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Melatonin potentiates the antitumor effect of curcumin by inhibiting IKKβ/NF-κB/COX-2 signaling pathway

  • Authors:
    • Sandeep Shrestha
    • Jiabin Zhu
    • Qi Wang
    • Xiaohui Du
    • Fen Liu
    • Jianing Jiang
    • Jing Song
    • Jinshan Xing
    • Dongdong Sun
    • Qingjuan Hou
    • Yulin Peng
    • Jun Zhao
    • Xiuzhen Sun
    • Xishuang Song
  • View Affiliations / Copyright

    Affiliations: Department of Urology, First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning 16011, P.R. China, Department of Respiratory Medicine, Affiliated Second Hospital of Dalian Medical University, Dalian, Liaoning 116023, P.R. China, Scientifc Research Center, Affiliated Second Hospital of Dalian Medical University, Dalian, Liaoning 116023, P.R. China, Department of Neurosurgery, Affiliated Second Hospital of Dalian Medical University, Dalian, Liaoning 116023, P.R. China, College of Pharmacy, Dalian Medical University, Dalian, Liaoning 116044, P.R. China, Department of Neurosurgery, First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning 116011, P.R. China, Department of Otorhinolaryngology, Affiliated Second Hospital of Dalian Medical University, Dalian, Liaoning 116023, P.R. China
    Copyright: © Shrestha et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1249-1260
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    Published online on: August 22, 2017
       https://doi.org/10.3892/ijo.2017.4097
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Abstract

Curcumin, a natural polyphenolic compound, has commonly been used as a food additive or in many traditional medicine remedies for over 2,000 years in many Asian countries. Melatonin is a hormone secreted from pineal glands of mammals and possesses diverse physiological functions. Both curcumin and melatonin have the effective potential to inhibit proliferation of various types of cancers, but there is no report on their combination for bladder cancer treatment, and the underlying mechanism remains poorly understood. In the present study, we investigated whether the combination of curcumin and melatonin leads to an enhanced inhibition of cell proliferation in bladder cancer cells. Our results showed that the combinational treatment enhanced the repression of nuclear translocation of NF-κB and their binding on COX-2 promoter via inhibiting IKKβ activity, resulting in inhibition of COX-2 expression. In addition, combined treatment with curcumin and melatonin induced cell apoptosis in bladder cancer through enhancing the release of cytochrome c from the mitochondrial intermembrane space into the cytosol. These results, therefore, indicated that melatonin synergized the inhibitory effect of curcumin against the growth of bladder cancer by enhancing the anti-proliferation, anti-migration, and pro-apoptotic activities, and provide strong evidence that combined treatment with curcumin and melatonin might exhibit an effective therapeutic option in bladder cancer therapy.
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1 

Antoni S, Ferlay J, Soerjomataram I, Znaor A, Jemal A and Bray F: Bladder cancer incidence and mortality: A global overview and recent trends. Eur Urol. 71:96–108. 2017. View Article : Google Scholar

2 

Witjes JA: Bladder cancer in 2015: Improving indication, technique and outcome of radical cystectomy. Nat Rev Urol. 13:74–76. 2016. View Article : Google Scholar

3 

Bellmunt J and Guix M: New agents for bladder cancer. Ann Oncol. 21(Suppl 7): vii56–vii58. 2010. View Article : Google Scholar : PubMed/NCBI

4 

Anghel RM, Gales LN and Trifanescu OG: Outcome of urinary bladder cancer after combined therapies. J Med Life. 9:95–100. 2016.PubMed/NCBI

5 

Shishodia S, Chaturvedi MM and Aggarwal BB: Role of curcumin in cancer therapy. Curr Probl Cancer. 31:243–305. 2007. View Article : Google Scholar : PubMed/NCBI

6 

Gupta SC, Kismali G and Aggarwal BB: Curcumin, a component of turmeric: From farm to pharmacy. Biofactors. 39:2–13. 2013. View Article : Google Scholar : PubMed/NCBI

