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FoxM1 overexpression promotes cell proliferation and migration and inhibits apoptosis in hypopharyngeal squamous cell carcinoma resulting in poor clinical prognosis

  • Authors:
    • Yan Chen
    • Yifei Liu
    • Haosheng Ni
    • Chuanjin Ding
    • Xiaobo Zhang
    • Zhenxin Zhang
  • View Affiliations / Copyright

    Affiliations: Department of Otorhinolaryngology Head and Neck Surgery, Affiliated Hospital of Nantong University, Nantong, Jiangsu 226001, P.R. China, Department of Pathology, Affiliated Hospital of Nantong University, Nantong, Jiangsu 226001, P.R. China
    Copyright: © Chen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1045-1054
    |
    Published online on: August 9, 2017
       https://doi.org/10.3892/ijo.2017.4094
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Abstract

Forkhead box M1 (FoxM1), a member of the Fox family of transcriptional factors, is involved in the development of various human malignancies. However, the expression level of FoxM1 and its functional role in hypopharyngeal squamous cell carcinoma (HSCC) remained unclear to date. The aim of the present study was to investigate the FoxM1 expression in 63 HSCC and 20 adjacent normal tissues, as well as to evaluate its association with the clinicopathological parameters and its diagnostic value in HSCC. To further explore the biological function of FoxM1 in vitro, siRNAs were used to knockdown the expression of FoxM1 in the HSCC cell line Fadu. The results revealed that FoxM1 protein was highly expressed in HSCC tissues and that its high expression was closely associated with HSCC tumor differentiation (P=0.004), tumor size (P=0.002), clinical stage (P=0.001), lymph node metastasis (P=0.002), treatment (P=0.045) and expression of the proliferation marker Ki-67 (P<0.001). Additionally, the elevated expression of FoxM1 in HSCC patients consistently predicted a poor survival time. Knockdown of FoxM1 expression blocked Fadu cell proliferation and promoted apoptosis, and also led to the downregulation of cyclin A1 expression. Furthermore, decreased expression of FoxM1 markedly impeded cell migration and reversed the epithelial-mesenchymal transition phenotype, as indicated by decreased expression of vimentin and increased expression of E-cadherin in Fadu cells. These results indicate that FoxM1 may act as an oncogene and serve as a therapeutic target against malignant progression in HSCC.
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1 

Torre LA, Bray F, Siegel RL, Ferlay J, Lortet-Tieulent J and Jemal A: Global cancer statistics, 2012. CA Cancer J Clin. 65:87–108. 2015. View Article : Google Scholar : PubMed/NCBI

2 

Cooper JS, Porter K, Mallin K, Hoffman HT, Weber RS, Ang KK, Gay EG and Langer CJ: National Cancer Database report on cancer of the head and neck: 10-year update. Head Neck. 31:748–758. 2009. View Article : Google Scholar : PubMed/NCBI

3 

Day D, Hansen AR and Siu LL: Hypopharyngeal cancer: looking back, moving forward. Curr Oncol. 23:221–222. 2016. View Article : Google Scholar : PubMed/NCBI

4 

Hall SF, Groome PA, Irish J and O'Sullivan B: The natural history of patients with squamous cell carcinoma of the hypopharynx. Laryngoscope. 118:1362–1371. 2008. View Article : Google Scholar : PubMed/NCBI

5 

Hanahan D and Weinberg RA: The hallmarks of cancer. Cell. 100:57–70. 2000. View Article : Google Scholar : PubMed/NCBI

6 

Martinez-Outschoorn UE, Peiris-Pages M, Pestell RG, Sotgia F and Lisanti MP: Cancer metabolism: A therapeutic perspective. Nat Rev Clin Oncol. 14:11–31. 2016. View Article : Google Scholar : PubMed/NCBI

7 

Wierstra I: The transcription factor FOXM1 (Forkhead box M1): Proliferation-specific expression, transcription factor function, target genes, mouse models, and normal biological roles. Adv Cancer Res. 118:97–398. 2013. View Article : Google Scholar : PubMed/NCBI

8 

Petrovic V: FoxM1 regulates cell cycle progression through multiple mechanisms. University of Illinois at Chicago; Dissertations & Theses - Gradworks. 2008

9 

Halasi M and Gartel AL: FOX(M1) news: it is cancer. Mol Cancer Ther. 12:245–254. 2013. View Article : Google Scholar : PubMed/NCBI

