|
1
|
Siegel RL, Miller KD and Jemal A: Cancer
Statistics, 2017. CA Cancer J Clin. 67:7–30. 2017. View Article : Google Scholar : PubMed/NCBI
|
|
2
|
Ghoneim MA, Abdel-Latif M, el-Mekresh M,
Abol-Enein H, Mosbah A, Ashamallah A and el-Baz MA: Radical
cystectomy for carcinoma of the bladder: 2,720 consecutive cases 5
years later. J Urol. 180:121–127. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
3
|
Park JC, Citrin DE, Agarwal PK and Apolo
AB: Multimodal management of muscle-invasive bladder cancer. Curr
Probl Cancer. 38:80–108. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
4
|
Geldart T, Chester J, Casbard A, Crabb S,
Elliott T, Protheroe A, Huddart RA, Mead G, Barber J, Jones RJ, et
al: SUCCINCT: An open-label, single-arm, non-randomised, phase 2
trial of gemcitabine and cisplatin chemotherapy in combination with
sunitinib as first-line treatment for patients with advanced
urothelial carcinoma. Eur Urol. 67:599–602. 2015. View Article : Google Scholar :
|
|
5
|
Toschi L, Finocchiaro G, Bartolini S,
Gioia V and Cappuzzo F: Role of gemcitabine in cancer therapy.
Future Oncol. 1:7–17. 2005. View Article : Google Scholar
|
|
6
|
Huang XL, Zhang H, Yang XY, Dong XY, Xie
XY, Yin HB, Gou X, Lin Y and He WY: Activation of a c-Jun
N-terminal kinase-mediated autophagy pathway attenuates the
anticancer activity of gemcitabine in human bladder cancer cells.
Anticancer Drugs. 28:596–602. 2017. View Article : Google Scholar : PubMed/NCBI
|
|
7
|
Dauer P, Nomura A, Saluja A and Banerjee
S: Microenvironment in determining chemo-resistance in pancreatic
cancer: Neighborhood matters. Pancreatology. 17:7–12. 2017.
View Article : Google Scholar :
|
|
8
|
Yasuda H: Solid tumor physiology and
hypoxia-induced chemo/radio-resistance: Novel strategy for cancer
therapy: Nitric oxide donor as a therapeutic enhancer. Nitric
Oxide. 19:205–216. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
9
|
Frolova O, Samudio I, Benito JM, Jacamo R,
Kornblau SM, Markovic A, Schober W, Lu H, Qiu YH, Buglio D, et al:
Regulation of HIF-1α signaling and chemoresistance in acute
lymphocytic leukemia under hypoxic conditions of the bone marrow
microenvironment. Cancer Biol Ther. 13:858–870. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
10
|
Qiu Y, Li P and Ji C: Cell death
conversion under hypoxic condition in tumor development and
therapy. Int J Mol Sci. 16:25536–25551. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
11
|
Schito L and Semenza GL: Hypoxia-inducible
factors: Master regulators of cancer progression. Trends Cancer.
2:758–770. 2016. View Article : Google Scholar
|
|
12
|
Song J, Qu Z, Guo X, Zhao Q, Zhao X, Gao
L, Sun K, Shen F, Wu M and Wei L: Hypoxia-induced autophagy
contributes to the chemoresistance of hepatocellular carcinoma
cells. Autophagy. 5:1131–1144. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
13
|
Mizushima N: Autophagy: Process and
function. Genes Dev. 21:2861–2873. 2007. View Article : Google Scholar : PubMed/NCBI
|
|
14
|
Wu HM, Jiang ZF, Ding PS, Shao LJ and Liu
RY: Hypoxia-induced autophagy mediates cisplatin resistance in lung
cancer cells. Sci Rep. 5:122912015. View Article : Google Scholar : PubMed/NCBI
|
|
15
|
Liu XW, Su Y, Zhu H, Cao J, Ding WJ, Zhao
YC, He QJ and Yang B: HIF-1α-dependent autophagy protects HeLa
cells from fenretinide (4-HPR)-induced apoptosis in hypoxia.
Pharmacol Res. 62:416–425. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
16
|
Helpap B: New WHO classification of
urothelial carcinoma of the urinary bladder. Verh Dtsch Ges Pathol.
86:57–66. 2002.In German.
|
|
17
|
Compérat EM, Burger M, Gontero P, Mostafid
AH, Palou J, Rouprêt M, van Rhijn BWG, Shariat SF, Sylvester RJ,
Zigeuner R, et al: Grading of urothelial carcinoma and the new
'World Health Organisation Classification of Tumours of the Urinary
System and Male Genital Organs 2016'. Eur Urol Focus.
S2405-4569(18)30004-X. 2018. View Article : Google Scholar
|
|
18
|
Lee JG, Shin JH, Shim HS, Lee CY, Kim DJ,
Kim YS and Chung KY: Autophagy contributes to the chemo-resistance
of non-small cell lung cancer in hypoxic conditions. Respir Res.
16:1382015. View Article : Google Scholar : PubMed/NCBI
|
|
19
|
Huang Z, Zhong Z, Zhang L, Wang X, Xu R,
Zhu L, Wang Z, Hu S and Zhao X: Down-regulation of HMGB1 expression
by shRNA constructs inhibits the bioactivity of urothelial
carcinoma cell lines via the NF-κB pathway. Sci Rep. 5:128072015.
