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Review

Molecular mechanism and targeted therapy of Hsp90 involved in lung cancer: New discoveries and developments (Review)

  • Authors:
    • Biaoxue Rong
    • Shuanying Yang
  • View Affiliations / Copyright

    Affiliations: Department of Oncology, First Affiliated Hospital, Xi'an Medical University, Xi'an, Shaanxi, P.R. China, Department of Respiratory Medicine, Second Affiliated Hospital, Xi'an Jiaotong University, Xi'an, Shaanxi, P.R. China
  • Pages: 321-336
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    Published online on: November 29, 2017
       https://doi.org/10.3892/ijo.2017.4214
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Abstract

The exploration of the molecular mechanisms and signaling pathways on lung cancer is very important for developing new strategies of diagnosis and treatment to this disease, such as finding valuable lung cancer markers and molecularly targeted therapies. Previously, a number of studies disclose that heat shock protein 90 (Hsp90) is upregulated in cancer cells, tissues and serum of lung cancer patients, and its upregulation intimately correlates with the occurrence, development and outcome of lung cancer. On the contrary, inhibition of Hsp90 can suppress cell proliferation, motility and metastasis of lung cancer and promote apoptosis of lung cancer cells via complex signaling pathways. In addition, a series of Hsp90 inhibitors have been investigated as effective molecular targeted therapy tactics fighting against lung cancer. This review, systematically summarizes the role of Hsp90 in lung cancer, the molecular mechanisms and development of anti-Hsp90 treatment in lung cancer.
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Copy and paste a formatted citation
Spandidos Publications style
Rong B and Yang S: Molecular mechanism and targeted therapy of Hsp90 involved in lung cancer: New discoveries and developments (Review). Int J Oncol 52: 321-336, 2018.
APA
Rong, B., & Yang, S. (2018). Molecular mechanism and targeted therapy of Hsp90 involved in lung cancer: New discoveries and developments (Review). International Journal of Oncology, 52, 321-336. https://doi.org/10.3892/ijo.2017.4214
MLA
Rong, B., Yang, S."Molecular mechanism and targeted therapy of Hsp90 involved in lung cancer: New discoveries and developments (Review)". International Journal of Oncology 52.2 (2018): 321-336.
Chicago
Rong, B., Yang, S."Molecular mechanism and targeted therapy of Hsp90 involved in lung cancer: New discoveries and developments (Review)". International Journal of Oncology 52, no. 2 (2018): 321-336. https://doi.org/10.3892/ijo.2017.4214
Copy and paste a formatted citation
x
Spandidos Publications style
Rong B and Yang S: Molecular mechanism and targeted therapy of Hsp90 involved in lung cancer: New discoveries and developments (Review). Int J Oncol 52: 321-336, 2018.
APA
Rong, B., & Yang, S. (2018). Molecular mechanism and targeted therapy of Hsp90 involved in lung cancer: New discoveries and developments (Review). International Journal of Oncology, 52, 321-336. https://doi.org/10.3892/ijo.2017.4214
MLA
Rong, B., Yang, S."Molecular mechanism and targeted therapy of Hsp90 involved in lung cancer: New discoveries and developments (Review)". International Journal of Oncology 52.2 (2018): 321-336.
Chicago
Rong, B., Yang, S."Molecular mechanism and targeted therapy of Hsp90 involved in lung cancer: New discoveries and developments (Review)". International Journal of Oncology 52, no. 2 (2018): 321-336. https://doi.org/10.3892/ijo.2017.4214
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