10 

Miao L, Xiong X, Lin Y, Cheng Y, Lu J, Zhang J and Cheng N: Down-regulation of FoxM1 leads to the inhibition of the epithelial-mesenchymal transition in gastric cancer cells. Cancer Genet. 207:75–82. 2014. View Article : Google Scholar : PubMed/NCBI

11 

Kong FF, Qu ZQ, Yuan HH, Wang JY, Zhao M, Guo YH, Shi J, Gong XD, Zhu YL, Liu F, et al: Overexpression of FOXM1 is associated with EMT and is a predictor of poor prognosis in non-small cell lung cancer. Oncol Rep. 31:2660–2668. 2014. View Article : Google Scholar : PubMed/NCBI

12 

Jiang L, Wang P and Chen H: Overexpression of FOXM1 is associated with metastases of nasopharyngeal carcinoma. Ups J Med Sci. 119:324–332. 2014. View Article : Google Scholar : PubMed/NCBI

13 

Sun HC, Li M, Lu JL, Yan DW, Zhou CZ, Fan JW, Qin XB, Tang HM and Peng ZH: Overexpression of Forkhead box M1 protein associates with aggressive tumor features and poor prognosis of hepatocellular carcinoma. Oncol Rep. 25:1533–1539. 2011.PubMed/NCBI

14 

Wu XR, Chen YH, Liu DM, Sha JJ, Xuan HQ, Bo JJ and Huang YR: Increased expression of forkhead box M1 protein is associated with poor prognosis in clear cell renal cell carcinoma. Med Oncol. 30:3462013. View Article : Google Scholar

15 

Xia JT, Wang H, Liang LJ, Peng BG, Wu ZF, Chen LZ, Xue L, Li Z and Li W: Overexpression of FOXM1 is associated with poor prognosis and clinicopathologic stage of pancreatic ductal adenocarcinoma. Pancreas. 41:629–635. 2012. View Article : Google Scholar : PubMed/NCBI

16 

Ahmad A, Wang Z, Kong D, Ali S, Li Y, Banerjee S, Ali R and Sarkar FH: FoxM1 down-regulation leads to inhibition of proliferation, migration and invasion of breast cancer cells through the modulation of extra-cellular matrix degrading factors. Breast Cancer Res Treat. 122:337–346. 2010. View Article : Google Scholar

17 

Nakamura S, Hirano I, Okinaka K, Takemura T, Yokota D, Ono T, Shigeno K, Shibata K, Fujisawa S and Ohnishi K: The FOXM1 transcriptional factor promotes the proliferation of leukemia cells through modulation of cell cycle progression in acute myeloid leukemia. Carcinogenesis. 31:2012–2021. 2010. View Article : Google Scholar : PubMed/NCBI

18 

Jiang L, Wu X, Wang P, Wen T, Yu C, Wei L and Chen H: Targeting FoxM1 by thiostrepton inhibits growth and induces apoptosis of laryngeal squamous cell carcinoma. J Cancer Res Clin Oncol. 141:971–981. 2015. View Article : Google Scholar

19 

Huang C, Qiu Z, Wang L, Peng Z, Jia Z, Logsdon CD, Le X, Wei D, Huang S and Xie K: A novel FoxM1-caveolin signaling pathway promotes pancreatic cancer invasion and metastasis. Cancer Res. 72:655–665. 2012. View Article : Google Scholar :

20 

Xue J, Lin X, Chiu WT, Chen YH, Yu G, Liu M, Feng XH, Sawaya R, Medema RH, Hung MC and Huang S: Sustained activation of SMAD3/SMAD4 by FOXM1 promotes TGF-β-dependent cancer metastasis. J Clin Invest. 124:564–579. 2014. View Article : Google Scholar : PubMed/NCBI

21 

Ghanim B, Klikovits T, Hoda MA, Lang G, Szirtes I, Setinek U, Rozsas A, Renyi-Vamos F, Laszlo V, Grusch M, et al: Ki67 index is an independent prognostic factor in epithelioid but not in non-epithelioid malignant pleural mesothelioma: A multicenter study. Br J Cancer. 112:783–792. 2015. View Article : Google Scholar : PubMed/NCBI

