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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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August-2017 Volume 51 Issue 2

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

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Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

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Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

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International Journal of Epigenetics

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Article

Hsp70 acetylation prevents caspase-dependent/independent apoptosis and autophagic cell death in cancer cells

  • Authors:
    • Yoo Hoi Park
    • Ji Hae Seo
    • Ji-Hyeon Park
    • Hye Shin Lee
    • Kyu-Won Kim
  • View Affiliations / Copyright

    Affiliations: SNU-Harvard NeuroVascular Protection Research Center, College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul 08826, Republic of Korea, Department of Biochemistry, School of Medicine, Keimyung University, Daegu 42601, Republic of Korea
  • Pages: 573-578
    |
    Published online on: June 12, 2017
       https://doi.org/10.3892/ijo.2017.4039
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Abstract

Cancer cells are continuously challenged by adverse environmental factors including hypoxia, metabolite restriction, and immune reactions, and must adopt diverse strategies to survive. Heat shock protein (Hsp) 70 plays a central role in protection against stress-induced cell death by maintaining protein homeostasis and interfering with the process of programmed cell death. Recent findings have suggested that Hsp70 acetylation is a key regulatory modification required for its chaperone activity, but its relevance in the process of programmed cell death and the underlying mechanisms involved are not well understood. In this study, we sought to investigate mechanisms mediated by Hsp70 acetylation in relation to apoptotic and autophagic programmed cell death. Upon stress-induced apoptosis, Hsp70 acetylation inhibits apoptotic cell death, mediated by Hsp70 association with apoptotic protease-activating factor (Apaf)-1 and apoptosis-inducing factor (AIF), key modulators of caspase-dependent and -independent apoptotic pathways, respectively. Hsp70 acetylation also attenuated autophagic cell death associated with upregulation of autophagy-related genes and autophagosome induction. Collectively, these results suggest that the acetylation of Hsp70 plays key regulatory roles in cell death pathways as well as in its function as a chaperone, together enabling cellular protection in response to stress.
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Copy and paste a formatted citation
Spandidos Publications style
Park YH, Seo JH, Park J, Lee HS and Kim K: Hsp70 acetylation prevents caspase-dependent/independent apoptosis and autophagic cell death in cancer cells. Int J Oncol 51: 573-578, 2017.
APA
Park, Y.H., Seo, J.H., Park, J., Lee, H.S., & Kim, K. (2017). Hsp70 acetylation prevents caspase-dependent/independent apoptosis and autophagic cell death in cancer cells. International Journal of Oncology, 51, 573-578. https://doi.org/10.3892/ijo.2017.4039
MLA
Park, Y. H., Seo, J. H., Park, J., Lee, H. S., Kim, K."Hsp70 acetylation prevents caspase-dependent/independent apoptosis and autophagic cell death in cancer cells". International Journal of Oncology 51.2 (2017): 573-578.
Chicago
Park, Y. H., Seo, J. H., Park, J., Lee, H. S., Kim, K."Hsp70 acetylation prevents caspase-dependent/independent apoptosis and autophagic cell death in cancer cells". International Journal of Oncology 51, no. 2 (2017): 573-578. https://doi.org/10.3892/ijo.2017.4039
Copy and paste a formatted citation
x
Spandidos Publications style
Park YH, Seo JH, Park J, Lee HS and Kim K: Hsp70 acetylation prevents caspase-dependent/independent apoptosis and autophagic cell death in cancer cells. Int J Oncol 51: 573-578, 2017.
APA
Park, Y.H., Seo, J.H., Park, J., Lee, H.S., & Kim, K. (2017). Hsp70 acetylation prevents caspase-dependent/independent apoptosis and autophagic cell death in cancer cells. International Journal of Oncology, 51, 573-578. https://doi.org/10.3892/ijo.2017.4039
MLA
Park, Y. H., Seo, J. H., Park, J., Lee, H. S., Kim, K."Hsp70 acetylation prevents caspase-dependent/independent apoptosis and autophagic cell death in cancer cells". International Journal of Oncology 51.2 (2017): 573-578.
Chicago
Park, Y. H., Seo, J. H., Park, J., Lee, H. S., Kim, K."Hsp70 acetylation prevents caspase-dependent/independent apoptosis and autophagic cell death in cancer cells". International Journal of Oncology 51, no. 2 (2017): 573-578. https://doi.org/10.3892/ijo.2017.4039
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