Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
International Journal of Oncology
Join Editorial Board Propose a Special Issue
Print ISSN: 1019-6439 Online ISSN: 1791-2423
Journal Cover
April-2017 Volume 50 Issue 4

Full Size Image

Cover Legend PDF

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
April-2017 Volume 50 Issue 4

Full Size Image

Cover Legend PDF

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Therapeutic effects of Schisandra chinensis on the hyperprolactinemia in rat

  • Authors:
    • So-Hye Hong
    • Mei Li
    • Eui-Bae Jeung
    • Geun-Shik Lee
    • Eui-Ju Hong
    • Young-Whan Choi
    • Beum-Soo An
  • View Affiliations / Copyright

    Affiliations: Department of Biomaterials Science, College of Natural Resources and Life Science, Pusan National University, Miryang‑si, Gyeongsangnam‑do, Republic of Korea, Department of Horticultural Bioscience, College of Natural Resources and Life Science, Pusan National University, Miryang-si, Gyeongsangnam‑do, Republic of Korea, Laboratory of Veterinary Biochemistry and Molecular Biology, College of Veterinary Medicine, Chungbuk National University, Cheongju, Chungbuk, Republic of Korea, College of Veterinary Medicine and Institute of Veterinary Science, Kangwon National University, Chuncheon, Gangwon 200‑701, Republic of Korea, Laboratory of Biochemistry and Molecular Biology, College of Veterinary Medicine, Chungnam National University, Daejeon, Gangwon, Republic of Korea
  • Pages: 1448-1454
    |
    Published online on: February 17, 2017
       https://doi.org/10.3892/ijo.2017.3881
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Prolactin (PRL) is secreted from the pituitary gland in response to eating, mating, and ovulation. Increased serum concentration of PRL during pregnancy contributes to enlargement of the mammary glands of the breasts and prepares for production of milk. However, high PRL levels derived from prolactinoma and hyperprolactinemia induce physiological disorders such as infertility and early menopause. Natural compounds isolated from S. chinensis have been known to possess anti-oxidative, anti-inflammatory and anti-diabetic effects. In the present study, we examined the therapeutic effect of S. chinensis and its single compounds on hyperprolactinemia in the pituitary gland. In rat pituitary cells, PRL expression levels were examined using real-time PCR and western blot assay. Crude S. chinensis extract and its single compound, gomisin N, reduced mRNA and protein levels of PRL in GH3 cells. In addition, cell proliferation and PRL target gene expression in cells were modulated by S. chinensis. Similar to the in vitro experiments, crude S. chinensis extract and gomisin N reduced PRL levels in the pituitary and serum of immature female rats. These results show that S. chinensis and its single compound, gomisin N, are regulators of PRL production and may be candidates for treatment of hyperprolactinemia and prolactinoma.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

View References

1 

Hong GK, Payne SC and Jane JA Jr: Anatomy, physiology, and laboratory evaluation of the pituitary gland. Otolaryngol Clin North Am. 49:21–32. 2016. View Article : Google Scholar

2 

Amar AP and Weiss MH: Pituitary anatomy and physiology. Neurosurg Clin N Am. 14:11–23. v2003. View Article : Google Scholar : PubMed/NCBI

3 

Blackwell RE, Rodgers-Neame NT, Bradley EL Jr and Asch RH: Regulation of human prolactin secretion by gonadotropin-releasing hormone in vitro. Fertil Steril. 46:26–31. 1986. View Article : Google Scholar : PubMed/NCBI

4 

Freeman ME, Kanyicska B, Lerant A and Nagy G: Prolactin: Structure, function, and regulation of secretion. Physiol Rev. 80:1523–1631. 2000.PubMed/NCBI

5 

Ben-Jonathan N and Hnasko R: Dopamine as a prolactin (PRL) inhibitor. Endocr Rev. 22:724–763. 2001. View Article : Google Scholar : PubMed/NCBI

6 

Rillema JA: Mechanism of prolactin action. Fed Proc. 39:2593–2598. 1980.PubMed/NCBI

