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β‑catenin nuclear translocation induced by HIF‑1α overexpression leads to the radioresistance of prostate cancer

  • Authors:
    • Yong Luo
    • Mingchuan Li
    • Xuemei Zuo
    • Spyridon P. Basourakos
    • Jiao Zhang
    • Jiahui Zhao
    • Yili Han
    • Yunhua Lin
    • Yongxing Wang
    • Yongguang Jiang
    • Ling Lan
  • View Affiliations / Copyright

    Affiliations: Department of Urology, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, P.R. China, Department of Clinical Laboratory, Tong Ren Hospital, Shanghai JiaoTong University School of Medicine, Shanghai 200233, P.R. China, Department of Genitourinary Medical Oncology, Cancer Medicine, MD Anderson Cancer Center, The University of Texas, Houston, TX 77030, USA, Department of Anatomy and Cell Biology, Brody School of Medicine, East Carolina University, Greenville, NC 27834, USA, Department of Endocrinology, Beijing Jishuitan Hospital, The 4th Medical College of Peking University, Beijing 100035, P.R. China
    Copyright: © Luo et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1827-1840
    |
    Published online on: April 12, 2018
       https://doi.org/10.3892/ijo.2018.4368
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Abstract

Hypoxia-inducible factor‑1α (HIF‑1α) is known to play crucial roles in tumor radioresistance; however, the molecular mechanisms responsible for the promotion of tumor radioresistance by HIF‑1α remain unclear. β‑catenin is known to be involved in the metastatic potential of prostate cancer (PCa). In this study, to investigate the role of HIF‑1α and β‑catenin in the radioresistance of PCa, two PCa cell lines, LNCaP and C4‑2B, were grouped as follows: Negative control (no treatment), HIF‑1α overexpression group (transfected with HIF‑1α overexpression plasmid) and β‑catenin silenced group (transfected with HIF‑1α plasmids and β‑catenin-shRNA). Cell proliferation, cell cycle, cell invasion and radiosensitivity were examined under normal or hypoxic conditions. In addition, radiosensitivity was examined in two mouse PCa models (the LNCaP orthotopic BALB/c-nu mice model and the C4‑2B subcutaneous SCID mice model). Our results revealed that in both the LNCaP and C4‑2B cells, transfection with HIF‑1α overexpression plasmid led to an enhanced β‑catenin nuclear translocation, while β‑catenin silencing inhibited β‑catenin nuclear translocation. The enhanced β‑catenin nuclear translocation induced by HIF‑1α overexpression resulted in an enhanced cell proliferation and cell invasion, an altered cell cycle distribution, decreased apoptosis, and improved non‑homologous end joining (NHEJ) repair under normal and irradiation conditions. Similar results were observed in the animal models. HIF‑1α overexpression enhanced β‑catenin nuclear translocation, which led to the activation of the β‑catenin/NHEJ signaling pathway and increased cell proliferation, cell invasion and DNA repair. These results thus suggest that HIF‑1α overexpression promotes the radioresistance of PCa cells.
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1 

Horwich A, Parker C and de Reijke T: Prostate cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol. 24(Suppl 6): vi106–vi114. 2013. View Article : Google Scholar : PubMed/NCBI

2 

Chen W, Zheng R, Baade PD, Zhang S, Zeng H, Bray F, Jemal A, Yu XQ and He J: Cancer statistics in China, 2015. CA Cancer J Clin. 66:115–132. 2016. View Article : Google Scholar : PubMed/NCBI

3 

Mohler JL, Kantoff PW, Armstrong AJ, Bahnson RR, Cohen M, D'Amico AV, Eastham JA, Enke CA, Farrington TA, Higano CS, et al National Comprehensive Cancer Network: Prostate cancer, version 2.2014. J Natl Compr Canc Netw. 12:686–718. 2014. View Article : Google Scholar : PubMed/NCBI

