Molecular profiling of locally-advanced rectal adenocarcinoma using microRNA expression (Review)

  • Authors:
    • Cory Pettit
    • Steve Walston
    • Patrick Wald
    • Amy Webb
    • Terence M. Williams
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  • Published online on: June 14, 2017     https://doi.org/10.3892/ijo.2017.4045
  • Pages: 393-404
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Abstract

Treatment for locally-advanced rectal cancer (LARC) typically consists of neoadjuvant chemoradiation followed by total mesorectal excision. Recently, there has been growing interest in non-operative management for patients who are medically-inoperable or wish to avoid surgical morbidity and permanent colostomy. Approximately 50% of patients who receive pre-operative neoadjuvant chemoradiation develop some degree of pathologic response. Approximately 10-20% of patients are found to have a complete pathologic response, a finding which has frequently been shown to predict better clinical outcomes, including local-regional control, distant metastasis and survival. Many recent studies have evaluated the role of molecular biomarkers in predicting response to neoadjuvant therapy. MicroRNAs (miRNAs) are an emerging class of biomarkers that have the potential to predict which patients are most likely to benefit from pre-operative therapy and from a selective surgical approach. Here, we review the published literature on microRNAs as prognostic and predictive biomarkers in rectal cancer after pre-operative therapy. In the future, the development of prospectively validated miRNA signatures will allow clinical implementation of miRNAs as prognostic and predictive signatures in LARC.
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August-2017
Volume 51 Issue 2

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Pettit C, Walston S, Wald P, Webb A and Williams TM: Molecular profiling of locally-advanced rectal adenocarcinoma using microRNA expression (Review). Int J Oncol 51: 393-404, 2017
APA
Pettit, C., Walston, S., Wald, P., Webb, A., & Williams, T.M. (2017). Molecular profiling of locally-advanced rectal adenocarcinoma using microRNA expression (Review). International Journal of Oncology, 51, 393-404. https://doi.org/10.3892/ijo.2017.4045
MLA
Pettit, C., Walston, S., Wald, P., Webb, A., Williams, T. M."Molecular profiling of locally-advanced rectal adenocarcinoma using microRNA expression (Review)". International Journal of Oncology 51.2 (2017): 393-404.
Chicago
Pettit, C., Walston, S., Wald, P., Webb, A., Williams, T. M."Molecular profiling of locally-advanced rectal adenocarcinoma using microRNA expression (Review)". International Journal of Oncology 51, no. 2 (2017): 393-404. https://doi.org/10.3892/ijo.2017.4045