Open Access

EPB41L3 is a potential tumor suppressor gene and prognostic indicator in esophageal squamous cell carcinoma

  • Authors:
    • Rong Zeng
    • Yi Liu
    • Zhao-Jing Jiang
    • Jun-Peng Huang
    • Yu Wang
    • Xu-Feng Li
    • Wei-Bin Xiong
    • Xiao-Cong Wu
    • Ji-Ren Zhang
    • Qi-En Wang
    • Yan-Fang Zheng
  • View Affiliations

  • Published online on: March 14, 2018     https://doi.org/10.3892/ijo.2018.4316
  • Pages: 1443-1454
  • Copyright: © Zeng et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Although there have been reports about the role of erythrocyte membrane protein band 4.1 like 3 (EPB41L3) in several types of cancer, primarily in non-small-cell lung carcinoma, the molecular function and modulatory mechanisms of EPB41L3 remain unclear. In specific, the functional and clinical significance of EPB41L3 in esophageal squamous cell carcinoma (ESCC) has not been explored to date. In the present study, reduced EPB41L3 expression was demonstrated in ESCC cell lines and tissues, which was due to its high methylation rate. Ectopic expression of EPB41L3 in ESCC cells inhibited cell proliferation in vivo and in vitro. In addition, EPB41L3 overexpression induced apoptosis and G2/M cell cycle arrest by activating Caspase-3/8/9 and Cyclin-dependent kinase 1/Cyclin B1 signaling, respectively. Notably, patients with higher EPB41L3 expression had markedly higher overall survival rates compared with patients with lower EPB41L3 expression. In summary, the present results suggest that EPB41L3 may be a tumor suppressor gene in ESCC development, representing a potential therapeutic target and a prognostic indicator for ESCC.
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May-2018
Volume 52 Issue 5

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Zeng R, Liu Y, Jiang Z, Huang J, Wang Y, Li X, Xiong W, Wu X, Zhang J, Wang Q, Wang Q, et al: EPB41L3 is a potential tumor suppressor gene and prognostic indicator in esophageal squamous cell carcinoma. Int J Oncol 52: 1443-1454, 2018
APA
Zeng, R., Liu, Y., Jiang, Z., Huang, J., Wang, Y., Li, X. ... Zheng, Y. (2018). EPB41L3 is a potential tumor suppressor gene and prognostic indicator in esophageal squamous cell carcinoma. International Journal of Oncology, 52, 1443-1454. https://doi.org/10.3892/ijo.2018.4316
MLA
Zeng, R., Liu, Y., Jiang, Z., Huang, J., Wang, Y., Li, X., Xiong, W., Wu, X., Zhang, J., Wang, Q., Zheng, Y."EPB41L3 is a potential tumor suppressor gene and prognostic indicator in esophageal squamous cell carcinoma". International Journal of Oncology 52.5 (2018): 1443-1454.
Chicago
Zeng, R., Liu, Y., Jiang, Z., Huang, J., Wang, Y., Li, X., Xiong, W., Wu, X., Zhang, J., Wang, Q., Zheng, Y."EPB41L3 is a potential tumor suppressor gene and prognostic indicator in esophageal squamous cell carcinoma". International Journal of Oncology 52, no. 5 (2018): 1443-1454. https://doi.org/10.3892/ijo.2018.4316