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Article Open Access

RIPK4/PEBP1 axis promotes pancreatic cancer cell migration and invasion by activating RAF1/MEK/ERK signaling

Corrigendum in: /10.3892/ijo.2025.5822
  • Authors:
    • Zi-Hao Qi
    • Hua-Xiang Xu
    • Shi-Rong Zhang
    • Jin-Zhi Xu
    • Shuo Li
    • He-Li Gao
    • Wei Jin
    • Wen-Quan Wang
    • Chun-Tao Wu
    • Quan-Xing Ni
    • Xian-Jun Yu
    • Liang Liu
  • View Affiliations / Copyright

    Affiliations: Department of Pancreatic Surgery, Fudan University Shanghai Cancer Center, Shanghai 200032, P.R. China
    Copyright: © Qi et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1105-1116
    |
    Published online on: February 7, 2018
       https://doi.org/10.3892/ijo.2018.4269
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Abstract

Pancreatic cancer is a lethal disease with a high metastatic potential. In our previous study, we identified a specific subgroup of patients with pancreatic cancer with a serum signature of carcinoembryonic antigen (CEA)+/cancer antigen (CA)125+/CA19-9 ≥1,000 U/ml. In this study, by using high-throughput screening analysis, we found that receptor-interacting protein kinases 4 (RIPK4) may be a key molecule involved in the high metastatic potential of this subgroup of patients with pancreatic cancer. A high RIPK4 expression predicted a poor prognosis and promoted pancreatic cancer cell migration and invasion via the RAF1/MEK/ERK pathway. Moreover, RIPK4 activated the RAF1/MEK/ERK pathway by regulating proteasome-mediated phosphatidylethanolamine binding protein 1 (PEBP1) degradation. The suppression of PEBP1 degradation eliminated the RIPK4-induced activation of RAF1/MEK/ERK signaling and pancreatic cancer cell migration or invasion. Thus, on the whole, the findings of this study indicated that RIPK4 was upregulated in the subgroup of pancreatic cancer with a high metastatic potential. RIPK4 overexpression promoted pancreatic cancer cell migration and invasion via the PEBP1 degradation-induced activation of the RAF1/MEK/ERK pathway.
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1 

Long J, Luo GP, Xiao ZW, Liu ZQ, Guo M, Liu L, Liu C, Xu J, Gao YT, Zheng Y, et al: Cancer statistics: Current diagnosis and treatment of pancreatic cancer in Shanghai, China. Cancer Lett. 346:273–277. 2014. View Article : Google Scholar : PubMed/NCBI

2 

Siegel RL, Miller KD and Jemal A: Cancer Statistics, 2017. CA Cancer J Clin. 67:7–30. 2017. View Article : Google Scholar : PubMed/NCBI

3 

Koay EJ, Amer AM, Baio FE, Ondari AO and Fleming JB: Toward stratification of patients with pancreatic cancer: Past lessons from traditional approaches and future applications with physical biomarkers. Cancer Lett. 381:237–243. 2016. View Article : Google Scholar : PubMed/NCBI

4 

Hackert T, Ulrich A and Büchler MW: Borderline resectable pancreatic cancer. Cancer Lett. 375:231–237. 2016. View Article : Google Scholar : PubMed/NCBI

5 

Hartwig W, Werner J, Jäger D, Debus J and Büchler MW: Improvement of surgical results for pancreatic cancer. Lancet Oncol. 14:e476-e4852013. View Article : Google Scholar

6 

Kamisawa T, Wood LD, Itoi T and Takaori K: Pancreatic cancer. Lancet. 388:73–85. 2016. View Article : Google Scholar : PubMed/NCBI

7 

Liu L, Xu H, Wang W, Wu C, Chen Y, Yang J, Cen P, Xu J, Liu C, Long J, et al: A preoperative serum signature of CEA+/CA125+/CA19-9 ≥ 1000 U/ml indicates poor outcome to pancreatectomy for pancreatic cancer. Int J Cancer. 136:2216–2227. 2015. View Article : Google Scholar

8 

Bhr C, Rohwer A, Stempka L, Rincke G, Marks F and Gschwendt M: DIK, a novel protein kinase that interacts with protein kinase Cdelta. Cloning, characterization, and gene analysis. J Biol Chem. 275:36350–36357. 2000. View Article : Google Scholar : PubMed/NCBI

9 

Zhang D, Lin J and Han J: Receptor-interacting protein (RIP) kinase family. Cell Mol Immunol. 7:243–249. 2010. View Article : Google Scholar : PubMed/NCBI

10 

Azizmohammadi S, Azizmohammadi S, Safari A, Kaghazian M, Sadrkhanlo M, Behnod V and Seifoleslami M: High-level expression of RIPK4 and EZH2 contributes to lymph node metastasis and predicts favorable prognosis in patients with cervical cancer. Oncol Res. 25:495–501. 2017. View Article : Google Scholar