4 

Zietman AL, Bae K, Slater JD, Shipley WU, Efstathiou JA, Coen JJ, Bush DA, Lunt M, Spiegel DY, Skowronski R, et al: Randomized trial comparing conventional-dose with high-dose conformal radiation therapy in early-stage adenocarcinoma of the prostate: Long-term results from proton radiation oncology group/american college of radiology 95-09. J Clin Oncol. 28:1106–1111. 2010. View Article : Google Scholar : PubMed/NCBI

5 

Baumann M, Krause M and Hill R: Exploring the role of cancer stem cells in radioresistance. Nat Rev Cancer. 8:545–554. 2008. View Article : Google Scholar : PubMed/NCBI

6 

Johansson S, Aström L, Sandin F, Isacsson U, Montelius A and Turesson I: Hypofractionated proton boost combined with external beam radiotherapy for treatment of localized prostate cancer. Prostate Cancer. 2012:6548612012. View Article : Google Scholar : PubMed/NCBI

7 

Khuntia D, Reddy CA, Mahadevan A, Klein EA and Kupelian PA: Recurrence-free survival rates after external-beam radiotherapy for patients with clinical T1-T3 prostate carcinoma in the prostate-specific antigen era: What should we expect? Cancer. 100:1283–1292. 2004. View Article : Google Scholar : PubMed/NCBI

8 

Cooper BT and Sanfilippo NJ: Concurrent chemoradiation for high-risk prostate cancer. World J Clin Oncol. 6:35–42. 2015. View Article : Google Scholar : PubMed/NCBI

9 

West CM, Davidson SE, Elyan SA, Swindell R, Roberts SA, Orton CJ, Coyle CA, Valentine H, Wilks DP, Hunter RD, et al: The intrinsic radiosensitivity of normal and tumour cells. Int J Radiat Biol. 73:409–413. 1998. View Article : Google Scholar : PubMed/NCBI

10 

Balmukhanov SB, Yefimov ML and Kleinbock TS: Acquired radioresistance of tumour cells. Nature. 216:709–711. 1967. View Article : Google Scholar : PubMed/NCBI

11 

Wei K, Kodym R and Jin C: Radioresistant cell strain of human fibrosarcoma cells obtained after long-term exposure to x-rays. Radiat Environ Biophys. 37:133–137. 1998. View Article : Google Scholar : PubMed/NCBI

12 

McDermott N, Meunier A, Mooney B, Nortey G, Hernandez C, Hurley S, Lynam-Lennon N, Barsoom SH, Bowman KJ, Marples B, et al: Fractionated radiation exposure amplifies the radioresistant nature of prostate cancer cells. Sci Rep. 6:347962016. View Article : Google Scholar : PubMed/NCBI

13 

Brown JM and Giaccia AJ: The unique physiology of solid tumors: Opportunities (and problems) for cancer therapy. Cancer Res. 58:1408–1416. 1998.PubMed/NCBI

14 

Brown JM and Wilson WR: Exploiting tumour hypoxia in cancer treatment. Nat Rev Cancer. 4:437–447. 2004. View Article : Google Scholar : PubMed/NCBI

15 

Harada H, Kizaka-Kondoh S, Li G, Itasaka S, Shibuya K, Inoue M and Hiraoka M: Significance of HIF-1-active cells in angiogenesis and radioresistance. Oncogene. 26:7508–7516. 2007. View Article : Google Scholar : PubMed/NCBI

16 

Harada H: Hypoxia-inducible factor 1-mediated characteristic features of cancer cells for tumor radioresistance. J Radiat Res (Tokyo). 57(Suppl 1): i99–i105. 2016. View Article : Google Scholar

17 

Chang HW, Nam HY, Kim HJ, Moon SY, Kim MR, Lee M, Kim GC, Kim SW and Kim SY: Effect of β-catenin silencing in overcoming radioresistance of head and neck cancer cells by antagonizing the effects of AMPK on Ku70/Ku80. Head Neck. 38(Suppl 1): E1909–E1917. 2016. View Article : Google Scholar

