Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
International Journal of Oncology
Join Editorial Board Propose a Special Issue
Print ISSN: 1019-6439 Online ISSN: 1791-2423
Journal Cover
December-2017 Volume 51 Issue 6

Full Size Image

Cover Legend PDF

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
December-2017 Volume 51 Issue 6

Full Size Image

Cover Legend PDF

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Antiproliferative activity of di-2-pyridylhydrazone dithiocarbamate acetate partly involved in p53 mediated apoptosis and autophagy

  • Authors:
    • Tingting Wang
    • Youxun Liu
    • Yun Fu
    • Tengfei Huang
    • Yun Yang
    • Shaoshan Li
    • Changzheng Li
  • View Affiliations / Copyright

    Affiliations: Department of Molecular Biology and Biochemistry, Xinxiang Medical University, Xinxiang, Henan 453003, P.R. China, Department of Surgery, The Third Affiliated Hospital of Xinxiang Medical University, Xinxiang, Henan 453003, P.R. China
  • Pages: 1909-1919
    |
    Published online on: October 10, 2017
       https://doi.org/10.3892/ijo.2017.4149
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Cancer cells have higher demand of iron and copper ions for growth, disturbing the metal's homeostasis can inhibit proliferation of cancer cell. Dithiocarbamates possessing excellent metal chelating ability and antitumor activity are considered as candidates in chelation therapy, however, their antitumor molecular mechanisms remain to be elucidated. In the present study, a dithiocarbamate derivative, di-2-pyridylhydrazone dithiocarbamate s-acetic acid (DpdtaA) was prepared to address the issue whether the molecular mechanism behind biological behavior showed by dithiocarbamate was p53 mediated. The proliferation inhibition assay showed that DpdtaA exhibited excellent antiproliferative effect for hepatocellular carcinoma (IC50= 3.0±0.4 µM for HepG2, 6.1±0.6 µM for Bel-7402 cell). However, in the presence of copper ion, the antiproliferative activity of DpdtaA significantly attenuated (~3-fold for HepG2) due to formation of copper chelate. The ROS assay revealed that the antiproliferative activity of DpdtaA correlated with ROS generation. Western blotting demonstrated that DpdtaA could upregulate p53 via down-regulating the Mdm2, accordingly leading to changes of bcl family proteins, indicating that a p53-dependent intrinsic apoptosis was partly involved. Simulation from molecular docking hinted that DpdtaA could disrupt interaction between p53 and Mdm2, indicating the disruption might also contribute to the upregulation of p53. The alternations in lysosome membrane permeability and acidic vacuoles as well as LC3-II upregulation indicated that autophagy was involved. The copper addition led to significantly attenuate biological activity of DpdtaA, with few dithiocarbamates, but the mechanism in apoptosis induction was not altered except for weaker ability.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

Figure 7

Figure 8

Figure 9

View References

1 

Spano D and Zollo M: Tumor microenvironment: A main actor in the metastasis process. Clin Exp Metastasis. 29:381–395. 2012. View Article : Google Scholar : PubMed/NCBI

2 

Catalano V, Turdo A, Di Franco S, Dieli F, Todaro M and Stassi G: Tumor and its microenvironment: A synergistic interplay. Semin Cancer Biol. 23:522–532. 2013. View Article : Google Scholar : PubMed/NCBI

3 

Sounni NE and Noel A: Targeting the tumor microenvironment for cancer therapy. Clin Chem. 59:85–93. 2013. View Article : Google Scholar

4 

Khan G and Merajver S: Copper chelation in cancer therapy using tetrathiomolybdate: An evolving paradigm. Expert Opin Investig Drugs. 18:541–548. 2009. View Article : Google Scholar : PubMed/NCBI

5 

Bogaard HJ, Mizuno S, Guignabert C, Al Hussaini AA, Farkas D, Ruiter G, Kraskauskas D, Fadel E, Allegood JC, Humbert M, et al: Copper dependence of angioproliferation in pulmonary arterial hypertension in rats and humans. Am J Respir Cell Mol Biol. 46:582–591. 2012. View Article : Google Scholar :

6 

Buac D, Schmitt S, Ventro G, Kona FR and Dou QP: Dithiocarbamate-based coordination compounds as potent proteasome inhibitors in human cancer cells. Mini Rev Med Chem. 12:1193–1201. 2012. View Article : Google Scholar : PubMed/NCBI

