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Expression of Wnt3a in hepatocellular carcinoma and its effects on cell cycle and metastasis

  • Authors:
    • Caijie Lu
    • Yifeng He
    • Juan Duan
    • Yongguang Yang
    • Chunqiang Zhong
    • Jian Zhang
    • Weiguo Liao
    • Xiaojie Huang
    • Runzhi Zhu
    • Mingyi Li
  • View Affiliations / Copyright

    Affiliations: Laboratory of Hepatobiliary Surgery, Affiliated Hospital of Guangdong Medical University, Zhanjiang Key Laboratory of Hepatobiliary Diseases, Zhanjiang, Guangdong 524001, P.R. China, Guangdong Medical University, Zhanjiang, Guangdong 524001, P.R. China
    Copyright: © Lu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1135-1145
    |
    Published online on: September 1, 2017
       https://doi.org/10.3892/ijo.2017.4112
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Abstract

Invasion and metastasis are the primary causes of mortality from hepatocellular carcinoma (HCC). Effective inhibition against participants in the tumourigenesis and metastasis process is critical for treatment of HCC. Wnt3a is involved in the development and metastasis of many malignant tumours. However, the specific mechanisms of Wnt3a-mediated cell proliferation, invasion and metastasis in HCC remain unclear. In this study, we found that Wnt3a and its target gene c‑Myc showed higher expression in tumour tissues than normal liver tissues in HCC patients; 71.8% of the cases studied had high Wnt3a and c‑Myc expression levels (n=32); Wnt3a expression positively correlated with its target genes MMP‑7 and c‑Myc. Intriguingly, the expression of Wnt3a, MMP‑7 and c‑Myc is significantly correlated with Notch3 and Hes1 expression. In vitro experiments showed that Wnt3a was highly expressed in MHcc97H and SK‑Hep‑1 cells. Therefore, Wnt3a expression was silenced with siRNA, and then, MTT, flow cytometry, wound healing and Transwell assays were performed to analyse cell proliferation, cycle, migration and invasion. The results demonstrated that downregulation of Wnt3a expression inhibited cell viability and induced G0/G1 cell cycle arrest via decreased expression of cyclin D1 and c‑Myc and increased expression of p21 and p27. In addition, deletion of Wnt3a significantly inhibited migration and invasion by downregulating MMP‑2/-7/-9 expression via the MAPK (p38, ERK1/2 and JNK) pathway. In conclusion, our data show that Wnt3a is involved in HCC development. Wnt3a may be an effective target for treatment of HCC.
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View References

1 

Fitzmaurice C, Dicker D, Pain A, Hamavid H, Moradi-Lakeh M, MacIntyre MF, Allen C, Hansen G, Woodbrook R, Wolfe C, et al Global Burden of Disease Cancer Collaboration: The global burden of cancer 2013. JAMA Oncol. 1:505–527. 2015. View Article : Google Scholar : PubMed/NCBI

2 

Du ZG, Wei YG, Chen KF and Li B: Risk factors associated with early and late recurrence after curative resection of hepatocellular carcinoma: A single institution's experience with 398 consecutive patients. Hepatobiliary Pancreat Dis Int. 13:153–161. 2014. View Article : Google Scholar : PubMed/NCBI

3 

Yang LY, Chang RM, Lau WY, Ou DP, Wu W and Zeng ZJ: Mesohepatectomy for centrally located large hepatocellular carcinoma: Indications, techniques, and outcomes. Surgery. 156:1177–1187. 2014. View Article : Google Scholar : PubMed/NCBI

4 

Clevers H and Nusse R: Wnt/β-catenin signaling and disease. Cell. 149:1192–1205. 2012. View Article : Google Scholar : PubMed/NCBI

5 

Oishi N, Yamashita T and Kaneko S: Molecular biology of liver cancer stem cells. Liver Cancer. 3:71–84. 2014. View Article : Google Scholar : PubMed/NCBI

6 

Cadigan KM and Nusse R: Wnt signaling: A common theme in animal development. Genes Dev. 11:3286–3305. 1997. View Article : Google Scholar