7 

McMurray RW: Estrogen, prolactin, and autoimmunity: Actions and interactions. Int Immunopharmacol. 1:995–1008. 2001. View Article : Google Scholar : PubMed/NCBI

8 

Capozzi A, Scambia G, Pontecorvi A and Lello S: Hyperprolactinemia: Pathophysiology and therapeutic approach. Gynecol Endocrinol. 31:506–510. 2015. View Article : Google Scholar : PubMed/NCBI

9 

Glezer A and Bronstein MD: Prolactinomas. Endocrinol Metab Clin North Am. 44:71–78. 2015. View Article : Google Scholar : PubMed/NCBI

10 

Panossian A and Wikman G: Pharmacology of Schisandra chinensis Bail: An overview of Russian research and uses in medicine. J Ethnopharmacol. 118:183–212. 2008. View Article : Google Scholar : PubMed/NCBI

11 

Hancke JL, Burgos RA and Ahumada F: Schisandra chinensis (Turcz) Baill. Fitoterapia. 70:451–471. 1999. View Article : Google Scholar

12 

Chang HM and But P: Pharmacology and applications of Chinese Materia Edica Volume 1. World Scientific; Singapore: pp. 199–209. 1986, View Article : Google Scholar

13 

Bao T-T, Tu G-F, Liu G-T, Sun R-H and Song Z-Y: A comparison of the pharmacological actions of seven constituents isolated from fructus schizadrae (author's transl). Yao Xue Xue Bao. 14:1–7. 1979.In Chinese.

14 

Cowie AT: Physiological actions of prolactin. Proc R Soc Med. 66:861–862. 1973.PubMed/NCBI

15 

Mancini T, Casanueva FF and Giustina A: Hyperprolactinemia and prolactinomas. Endocrinol Metab Clin North Am. 37:67–99. viii2008. View Article : Google Scholar : PubMed/NCBI

16 

Schwärzler P, Untergasser G, Hermann M, Dirnhofer S, Abendstein B and Berger P: Prolactin gene expression and prolactin protein in premenopausal and postmenopausal human ovaries. Fertil Steril. 68:696–701. 1997. View Article : Google Scholar : PubMed/NCBI

17 

Ufearo CS and Orisakwe OE: Restoration of normal sperm characteristics in hypoprolactinemic infertile men treated with metoclopramide and exogenous human prolactin. Clin Pharmacol Ther. 58:354–359. 1995. View Article : Google Scholar : PubMed/NCBI

18 

Bronstein MD: Potential for long-term remission of microprolactinoma after withdrawal of dopamine-agonist therapy. Nat Clin Pract Endocrinol Metab. 2:130–131. 2006. View Article : Google Scholar : PubMed/NCBI

19 

Auriemma RS, Pivonello R, Ferreri L, Priscitelli P and Colao A: Cabergoline use for pituitary tumors and valvular disorders. Endocrinol Metab Clin North Am. 44:89–97. 2015. View Article : Google Scholar : PubMed/NCBI

20 

Murphy LL and Lee TJ: Ginseng, sex behavior, and nitric oxide. Ann N Y Acad Sci. 962:372–377. 2002. View Article : Google Scholar : PubMed/NCBI

21 

Yeh KY, Pu HF, Kaphle K, Lin SF, Wu LS, Lin JH and Tsai YF: Ginkgo biloba extract enhances male copulatory behavior and reduces serum prolactin levels in rats. Horm Behav. 53:225–231. 2008. View Article : Google Scholar

22 

Lu JC, Piazza TM and Schuler LA: Proteasomes mediate prolactin-induced receptor down-regulation and fragment generation in breast cancer cells. J Biol Chem. 280:33909–33916. 2005. View Article : Google Scholar : PubMed/NCBI

23 

Zinger M, McFarland M and Ben-Jonathan N: Prolactin expression and secretion by human breast glandular and adipose tissue explants. J Clin Endocrinol Metab. 88:689–696. 2003. View Article : Google Scholar : PubMed/NCBI