7 

Shehzad A and Lee YS: Curcumin: Multiple molecular targets mediate multiple pharmacological actions - A review. Drugs Future. 35:113–119. 2010. View Article : Google Scholar

8 

Basile V, Ferrari E, Lazzari S, Belluti S, Pignedoli F and Imbriano C: Curcumin derivatives: Molecular basis of their anti-cancer activity. Biochem Pharmacol. 78:1305–1315. 2009. View Article : Google Scholar : PubMed/NCBI

9 

Shehzad A, Wahid F and Lee YS: Curcumin in cancer chemo-prevention: Molecular targets, pharmacokinetics, bioavailability, and clinical trials. Arch Pharm (Weinheim). 343:489–499. 2010. View Article : Google Scholar

10 

Gupta SC, Patchva S, Koh W and Aggarwal BB: Discovery of curcumin, a component of golden spice, and its miraculous biological activities. Clin Exp Pharmacol Physiol. 39:283–299. 2012. View Article : Google Scholar :

11 

Chen J, He ZM, Wang FL, Zhang ZS, Liu XZ, Zhai DD and Chen WD: Curcumin and its promise as an anticancer drug: An analysis of its anticancer and antifungal effects in cancer and associated complications from invasive fungal infections. Eur J Pharmacol. 772:33–42. 2016. View Article : Google Scholar : PubMed/NCBI

12 

Kasi PD, Tamilselvam R, Skalicka-Wozniak K, Nabavi SF, Daglia M, Bishayee A, Pazoki-Toroudi H and Nabavi SM: Molecular targets of curcumin for cancer therapy: An updated review. Tumour Biol. 37:13017–13028. 2016. View Article : Google Scholar : PubMed/NCBI

13 

Rahmani AH, Al Zohairy MA, Aly SM and Khan MA: Curcumin: A potential candidate in prevention of cancer via modulation of molecular pathways. BioMed Res Int. 2014:7616082014. View Article : Google Scholar : PubMed/NCBI

14 

Li Y and Zhang T: Targeting cancer stem cells by curcumin and clinical applications. Cancer Lett. 346:197–205. 2014. View Article : Google Scholar : PubMed/NCBI

15 

Tuorkey MJ: Curcumin a potent cancer preventive agent: Mechanisms of cancer cell killing. Interv Med Appl Sci. 6:139–146. 2014.

16 

Kang M, Ho JN, Kook HR, Lee S, Oh JJ, Hong SK, Lee SE and Byun SS: Theracurmin® efficiently inhibits the growth of human prostate and bladder cancer cells via induction of apoptotic cell death and cell cycle arrest. Oncol Rep. 35:1463–1472. 2016. View Article : Google Scholar : PubMed/NCBI

17 

Liu HS, Ke CS, Cheng HC, Huang CY and Su CL: Curcumin-induced mitotic spindle defect and cell cycle arrest in human bladder cancer cells occurs partly through inhibition of aurora A. Mol Pharmacol. 80:638–646. 2011. View Article : Google Scholar : PubMed/NCBI

18 

Anand P, Kunnumakkara AB, Newman RA and Aggarwal BB: Bioavailability of curcumin: Problems and promises. Mol Pharm. 4:807–818. 2007. View Article : Google Scholar : PubMed/NCBI

19 

McIsaac WM, Farrell G, Taborsky RG and Taylor AN: Indole compounds: Isolation from pineal tissue. Science. 148:102–103. 1965. View Article : Google Scholar : PubMed/NCBI

20 

Lerner AB, Case JD and Takahashi Y: Isolation of melatonin and 5-methoxyindole-3-acetic acid from bovine pineal glands. J Biol Chem. 235:1992–1997. 1960.PubMed/NCBI

21 

Slominski RM, Reiter RJ, Schlabritz-Loutsevitch N, Ostrom RS and Slominski AT: Melatonin membrane receptors in peripheral tissues: Distribution and functions. Mol Cell Endocrinol. 351:152–166. 2012. View Article : Google Scholar : PubMed/NCBI

