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Article

HOXB4 knockdown reverses multidrug resistance of human myelogenous leukemia K562/ADM cells by downregulating P-gp, MRP1 and BCRP expression via PI3K/Akt signaling pathway

  • Authors:
    • Hong Wang
    • Xiu-Hong Jia
    • Jie-Ru Chen
    • Ying-Jie Yi
    • Jian-Yong Wang
    • You-Jie Li
    • Shu-Yang Xie
  • View Affiliations / Copyright

    Affiliations: Department of Pediatrics, The Affiliated Hospital of Binzhou Medical University, Binzhou, Shandong 256603, P.R. China, Department of Biochemistry and Molecular Biology, Key Laboratory of Tumour Molecular Biology, Binzhou Medical University, Yantai, Shandong 264003, P.R. China
  • Pages: 2529-2537
    |
    Published online on: October 18, 2016
       https://doi.org/10.3892/ijo.2016.3738
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Abstract

Multidrug resistance (MDR) plays a pivotal role in human chronic myelogenous leukemia (CML) chemotherapy failure. MDR is mainly associated with the overexpression of drug efflux transporters of the ATP-binding cassette (ABC) proteins. Phosphoinositide 3-kinase (PI3K)/Akt signaling cascade is involved in the MDR phenotype and is correlated with multidrug resistance 1 (MDR1)/P-glycoprotein (P-gp), multidrug resistance-associated protein 1 (MRP1) and breast cancer resistance protein (BCRP) expression in many human malignancies. Homeobox (HOX) B4, a member of the HOX gene family, has been reported to be correlated with occurrence, development, poor prognosis and drug resistance of human leukemia. In the present study, HOXB4 expression was analyzed in K562 cell line and its MDR subline K562/ADM. Compared with K562 cells, drug-resistant K562/ADM cells demonstrated evidently higher HOXB4 expression. In addition, we firstly investigated the reversal effect of HOXB4 deletion on K562/ADM cells and the underlying mechanism. The Cell Counting kit-8 (CCK-8) and flow cytometry assays showed that knockdown of HOXB4 enhanced chemosensitivity and decreased drug efflux in K562/ADM cells. Moreover, HOXB4 knockout led to downregulation of P-gp, MRP1 and BCRP expression and PI3K/Akt signaling activity, suggesting that repression of HOXB4 might be a key point to reverse MDR of K562/ADM cells.
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1 

Cao R, Wang Y and Huang N: Discovery of 2-acylaminothiophene-3-carboxamides as multitarget inhibitors for BCR-ABL kinase and microtubules. J Chem Inf Model. 55:2435–2442. 2015. View Article : Google Scholar : PubMed/NCBI

2 

Mathisen MS, Kantarjian HM, Cortes J and Jabbour E: Mutant BCR-ABL clones in chronic myeloid leukemia. Haematologica. 96:347–349. 2011. View Article : Google Scholar : PubMed/NCBI

3 

Yandim MK, Ceylan C, Elmas E and Baran Y: A molecular and biophysical comparison of macromolecular changes in imatinib-sensitive and imatinib-resistant K562 cells exposed to ponatinib. Tumour Biol. 37:2365–2378. 2016. View Article : Google Scholar

4 

O’Hare T, Shakespeare WC, Zhu X, Eide CA, Rivera VM, Wang F, Adrian LT, Zhou T, Huang WS, Xu Q, et al: AP24534, a pan-BCR-ABL inhibitor for chronic myeloid leukemia, potently inhibits the T315I mutant and overcomes mutation-based resistance. Cancer Cell. 16:401–412. 2009. View Article : Google Scholar

5 

Sweet K and Pinilla-Ibarz J: Early switch in tyrosine kinase inhibitor therapy for patients with chronic myeloid leukemia: An emerging clinical question. Crit Rev Oncol Hematol. 103:99–108. 2016. View Article : Google Scholar : PubMed/NCBI

6 

Hochhaus A, Ernst T, Eigendorff E and La Rosée P: Causes of resistance and treatment choices of second- and third-line treatment in chronic myelogenous leukemia patients. Ann Hematol. 94(Suppl 2): S133–S140. 2015. View Article : Google Scholar : PubMed/NCBI

7 

La Rosée P, Corbin AS, Stoffregen EP, Deininger MW and Druker BJ: Activity of the Bcr-Abl kinase inhibitor PD180970 against clinically relevant Bcr-Abl isoforms that cause resistance to imatinib mesylate (Gleevec, STI571). Cancer Res. 62:7149–7153. 2002.PubMed/NCBI