22 

Mego M, Reuben J and Mani S: Epithelial-mesenchymal transition (EMT) and cancer stem cells (CSCs): The Traveling Metastasis. Liquid Biopsies in Solid Tumors. Cancer Drug Discovery and Development. Cristofanilli M: Humana Press; Totowa, NJ: pp. 67–80. 2017, View Article : Google Scholar

23 

Chen T, You Y, Jiang H and Wang ZZ: Epithelial-mesenchymal transition (EMT): A biological process in the development, stem cell differentiation, and tumorigenesis. J Cell Physiol. Jan 12–2017, (Epub ahead of print). https://doi.org/10.1002/jcp.25797. View Article : Google Scholar

24 

Chodniewicz D and Klemke RL: Guiding cell migration through directed extension and stabilization of pseudopodia. Exp Cell Res. 301:31–37. 2004. View Article : Google Scholar : PubMed/NCBI

25 

Mochizuki M, Tamai K, Imai T, Sugawara S, Ogama N, Nakamura M, Matsuura K, Yamaguchi K, Satoh K, Sato I, et al: CD271 regulates the proliferation and motility of hypopharyngeal cancer cells. Sci Rep. 6:307072016. View Article : Google Scholar : PubMed/NCBI

26 

Huang L, Chen C, Zhang G, Ju Y, Zhang J, Wang H and Li J: STK33 overexpression in hypopharyngeal squamous cell carcinoma: Possible role in tumorigenesis. BMC Cancer. 15:132015. View Article : Google Scholar : PubMed/NCBI

27 

Chen C, Huang L, Zhang G, Li Y, Li L, Bai X, Liu W, Wang H and Li J: STK33 potentiates the malignancy of hypopharyngeal squamous carcinoma: Possible relation to calcium. Cancer Biol Ther. 17:976–984. 2016. View Article : Google Scholar : PubMed/NCBI

28 

Wierstra I: FOXM1 (Forkhead box M1) in tumorigenesis: Overexpression in human cancer, implication in tumorigenesis, oncogenic functions, tumor-suppressive properties, and target of anticancer therapy. Adv Cancer Res. 119:191–419. 2013. View Article : Google Scholar : PubMed/NCBI

29 

Ahn H, Sim J, Abdul R, Chung MS, Paik SS, Oh YH, Park CK and Jang K: Increased expression of forkhead box M1 is associated with aggressive phenotype and poor prognosis in estrogen receptor-positive breast cancer. J Korean Med Sci. 30:390–397. 2015. View Article : Google Scholar : PubMed/NCBI

30 

Ito T, Kohashi K, Yamada Y, Iwasaki T, Maekawa A, Kuda M, Hoshina D, Abe R, Furue M and Oda Y: Prognostic significance of forkhead Box M1 (FOXM1) expression and antitumor effect of FOXM1 inhibition in angiosarcoma. J Cancer. 7:823–830. 2016. View Article : Google Scholar : PubMed/NCBI

31 

Wierstra I and Alves J: FOXM1, a typical proliferation-associated transcription factor. Biol Chem. 388:1257–1274. 2007. View Article : Google Scholar : PubMed/NCBI

32 

Chen H, Yang C, Yu L, Xie L, Hu J, Zeng L and Tan Y: Adenovirus-mediated RNA interference targeting FOXM1 transcription factor suppresses cell proliferation and tumor growth of nasopharyngeal carcinoma. J Gene Med. 14:231–240. 2012. View Article : Google Scholar : PubMed/NCBI

33 

Yang C, Chen H, Yu L, Shan L, Xie L, Hu J, Chen T and Tan Y: Inhibition of FOXM1 transcription factor suppresses cell proliferation and tumor growth of breast cancer. Cancer Gene Ther. 20:117–124. 2013. View Article : Google Scholar : PubMed/NCBI

34 

Xue Y, Zhang G, Xu R, Zou X, Zhong X, Wu G, Wang X, Long D, Wu Y, Xu H, et al: Overexpression of FoxM1 is associated with tumor progression. J Urol. 189:e7832013. View Article : Google Scholar

35 

Bhat UG, Halasi M and Gartel AL: Thiazole antibiotics target FoxM1 and induce apoptosis in human cancer cells. PLoS One. 4:e5592. 2009. View Article : Google Scholar : PubMed/NCBI

36 

Park HJ, Gusarova G, Wang Z, Carr JR, Li J, Kim KH, Qiu J, Park YD, Williamson PR, Hay N, et al: Deregulation of FoxM1b leads to tumour metastasis. EMBO Mol Med. 3:21–34. 2011. View Article : Google Scholar : PubMed/NCBI