7 

Pai SG, Carneiro BA, Mota JM, Costa R, Leite CA, Barroso-Sousa R, Kaplan JB, Chae YK and Giles FJ: Wnt/beta-catenin pathway: Modulating anticancer immune response. J Hematol Oncol. 10:1012017. View Article : Google Scholar : PubMed/NCBI

8 

Eterno V, Zambelli A, Villani L, Tuscano A, Manera S, Spitaleri A, Pavesi L and Amato A: AurkA controls self-renewal of breast cancer-initiating cells promoting wnt3a stabilization through suppression of miR-128. Sci Rep. 6:284362016. View Article : Google Scholar : PubMed/NCBI

9 

Lee MA, Park JH, Rhyu SY, Oh ST, Kang WK and Kim HN: Wnt3a expression is associated with MMP-9 expression in primary tumor and metastatic site in recurrent or stage IV colorectal cancer. BMC Cancer. 14:1252014. View Article : Google Scholar : PubMed/NCBI

10 

Li C, Song G, Zhang S, Wang E and Cui Z: Wnt3a increases the metastatic potential of non-small cell lung cancer cells in vitro in part via its upregulation of Notch3. Oncol Rep. 33:1207–1214. 2015. View Article : Google Scholar : PubMed/NCBI

11 

Tanaka M, Kuriyama S, Itoh G, Maeda D, Goto A, Tamiya Y, Yanagihara K, Yashiro M and Aiba N: Mesothelial cells create a novel tissue niche that facilitates gastric cancer invasion. Cancer Res. 77:684–695. 2017. View Article : Google Scholar

12 

Leung WK, He M, Chan AW, Law PT and Wong N: Wnt/β-catenin activates MiR-183/96/182 expression in hepatocellular carcinoma that promotes cell invasion. Cancer Lett. 362:97–105. 2015. View Article : Google Scholar : PubMed/NCBI

13 

Peng YY, He YH, Chen C, Xu T, Li L, Ni MM, Meng XM, Huang C and Li J: NLRC5 regulates cell proliferation, migration and invasion in hepatocellular carcinoma by targeting the Wnt/β-catenin signaling pathway. Cancer Lett. 376:10–21. 2016. View Article : Google Scholar : PubMed/NCBI

14 

Liao CH, Yeh CT, Huang YH, Wu SM, Chi HC, Tsai MM, Tsai CY, Liao CJ, Tseng YH, Lin YH, et al: Dickkopf 4 positively regulated by the thyroid hormone receptor suppresses cell invasion in human hepatoma cells. Hepatology. 55:910–920. 2012. View Article : Google Scholar

15 

Zhang Q, Lu C, Fang T, Wang Y, Hu W, Qiao J, Liu B, Liu J, Chen N, Li M, et al: Notch3 functions as a regulator of cell self-renewal by interacting with the β-catenin pathway in hepatocellular carcinoma. Oncotarget. 6:3669–3679. 2015. View Article : Google Scholar : PubMed/NCBI

16 

Jia S, Lu J, Qu T, Feng Y, Wang X, Liu C and Ji J: MAGI1 inhibits migration and invasion via blocking MAPK/ERK signaling pathway in gastric cancer. Chin J Cancer Res. 29:25–35. 2017. View Article : Google Scholar : PubMed/NCBI

17 

Shao Q, Luo X, Yang D, Wang C, Cheng Q, Xiang T and Ren G: Phospholipase Cδ1 suppresses cell migration and invasion of breast cancer cells by modulating KIF3A-mediated ERK1/2/β-catenin/MMP7 signalling. Oncotarget. 8:29056–29066. 2017.PubMed/NCBI

18 

Cheng Q, Yuan F, Lu F, Zhang B, Chen T, Chen X, Cheng Y, Li N, Ma L and Tong T: CSIG promotes hepatocellular carcinoma proliferation by activating c-MYC expression. Oncotarget. 6:4733–4744. 2015. View Article : Google Scholar : PubMed/NCBI

