Open Access

Induced overexpression of CD44 associated with resistance to apoptosis on DNA damage response in human head and neck squamous cell carcinoma cells

  • Authors:
    • Emika Ohkoshi
    • Naoki Umemura
  • View Affiliations

  • Published online on: December 28, 2016     https://doi.org/10.3892/ijo.2016.3821
  • Pages: 387-395
  • Copyright: © Ohkoshi et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

CD44 is a marker of cancer stem cells in head and neck squamous cell carcinoma, and CD44 expression is related to prognosis in cancer patients. We examined whether herbal medicine components affect CD44 expression and induce cancer cell apoptosis. Baicalin enhanced apoptosis with no effect on CD44 levels, while baicalein did not enhance apoptosis and upregulated CD44 in head and neck squamous cell carcinoma. Furthermore, baicalein induced phosphorylation of CHK1, as a marker of DNA damage response to S-to-G2/M phase arrest. Our results clearly demonstrated that baicalein enhanced expression of CD44 and accordingly enhanced the DNA damage response. These data suggest that induction of CD44 inhibited cancer cell induction of apoptosis by increasing the DNA damage response. Together, our findings suggest that CD44 expression in head and neck squamous cell carcinoma plays a role in enhancing the DNA damage response.
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February-2017
Volume 50 Issue 2

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Ohkoshi E and Ohkoshi E: Induced overexpression of CD44 associated with resistance to apoptosis on DNA damage response in human head and neck squamous cell carcinoma cells. Int J Oncol 50: 387-395, 2017
APA
Ohkoshi, E., & Ohkoshi, E. (2017). Induced overexpression of CD44 associated with resistance to apoptosis on DNA damage response in human head and neck squamous cell carcinoma cells. International Journal of Oncology, 50, 387-395. https://doi.org/10.3892/ijo.2016.3821
MLA
Ohkoshi, E., Umemura, N."Induced overexpression of CD44 associated with resistance to apoptosis on DNA damage response in human head and neck squamous cell carcinoma cells". International Journal of Oncology 50.2 (2017): 387-395.
Chicago
Ohkoshi, E., Umemura, N."Induced overexpression of CD44 associated with resistance to apoptosis on DNA damage response in human head and neck squamous cell carcinoma cells". International Journal of Oncology 50, no. 2 (2017): 387-395. https://doi.org/10.3892/ijo.2016.3821