8 

Corrêa S, Binato R, Du Rocher B, Castelo-Branco MT, Pizzatti L and Abdelhay E: Wnt/β-catenin pathway regulates ABCB1 transcription in chronic myeloid leukemia. BMC Cancer. 12:3032012. View Article : Google Scholar

9 

Gottesman MM: Mechanisms of cancer drug resistance. Annu Rev Med. 53:615–627. 2002. View Article : Google Scholar : PubMed/NCBI

10 

Ambudkar SV, Kimchi-Sarfaty C, Sauna ZE and Gottesman MM: P-glycoprotein: From genomics to mechanism. Oncogene. 22:7468–7485. 2003. View Article : Google Scholar : PubMed/NCBI

11 

Kalle AM, Sachchidanand S and Pallu R: Bcr-Abl-independent mechanism of resistance to imatinib in K562 cells: Induction of cyclooxygenase-2 (COX-2) by histone deacetylases (HDACs). Leuk Res. 34:1132–1138. 2010. View Article : Google Scholar : PubMed/NCBI

12 

Hoegg S and Meyer A: Hox clusters as models for vertebrate genome evolution. Trends Genet. 21:421–424. 2005. View Article : Google Scholar : PubMed/NCBI

13 

Cillo C, Cantile M, Faiella A and Boncinelli E: Homeobox genes in normal and malignant cells. J Cell Physiol. 188:161–169. 2001. View Article : Google Scholar : PubMed/NCBI

14 

Li N, Jia X, Wang J, Li Y and Xie S: Knockdown of homeobox A5 by small hairpin RNA inhibits proliferation and enhances cytarabine chemosensitivity of acute myeloid leukemia cells. Mol Med Rep. 12:6861–6866. 2015.PubMed/NCBI

15 

Yi YJ, Jia XH, Wang JY, Li YJ, Wang H and Xie SY: Knockdown of HOXA10 reverses the multidrug resistance of human chronic mylogenous leukemia K562/ADM cells by downregulating P-gp and MRP-1. Int J Mol Med. 37:1405–1411. 2016.PubMed/NCBI

16 

Kavalerchik E, Goff D and Jamieson CH: Chronic myeloid leukemia stem cells. J Clin Oncol. 26:2911–2915. 2008. View Article : Google Scholar : PubMed/NCBI

17 

Thorén LA, Liuba K, Bryder D, Nygren JM, Jensen CT, Qian H, Antonchuk J and Jacobsen SE: Kit regulates maintenance of quiescent hematopoietic stem cells. J Immunol. 180:2045–2053. 2008. View Article : Google Scholar : PubMed/NCBI

18 

Zhang XB, Beard BC, Trobridge GD, Wood BL, Sale GE, Sud R, Humphries RK and Kiem HP: High incidence of leukemia in large animals after stem cell gene therapy with a HOXB4-expressing retroviral vector. J Clin Invest. 118:1502–1510. 2008. View Article : Google Scholar : PubMed/NCBI

19 

Bodey B, Bodey B Jr, Siegel SE and Kaiser HE: Immunocytochemical detection of the homeobox B3, B4, and C6 gene products in breast carcinomas. Anticancer Res. 20(5A): 3281–3286. 2000.PubMed/NCBI

20 

Bodey B, Bodey B Jr, Gröger AM, Siegel SE and Kaiser HE: Immunocytochemical detection of homeobox B3, B4, and C6 gene product expression in lung carcinomas. Anticancer Res. 20:2711–2716. 2000.PubMed/NCBI

21 

Hwang SH, Kim KU, Kim JE, Kim HH, Lee MK, Lee CH, Lee SY, Oh T and An S: Detection of HOXA9 gene methylation in tumor tissues and induced sputum samples from primary lung cancer patients. Clin Chem Lab Med. 49:699–704. 2011. View Article : Google Scholar : PubMed/NCBI

22 

Rodríguez-Rodero S, Fernández AF, Fernández-Morera JL, Castro-Santos P, Bayon GF, Ferrero C, Urdinguio RG, Gonzalez-Marquez R, Suarez C, Fernández-Vega I, et al: DNA methylation signatures identify biologically distinct thyroid cancer subtypes. J Clin Endocrinol Metab. 98:2811–2821. 2013. View Article : Google Scholar : PubMed/NCBI

23 

Jamieson CH, Ailles LE, Dylla SJ, Muijtjens M, Jones C, Zehnder JL, Gotlib J, Li K, Manz MG, Keating A, et al: Granulocyte-macrophage progenitors as candidate leukemic stem cells in blast-crisis CML. N Engl J Med. 351:657–667. 2004. View Article : Google Scholar : PubMed/NCBI