19 

Okazaki I and Inagaki Y: Novel strategies for hepatocellular carcinoma based on MMPs science. Anticancer Agents Med Chem. 12:753–763. 2012. View Article : Google Scholar : PubMed/NCBI

20 

DeSantis CE, Lin CC, Mariotto AB, Siegel RL, Stein KD, Kramer JL, Alteri R, Robbins AS and Jemal A: Cancer treatment and survivorship statistics, 2014. CA Cancer J Clin. 64:252–271. 2014. View Article : Google Scholar : PubMed/NCBI

21 

Siegel R, Ma J, Zou Z and Jemal A: Cancer statistics, 2014. CA Cancer J Clin. 64:9–29. 2014. View Article : Google Scholar : PubMed/NCBI

22 

Gai JQ, Sheng X, Qin JM, Sun K, Zhao W and Ni L: The effect and mechanism of bufalin on regulating hepatocellular carcinoma cell invasion and metastasis via Wnt/β-catenin signaling pathway. Int J Oncol. 48:338–348. 2016. View Article : Google Scholar

23 

Lian J, Tang J, Shi H, Li H, Zhen T, Xie W, Zhang F, Yang Y and Han A: Positive feedback loop of hepatoma-derived growth factor and β-catenin promotes carcinogenesis of colorectal cancer. Oncotarget. 6:29357–29374. 2015. View Article : Google Scholar : PubMed/NCBI

24 

Driskell RR, Goodheart M, Neff T, Liu X, Luo M, Moothart C, Sigmund CD, Hosokawa R, Chai Y and Engelhardt JF: Wnt3a regulates Lef-1 expression during airway submucosal gland morphogenesis. Dev Biol. 305:90–102. 2007. View Article : Google Scholar : PubMed/NCBI

25 

Galceran J, Fariñas I, Depew MJ, Clevers H and Grosschedl R: Wnt3a−/−-like phenotype and limb deficiency in Lef1 (−/−)Tcf1 (−/−) mice. Genes Dev. 13:709–717. 1999. View Article : Google Scholar : PubMed/NCBI

26 

Qiang YW, Chen Y, Brown N, Hu B, Epstein J, Barlogie B and Shaughnessy JD Jr: Characterization of Wnt/beta-catenin signalling in osteoclasts in multiple myeloma. Br J Haematol. 148:726–738. 2010. View Article : Google Scholar

27 

Wallace K, Marek CJ, Hoppler S and Wright MC: Glucocorticoid-dependent transdifferentiation of pancreatic progenitor cells into hepatocytes is dependent on transient suppression of WNT signalling. J Cell Sci. 123:2103–2110. 2010. View Article : Google Scholar : PubMed/NCBI

28 

Wang SH, Li N, Wei Y, Li QR and Yu ZP: β-catenin deacetylation is essential for WNT-induced proliferation of breast cancer cells. Mol Med Rep. 9:973–978. 2014. View Article : Google Scholar : PubMed/NCBI

29 

Brabletz T, Jung A, Dag S, Hlubek F and Kirchner T: beta-catenin regulates the expression of the matrix metalloproteinase-7 in human colorectal cancer. Am J Pathol. 155:1033–1038. 1999. View Article : Google Scholar : PubMed/NCBI

30 

Liu D, Nakano J, Ishikawa S, Yokomise H, Ueno M, Kadota K, Urushihara M and Huang CL: Overexpression of matrix metalloproteinase-7 (MMP-7) correlates with tumor proliferation, and a poor prognosis in non-small cell lung cancer. Lung Cancer. 58:384–391. 2007. View Article : Google Scholar : PubMed/NCBI

31 

Erdal E, Ozturk N, Cagatay T, Eksioglu-Demiralp E and Ozturk M: Lithium-mediated downregulation of PKB/Akt and cyclin E with growth inhibition in hepatocellular carcinoma cells. Int J Cancer. 115:903–910. 2005. View Article : Google Scholar : PubMed/NCBI

