Open Access

miR‑150 inhibits proliferation and tumorigenicity via retarding G1/S phase transition in nasopharyngeal carcinoma

  • Authors:
    • Xiangyong Li
    • Fumei Liu
    • Bihua Lin
    • Haiqing Luo
    • Meilian Liu
    • Jinhua Wu
    • Caihong Li
    • Ronggang Li
    • Xin Zhang
    • Keyuan Zhou
    • Dong Ren
  • View Affiliations

  • Published online on: March 10, 2017     https://doi.org/10.3892/ijo.2017.3909
  • Pages: 1097-1108
  • Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Cancer cells are characterized by a pathological manifestation of uncontrolled proliferation, which results in tumor formation. Therefore, it is necessary to improve understanding of the underlying mechanism of cell cycle control. Here, we report that miR‑150 is downregulated in nasopharyngeal carcinoma tissues and cells. Upregulation of miR‑150 suppresses nasopharyngeal carcinoma (NPC) cell proliferation and induces G1/S arrest in vitro, and inhibits tumorigenesis in vivo. Conversely, silencing miR‑150 yields the opposite effect. Our results further demonstrate that miR‑150 retards nasopharyngeal carcinoma cell proliferation and G1/S transition via targeting multiple cell cycle-related genes, including CCND1, CCND2, CDK2 and CCNE2. Therefore, our results uncover a novel mechanistic understanding of miR‑150-mediated tumor suppression in NPC, which will facilitate the development of effective cancer therapies against nasopharyngeal carcinoma.
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April-2017
Volume 50 Issue 4

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Copy and paste a formatted citation
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Spandidos Publications style
Li X, Liu F, Lin B, Luo H, Liu M, Wu J, Li C, Li R, Zhang X, Zhou K, Zhou K, et al: miR‑150 inhibits proliferation and tumorigenicity via retarding G1/S phase transition in nasopharyngeal carcinoma. Int J Oncol 50: 1097-1108, 2017
APA
Li, X., Liu, F., Lin, B., Luo, H., Liu, M., Wu, J. ... Ren, D. (2017). miR‑150 inhibits proliferation and tumorigenicity via retarding G1/S phase transition in nasopharyngeal carcinoma. International Journal of Oncology, 50, 1097-1108. https://doi.org/10.3892/ijo.2017.3909
MLA
Li, X., Liu, F., Lin, B., Luo, H., Liu, M., Wu, J., Li, C., Li, R., Zhang, X., Zhou, K., Ren, D."miR‑150 inhibits proliferation and tumorigenicity via retarding G1/S phase transition in nasopharyngeal carcinoma". International Journal of Oncology 50.4 (2017): 1097-1108.
Chicago
Li, X., Liu, F., Lin, B., Luo, H., Liu, M., Wu, J., Li, C., Li, R., Zhang, X., Zhou, K., Ren, D."miR‑150 inhibits proliferation and tumorigenicity via retarding G1/S phase transition in nasopharyngeal carcinoma". International Journal of Oncology 50, no. 4 (2017): 1097-1108. https://doi.org/10.3892/ijo.2017.3909