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Article

Tetrandrine inhibits glioma stem-like cells by repressing β-catenin expression

  • Authors:
    • Yong Zhang
    • Yu-Lin Wen
    • Ji-Wei Ma
    • Jie-Cheng Ye
    • Xiao Wang
    • Jian-Xian Huang
    • Chao-Yue Meng
    • Xiao-Ze Xu
    • Shao-Xiang Wang
    • Xue-Yun Zhong
  • View Affiliations / Copyright

    Affiliations: Department of Pathology, Medical School of Jinan University, Guangzhou, Guangdong 510632, P.R. China, Guangzhou Jinan Biomedicine Research and Development Center, National Engineering Research Center of Genetic Medicine, Jinan University, Guangzhou, Guangdong 510632, P.R. China, School of Medicine, Shenzhen University, Shenzhen, Guangdong 518060, P.R. China
  • Pages: 101-110
    |
    Published online on: November 23, 2016
       https://doi.org/10.3892/ijo.2016.3780
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Abstract

Cancer stem cells (CSCs) in glioma are often responsible for relapse and resistance to therapy. The purpose of the present study was to confirm the self-renewal and migration inhibitory effects of tetrandrine (Tet), which is a compound extracted from the dried root of Stephania tetrandra S. Moore, toward glioma stem-like cells (GSLCs) and to examine the associated molecular mechanisms. Using a neurosphere culture technique, we enriched the GSLC population from the human glioblastoma cell lines U87 and U251. Cells were analyzed using cell counting kit-8 (CCK-8), western blotting, flow cytometry, transwell assay and immunofluorescence staining. GSLCs displayed properties of neural stem cells, including elevated expression of the cancer stem cell marker ALDH1 and β-catenin. We found that Tet treatment decreased sphere formation in GSLCs in a dose-dependent manner using tumor spheroid formation assay. The GSK3β inhibitor BIO maintained sphere formation and migration capacity in GSLCs, whereas the β-catenin/TCF transcription inhibitor ICG-001 decreased sphere formation and the migration capacity of GSLCs. The proportion of apoptotic GSLCs also increased in response to ICG-001 treatment. These results indicate that β-catenin activity is vital in maintaining neural stem cell traits of GSLCs. Tet inhibits cell viability, neurosphere formation and migration of GSLCs in vitro. Importantly, Tet treatment significantly repressed the nuclear translocation and expression of β-catenin and induced apoptosis in GSLCs, as indicated in part by the upregulation of Bax, the cleavage of PARP and the downregulation of Bcl-2. The present study demonstrates that the inhibition of β-catenin in CSCs by Tet could be an effective strategy for the treatment of glioma.
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1 

Parsons DW, Jones S, Zhang X, Lin JC, Leary RJ, Angenendt P, Mankoo P, Carter H, Siu IM, Gallia GL, et al: An integrated genomic analysis of human glioblastoma multiforme. Science. 321:1807–1812. 2008. View Article : Google Scholar : PubMed/NCBI

2 

You G, Sha ZY, Yan W, Zhang W, Wang YZ, Li SW, Sang L, Wang Z, Li GL, Li SW, et al: Seizure characteristics and outcomes in 508 Chinese adult patients undergoing primary resection of low-grade gliomas: A clinicopathological study. Neuro Oncol. 14:230–241. 2012. View Article : Google Scholar :

3 

Dahlrot RH: The prognostic value of clinical factors and cancer stem cell-related markers in gliomas. Dan Med J. 61:B49442014.PubMed/NCBI

4 

Tabatabai G and Weller M: Glioblastoma stem cells. Cell Tissue Res. 343:459–465. 2011. View Article : Google Scholar : PubMed/NCBI

5 

D'Uva G, Bertoni S, Lauriola M, De Carolis S, Pacilli A, D'Anello L, Santini D, Taffurelli M, Ceccarelli C, Yarden Y, et al: Beta-catenin/HuR post-transcriptional machinery governs cancer stem cell features in response to hypoxia. PLoS One. 8:e807422013. View Article : Google Scholar : PubMed/NCBI

6 

Korkaya H, Kim GI, Davis A, Malik F, Henry NL, Ithimakin S, Quraishi AA, Tawakkol N, D'Angelo R, Paulson AK, et al: Activation of an IL6 inflammatory loop mediates trastuzumab resistance in HER2+ breast cancer by expanding the cancer stem cell population. Mol Cell. 47:570–584. 2012. View Article : Google Scholar : PubMed/NCBI