32 

Kim W, Khan SK and Yang Y: Interacting network of Hippo, Wnt/β-catenin and Notch signaling represses liver tumor formation. BMB Rep. 50:1–2. 2017. View Article : Google Scholar :

33 

Li J, Dai W, Xia Y, Chen K, Li S, Liu T, Zhang R, Wang J, Lu W and Zhou Y: et al Astaxanthin inhibits proliferation and induces apoptosis of human hepatocellular carcinoma cells via Inhibition of NF-κB P65 and Wnt/β-catenin in vitro. Mar Drugs. 13:6064–6081. 2015. View Article : Google Scholar : PubMed/NCBI

34 

Wang R, Sun Q, Wang P, Liu M, Xiong S, Luo J, Huang H, Du Q, Geller DA and Cheng B: Notch and Wnt/β-catenin signaling pathway play important roles in activating liver cancer stem cells. Oncotarget. 7:5754–5768. 2016. View Article : Google Scholar : PubMed/NCBI

35 

Sun Q, Wang R, Luo J, Wang P, Xiong S, Liu M and Cheng B: Notch1 promotes hepatitis B virus X protein-induced hepatocarcinogenesis via Wnt/β-catenin pathway. Int J Oncol. 45:1638–1648. 2014. View Article : Google Scholar : PubMed/NCBI

36 

Gao W, Kim H, Feng M, Phung Y, Xavier CP, Rubin JS and Ho M: Inactivation of Wnt signaling by a human antibody that recognizes the heparan sulfate chains of glypican-3 for liver cancer therapy. Hepatology. 60:576–587. 2014. View Article : Google Scholar : PubMed/NCBI

37 

Koch A, Waha A, Hartmann W, Hrychyk A, Schüller U, Waha A, Wharton KA Jr, Fuchs SY, von Schweinitz D and Pietsch T: Elevated expression of Wnt antagonists is a common event in hepatoblastomas. Clin Cancer Res. 11:4295–4304. 2005. View Article : Google Scholar : PubMed/NCBI

38 

Hanahan D and Weinberg RA: The hallmarks of cancer. Cell. 100:57–70. 2000. View Article : Google Scholar : PubMed/NCBI

39 

Akinyeke T, Matsumura S, Wang X, Wu Y, Schalfer ED, Saxena A, Yan W, Logan SK and Li X: Metformin targets c-MYC oncogene to prevent prostate cancer. Carcinogenesis. 34:2823–2832. 2013. View Article : Google Scholar : PubMed/NCBI

40 

Li Y, Liu H, Lai C, Du X, Su Z and Gao S: The Lin28/let-7a/c-Myc pathway plays a role in non-muscle invasive bladder cancer. Cell Tissue Res. 354:533–541. 2013. View Article : Google Scholar : PubMed/NCBI

41 

Bruyère C and Meijer L: Targeting cyclin-dependent kinases in anti-neoplastic therapy. Curr Opin Cell Biol. 25:772–779. 2013. View Article : Google Scholar : PubMed/NCBI

42 

Wang ST, Ho HJ, Lin JT, Shieh JJ and Wu CY: Simvastatin-induced cell cycle arrest through inhibition of STAT3/SKP2 axis and activation of AMPK to promote p27 and p21 accumulation in hepatocellular carcinoma cells. Cell Death Dis. 8:e26262017. View Article : Google Scholar : PubMed/NCBI

43 

Yoon MK, Mitrea DM, Ou L and Kriwacki RW: Cell cycle regulation by the intrinsically disordered proteins p21 and p27. Biochem Soc Trans. 40:981–988. 2012. View Article : Google Scholar : PubMed/NCBI

44 

Gao J, Ding F, Liu Q and Yao Y: Knockdown of MACC1 expression suppressed hepatocellular carcinoma cell migration and invasion and inhibited expression of MMP2 and MMP9. Mol Cell Biochem. 376:21–32. 2013. View Article : Google Scholar

