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Article

Long non-coding RNA KCNQ1OT1 mediates the growth of hepatocellular carcinoma by functioning as a competing endogenous RNA of miR-504

Corrigendum in: /10.3892/ijo.2020.4971
  • Authors:
    • Chao Li
    • Runchen Miao
    • Jingyao Zhang
    • Kai Qu
    • Chang Liu
  • View Affiliations / Copyright

    Affiliations: Department of Hepatobiliary Surgery, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, P.R. China
  • Pages: 1603-1612
    |
    Published online on: March 12, 2018
       https://doi.org/10.3892/ijo.2018.4313
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Abstract

Accumulating evidence highlights the fact that long non‑coding RNAs (lncRNAs) serve as critical factors in the growth of hepatocellular carcinoma (HCC). The dysregulation of lncRNA KCNQ1 opposite strand/antisense transcript 1 (KCNQ1OT1) has been reported in numerous human benign diseases. However, the role of KCNQ1OT1 in human HCC remains poorly understood. In this study, we demonstrated that the expression of KCNQ1OT1 was abnormally increased in HCC tissues. The ectopic high expression of KCNQ1OT1 was associated with liver cirrhosis, a larger tumor size, an advanced TNM stage, and a worse overall survival and tumor‑free survival. For the first time, to the best of our knowledge, we report that KCNQ1OT1 knockdown results in a decreased cell viability and colony formation ability, and an increased rate of apoptosis in vitro. The results from our in vivo results demonstrated that KCNQ1OT1 silencing attenuated tumor growth by impairing cell proliferation. Additionally, we found that KCNQ1OT1 exerted its effects partly by relying on the microRNA‑504 (miR‑504)‑mediated regulation of cyclin‑dependent kinase 16 (CDK16), in addition to the regulation of the glycogen synthase kinase 3β (GSK3β)/β‑catenin/Bcl‑2 signaling pathway. The present study revealed the functions and mechanisms of action of lncRNA KCNQ1OT1 regarding its role in promoting the growth of HCC. Thus, lncRNA KCNQ1OT1 may prove to be a potential therapeutic target for human HCC.
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Copy and paste a formatted citation
Spandidos Publications style
Li C, Miao R, Zhang J, Qu K and Liu C: Long non-coding RNA KCNQ1OT1 mediates the growth of hepatocellular carcinoma by functioning as a competing endogenous RNA of miR-504 Corrigendum in /10.3892/ijo.2020.4971. Int J Oncol 52: 1603-1612, 2018.
APA
Li, C., Miao, R., Zhang, J., Qu, K., & Liu, C. (2018). Long non-coding RNA KCNQ1OT1 mediates the growth of hepatocellular carcinoma by functioning as a competing endogenous RNA of miR-504 Corrigendum in /10.3892/ijo.2020.4971. International Journal of Oncology, 52, 1603-1612. https://doi.org/10.3892/ijo.2018.4313
MLA
Li, C., Miao, R., Zhang, J., Qu, K., Liu, C."Long non-coding RNA KCNQ1OT1 mediates the growth of hepatocellular carcinoma by functioning as a competing endogenous RNA of miR-504 Corrigendum in /10.3892/ijo.2020.4971". International Journal of Oncology 52.5 (2018): 1603-1612.
Chicago
Li, C., Miao, R., Zhang, J., Qu, K., Liu, C."Long non-coding RNA KCNQ1OT1 mediates the growth of hepatocellular carcinoma by functioning as a competing endogenous RNA of miR-504 Corrigendum in /10.3892/ijo.2020.4971". International Journal of Oncology 52, no. 5 (2018): 1603-1612. https://doi.org/10.3892/ijo.2018.4313
Copy and paste a formatted citation
x
Spandidos Publications style
Li C, Miao R, Zhang J, Qu K and Liu C: Long non-coding RNA KCNQ1OT1 mediates the growth of hepatocellular carcinoma by functioning as a competing endogenous RNA of miR-504 Corrigendum in /10.3892/ijo.2020.4971. Int J Oncol 52: 1603-1612, 2018.
APA
Li, C., Miao, R., Zhang, J., Qu, K., & Liu, C. (2018). Long non-coding RNA KCNQ1OT1 mediates the growth of hepatocellular carcinoma by functioning as a competing endogenous RNA of miR-504 Corrigendum in /10.3892/ijo.2020.4971. International Journal of Oncology, 52, 1603-1612. https://doi.org/10.3892/ijo.2018.4313
MLA
Li, C., Miao, R., Zhang, J., Qu, K., Liu, C."Long non-coding RNA KCNQ1OT1 mediates the growth of hepatocellular carcinoma by functioning as a competing endogenous RNA of miR-504 Corrigendum in /10.3892/ijo.2020.4971". International Journal of Oncology 52.5 (2018): 1603-1612.
Chicago
Li, C., Miao, R., Zhang, J., Qu, K., Liu, C."Long non-coding RNA KCNQ1OT1 mediates the growth of hepatocellular carcinoma by functioning as a competing endogenous RNA of miR-504 Corrigendum in /10.3892/ijo.2020.4971". International Journal of Oncology 52, no. 5 (2018): 1603-1612. https://doi.org/10.3892/ijo.2018.4313
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