37 

Zhang C, Wang Y, Feng Y, Zhang Y, Ji B, Wang S and Sun Y, Zhu C, Zhang D and Sun Y: Gli1 promotes colorectal cancer metastasis in a Foxm1-dependent manner by activating EMT and PI3K-AKT signaling. Oncotarget. 7:86134–86147. 2016.PubMed/NCBI

38 

Lamouille S, Xu J and Derynck R: Molecular mechanisms of epithelial-mesenchymal transition. Nat Rev Mol Cell Biol. 15:178–196. 2014. View Article : Google Scholar : PubMed/NCBI

39 

Chen B, Zeng X, He Y, Wang X, Liang Z, Liu J, Zhang P, Zhu H, Xu N and Liang S: STC2 promotes the epithelial-mesenchymal transition of colorectal cancer cells through AKT-ERK signaling pathways. Oncotarget. 7:71400–71416. 2016.PubMed/NCBI

40 

Xiang J, Fu X, Ran W and Wang Z: Grhl2 reduces invasion and migration through inhibition of TGFβ-induced EMT in gastric cancer. Oncogenesis. 6:e2842017. View Article : Google Scholar

41 

Ganguly A and Cabral F: The arresting action of microtubules in cell motility. Cell Cycle. 10:2614–2615. 2011. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Chen Y, Liu Y, Ni H, Ding C, Zhang X and Zhang Z: FoxM1 overexpression promotes cell proliferation and migration and inhibits apoptosis in hypopharyngeal squamous cell carcinoma resulting in poor clinical prognosis. Int J Oncol 51: 1045-1054, 2017.
APA
Chen, Y., Liu, Y., Ni, H., Ding, C., Zhang, X., & Zhang, Z. (2017). FoxM1 overexpression promotes cell proliferation and migration and inhibits apoptosis in hypopharyngeal squamous cell carcinoma resulting in poor clinical prognosis. International Journal of Oncology, 51, 1045-1054. https://doi.org/10.3892/ijo.2017.4094
MLA
Chen, Y., Liu, Y., Ni, H., Ding, C., Zhang, X., Zhang, Z."FoxM1 overexpression promotes cell proliferation and migration and inhibits apoptosis in hypopharyngeal squamous cell carcinoma resulting in poor clinical prognosis". International Journal of Oncology 51.4 (2017): 1045-1054.
Chicago
Chen, Y., Liu, Y., Ni, H., Ding, C., Zhang, X., Zhang, Z."FoxM1 overexpression promotes cell proliferation and migration and inhibits apoptosis in hypopharyngeal squamous cell carcinoma resulting in poor clinical prognosis". International Journal of Oncology 51, no. 4 (2017): 1045-1054. https://doi.org/10.3892/ijo.2017.4094
Copy and paste a formatted citation
x
Spandidos Publications style
Chen Y, Liu Y, Ni H, Ding C, Zhang X and Zhang Z: FoxM1 overexpression promotes cell proliferation and migration and inhibits apoptosis in hypopharyngeal squamous cell carcinoma resulting in poor clinical prognosis. Int J Oncol 51: 1045-1054, 2017.
APA
Chen, Y., Liu, Y., Ni, H., Ding, C., Zhang, X., & Zhang, Z. (2017). FoxM1 overexpression promotes cell proliferation and migration and inhibits apoptosis in hypopharyngeal squamous cell carcinoma resulting in poor clinical prognosis. International Journal of Oncology, 51, 1045-1054. https://doi.org/10.3892/ijo.2017.4094
MLA
Chen, Y., Liu, Y., Ni, H., Ding, C., Zhang, X., Zhang, Z."FoxM1 overexpression promotes cell proliferation and migration and inhibits apoptosis in hypopharyngeal squamous cell carcinoma resulting in poor clinical prognosis". International Journal of Oncology 51.4 (2017): 1045-1054.
Chicago
Chen, Y., Liu, Y., Ni, H., Ding, C., Zhang, X., Zhang, Z."FoxM1 overexpression promotes cell proliferation and migration and inhibits apoptosis in hypopharyngeal squamous cell carcinoma resulting in poor clinical prognosis". International Journal of Oncology 51, no. 4 (2017): 1045-1054. https://doi.org/10.3892/ijo.2017.4094
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