22 

Singh M and Jadhav HR: Melatonin: Functions and ligands. Drug Discov Today. 19:1410–1418. 2014. View Article : Google Scholar : PubMed/NCBI

23 

Rondanelli M, Faliva MA, Perna S and Antoniello N: Update on the role of melatonin in the prevention of cancer tumorigenesis and in the management of cancer correlates, such as sleep-wake and mood disturbances: Review and remarks. Aging Clin Exp Res. 25:499–510. 2013. View Article : Google Scholar : PubMed/NCBI

24 

García JJ, López-Pingarrón L, Almeida-Souza P, Tres A, Escudero P, García-Gil FA, Tan DX, Reiter RJ, Ramírez JM and Bernal-Pérez M: Protective effects of melatonin in reducing oxidative stress and in preserving the fluidity of biological membranes: A review. J Pineal Res. 56:225–237. 2014. View Article : Google Scholar : PubMed/NCBI

25 

Xin Z, Jiang S, Jiang P, Yan X, Fan C, Di S, Wu G, Yang Y, Reiter RJ and Ji G: Melatonin as a treatment for gastrointestinal cancer: A review. J Pineal Res. 58:375–387. 2015. View Article : Google Scholar : PubMed/NCBI

26 

Hill SM, Belancio VP, Dauchy RT, Xiang S, Brimer S, Mao L, Hauch A, Lundberg PW, Summers W, Yuan L, et al: Melatonin: An inhibitor of breast cancer. Endocr Relat Cancer. 22:R183–R204. 2015. View Article : Google Scholar : PubMed/NCBI

27 

Ordoñez R, Carbajo-Pescador S, Prieto-Dominguez N, García-Palomo A, González-Gallego J and Mauriz JL: Inhibition of matrix metalloproteinase-9 and nuclear factor kappa B contribute to melatonin prevention of motility and invasiveness in HepG2 liver cancer cells. J Pineal Res. 56:20–30. 2014. View Article : Google Scholar

28 

Marks F and Müller-Decker K: Fürstenberger G. A causal relationship between unscheduled eicosanoid signaling and tumor development: Cancer chemoprevention by inhibitors of arachidonic acid metabolism. Toxicology. 153:11–26. 2000. View Article : Google Scholar : PubMed/NCBI

29 

Federico A, Morgillo F, Tuccillo C, Ciardiello F and Loguercio C: Chronic inflammation and oxidative stress in human carcinogenesis. Int J Cancer. 121:2381–2386. 2007. View Article : Google Scholar : PubMed/NCBI

30 

Nakanishi M and Rosenberg DW: Roles of cPLA2alpha and arachidonic acid in cancer. Biochim Biophys Acta. 1761:1335–1343. 2006. View Article : Google Scholar : PubMed/NCBI

31 

Wan GX, Chen P, Yu XJ, Di QS, Yu YD, Lei JH, Tai YY and Cao FJ: Cyclooxygenase-2 polymorphisms and bladder cancer risk: A meta-analysis based on case-control studies. Int J Clin Exp Med. 8:3935–3945. 2015.PubMed/NCBI

32 

Matsuo T, Miyata Y, Mitsunari K, Yasuda T, Ohba K and Sakai H: Pathological significance and prognostic implications of heme oxygenase 1 expression in non-muscle-invasive bladder cancer: Correlation with cell proliferation, angiogenesis, lymphangiogenesis and expression of VEGFs and COX-2. Oncol Lett. 13:275–280. 2017.PubMed/NCBI

33 

Festa-Vasconcellos JS, Piranda DN, Amaral LM, Indio-do-Brasil V, Koifman S and Vianna-Jorge R: Polymorphisms in cycloxygenase-2 gene and breast cancer prognosis: Association between PTGS2 haplotypes and histopathological features. Breast Cancer Res Treat. 132:251–258. 2012. View Article : Google Scholar

