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Inhibition of CDH17 gene expression via RNA interference reduces proliferation and apoptosis of human MKN28 gastric cancer cells

  • Authors:
    • Rui Li
    • Hong‑Qiang Yang
    • Hai‑Lin Xi
    • Su Feng
    • Rui‑Hao Qin
  • View Affiliations / Copyright

    Affiliations: Department of Central Laboratory, Xuzhou Central Hospital, Xuzhou Clinical School of Xuzhou Medical College, Affiliated Hospital of Southeast University, Xuzhou, Jiangsu 221009, P.R. China, Department of General Surgery, Xuzhou Central Hospital, Xuzhou Clinical School of Xuzhou Medical College, Affiliated Hospital of Southeast University, Xuzhou, Jiangsu 221009, P.R. China
    Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 15-22
    |
    Published online on: November 28, 2016
       https://doi.org/10.3892/ijo.2016.3783
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Abstract

Gastric cancer is the fourth most common type of cancer and the second cause of cancer‑related mortalities worldwide despite the use of multimodal therapy. Cadherins are transmembrane glycoproteins that are involved in tumorigenesis. CDH17 has been found to be over‑expressed in gastric cancer and its overexpression was associated with lymph node metastasis and tumor‑node‑metastasis stage of the patients, yet the exact role and molecular mechanism of CDH17 in gastric cancer have not been determined. Using a lentiviral system as a delivery mediator of RNA interference, we found that inhibition of CDH17 can lead to reduce proliferation and increase apoptosis of gastric cancer cell line MKN28 in vitro and significantly diminish their tumorigenicity in vivo. Our results of the present study suggest that CDH17 may be a promising candidate for the therapeutic targeting of gastric cancer.
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Copy and paste a formatted citation
Spandidos Publications style
Li R, Yang HQ, Xi HL, Feng S and Qin RH: Inhibition of CDH17 gene expression via RNA interference reduces proliferation and apoptosis of human MKN28 gastric cancer cells. Int J Oncol 50: 15-22, 2017.
APA
Li, R., Yang, H., Xi, H., Feng, S., & Qin, R. (2017). Inhibition of CDH17 gene expression via RNA interference reduces proliferation and apoptosis of human MKN28 gastric cancer cells. International Journal of Oncology, 50, 15-22. https://doi.org/10.3892/ijo.2016.3783
MLA
Li, R., Yang, H., Xi, H., Feng, S., Qin, R."Inhibition of CDH17 gene expression via RNA interference reduces proliferation and apoptosis of human MKN28 gastric cancer cells". International Journal of Oncology 50.1 (2017): 15-22.
Chicago
Li, R., Yang, H., Xi, H., Feng, S., Qin, R."Inhibition of CDH17 gene expression via RNA interference reduces proliferation and apoptosis of human MKN28 gastric cancer cells". International Journal of Oncology 50, no. 1 (2017): 15-22. https://doi.org/10.3892/ijo.2016.3783
Copy and paste a formatted citation
x
Spandidos Publications style
Li R, Yang HQ, Xi HL, Feng S and Qin RH: Inhibition of CDH17 gene expression via RNA interference reduces proliferation and apoptosis of human MKN28 gastric cancer cells. Int J Oncol 50: 15-22, 2017.
APA
Li, R., Yang, H., Xi, H., Feng, S., & Qin, R. (2017). Inhibition of CDH17 gene expression via RNA interference reduces proliferation and apoptosis of human MKN28 gastric cancer cells. International Journal of Oncology, 50, 15-22. https://doi.org/10.3892/ijo.2016.3783
MLA
Li, R., Yang, H., Xi, H., Feng, S., Qin, R."Inhibition of CDH17 gene expression via RNA interference reduces proliferation and apoptosis of human MKN28 gastric cancer cells". International Journal of Oncology 50.1 (2017): 15-22.
Chicago
Li, R., Yang, H., Xi, H., Feng, S., Qin, R."Inhibition of CDH17 gene expression via RNA interference reduces proliferation and apoptosis of human MKN28 gastric cancer cells". International Journal of Oncology 50, no. 1 (2017): 15-22. https://doi.org/10.3892/ijo.2016.3783
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