7 

Chen X, Hu W, Xie B, Gao H, Xu C and Chen J: Downregulation of SCAI enhances glioma cell invasion and stem cell like phenotype by activating Wnt/β-catenin signaling. Biochem Biophys Res Commun. 448:206–211. 2014. View Article : Google Scholar : PubMed/NCBI

8 

Rathod SS, Rani SB, Khan M, Muzumdar D and Shiras A: Tumor suppressive miRNA-34a suppresses cell proliferation and tumor growth of glioma stem cells by targeting Akt and Wnt signaling pathways. FEBS Open Bio. 4:485–495. 2014. View Article : Google Scholar : PubMed/NCBI

9 

Brabletz S, Schmalhofer O and Brabletz T: Gastrointestinal stem cells in development and cancer. J Pathol. 217:307–317. 2009. View Article : Google Scholar

10 

Wang H and Chen X: Tetrandrine ameliorates cirrhosis and portal hypertension by inhibiting nitric oxide in cirrhotic rats. J Huazhong Univ Sci Technolog Med Sci. 24:385–388. 3952004. View Article : Google Scholar : PubMed/NCBI

11 

Chen Y, Chen JC and Tseng SH: Effects of tetrandrine plus radiation on neuroblastoma cells. Anticancer Res. 29:3163–3171. 2009.PubMed/NCBI

12 

Gao JL, Ji X, He TC, Zhang Q, He K, Zhao Y, Chen SH and Lv GY: Tetrandrine suppresses cancer angiogenesis and metastasis in 4T1 tumor bearing mice. Evid Based Complement Alternat Med. 2013:2650612013. View Article : Google Scholar : PubMed/NCBI

13 

Cho HS, Chang SH, Chung YS, Shin JY, Park SJ, Lee ES, Hwang SK, Kwon JT, Tehrani AM, Woo M, et al: Synergistic effect of ERK inhibition on tetrandrine-induced apoptosis in A549 human lung carcinoma cells. J Vet Sci. 10:23–28. 2009. View Article : Google Scholar : PubMed/NCBI

14 

Wu K, Zhou M, Wu QX, Yuan SX, Wang DX, Jin JL, Huang J, Yang JQ, Sun WJ, Wan LH, et al: The role of IGFBP-5 in mediating the anti-proliferation effect of tetrandrine in human colon cancer cells. Int J Oncol. 46:1205–1213. 2015.

15 

Kou B, Liu W, He W, Zhang Y, Zheng J, Yan Y, Zhang Y, Xu S and Wang H: Tetrandrine suppresses metastatic phenotype of prostate cancer cells by regulating Akt/mTOR/MMP-9 signaling pathway. Oncol Rep. 35:2880–2886. 2016.PubMed/NCBI

16 

Kida K, Ishikawa T, Yamada A, Shimada K, Narui K, Sugae S, Shimizu D, Tanabe M, Sasaki T, Ichikawa Y, et al: Effect of ALDH1 on prognosis and chemoresistance by breast cancer subtype. Breast Cancer Res Treat. 156:261–269. 2016. View Article : Google Scholar : PubMed/NCBI

17 

Gehlot P, Shukla V, Gupta S and Makidon PE: Detection of ALDH1 activity in rabbit hepatic VX2 tumors and isolation of ALDH1 positive cancer stem cells. J Transl Med. 14:492016. View Article : Google Scholar : PubMed/NCBI

18 

Zhang Y, Wang SX, Ma JW, Li HY, Ye JC, Xie SM, Du B and Zhong XY: EGCG inhibits properties of glioma stem-like cells and synergizes with temozolomide through downregulation of P-glycoprotein inhibition. J Neurooncol. 121:41–52. 2015. View Article : Google Scholar

19 

Nakahata K, Uehara S, Nishikawa S, Kawatsu M, Zenitani M, Oue T and Okuyama H: Aldehyde dehydrogenase 1 (ALDH1) is a potential marker for cancer stem cells in embryonal rhabdomyosarcoma. PLoS One. 10:e01254542015. View Article : Google Scholar : PubMed/NCBI

20 

Liu M, Inoue K, Leng T, Guo S and Xiong ZG: TRPM7 channels regulate glioma stem cell through STAT3 and Notch signaling pathways. Cell Signal. 26:2773–2781. 2014. View Article : Google Scholar : PubMed/NCBI

