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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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December-2017 Volume 51 Issue 6

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

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Article

Antitumoral effect of arsenic compound, sodium metaarsenite (KML001), on multiple myeloma cells

  • Authors:
    • Seo Ju Kim
    • Eun Shil Kim
    • Sujong Kim
    • Jieun Uhm
    • Young Woong Won
    • Byeong Bae Park
    • Jung Hye Choi
    • Young Yiul Lee
  • View Affiliations / Copyright

    Affiliations: Department of Internal Medicine, Hanyang University College of Medicine, Seoul, Republic of Korea, Pharmaceutical Division, Komipharm International Co., Ltd., Gyeonggi-do, Republic of Korea
  • Pages: 1739-1746
    |
    Published online on: October 16, 2017
       https://doi.org/10.3892/ijo.2017.4161
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Abstract

KML001 (sodium metaarsenite;NaAs2O3) is known to have antitumor activity against a variety of cancers. In this study, we examined its effect on multiple myeloma (MM). KML001 reduced the growth of all MM cell lines examined with an IC50 of 5x10‑8 M. Exposure to KML001 (5x10‑8 M) decreased levels of cyclins A/B1/D1/E1, CDK2/4/6 in U266 cells and increased the p21 and p27 levels. Furthermore, p21 became bound to CDK2/4/6, resulting in a reduction of CDK2/4/6 kinase activity. The cleaved forms of Bcl-2, and caspases‑3, ‑8 and ‑9 were detected, and the anti-apoptotic molecule, Bax, also increased. Activation of STAT1/3, NF-κB (p65 and p50 subunits), pAKT and pERK decreased, and p‑PTEN increased. There was also a significant reduction of hTERT at 12 h and upregulation of γ-H2AX and CHK1/2 molecules at 24 h. Thus, KML001 appears to have antitumor activity against MM by inhibiting various oncogenic signaling pathways. It may be useful for treating MM.
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Copy and paste a formatted citation
Spandidos Publications style
Kim SJ, Kim ES, Kim S, Uhm J, Won YW, Park BB, Choi JH and Lee YY: Antitumoral effect of arsenic compound, sodium metaarsenite (KML001), on multiple myeloma cells. Int J Oncol 51: 1739-1746, 2017.
APA
Kim, S.J., Kim, E.S., Kim, S., Uhm, J., Won, Y.W., Park, B.B. ... Lee, Y.Y. (2017). Antitumoral effect of arsenic compound, sodium metaarsenite (KML001), on multiple myeloma cells. International Journal of Oncology, 51, 1739-1746. https://doi.org/10.3892/ijo.2017.4161
MLA
Kim, S. J., Kim, E. S., Kim, S., Uhm, J., Won, Y. W., Park, B. B., Choi, J. H., Lee, Y. Y."Antitumoral effect of arsenic compound, sodium metaarsenite (KML001), on multiple myeloma cells". International Journal of Oncology 51.6 (2017): 1739-1746.
Chicago
Kim, S. J., Kim, E. S., Kim, S., Uhm, J., Won, Y. W., Park, B. B., Choi, J. H., Lee, Y. Y."Antitumoral effect of arsenic compound, sodium metaarsenite (KML001), on multiple myeloma cells". International Journal of Oncology 51, no. 6 (2017): 1739-1746. https://doi.org/10.3892/ijo.2017.4161
Copy and paste a formatted citation
x
Spandidos Publications style
Kim SJ, Kim ES, Kim S, Uhm J, Won YW, Park BB, Choi JH and Lee YY: Antitumoral effect of arsenic compound, sodium metaarsenite (KML001), on multiple myeloma cells. Int J Oncol 51: 1739-1746, 2017.
APA
Kim, S.J., Kim, E.S., Kim, S., Uhm, J., Won, Y.W., Park, B.B. ... Lee, Y.Y. (2017). Antitumoral effect of arsenic compound, sodium metaarsenite (KML001), on multiple myeloma cells. International Journal of Oncology, 51, 1739-1746. https://doi.org/10.3892/ijo.2017.4161
MLA
Kim, S. J., Kim, E. S., Kim, S., Uhm, J., Won, Y. W., Park, B. B., Choi, J. H., Lee, Y. Y."Antitumoral effect of arsenic compound, sodium metaarsenite (KML001), on multiple myeloma cells". International Journal of Oncology 51.6 (2017): 1739-1746.
Chicago
Kim, S. J., Kim, E. S., Kim, S., Uhm, J., Won, Y. W., Park, B. B., Choi, J. H., Lee, Y. Y."Antitumoral effect of arsenic compound, sodium metaarsenite (KML001), on multiple myeloma cells". International Journal of Oncology 51, no. 6 (2017): 1739-1746. https://doi.org/10.3892/ijo.2017.4161
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