7 

Li Y, Qi H, Li X, Hou X, Lu X and Xiao X: A novel dithiocarbamate derivative induces cell apoptosis through p53-dependent intrinsic pathway and suppresses the expression of the E6 oncogene of human papillomavirus 18 in HeLa cells. Apoptosis. 20:787–795. 2015. View Article : Google Scholar : PubMed/NCBI

8 

Wang XJ, Xu HW, Guo LL, Zheng JX, Xu B, Guo X, Zheng CX and Liu HM: Synthesis and in vitro antitumor activity of new butenolide-containing dithiocarbamates. Bioorg Med Chem Lett. 21:3074–3077. 2011. View Article : Google Scholar : PubMed/NCBI

9 

Mansouri-Torshizi H, Saeidifar M, Khosravi F, Divsalar A, Saboury AA and Hassani F: DNA binding and antitumor activity of α-diimineplatinum(II) and palladium(II) dithiocarbamate complexes. Bioinorg Chem Appl. 2011:3945062011. View Article : Google Scholar

10 

Milacic V, Chen D, Ronconi L, Landis-Piwowar KR, Fregona D and Dou QP: A novel anticancer gold(III) dithiocarbamate compound inhibits the activity of a purified 20S proteasome and 26S proteasome in human breast cancer cell cultures and xenografts. Cancer Res. 66:10478–10486. 2006. View Article : Google Scholar : PubMed/NCBI

11 

Nardon C, Schmitt SM, Yang H, Zuo J, Fregona D and Dou QP: Gold(III)-dithiocarbamato peptidomimetics in the forefront of the targeted anticancer therapy: Preclinical studies against human breast neoplasia. PLoS One. 9:e842482014. View Article : Google Scholar : PubMed/NCBI

12 

Cattaruzza L, Fregona D, Mongiat M, Ronconi L, Fassina A, Colombatti A and Aldinucci D: Antitumor activity of gold(III)-dithiocarbamato derivatives on prostate cancer cells and xenografts. Int J Cancer. 128:206–215. 2011. View Article : Google Scholar

13 

Schreck R, Meier B, Männel DN, Dröge W and Baeuerle PA: Dithiocarbamates as potent inhibitors of nuclear factor kappa B activation in intact cells. J Exp Med. 175:1181–1194. 1992. View Article : Google Scholar : PubMed/NCBI

14 

Ronconi L, Marzano C, Zanello P, Corsini M, Miolo G, Maccà C, Trevisan A and Fregona D: Gold(III) dithiocarbamate derivatives for the treatment of cancer: Solution chemistry, DNA binding, and hemolytic properties. J Med Chem. 49:1648–1657. 2006. View Article : Google Scholar : PubMed/NCBI

15 

Nobel CSI, Burgess DH, Zhivotovsky B, Burkitt MJ, Orrenius S and Slater AF: Mechanism of dithiocarbamate inhibition of apoptosis: Thiol oxidation by dithiocarbamate disulfides directly inhibits processing of the caspase-3 proenzyme. Chem Res Toxicol. 10:636–643. 1997. View Article : Google Scholar : PubMed/NCBI

16 

Wu HH, Thomas JA and Momand J: p53 protein oxidation in cultured cells in response to pyrrolidine dithiocarbamate: A novel method for relating the amount of p53 oxidation in vivo to the regulation of p53-responsive genes. Biochem J. 351:87–93. 2000. View Article : Google Scholar : PubMed/NCBI

17 

Wu HH and Momand J: Pyrrolidine dithiocarbamate prevents p53 activation and promotes p53 cysteine residue oxidation. J Biol Chem. 273:18898–18905. 1998. View Article : Google Scholar : PubMed/NCBI

18 

Verhaegh GW, Richard MJ and Hainaut P: Regulation of p53 by metal ions and by antioxidants: Dithiocarbamate down-regulates p53 DNA-binding activity by increasing the intracellular level of copper. Mol Cell Biol. 17:5699–5706. 1997. View Article : Google Scholar : PubMed/NCBI

19 

Wang T, Fu Y, Huang T, Liu Y, Wu M, Yuan Y, Li S and Li C: Copper ion attenuated the antiproliferative activity of di-2-pyri-dylhydrazone dithiocarbamate derivative; however, there was a lack of correlation between ROS generation and antiproliferative activity. Molecules. 21:10882016. View Article : Google Scholar