34 

Chen G, Li X, Yang J, Li J, Wang X, He J and Huang Z: Prognostic significance of cyclooxygenase-2 expression in patients with hepatocellular carcinoma: A meta-analysis. Arch Med Sci. 12:1110–1117. 2016. View Article : Google Scholar : PubMed/NCBI

35 

Park E-J, Cheenpracha S, Chang LC, Kondratyuk TP and Pezzuto JM: Inhibition of lipopolysaccharide-induced cyclooxygenase-2 and inducible nitric oxide synthase expression by 4-[ (2′-O-acetyl-α-L-rhamnosyloxy)benzyl]isothiocyanate from Moringa oleifera. Nutr Cancer. 63:971–982. 2011. View Article : Google Scholar

36 

Asting AG, Carén H, Andersson M, Lönnroth C, Lagerstedt K and Lundholm K: COX-2 gene expression in colon cancer tissue related to regulating factors and promoter methylation status. BMC Cancer. 11:2382011. View Article : Google Scholar : PubMed/NCBI

37 

Jiang J and Dingledine R: Role of prostaglandin receptor EP2 in the regulations of cancer cell proliferation, invasion, and inflammation. J Pharmacol Exp Ther. 344:360–367. 2013. View Article : Google Scholar :

38 

Jiang J and Dingledine R: Prostaglandin receptor EP2 in the crosshairs of anti-inflammation, anti-cancer, and neuroprotection. Trends Pharmacol Sci. 34:413–423. 2013. View Article : Google Scholar : PubMed/NCBI

39 

Zhang C, Su Z-Y, Wang L, Shu L, Yang Y, Guo Y, Pung D, Bountra C and Kong AN: Epigenetic blockade of neoplastic transformation by bromodomain and extra-terminal (BET) domain protein inhibitor JQ-1. Biochem Pharmacol. 117:35–45. 2016. View Article : Google Scholar : PubMed/NCBI

40 

Yu ZL, Guo W, Ma XC, Zhang B, Dong P, Huang L, Wang X, Wang C, Huo X, Yu W, et al: Gamabufotalin, a bufadienolide compound from toad venom, suppresses COX-2 expression through targeting IKKβ/NF-κB signaling pathway in lung cancer cells. Mol Cancer. 13:2032014. View Article : Google Scholar

41 

Karin M and Ben-Neriah Y: Phosphorylation meets ubiquitination: The control of NF-[kappa]B activity. Annu Rev Immunol. 18:621–663. 2000. View Article : Google Scholar

42 

Bimonte S, Barbieri A, Leongito M, Piccirillo M, Giudice A, Pivonello C, de Angelis C, Granata V, Palaia R and Izzo F: Curcumin anticancer studies in pancreatic cancer. Nutrients. 8:82016. View Article : Google Scholar

43 

Charpentier MS, Whipple RA, Vitolo MI, Boggs AE, Slovic J, Thompson KN, Bhandary L and Martin SS: Curcumin targets breast cancer stem-like cells with microtentacles that persist in mammospheres and promote reattachment. Cancer Res. 74:1250–1260. 2014. View Article : Google Scholar :

44 

Bayet-Robert M, Kwiatkowski F, Leheurteur M, Gachon F, Planchat E, Abrial C, Mouret-Reynier MA, Durando X, Barthomeuf C and Chollet P: Phase I dose escalation trial of docetaxel plus curcumin in patients with advanced and metastatic breast cancer. Cancer Biol Ther. 9:8–14. 2010. View Article : Google Scholar

45 

García-Rivera D, Delgado R, Bougarne N, Haegeman G and Berghe WV: Gallic acid indanone and mangiferin xanthone are strong determinants of immunosuppressive anti-tumour effects of Mangifera indica L. bark in MDA-MB231 breast cancer cells. Cancer Lett. 305:21–31. 2011. View Article : Google Scholar : PubMed/NCBI

46 

Kim H-N, Kim D-H, Kim E-H, Lee MH, Kundu JK, Na HK, Cha YN and Surh YJ: Sulforaphane inhibits phorbol ester-stimulated IKK-NF-κB signaling and COX-2 expression in human mammary epithelial cells by targeting NF-κB activating kinase and ERK. Cancer Lett. 351:41–49. 2014. View Article : Google Scholar : PubMed/NCBI