45 

Ha TY, Hwang S, Moon KM, Won YJ, Song GW, Kim N, Tak E, Ryoo BY and Hong HN: Sorafenib inhibits migration and invasion of hepatocellular carcinoma cells through suppression of matrix metalloproteinase expression. Anticancer Res. 35:1967–1976. 2015.PubMed/NCBI

46 

Guo JR, Li W, Wu Y, Wu LQ, Li X, Guo YF, Zheng XH, Lian XL, Huang HF and Chen YZ: Hepatocyte growth factor promotes proliferation, invasion, and metastasis of myeloid leukemia cells through PI3K-AKT and MAPK/ERK signaling pathway. Am J Transl Res. 8:3630–3644. 2016.PubMed/NCBI

47 

Luo Y, Wu JY, Lu M-H, Shi Z, Na N and Di J-M: Carvacrol alleviates prostate cancer cell proliferation, migration, and invasion through regulation of PI3K/Akt and MAPK signaling pathways. Oxid Med Cell Longev. 2016:14696932016. View Article : Google Scholar : PubMed/NCBI

48 

Yang Y, Ye Y, Qiu Q, Xiao Y, Huang M, Shi M, Liang L, Yang X and Xu H: Triptolide inhibits the migration and invasion of rheumatoid fibroblast-like synoviocytes by blocking the activation of the JNK MAPK pathway. Int Immunopharmacol. 41:8–16. 2016. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Lu C, He Y, Duan J, Yang Y, Zhong C, Zhang J, Liao W, Huang X, Zhu R, Li M, Li M, et al: Expression of Wnt3a in hepatocellular carcinoma and its effects on cell cycle and metastasis. Int J Oncol 51: 1135-1145, 2017.
APA
Lu, C., He, Y., Duan, J., Yang, Y., Zhong, C., Zhang, J. ... Li, M. (2017). Expression of Wnt3a in hepatocellular carcinoma and its effects on cell cycle and metastasis. International Journal of Oncology, 51, 1135-1145. https://doi.org/10.3892/ijo.2017.4112
MLA
Lu, C., He, Y., Duan, J., Yang, Y., Zhong, C., Zhang, J., Liao, W., Huang, X., Zhu, R., Li, M."Expression of Wnt3a in hepatocellular carcinoma and its effects on cell cycle and metastasis". International Journal of Oncology 51.4 (2017): 1135-1145.
Chicago
Lu, C., He, Y., Duan, J., Yang, Y., Zhong, C., Zhang, J., Liao, W., Huang, X., Zhu, R., Li, M."Expression of Wnt3a in hepatocellular carcinoma and its effects on cell cycle and metastasis". International Journal of Oncology 51, no. 4 (2017): 1135-1145. https://doi.org/10.3892/ijo.2017.4112
Copy and paste a formatted citation
x
Spandidos Publications style
Lu C, He Y, Duan J, Yang Y, Zhong C, Zhang J, Liao W, Huang X, Zhu R, Li M, Li M, et al: Expression of Wnt3a in hepatocellular carcinoma and its effects on cell cycle and metastasis. Int J Oncol 51: 1135-1145, 2017.
APA
Lu, C., He, Y., Duan, J., Yang, Y., Zhong, C., Zhang, J. ... Li, M. (2017). Expression of Wnt3a in hepatocellular carcinoma and its effects on cell cycle and metastasis. International Journal of Oncology, 51, 1135-1145. https://doi.org/10.3892/ijo.2017.4112
MLA
Lu, C., He, Y., Duan, J., Yang, Y., Zhong, C., Zhang, J., Liao, W., Huang, X., Zhu, R., Li, M."Expression of Wnt3a in hepatocellular carcinoma and its effects on cell cycle and metastasis". International Journal of Oncology 51.4 (2017): 1135-1145.
Chicago
Lu, C., He, Y., Duan, J., Yang, Y., Zhong, C., Zhang, J., Liao, W., Huang, X., Zhu, R., Li, M."Expression of Wnt3a in hepatocellular carcinoma and its effects on cell cycle and metastasis". International Journal of Oncology 51, no. 4 (2017): 1135-1145. https://doi.org/10.3892/ijo.2017.4112
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