24 

Chen CL and Meites J: Effects of estrogen and progesterone on serum and pituitary prolactin levels in ovariectomized rats. Endocrinology. 86:503–505. 1970. View Article : Google Scholar : PubMed/NCBI

25 

Kang EJ, Hong SH, Lee JE, Kim SC, Yang HS, Yi PI, Lee SM and An BS: Pregnenolone sulfate regulates prolactin production in the rat pituitary. J Endocrinol. 230:339–346. 2016. View Article : Google Scholar : PubMed/NCBI

26 

Yim SY, Lee YJ, Lee YK, Jung SE, Kim JH, Kim HJ, Son BG, Park YH, Lee YG, Choi YW, et al: Gomisin N isolated from Schisandra chinensis significantly induces anti-proliferative and pro-apoptotic effects in hepatic carcinoma. Mol Med Rep. 2:725–732. 2009.PubMed/NCBI

27 

Kim JH, Choi YW, Park C, Jin CY, Lee YJ, Park DJ, Kim SG, Kim GY, Choi IW, Hwang WD, et al: Apoptosis induction of human leukemia U937 cells by gomisin N, a dibenzocyclooctadiene lignan, isolated from Schizandra chinensis Baill. Food Chem Toxicol. 48:807–813. 2010. View Article : Google Scholar

28 

Casarin E, Dall'Acqua S, Smejkal K, Slapetova T, Innocenti G and Carrara M: Molecular mechanisms of antiproliferative effects induced by Schisandra-derived dienzocyclooctadiene lignin ()-deoxychisandrin and (-)-gomisin N in human tumor cell lines. Fitoterapia. 98:241–247. 2014. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Hong S, Li M, Jeung E, Lee G, Hong E, Choi Y and An B: Therapeutic effects of Schisandra chinensis on the hyperprolactinemia in rat. Int J Oncol 50: 1448-1454, 2017.
APA
Hong, S., Li, M., Jeung, E., Lee, G., Hong, E., Choi, Y., & An, B. (2017). Therapeutic effects of Schisandra chinensis on the hyperprolactinemia in rat. International Journal of Oncology, 50, 1448-1454. https://doi.org/10.3892/ijo.2017.3881
MLA
Hong, S., Li, M., Jeung, E., Lee, G., Hong, E., Choi, Y., An, B."Therapeutic effects of Schisandra chinensis on the hyperprolactinemia in rat". International Journal of Oncology 50.4 (2017): 1448-1454.
Chicago
Hong, S., Li, M., Jeung, E., Lee, G., Hong, E., Choi, Y., An, B."Therapeutic effects of Schisandra chinensis on the hyperprolactinemia in rat". International Journal of Oncology 50, no. 4 (2017): 1448-1454. https://doi.org/10.3892/ijo.2017.3881
Copy and paste a formatted citation
x
Spandidos Publications style
Hong S, Li M, Jeung E, Lee G, Hong E, Choi Y and An B: Therapeutic effects of Schisandra chinensis on the hyperprolactinemia in rat. Int J Oncol 50: 1448-1454, 2017.
APA
Hong, S., Li, M., Jeung, E., Lee, G., Hong, E., Choi, Y., & An, B. (2017). Therapeutic effects of Schisandra chinensis on the hyperprolactinemia in rat. International Journal of Oncology, 50, 1448-1454. https://doi.org/10.3892/ijo.2017.3881
MLA
Hong, S., Li, M., Jeung, E., Lee, G., Hong, E., Choi, Y., An, B."Therapeutic effects of Schisandra chinensis on the hyperprolactinemia in rat". International Journal of Oncology 50.4 (2017): 1448-1454.
Chicago
Hong, S., Li, M., Jeung, E., Lee, G., Hong, E., Choi, Y., An, B."Therapeutic effects of Schisandra chinensis on the hyperprolactinemia in rat". International Journal of Oncology 50, no. 4 (2017): 1448-1454. https://doi.org/10.3892/ijo.2017.3881
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team