18 

Cojoc M, Peitzsch C, Kurth I, Trautmann F, Kunz-Schughart LA, Telegeev GD, Stakhovsky EA, Walker JR, Simin K, Lyle S, et al: Aldehyde dehydrogenase is regulated by β-catenin/TCF and promotes radioresistance in prostate cancer progenitor cells. Cancer Res. 75:1482–1494. 2015. View Article : Google Scholar : PubMed/NCBI

19 

Zhao JH, Luo Y, Jiang YG, He DL and Wu CT: Knockdown of β-catenin through shRNA cause a reversal of EMT and metastatic phenotypes induced by HIF-1α. Cancer Invest. 29:377–382. 2011. View Article : Google Scholar : PubMed/NCBI

20 

Luo Y, Lan L, Jiang YG, Zhao JH, Li MC, Wei NB and Lin YH: Epithelial-mesenchymal transition and migration of prostate cancer stem cells is driven by cancer-associated fibroblasts in an HIF-1α/β-catenin-dependent pathway. Mol Cells. 36:138–144. 2013. View Article : Google Scholar : PubMed/NCBI

21 

Wang J, Zhou D, He X, Wang Y, Hu W, Jiang L and Dou J: Effect of downregulated β-catenin on cell proliferative activity, the sensitivity to chemotherapy drug and tumorigenicity of ovarian cancer cells. Cell Mol Biol (Noisy-le-grand). 57(Suppl): OL1606–OL1613. 2011.

22 

Rahbar Saadat Y, Saeidi N, Zununi Vahed S, Barzegari A and Barar J: An update to DNA ladder assay for apoptosis detection. Bioimpacts. 5:25–28. 2015. View Article : Google Scholar : PubMed/NCBI

23 

Gouazé-Andersson V, Delmas C, Taurand M, Martinez-Gala J, Evrard S, Mazoyer S, Toulas C and Cohen-Jonathan-Moyal E: FGFR1 induces glioblastoma radioresistance through the PLCγ/Hif1α pathway. Cancer Res. 76:3036–3044. 2016. View Article : Google Scholar

24 

Marampon F, Gravina GL, Zani BM, Popov VM, Fratticci A, Cerasani M, Di Genova D, Mancini M, Ciccarelli C, Ficorella C, et al: Hypoxia sustains glioblastoma radioresistance through ERKs/DNA-PKcs/HIF-1α functional interplay. Int J Oncol. 44:2121–2131. 2014. View Article : Google Scholar : PubMed/NCBI

25 

Orsulic S, Huber O, Aberle H, Arnold S and Kemler R: E-cadherin binding prevents beta-catenin nuclear localization and beta-catenin/LEF-1-mediated transactivation. J Cell Sci. 112:1237–1245. 1999.PubMed/NCBI

26 

Zhang Y, Fan N and Yang J: Expression and clinical significance of hypoxia-inducible factor 1α, Snail and E-cadherin in human ovarian cancer cell lines. Mol Med Rep. 12:3393–3399. 2015. View Article : Google Scholar : PubMed/NCBI

27 

Wang L, Zhang XM, Li Z, Liu XJ, Chai J, Zhang GY and Cheng YF: Overexpression of nuclear β-catenin in rectal adenocarcinoma is associated with radioresistance. World J Gastroenterol. 19:6876–6882. 2013. View Article : Google Scholar : PubMed/NCBI

28 

Zhang Q, Gao M, Luo G, Han X, Bao W, Cheng Y, Tian W, Yan M, Yang G and An J: Enhancement of radiation sensitivity in lung cancer cells by a novel small molecule inhibitor that targets the β-catenin/Tcf4 interaction. PLoS One. 11:e01524072016. View Article : Google Scholar

29 

Nelson WJ and Nusse R: Convergence of Wnt, beta-catenin, and cadherin pathways. Science. 303:1483–1487. 2004. View Article : Google Scholar : PubMed/NCBI

30 

Guarino M: Epithelial-mesenchymal transition and tumour invasion. Int J Biochem Cell Biol. 39:2153–2160. 2007. View Article : Google Scholar : PubMed/NCBI

31 

Bütof R, Dubrovska A and Baumann M: Clinical perspectives of cancer stem cell research in radiation oncology. Radiother Oncol. 108:388–396. 2013. View Article : Google Scholar : PubMed/NCBI