20 

Yang Y, Li C, Fu Y, Liu Y, Zhang Y, Zhang Y, Zhou P, Yuan Y, Zhou S, Li S, et al: Redox cycling of a copper complex with benz-aldehyde nitrogen mustard-2-pyridine carboxylic acid hydrazone contributes to its enhanced antitumor activity, but no change in the mechanism of action occurs after chelation. Oncol Rep. 35:1636–1644. 2016. View Article : Google Scholar : PubMed/NCBI

21 

Huang T and Li C, Sun X, Zhu Z, Fu Y, Liu Y, Yuan Y, Li S and Li C: The antitumor mechanism of di-2-pyridylketone 2-pyridine carboxylic acid hydrazone and its copper complex in ROS generation and topoisomerase inhibition, and hydrazone involvement in oxygen-catalytic iron mobilization. Int J Oncol. 47:1854–1862. 2015. View Article : Google Scholar : PubMed/NCBI

22 

DeLano WL: The PyMOL Molecular Graphics System. DeLano Scientific; San Carlos, CA, USA: 2002

23 

Laskowski RA and Swindells MB: LigPlot+: Multiple ligand-protein interaction diagrams for drug discovery. J Chem Inf Model. 51:2778–2786. 2011. View Article : Google Scholar : PubMed/NCBI

24 

Trott O and Olson AJ: AutoDock Vina: Improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading. J Comput Chem. 31:455–461. 2010.

25 

Paris C, Bertoglio J and Bréard J: Lysosomal and mitochondrial pathways in miltefosine-induced apoptosis in U937 cells. Apoptosis. 12:1257–1267. 2007. View Article : Google Scholar : PubMed/NCBI

26 

Brooks CL and Gu W: p53 ubiquitination: Mdm2 and beyond. Mol Cell. 21:307–315. 2006. View Article : Google Scholar : PubMed/NCBI

27 

Kruse JP and Gu W: Modes of p53 regulation. Cell. 137:609–622. 2009. View Article : Google Scholar : PubMed/NCBI

28 

Haupt Y, Maya R, Kazaz A and Oren M: Mdm2 promotes the rapid degradation of p53. Nature. 387:296–299. 1997. View Article : Google Scholar : PubMed/NCBI

29 

Shangary S and Wang S: Small-molecule inhibitors of the MDM2-p53 protein-protein interaction to reactivate p53 function: A novel approach for cancer therapy. Annu Rev Pharmacol Toxicol. 49:223–241. 2009. View Article : Google Scholar :

30 

Johansson AC, Appelqvist H, Nilsson C, Kågedal K, Roberg K and Ollinger K: Regulation of apoptosis-associated lysosomal membrane permeabilization. Apoptosis. 15:527–540. 2010. View Article : Google Scholar : PubMed/NCBI

31 

Rehman SU, Zubair H, Sarwar T, Husain MA, Ishqi HM, Nehar S and Tabish M: Redox cycling of Cu(II) by 6-mercaptopurine leads to ROS generation and DNA breakage: Possible mechanism of anticancer activity. Tumour Biol. 36:1237–1244. 2015. View Article : Google Scholar

32 

Fussell KC, Udasin RG, Gray JP, Mishin V, Smith PJ, Heck DE and Laskin JD: Redox cycling and increased oxygen utilization contribute to diquat-induced oxidative stress and cytotoxicity in Chinese hamster ovary cells overexpressing NADPH-cytochrome P450 reductase. Free Radic Biol Med. 50:874–882. 2011. View Article : Google Scholar : PubMed/NCBI

33 

Kello M, Drutovic D, Chripkova M, Pilatova M, Budovska M, Kulikova L, Urdzik P and Mojzis J: ROS-dependent antiproliferative effect of brassinin derivative homobrassinin in human colorectal cancer Caco2 cells. Molecules. 19:10877–10897. 2014. View Article : Google Scholar : PubMed/NCBI

34 

Donadelli M, Dando I, Zaniboni T, Costanzo C, Dalla Pozza E, Scupoli MT, Scarpa A, Zappavigna S, Marra M, Abbruzzese A, et al: Gemcitabine/cannabinoid combination triggers autophagy in pancreatic cancer cells through a ROS-mediated mechanism. Cell Death Dis. 2:e1522011. View Article : Google Scholar : PubMed/NCBI