11 

Liu DQ, Li FF, Zhang JB, Zhou TJ, Xue WQ, Zheng XH, Chen YB, Liao XY, Zhang L, Zhang SD, et al: Increased RIPK4 expression is associated with progression and poor prognosis in cervical squamous cell carcinoma patients. Sci Rep. 5:119552015. View Article : Google Scholar : PubMed/NCBI

12 

Huang X, McGann JC, Liu BY, Hannoush RN, Lill JR, Pham V, Newton K, Kakunda M, Liu J, Yu C, et al: Phosphorylation of Dishevelled by protein kinase RIPK4 regulates Wnt signaling. Science. 339:1441–1445. 2013. View Article : Google Scholar : PubMed/NCBI

13 

Lee P, Jiang S, Li Y, Yue J, Gou X, Chen SY, Zhao Y, Schober M, Tan M and Wu X: Phosphorylation of Pkp1 by RIPK4 regulates epidermal differentiation and skin tumorigenesis. EMBO J. 36:1963–1980. 2017. View Article : Google Scholar : PubMed/NCBI

14 

Wang X, Zhu W, Zhou Y, Xu W and Wang H: RIPK4 is down-regulated in poorly differentiated tongue cancer and is associated with migration/invasion and cisplatin-induced apoptosis. Int J Biol Markers. 29:e150-e1592014. View Article : Google Scholar

15 

Yeung K, Janosch P, McFerran B, Rose DW, Mischak H, Sedivy JM and Kolch W: Mechanism of suppression of the Raf/MEK/extracellular signal-regulated kinase pathway by the raf kinase inhibitor protein. Mol Cell Biol. 20:3079–3085. 2000. View Article : Google Scholar : PubMed/NCBI

16 

Yeung K, Seitz T, Li S, Janosch P, McFerran B, Kaiser C, Fee F, Katsanakis KD, Rose DW, Mischak H, et al: Suppression of Raf-1 kinase activity and MAP kinase signalling by RKIP. Nature. 401:173–177. 1999. View Article : Google Scholar : PubMed/NCBI

17 

Song SP, Zhang SB, Li ZH, Zhou YS, Li B, Bian ZW, Liao QD and Zhang YD: Reduced expression of Raf kinase inhibitor protein correlates with poor prognosis in pancreatic cancer. Clin Transl Oncol. 14:848–852. 2012. View Article : Google Scholar : PubMed/NCBI

18 

Karamitopoulou E, Zlobec I, Gloor B, Kondi-Pafiti A, Lugli A and Perren A: Loss of Raf-1 kinase inhibitor protein (RKIP) is strongly associated with high-grade tumor budding and correlates with an aggressive phenotype in pancreatic ductal adenocarcinoma (PDAC). J Transl Med. 11:3112013. View Article : Google Scholar : PubMed/NCBI

19 

Kim HS, Kim GY, Lim SJ and Kim YW: Loss of Raf-1 kinase inhibitory protein in pancreatic ductal adenocarcinoma. Pathology. 42:655–660. 2010. View Article : Google Scholar : PubMed/NCBI

20 

Hellmann J, Rommelspacher H and Wernicke C: Long-term ethanol exposure impairs neuronal differentiation of human neuroblastoma cells involving neurotrophin-mediated intracellular signaling and in particular protein kinase C. Alcohol Clin Exp Res. 33:538–550. 2009. View Article : Google Scholar : PubMed/NCBI

21 

Moen EL, Wen S, Anwar T, Cross-Knorr S, Brilliant K, Birnbaum F, Rahaman S, Sedivy JM, Moss SF and Chatterjee D: Regulation of RKIP function by Helicobacter pylori in gastric cancer. PLoS One. 7:e378192012. View Article : Google Scholar : PubMed/NCBI

22 

Furukawa T, Duguid WP, Rosenberg L, Viallet J, Galloway DA and Tsao MS: Long-term culture and immortalization of epithelial cells from normal adult human pancreatic ducts trans-fected by the E6E7 gene of human papilloma virus 16. Am J Pathol. 148:1763–1770. 1996.PubMed/NCBI

23 

Qi Z, Liu M, Liu Y, Zhang M and Yang G: Tetramethoxychalcone, a chalcone derivative, suppresses proliferation, blocks cell cycle progression, and induces apoptosis of human ovarian cancer cells. PLoS One. 9:e1062062014. View Article : Google Scholar : PubMed/NCBI

24 

Warde-Farley D, Donaldson SL, Comes O, Zuberi K, Badrawi R, Chao P, Franz M, Grouios C, Kazi F, Lopes CT, et al: The GeneMANIA prediction server: Biological network integration for gene prioritization and predicting gene function. Nucleic Acids Res. 38(Suppl 2): W214–W220. 2010. View Article : Google Scholar : PubMed/NCBI

25 

Maines MD: Biliverdin reductase: PKC interaction at the crosstalk of MAPK and PI3K signaling pathways. Antioxid Redox Signal. 9:2187–2195. 2007. View Article : Google Scholar : PubMed/NCBI