21 

Venugopal A, Subramaniam D, Balmaceda J, Roy B, Dixon DA, Umar S, Weir SJ and Anant S: RNA binding protein RBM3 increases beta-catenin signaling to increase stem cell characteristics in colorectal cancer cells. Mol Carcinog. 55:1503–1516. 2015. View Article : Google Scholar

22 

Gong A and Huang S: FoxM1 and Wnt/β-catenin signaling in glioma stem cells. Cancer Res. 72:5658–5662. 2012. View Article : Google Scholar : PubMed/NCBI

23 

Kim KH, Seol HJ, Kim EH, Rheey J, Jin HJ, Lee Y, Joo KM, Lee J and Nam DH: Wnt/β-catenin signaling is a key downstream mediator of MET signaling in glioblastoma stem cells. Neuro Oncol. 15:161–171. 2013. View Article : Google Scholar

24 

Shi L, Fei X, Wang Z and You Y: PI3K inhibitor combined with miR-125b inhibitor sensitize TMZ-induced anti-glioma stem cancer effects through inactivation of Wnt/beta-catenin signaling pathway. In Vitro Cell Dev Biol Anim. 51:1047–1055. 2015. View Article : Google Scholar : PubMed/NCBI

25 

Bhagya N and Chandrashekar KR: Tetrandrine - A molecule of wide bioactivity. Phytochemistry. 125:5–13. 2016. View Article : Google Scholar : PubMed/NCBI

26 

Xu XH, Gan YC, Xu GB, Chen T, Zhou H, Tang JF, Gu Y, Xu F, Xie YY, Zhao XY, et al: Tetrandrine citrate eliminates imatinib-resistant chronic myeloid leukemia cells in vitro and in vivo by inhibiting Bcr-Abl/β-catenin axis. J Zhejiang Univ Sci B. 13:867–874. 2012. View Article : Google Scholar : PubMed/NCBI

27 

He BC, Gao JL, Zhang BQ, Luo Q, Shi Q, Kim SH, Huang E, Gao Y, Yang K, Wagner ER, et al: Tetrandrine inhibits Wnt/β-catenin signaling and suppresses tumor growth of human colorectal cancer. Mol Pharmacol. 79:211–219. 2011. View Article : Google Scholar :

28 

Zhang YX, Liu XM, Wang J, Li J, Liu Y, Zhang H, Yu XW and Wei N: Inhibition of AKT/FoxO3a signaling induced PUMA expression in response to p53-independent cytotoxic effects of H1: A derivative of tetrandrine. Cancer Biol Ther. 16:965–975. 2015. View Article : Google Scholar : PubMed/NCBI

29 

Zhu R, Liu T, Tan Z, Wu X, Li M, Jiang L, Bao R, Shu Y, Lu A and Liu Y: Tetrandrine induces apoptosis in gallbladder carcinoma in vitro. Int J Clin Pharmacol Ther. 52:900–905. 2014. View Article : Google Scholar : PubMed/NCBI

30 

Yu VW and Ho WS: Tetrandrine inhibits hepatocellular carcinoma cell growth through the caspase pathway and G2/M phase. Oncol Rep. 29:2205–2210. 2013.PubMed/NCBI

31 

Zheng H, Ying H, Wiedemeyer R, Yan H, Quayle SN, Ivanova EV, Paik JH, Zhang H, Xiao Y, Perry SR, et al: PLAGL2 regulates Wnt signaling to impede differentiation in neural stem cells and gliomas. Cancer Cell. 17:497–509. 2010. View Article : Google Scholar : PubMed/NCBI

32 

Náger M, Santacana M, Bhardwaj D, Valls J, Ferrer I, Nogués P, Cantí C and Herreros J: Nuclear phosphorylated Y142 β-catenin accumulates in astrocytomas and glioblastomas and regulates cell invasion. Cell Cycle. 14:3644–3655. 2015. View Article : Google Scholar

33 

Kahlert UD, Suwala AK, Koch K, Natsumeda M, Orr BA, Hayashi M, Maciaczyk J and Eberhart CG: Pharmacologic Wnt inhibition reduces proliferation, survival, and clonogenicity of glioblastoma cells. J Neuropathol Exp Neurol. 74:889–900. 2015. View Article : Google Scholar : PubMed/NCBI