35 

Chripkova M, Zigo F and Mojzis J: Antiproliferative effect of indole phytoalexins. Molecules. 21:16262016. View Article : Google Scholar

36 

Gillardon F, Wickert H and Zimmermann M: Up-regulation of bax and down-regulation of bcl-2 is associated with kainate-induced apoptosis in mouse brain. Neurosci Lett. 192:85–88. 1995. View Article : Google Scholar : PubMed/NCBI

37 

Amaral JD, Xavier JM, Steer CJ and Rodrigues CM: The role of p53 in apoptosis. Discov Med. 9:145–152. 2010.PubMed/NCBI

38 

Chen Y, Azad MB and Gibson SB: Methods for detecting autophagy and determining autophagy-induced cell death. Can J Physiol Pharmacol. 88:285–295. 2010. View Article : Google Scholar : PubMed/NCBI

39 

Paglin S, Hollister T, Delohery T, Hackett N, McMahill M, Sphicas E, Domingo D and Yahalom J: A novel response of cancer cells to radiation involves autophagy and formation of acidic vesicles. Cancer Res. 61:439–444. 2001.PubMed/NCBI

40 

Lin J, Huang Z, Wu H, Zhou W, Jin P, Wei P, Zhang Y, Zheng F, Zhang J, Xu J, et al: Inhibition of autophagy enhances the anticancer activity of silver nanoparticles. Autophagy. 10:2006–2020. 2014. View Article : Google Scholar : PubMed/NCBI

41 

Donohue E, Thomas A, Maurer N, Manisali I, Zeisser-Labouebe M, Zisman N, Anderson HJ, Ng SS, Webb M, Bally M, et al: The autophagy inhibitor verteporfin moderately enhances the antitumor activity of gemcitabine in a pancreatic ductal adenocarcinoma model. J Cancer. 4:585–596. 2013. View Article : Google Scholar : PubMed/NCBI

42 

Zhang X, Xu Q, Zhang Z, Cheng W, Cao W, Jiang C, Han C, Li J and Hua Z: Chloroquine enhanced the anticancer capacity of VNP20009 by inhibiting autophagy. Sci Rep. 6:297742016. View Article : Google Scholar : PubMed/NCBI

43 

Serrano-Puebla A and Boya P: Lysosomal membrane permeabilization in cell death: New evidence and implications for health and disease. Ann N Y Acad Sci. 1371:30–44. 2016. View Article : Google Scholar

44 

Aits S and Jäättelä M: Lysosomal cell death at a glance. J Cell Sci. 126:1905–1912. 2013. View Article : Google Scholar : PubMed/NCBI

45 

Bové J, Martínez-Vicente M, Dehay B, Perier C, Recasens A, Bombrun A, Antonsson B and Vila M: BAX channel activity mediates lysosomal disruption linked to Parkinson disease. Autophagy. 10:889–900. 2014. View Article : Google Scholar : PubMed/NCBI

46 

Guan JJ, Zhang XD, Sun W, Qi L, Wu JC and Qin ZH: DRAM1 regulates apoptosis through increasing protein levels and lysosomal localization of BAX. Cell Death Dis. 6:e16242015. View Article : Google Scholar : PubMed/NCBI

47 

Fu Y, Yang Y, Zhou S, Liu Y, Yuan Y, Li S and Li C: Ciprofloxacin containing Mannich base and its copper complex induce antitumor activity via different mechanism of action. Int J Oncol. 45:2092–2100. 2014. View Article : Google Scholar : PubMed/NCBI

48 

Oberle C, Huai J, Reinheckel T, Tacke M, Rassner M, Ekert PG, Buellesbach J and Borner C: Lysosomal membrane permeabilization and cathepsin release is a Bax/Bak-dependent, amplifying event of apoptosis in fibroblasts and monocytes. Cell Death Differ. 17:1167–1178. 2010. View Article : Google Scholar : PubMed/NCBI

49 

Yang Y, Huang T, Zhou S, Fu Y, Liu Y, Yuan Y, Zhang Q, Li S and Li C: Antitumor activity of a 2-pyridinecarboxaldehyde 2-pyridinecarboxylic acid hydrazone copper complex and the related mechanism. Oncol Rep. 34:1311–1318. 2015. View Article : Google Scholar : PubMed/NCBI