24 

Morgan R, Simpson G, Gray S, Gillett C, Tabi Z, Spicer J, Harrington KJ and Pandha HS: HOX transcription factors are potential targets and markers in malignant mesothelioma. BMC Cancer. 16:852016. View Article : Google Scholar : PubMed/NCBI

25 

Kelly Z, Moller-Levet C, McGrath S, Butler-Manuel S, Kavitha Madhuri T, Kierzek AM, Pandha H, Morgan R and Michael A: The prognostic significance of specific HOX gene expression patterns in ovarian cancer. Int J Cancer. 139:1608–1617. 2016. View Article : Google Scholar : PubMed/NCBI

26 

Gordon-Keylock SA, Jackson M, Huang C, Samuel K, Axton RA, Oostendorp RA, Taylor H, Wilson J and Forrester LM: Induction of hematopoietic differentiation of mouse embryonic stem cells by an AGM-derived stromal cell line is not further enhanced by overexpression of HOXB4. Stem Cells Dev. 19:1687–1698. 2010. View Article : Google Scholar : PubMed/NCBI

27 

Lehne G, Grasmo-Wendler UH, Berner JM, Meza-Zepeda LA, Adamsen BL, Flack A, Reiner A, Clausen OP, Hovig E and Myklebost O: Upregulation of stem cell genes in multidrug resistant K562 leukemia cells. Leuk Res. 33:1379–1385. 2009. View Article : Google Scholar : PubMed/NCBI

28 

Sheng Z, Ma L, Sun JE, Zhu LJ and Green MR: BCR-ABL suppresses autophagy through ATF5-mediated regulation of mTOR transcription. Blood. 118:2840–2848. 2011. View Article : Google Scholar : PubMed/NCBI

29 

Xie X, Tang B, Zhou J, Gao Q and Zhang P: Inhibition of the PI3K/Akt pathway increases the chemosensitivity of gastric cancer to vincristine. Oncol Rep. 30:773–782. 2013.PubMed/NCBI

30 

Cheng L, Luo S, Jin C, Ma H, Zhou H and Jia L: FUT family mediates the multidrug resistance of human hepatocellular carcinoma via the PI3K/Akt signaling pathway. Cell Death Dis. 4:e9232013. View Article : Google Scholar : PubMed/NCBI

31 

Mao Z, Zhou J, Luan J, Sheng W, Shen X and Dong X: Tamoxifen reduces P-gp-mediated multidrug resistance via inhibiting the PI3K/Akt signaling pathway in ER-negative human gastric cancer cells. Biomed Pharmacother. 68:179–183. 2014. View Article : Google Scholar

32 

Tazzari PL, Cappellini A, Ricci F, Evangelisti C, Papa V, Grafone T, Martinelli G, Conte R, Cocco L, McCubrey JA, et al: Multidrug resistance-associated protein 1 expression is under the control of the phosphoinositide 3 kinase/Akt signal transduction network in human acute myelogenous leukemia blasts. Leukemia. 21:427–438. 2007. View Article : Google Scholar : PubMed/NCBI

33 

Wang H, Jia XH, Chen JR, Wang JY and Li YJ: Osthole shows the potential to overcome P-glycoprotein-mediated multidrug resistance in human myelogenous leukemia K562/ADM cells by inhibiting the PI3K/Akt signaling pathway. Oncol Rep. 35:3659–3668. 2016.PubMed/NCBI

34 

Chen JR, Jia XH, Wang H, Yi YJ, Wang JY and Li YJ: Timosaponin A-III reverses multi-drug resistance in human chronic myelogenous leukemia K562/ADM cells via downregulation of MDR1 and MRP1 expression by inhibiting PI3K/Akt signaling pathway. Int J Oncol. 48:2063–2070. 2016.PubMed/NCBI

35 

Huang FF, Wu DS, Zhang L, Yu YH, Yuan XY, Li WJ, Chen XP, Zhao XL, Chen FP and Zeng H: Inactivation of PTEN increases ABCG2 expression and the side population through the PI3K/Akt pathway in adult acute leukemia. Cancer Lett. 336:96–105. 2013. View Article : Google Scholar : PubMed/NCBI

36 

Ma H, Cheng L, Hao K, Li Y, Song X, Zhou H and Jia L: Reversal effect of ST6GAL 1 on multidrug resistance in human leukemia by regulating the PI3K/Akt pathway and the expression of P-gp and MRP1. PLoS One. 9:e851132014. View Article : Google Scholar : PubMed/NCBI