26 

Mugami S, Dobkin-Bekman M, Rahamim-Ben Navi L and Naor Z: Differential roles of PKC isoforms (PKCs) in GnRH stimulation of MAPK phosphorylation in gonadotrope derived cells. Mol Cell Endocrinol. Apr 6–2017.Epub ahead of print. View Article : Google Scholar : PubMed/NCBI

27 

Dai H, Chen H, Liu W, You Y, Tan J, Yang A, Lai X and Bie P: Effects of Raf kinase inhibitor protein expression on pancreatic cancer cell growth and motility: An in vivo and in vitro study. J Cancer Res Clin Oncol. 142:2107–2117. 2016. View Article : Google Scholar : PubMed/NCBI

28 

Corbit KC, Trakul N, Eves EM, Diaz B, Marshall M and Rosner MR: Activation of Raf-1 signaling by protein kinase C through a mechanism involving Raf kinase inhibitory protein. J Biol Chem. 278:13061–13068. 2003. View Article : Google Scholar : PubMed/NCBI

29 

Baritaki S, Yeung K, Palladino M, Berenson J and Bonavida B: Pivotal roles of snail inhibition and RKIP induction by the proteasome inhibitor NPI-0052 in tumor cell chemoimmunosensitization. Cancer Res. 69:8376–8385. 2009. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Qi Z, Xu H, Zhang S, Xu J, Li S, Gao H, Jin W, Wang W, Wu C, Ni Q, Ni Q, et al: RIPK4/PEBP1 axis promotes pancreatic cancer cell migration and invasion by activating RAF1/MEK/ERK signaling Corrigendum in /10.3892/ijo.2025.5822. Int J Oncol 52: 1105-1116, 2018.
APA
Qi, Z., Xu, H., Zhang, S., Xu, J., Li, S., Gao, H. ... Liu, L. (2018). RIPK4/PEBP1 axis promotes pancreatic cancer cell migration and invasion by activating RAF1/MEK/ERK signaling Corrigendum in /10.3892/ijo.2025.5822. International Journal of Oncology, 52, 1105-1116. https://doi.org/10.3892/ijo.2018.4269
MLA
Qi, Z., Xu, H., Zhang, S., Xu, J., Li, S., Gao, H., Jin, W., Wang, W., Wu, C., Ni, Q., Yu, X., Liu, L."RIPK4/PEBP1 axis promotes pancreatic cancer cell migration and invasion by activating RAF1/MEK/ERK signaling Corrigendum in /10.3892/ijo.2025.5822". International Journal of Oncology 52.4 (2018): 1105-1116.
Chicago
Qi, Z., Xu, H., Zhang, S., Xu, J., Li, S., Gao, H., Jin, W., Wang, W., Wu, C., Ni, Q., Yu, X., Liu, L."RIPK4/PEBP1 axis promotes pancreatic cancer cell migration and invasion by activating RAF1/MEK/ERK signaling Corrigendum in /10.3892/ijo.2025.5822". International Journal of Oncology 52, no. 4 (2018): 1105-1116. https://doi.org/10.3892/ijo.2018.4269
Copy and paste a formatted citation
x
Spandidos Publications style
Qi Z, Xu H, Zhang S, Xu J, Li S, Gao H, Jin W, Wang W, Wu C, Ni Q, Ni Q, et al: RIPK4/PEBP1 axis promotes pancreatic cancer cell migration and invasion by activating RAF1/MEK/ERK signaling Corrigendum in /10.3892/ijo.2025.5822. Int J Oncol 52: 1105-1116, 2018.
APA
Qi, Z., Xu, H., Zhang, S., Xu, J., Li, S., Gao, H. ... Liu, L. (2018). RIPK4/PEBP1 axis promotes pancreatic cancer cell migration and invasion by activating RAF1/MEK/ERK signaling Corrigendum in /10.3892/ijo.2025.5822. International Journal of Oncology, 52, 1105-1116. https://doi.org/10.3892/ijo.2018.4269
MLA
Qi, Z., Xu, H., Zhang, S., Xu, J., Li, S., Gao, H., Jin, W., Wang, W., Wu, C., Ni, Q., Yu, X., Liu, L."RIPK4/PEBP1 axis promotes pancreatic cancer cell migration and invasion by activating RAF1/MEK/ERK signaling Corrigendum in /10.3892/ijo.2025.5822". International Journal of Oncology 52.4 (2018): 1105-1116.
Chicago
Qi, Z., Xu, H., Zhang, S., Xu, J., Li, S., Gao, H., Jin, W., Wang, W., Wu, C., Ni, Q., Yu, X., Liu, L."RIPK4/PEBP1 axis promotes pancreatic cancer cell migration and invasion by activating RAF1/MEK/ERK signaling Corrigendum in /10.3892/ijo.2025.5822". International Journal of Oncology 52, no. 4 (2018): 1105-1116. https://doi.org/10.3892/ijo.2018.4269
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