50 

Cvek B, Milacic V, Taraba J and Dou QP: Ni(II), Cu(II), and Zn(II) diethyldithiocarbamate complexes show various activities against the proteasome in breast cancer cells. J Med Chem. 51:6256–6258. 2008. View Article : Google Scholar : PubMed/NCBI

51 

Cvek B and Dvorak Z: Targeting of nuclear factor-kappaB and proteasome by dithiocarbamate complexes with metals. Curr Pharm Des. 13:3155–3167. 2007. View Article : Google Scholar : PubMed/NCBI

52 

Yu Z, Wang F, Milacic V, Li X, Cui QC, Zhang B, Yan B and Dou QP: Evaluation of copper-dependent proteasome-inhibitory and apoptosis-inducing activities of novel pyrrolidine dithiocarbamate analogues. Int J Mol Med. 20:919–925. 2007.PubMed/NCBI

53 

Skrott Z and Cvek B: Diethyldithiocarbamate complex with copper: The mechanism of action in cancer cells. Mini Rev Med Chem. 12:1184–1192. 2012. View Article : Google Scholar : PubMed/NCBI

54 

Zhang H, Wu JS and Peng F: Potent anticancer activity of pyrrolidine dithiocarbamate-copper complex against cisplatin-resistant neuroblastoma cells. Anticancer Drugs. 19:125–132. 2008. View Article : Google Scholar : PubMed/NCBI

55 

Zhu C, Hu W, Wu H and Hu X: No evident dose-response relationship between cellular ROS level and its cytotoxicity - a paradoxical issue in ROS-based cancer therapy. Sci Rep. 4:50292014. View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Wang T, Liu Y, Fu Y, Huang T, Yang Y, Li S and Li C: Antiproliferative activity of di-2-pyridylhydrazone dithiocarbamate acetate partly involved in p53 mediated apoptosis and autophagy. Int J Oncol 51: 1909-1919, 2017.
APA
Wang, T., Liu, Y., Fu, Y., Huang, T., Yang, Y., Li, S., & Li, C. (2017). Antiproliferative activity of di-2-pyridylhydrazone dithiocarbamate acetate partly involved in p53 mediated apoptosis and autophagy. International Journal of Oncology, 51, 1909-1919. https://doi.org/10.3892/ijo.2017.4149
MLA
Wang, T., Liu, Y., Fu, Y., Huang, T., Yang, Y., Li, S., Li, C."Antiproliferative activity of di-2-pyridylhydrazone dithiocarbamate acetate partly involved in p53 mediated apoptosis and autophagy". International Journal of Oncology 51.6 (2017): 1909-1919.
Chicago
Wang, T., Liu, Y., Fu, Y., Huang, T., Yang, Y., Li, S., Li, C."Antiproliferative activity of di-2-pyridylhydrazone dithiocarbamate acetate partly involved in p53 mediated apoptosis and autophagy". International Journal of Oncology 51, no. 6 (2017): 1909-1919. https://doi.org/10.3892/ijo.2017.4149
Copy and paste a formatted citation
x
Spandidos Publications style
Wang T, Liu Y, Fu Y, Huang T, Yang Y, Li S and Li C: Antiproliferative activity of di-2-pyridylhydrazone dithiocarbamate acetate partly involved in p53 mediated apoptosis and autophagy. Int J Oncol 51: 1909-1919, 2017.
APA
Wang, T., Liu, Y., Fu, Y., Huang, T., Yang, Y., Li, S., & Li, C. (2017). Antiproliferative activity of di-2-pyridylhydrazone dithiocarbamate acetate partly involved in p53 mediated apoptosis and autophagy. International Journal of Oncology, 51, 1909-1919. https://doi.org/10.3892/ijo.2017.4149
MLA
Wang, T., Liu, Y., Fu, Y., Huang, T., Yang, Y., Li, S., Li, C."Antiproliferative activity of di-2-pyridylhydrazone dithiocarbamate acetate partly involved in p53 mediated apoptosis and autophagy". International Journal of Oncology 51.6 (2017): 1909-1919.
Chicago
Wang, T., Liu, Y., Fu, Y., Huang, T., Yang, Y., Li, S., Li, C."Antiproliferative activity of di-2-pyridylhydrazone dithiocarbamate acetate partly involved in p53 mediated apoptosis and autophagy". International Journal of Oncology 51, no. 6 (2017): 1909-1919. https://doi.org/10.3892/ijo.2017.4149
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team