47 

Xia Y, Shen S and Verma IM: NF-κB, an active player in human cancers. Cancer Immunol Res. 2:823–830. 2014. View Article : Google Scholar : PubMed/NCBI

48 

Pittayapruek P, Meephansan J, Prapapan O, Komine M and Ohtsuki M: Role of matrix metalloproteinases in photoaging and photocarcinogenesis. Int J Mol Sci. 17:8682016. View Article : Google Scholar :

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Copy and paste a formatted citation
Spandidos Publications style
Shrestha S, Zhu J, Wang Q, Du X, Liu F, Jiang J, Song J, Xing J, Sun D, Hou Q, Hou Q, et al: Melatonin potentiates the antitumor effect of curcumin by inhibiting IKKβ/NF-κB/COX-2 signaling pathway. Int J Oncol 51: 1249-1260, 2017.
APA
Shrestha, S., Zhu, J., Wang, Q., Du, X., Liu, F., Jiang, J. ... Song, X. (2017). Melatonin potentiates the antitumor effect of curcumin by inhibiting IKKβ/NF-κB/COX-2 signaling pathway. International Journal of Oncology, 51, 1249-1260. https://doi.org/10.3892/ijo.2017.4097
MLA
Shrestha, S., Zhu, J., Wang, Q., Du, X., Liu, F., Jiang, J., Song, J., Xing, J., Sun, D., Hou, Q., Peng, Y., Zhao, J., Sun, X., Song, X."Melatonin potentiates the antitumor effect of curcumin by inhibiting IKKβ/NF-κB/COX-2 signaling pathway". International Journal of Oncology 51.4 (2017): 1249-1260.
Chicago
Shrestha, S., Zhu, J., Wang, Q., Du, X., Liu, F., Jiang, J., Song, J., Xing, J., Sun, D., Hou, Q., Peng, Y., Zhao, J., Sun, X., Song, X."Melatonin potentiates the antitumor effect of curcumin by inhibiting IKKβ/NF-κB/COX-2 signaling pathway". International Journal of Oncology 51, no. 4 (2017): 1249-1260. https://doi.org/10.3892/ijo.2017.4097
Copy and paste a formatted citation
x
Spandidos Publications style
Shrestha S, Zhu J, Wang Q, Du X, Liu F, Jiang J, Song J, Xing J, Sun D, Hou Q, Hou Q, et al: Melatonin potentiates the antitumor effect of curcumin by inhibiting IKKβ/NF-κB/COX-2 signaling pathway. Int J Oncol 51: 1249-1260, 2017.
APA
Shrestha, S., Zhu, J., Wang, Q., Du, X., Liu, F., Jiang, J. ... Song, X. (2017). Melatonin potentiates the antitumor effect of curcumin by inhibiting IKKβ/NF-κB/COX-2 signaling pathway. International Journal of Oncology, 51, 1249-1260. https://doi.org/10.3892/ijo.2017.4097
MLA
Shrestha, S., Zhu, J., Wang, Q., Du, X., Liu, F., Jiang, J., Song, J., Xing, J., Sun, D., Hou, Q., Peng, Y., Zhao, J., Sun, X., Song, X."Melatonin potentiates the antitumor effect of curcumin by inhibiting IKKβ/NF-κB/COX-2 signaling pathway". International Journal of Oncology 51.4 (2017): 1249-1260.
Chicago
Shrestha, S., Zhu, J., Wang, Q., Du, X., Liu, F., Jiang, J., Song, J., Xing, J., Sun, D., Hou, Q., Peng, Y., Zhao, J., Sun, X., Song, X."Melatonin potentiates the antitumor effect of curcumin by inhibiting IKKβ/NF-κB/COX-2 signaling pathway". International Journal of Oncology 51, no. 4 (2017): 1249-1260. https://doi.org/10.3892/ijo.2017.4097
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