37 

Zhang X, Dong W, Zhou H, Li H, Wang N, Miao X and Jia L: α-2,8-sialyltransferase is involved in the development of multidrug resistance via PI3K/Akt pathway in human chronic myeloid leukemia. IUBMB Life. 67:77–87. 2015. View Article : Google Scholar : PubMed/NCBI

38 

Cheng Z, Yang N, Liang W, Yan X, Li L and Pan L: Effect of phosphatase and tensin homology deleted on chromosome 10 (PTEN) gene transfection on reversal of multidrug resistance in K562/ADM cells. Leuk Lymphoma. 53:1383–1389. 2012. View Article : Google Scholar

39 

Morishita N, Tsukahara H, Chayama K, Ishida T, Washio K, Miyamura T, Yamashita N, Oda M and Morishima T: Activation of Akt is associated with poor prognosis and chemotherapeutic resistance in pediatric B-precursor acute lymphoblastic leukemia. Pediatr Blood Cancer. 59:83–89. 2012. View Article : Google Scholar

40 

Jung KA, Choi BH and Kwak MK: The c-MET/PI3K signaling is associated with cancer resistance to doxorubicin and photodynamic therapy by elevating BCRP/ABCG2 expression. Mol Pharmacol. 87:465–476. 2015. View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Wang H, Jia X, Chen J, Yi Y, Wang J, Li Y and Xie S: HOXB4 knockdown reverses multidrug resistance of human myelogenous leukemia K562/ADM cells by downregulating P-gp, MRP1 and BCRP expression via PI3K/Akt signaling pathway. Int J Oncol 49: 2529-2537, 2016.
APA
Wang, H., Jia, X., Chen, J., Yi, Y., Wang, J., Li, Y., & Xie, S. (2016). HOXB4 knockdown reverses multidrug resistance of human myelogenous leukemia K562/ADM cells by downregulating P-gp, MRP1 and BCRP expression via PI3K/Akt signaling pathway. International Journal of Oncology, 49, 2529-2537. https://doi.org/10.3892/ijo.2016.3738
MLA
Wang, H., Jia, X., Chen, J., Yi, Y., Wang, J., Li, Y., Xie, S."HOXB4 knockdown reverses multidrug resistance of human myelogenous leukemia K562/ADM cells by downregulating P-gp, MRP1 and BCRP expression via PI3K/Akt signaling pathway". International Journal of Oncology 49.6 (2016): 2529-2537.
Chicago
Wang, H., Jia, X., Chen, J., Yi, Y., Wang, J., Li, Y., Xie, S."HOXB4 knockdown reverses multidrug resistance of human myelogenous leukemia K562/ADM cells by downregulating P-gp, MRP1 and BCRP expression via PI3K/Akt signaling pathway". International Journal of Oncology 49, no. 6 (2016): 2529-2537. https://doi.org/10.3892/ijo.2016.3738
Copy and paste a formatted citation
x
Spandidos Publications style
Wang H, Jia X, Chen J, Yi Y, Wang J, Li Y and Xie S: HOXB4 knockdown reverses multidrug resistance of human myelogenous leukemia K562/ADM cells by downregulating P-gp, MRP1 and BCRP expression via PI3K/Akt signaling pathway. Int J Oncol 49: 2529-2537, 2016.
APA
Wang, H., Jia, X., Chen, J., Yi, Y., Wang, J., Li, Y., & Xie, S. (2016). HOXB4 knockdown reverses multidrug resistance of human myelogenous leukemia K562/ADM cells by downregulating P-gp, MRP1 and BCRP expression via PI3K/Akt signaling pathway. International Journal of Oncology, 49, 2529-2537. https://doi.org/10.3892/ijo.2016.3738
MLA
Wang, H., Jia, X., Chen, J., Yi, Y., Wang, J., Li, Y., Xie, S."HOXB4 knockdown reverses multidrug resistance of human myelogenous leukemia K562/ADM cells by downregulating P-gp, MRP1 and BCRP expression via PI3K/Akt signaling pathway". International Journal of Oncology 49.6 (2016): 2529-2537.
Chicago
Wang, H., Jia, X., Chen, J., Yi, Y., Wang, J., Li, Y., Xie, S."HOXB4 knockdown reverses multidrug resistance of human myelogenous leukemia K562/ADM cells by downregulating P-gp, MRP1 and BCRP expression via PI3K/Akt signaling pathway". International Journal of Oncology 49, no. 6 (2016): 2529-2537. https://doi.org/10.3892/ijo.2016.3738
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