34 

Zhang N, Wei P, Gong A, Chiu WT, Lee HT, Colman H, Huang H, Xue J, Liu M, Wang Y, et al: FoxM1 promotes β-catenin nuclear localization and controls Wnt target-gene expression and glioma tumorigenesis. Cancer Cell. 20:427–442. 2011. View Article : Google Scholar : PubMed/NCBI

35 

Holland JD, Klaus A, Garratt AN and Birchmeier W: Wnt signaling in stem and cancer stem cells. Curr Opin Cell Biol. 25:254–264. 2013. View Article : Google Scholar : PubMed/NCBI

36 

Takebe N, Harris PJ, Warren RQ and Ivy SP: Targeting cancer stem cells by inhibiting Wnt, Notch, and Hedgehog pathways. Nat Rev Clin Oncol. 8:97–106. 2011. View Article : Google Scholar

37 

Chenn A and Walsh CA: Regulation of cerebral cortical size by control of cell cycle exit in neural precursors. Science. 297:365–369. 2002. View Article : Google Scholar : PubMed/NCBI

38 

Clevers H, Loh KM and Nusse R: Stem cell signaling. An integral program for tissue renewal and regeneration: Wnt signaling and stem cell control. Science. 346:12480122014. View Article : Google Scholar : PubMed/NCBI

39 

Nusse R: Wnt signaling and stem cell control. Cell Res. 18:523–527. 2008. View Article : Google Scholar : PubMed/NCBI

40 

Kierulf-Vieira KS, Sandberg CJ, Grieg Z, Günther CC, Langmoen IA and Vik-Mo EO: Wnt inhibition is dysregulated in gliomas and its re-establishment inhibits proliferation and tumor sphere formation. Exp Cell Res. 340:53–61. 2016. View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Zhang Y, Wen Y, Ma J, Ye J, Wang X, Huang J, Meng C, Xu X, Wang S, Zhong X, Zhong X, et al: Tetrandrine inhibits glioma stem-like cells by repressing β-catenin expression. Int J Oncol 50: 101-110, 2017.
APA
Zhang, Y., Wen, Y., Ma, J., Ye, J., Wang, X., Huang, J. ... Zhong, X. (2017). Tetrandrine inhibits glioma stem-like cells by repressing β-catenin expression. International Journal of Oncology, 50, 101-110. https://doi.org/10.3892/ijo.2016.3780
MLA
Zhang, Y., Wen, Y., Ma, J., Ye, J., Wang, X., Huang, J., Meng, C., Xu, X., Wang, S., Zhong, X."Tetrandrine inhibits glioma stem-like cells by repressing β-catenin expression". International Journal of Oncology 50.1 (2017): 101-110.
Chicago
Zhang, Y., Wen, Y., Ma, J., Ye, J., Wang, X., Huang, J., Meng, C., Xu, X., Wang, S., Zhong, X."Tetrandrine inhibits glioma stem-like cells by repressing β-catenin expression". International Journal of Oncology 50, no. 1 (2017): 101-110. https://doi.org/10.3892/ijo.2016.3780
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang Y, Wen Y, Ma J, Ye J, Wang X, Huang J, Meng C, Xu X, Wang S, Zhong X, Zhong X, et al: Tetrandrine inhibits glioma stem-like cells by repressing β-catenin expression. Int J Oncol 50: 101-110, 2017.
APA
Zhang, Y., Wen, Y., Ma, J., Ye, J., Wang, X., Huang, J. ... Zhong, X. (2017). Tetrandrine inhibits glioma stem-like cells by repressing β-catenin expression. International Journal of Oncology, 50, 101-110. https://doi.org/10.3892/ijo.2016.3780
MLA
Zhang, Y., Wen, Y., Ma, J., Ye, J., Wang, X., Huang, J., Meng, C., Xu, X., Wang, S., Zhong, X."Tetrandrine inhibits glioma stem-like cells by repressing β-catenin expression". International Journal of Oncology 50.1 (2017): 101-110.
Chicago
Zhang, Y., Wen, Y., Ma, J., Ye, J., Wang, X., Huang, J., Meng, C., Xu, X., Wang, S., Zhong, X."Tetrandrine inhibits glioma stem-like cells by repressing β-catenin expression". International Journal of Oncology 50, no. 1 (2017): 101-110. https://doi.org/10.3892/ijo.2016.3780
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