genet. 37:495–500. 2005. View Article : Google Scholar : PubMed/NCBI

37 

John B, Enright AJ, Aravin A, Tuschl T, Sander C and Marks DS: Human microRNA targets. PLoS Biol. 2:e3632004. View Article : Google Scholar : PubMed/NCBI

38 

Creighton CJ, Nagaraja AK, Hanash SM, Matzuk MM and Gunaratne PH: A bioinformatics tool for linking gene expression profiling results with public databases of microRNA target predictions. RNA. 14:2290–2296. 2008. View Article : Google Scholar : PubMed/NCBI

39 

Shalgi R, Lieber D, Oren M and Pilpel Y: Global and local architecture of the mammalian microRNA-transcription factor regulatory network. PLoS Comput Biol. 3:e1312007. View Article : Google Scholar : PubMed/NCBI

40 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(−Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar

41 

Ishihara A, Tsuda H, Kitagawa K, Yoneda M and Shiraishi T: Morphological characteristics of basal-like subtype of breast carcinoma with special reference to cytopathological features. Breast Cancer. 16:179–185. 2009. View Article : Google Scholar : PubMed/NCBI

42 

Wu H and Mo YY: Targeting miR-205 in breast cancer. Expert Opin Ther Targets. 13:1439–1448. 2009. View Article : Google Scholar : PubMed/NCBI

43 

Piovan C, Palmieri D, Di Leva G, Braccioli L, Casalini P, Nuovo G, Tortoreto M, Sasso M, Plantamura I, Triulzi T, et al: Oncosuppressive role of p53-induced miR-205 in triple negative breast cancer. Mol Oncol. 6:458–472. 2012. View Article : Google Scholar : PubMed/NCBI

44 

Wang S, Huang J, Lyu H, Lee CK, Tan J, Wang J and Liu B: Functional cooperation of miR-125a, miR-125b, and miR-205 in entinostat-induced downregulation of erbB2/erbB3 and apoptosis in breast cancer cells. Cell Death Dis. 4:e5562013. View Article : Google Scholar : PubMed/NCBI

45 

Kim JS, Yu SK, Lee MH, Park MG, Park E, Kim SG, Lee SY, Kim CS, Kim HJ, Chun HS, et al: MicroRNA-205 directly regulates the tumor suppressor, interleukin-24, in human KB oral cancer cells. Mol Cells. 35:17–24. 2013. View Article : Google Scholar

46 

Zhang Q, Zhang H, Jiang Y, Xue B, Diao Z, Ding L, Zhen X, Sun H, Yan G and Hu Y: MicroRNA-181a is involved in the regulation of human endometrial stromal cell decidualization by inhibiting Krüppel-like factor 12. Reprod Biol Endocrinol. 13:232015. View Article : Google Scholar

47 

Bosher JM, Williams T and Hurst HC: The developmentally regulated transcription factor AP-2 is involved in c-erbB-2 over-expression in human mammary carcinoma. Proc Natl Acad Sci USA. 92:744–747. 1995. View Article : Google Scholar

48 

Moser M, Pscherer A, Roth C, Becker J, Mücher G, Zerres K, Dixkens C, Weis J, Guay-Woodford L, Buettner R, et al: Enhanced apoptotic cell death of renal epithelial cells in mice lacking transcription factor AP-2beta. Genes Dev. 11:1938–1948. 1997. View Article : Google Scholar : PubMed/NCBI

49 

Gaubatz S, Imhof A, Dosch R, Werner O, Mitchell P, Buettner R and Eilers M: Transcriptional activation by Myc is under negative control by the transcription factor AP-2. EMBO J. 14:1508–1519. 1995.PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Guan B, Li Q, Shen L, Rao Q, Wang Y, Zhu Y, Zhou X and Li X: MicroRNA-205 directly targets Krüppel-like factor 12 and is involved in invasion and apoptosis in basal-like breast carcinoma. Int J Oncol 49: 720-734, 2016.
APA
Guan, B., Li, Q., Shen, L., Rao, Q., Wang, Y., Zhu, Y. ... Li, X. (2016). MicroRNA-205 directly targets Krüppel-like factor 12 and is involved in invasion and apoptosis in basal-like breast carcinoma. International Journal of Oncology, 49, 720-734. https://doi.org/10.3892/ijo.2016.3573
MLA
Guan, B., Li, Q., Shen, L., Rao, Q., Wang, Y., Zhu, Y., Zhou, X., Li, X."MicroRNA-205 directly targets Krüppel-like factor 12 and is involved in invasion and apoptosis in basal-like breast carcinoma". International Journal of Oncology 49.2 (2016): 720-734.
Chicago
Guan, B., Li, Q., Shen, L., Rao, Q., Wang, Y., Zhu, Y., Zhou, X., Li, X."MicroRNA-205 directly targets Krüppel-like factor 12 and is involved in invasion and apoptosis in basal-like breast carcinoma". International Journal of Oncology 49, no. 2 (2016): 720-734. https://doi.org/10.3892/ijo.2016.3573
Copy and paste a formatted citation
x
Spandidos Publications style
Guan B, Li Q, Shen L, Rao Q, Wang Y, Zhu Y, Zhou X and Li X: MicroRNA-205 directly targets Krüppel-like factor 12 and is involved in invasion and apoptosis in basal-like breast carcinoma. Int J Oncol 49: 720-734, 2016.
APA
Guan, B., Li, Q., Shen, L., Rao, Q., Wang, Y., Zhu, Y. ... Li, X. (2016). MicroRNA-205 directly targets Krüppel-like factor 12 and is involved in invasion and apoptosis in basal-like breast carcinoma. International Journal of Oncology, 49, 720-734. https://doi.org/10.3892/ijo.2016.3573
MLA
Guan, B., Li, Q., Shen, L., Rao, Q., Wang, Y., Zhu, Y., Zhou, X., Li, X."MicroRNA-205 directly targets Krüppel-like factor 12 and is involved in invasion and apoptosis in basal-like breast carcinoma". International Journal of Oncology 49.2 (2016): 720-734.
Chicago
Guan, B., Li, Q., Shen, L., Rao, Q., Wang, Y., Zhu, Y., Zhou, X., Li, X."MicroRNA-205 directly targets Krüppel-like factor 12 and is involved in invasion and apoptosis in basal-like breast carcinoma". International Journal of Oncology 49, no. 2 (2016): 720-734. https://doi.org/10.3892/ijo.2016.3573
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