32 

Peitzsch C, Kurth I, Kunz-Schughart L, Baumann M and Dubrovska A: Discovery of the cancer stem cell related determinants of radioresistance. Radiother Oncol. 108:378–387. 2013. View Article : Google Scholar : PubMed/NCBI

33 

Xi Y, Wei Y, Sennino B, Ulsamer A, Kwan I, Brumwell AN, Tan K, Aghi MK, McDonald DM, Jablons DM, et al: Identification of pY654-β-catenin as a critical co-factor in hypoxia-inducible factor-1α signaling and tumor responses to hypoxia. Oncogene. 32:5048–5057. 2013. View Article : Google Scholar

34 

Roura S, Miravet S, Piedra J, García de Herreros A and Duñach M: Regulation of E-cadherin/Catenin association by tyrosine phosphorylation. J Biol Chem. 274:36734–36740. 1999. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Luo Y, Li M, Zuo X, Basourakos SP, Zhang J, Zhao J, Han Y, Lin Y, Wang Y, Jiang Y, Jiang Y, et al: β‑catenin nuclear translocation induced by HIF‑1α overexpression leads to the radioresistance of prostate cancer. Int J Oncol 52: 1827-1840, 2018.
APA
Luo, Y., Li, M., Zuo, X., Basourakos, S.P., Zhang, J., Zhao, J. ... Lan, L. (2018). β‑catenin nuclear translocation induced by HIF‑1α overexpression leads to the radioresistance of prostate cancer. International Journal of Oncology, 52, 1827-1840. https://doi.org/10.3892/ijo.2018.4368
MLA
Luo, Y., Li, M., Zuo, X., Basourakos, S. P., Zhang, J., Zhao, J., Han, Y., Lin, Y., Wang, Y., Jiang, Y., Lan, L."β‑catenin nuclear translocation induced by HIF‑1α overexpression leads to the radioresistance of prostate cancer". International Journal of Oncology 52.6 (2018): 1827-1840.
Chicago
Luo, Y., Li, M., Zuo, X., Basourakos, S. P., Zhang, J., Zhao, J., Han, Y., Lin, Y., Wang, Y., Jiang, Y., Lan, L."β‑catenin nuclear translocation induced by HIF‑1α overexpression leads to the radioresistance of prostate cancer". International Journal of Oncology 52, no. 6 (2018): 1827-1840. https://doi.org/10.3892/ijo.2018.4368
Copy and paste a formatted citation
x
Spandidos Publications style
Luo Y, Li M, Zuo X, Basourakos SP, Zhang J, Zhao J, Han Y, Lin Y, Wang Y, Jiang Y, Jiang Y, et al: β‑catenin nuclear translocation induced by HIF‑1α overexpression leads to the radioresistance of prostate cancer. Int J Oncol 52: 1827-1840, 2018.
APA
Luo, Y., Li, M., Zuo, X., Basourakos, S.P., Zhang, J., Zhao, J. ... Lan, L. (2018). β‑catenin nuclear translocation induced by HIF‑1α overexpression leads to the radioresistance of prostate cancer. International Journal of Oncology, 52, 1827-1840. https://doi.org/10.3892/ijo.2018.4368
MLA
Luo, Y., Li, M., Zuo, X., Basourakos, S. P., Zhang, J., Zhao, J., Han, Y., Lin, Y., Wang, Y., Jiang, Y., Lan, L."β‑catenin nuclear translocation induced by HIF‑1α overexpression leads to the radioresistance of prostate cancer". International Journal of Oncology 52.6 (2018): 1827-1840.
Chicago
Luo, Y., Li, M., Zuo, X., Basourakos, S. P., Zhang, J., Zhao, J., Han, Y., Lin, Y., Wang, Y., Jiang, Y., Lan, L."β‑catenin nuclear translocation induced by HIF‑1α overexpression leads to the radioresistance of prostate cancer". International Journal of Oncology 52, no. 6 (2018): 1827-1840. https://doi.org/10.3892/ijo.2018.4368
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