View Article : Google Scholar
|
|
20
|
He X, Wang J, Wei W, Shi M, Xin B, Zhang T
and Shen X: Hypoxia regulates ABCG2 activity through the
activivation of ERK1/2/HIF-1α and contributes to chemoresistance in
pancreatic cancer cells. Cancer Biol Ther. 17:188–198. 2016.
View Article : Google Scholar :
|
|
21
|
Ko YH, Cho Y-S, Won HS, Jeon EK and Hong
YS: Possible role of autophagy inhibition in hypoxia-induced
chemoresistance of pancreatic cancer cells. J Clin Oncol. 30(Suppl
4): 2242012. View Article : Google Scholar
|
|
22
|
Ma Q, Zhang Y, Liu T, Jiang K, Wen Y, Fan
Q and Qiu X: Hypoxia promotes chemotherapy resistance by
down-regulating SKA1 gene expression in human osteosarcoma. Cancer
Biol Ther. 18:177–185. 2017. View Article : Google Scholar : PubMed/NCBI
|
|
23
|
Guo Q and Qin W: DKK3 blocked
translocation of β-catenin/EMT induced by hypoxia and improved
gemcitabine therapeutic effect in pancreatic cancer Bxpc-3 cell. J
Cell Mol Med. 19:2832–2841. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
24
|
Guo XL, Li D, Sun K, Wang J, Liu Y, Song
JR, Zhao QD, Zhang SS, Deng WJ, Zhao X, et al: Inhibition of
autophagy enhances anticancer effects of bevacizumab in
hepatocarcinoma. J Mol Med (Berl). 91:473–483. 2013. View Article : Google Scholar
|
|
25
|
Wang Q, Yang Y, Wang L, Zhang PZ and Yu L:
Acidic domain is indispensable for MDM2 to negatively regulate the
acetylation of p53. Biochem Biophys Res Commun. 374:437–441. 2008.
View Article : Google Scholar : PubMed/NCBI
|
|
26
|
Wartenberg M, Hoffmann E, Schwindt H,
Grünheck F, Petros J, Arnold JR, Hescheler J and Sauer H: Reactive
oxygen species-linked regulation of the multidrug resistance
transporter P-glycoprotein in Nox-1 overexpressing prostate tumor
spheroids. FEBS Lett. 579:4541–4549. 2005. View Article : Google Scholar : PubMed/NCBI
|
|
27
|
Chen WL, Wang CC, Lin YJ, Wu CP and Hsieh
CH: Cycling hypoxia induces chemoresistance through the activation
of reactive oxygen species-mediated B-cell lymphoma extra-long
pathway in glioblastoma multiforme. J Transl Med. 13:3892015.
View Article : Google Scholar : PubMed/NCBI
|
|
28
|
Ravanan P, Srikumar IF and Talwar P:
Autophagy: The spotlight for cellular stress responses. Life Sci.
188:53–67. 2017. View Article : Google Scholar
|
|
29
|
Yin H, Yang X, Gu W, Liu Y, Li X, Huang X,
Zhu X, Tao Y, Gou X and He W: HMGB1-mediated autophagy attenuates
gemcitabine-induced apoptosis in bladder cancer cells involving JNK
and ERK activation. Oncotarget. 8:71642–71656. 2017. View Article : Google Scholar : PubMed/NCBI
|
|
30
|
Kabir N and Yong Y: Hypoxia-induced
autophagy in hepatocellular carcinoma and anticancer therapy. Natl
J Physiol Pharm Pharmacol. 7:771–780. 2017.
|
|
31
|
Notte A, Ninane N, Arnould T and Michiels
C: Hypoxia counteracts taxol-induced apoptosis in MDA-MB-231 breast
cancer cells: Role of autophagy and JNK activation. Cell Death Dis.
4:e6382013. View Article : Google Scholar : PubMed/NCBI
|
|
32
|
Selvakumaran M, Amaravadi RK, Vasilevskaya
IA and O'Dwyer PJ: Autophagy inhibition sensitizes colon cancer
cells to antiangiogenic and cytotoxic therapy. Clin Cancer Res.
19:2995–3007. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
33
|
Zou YM, Hu GY, Zhao XQ, Lu T, Zhu F, Yu SY
and Xiong H: Hypoxia-induced autophagy contributes to
radioresistance via c-Jun-mediated Beclin1 expression in lung
cancer cells. J Huazhong Univ Sci Technolog Med Sci. 34:761–767.
2014. View Article : Google Scholar : PubMed/NCBI
|
|
34
|
Vergne I, Roberts E, Elmaoued RA, Tosch V,
Delgado MA, Proikas-Cezanne T, Laporte J and Deretic V: Control of
autophagy initiation by phosphoinositide 3-phosphatase Jumpy. EMBO
J. 28:2244–2258. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
35
|
Adams JM, Difazio LT, Rolandelli RH, Luján
JJ, Haskó G, Csóka B, Selmeczy Z and Németh ZH: HIF-1: A key
mediator in hypoxia. Acta Physiol Hung. 96:19–28. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
36
|
Li YN, Hu JA and Wang HM: Inhibition of
HIF-1α affects autophagy mediated glycosylation in oral squamous
cell carcinoma cells. Dis Markers. 2015:2394792015. View Article : Google Scholar
|
|
37
|
Harada H, Itasaka S, Kizaka-Kondoh S,
Shibuya K, Morinibu A, Shinomiya K and Hiraoka M: The Akt/mTOR
pathway assures the synthesis of HIF-1alpha protein in a glucose-
and reoxygenation-dependent manner in irradiated tumors. J Biol
Chem. 284:5332–5342. 2009. View Article : Google Scholar
|
|
38
|
Hu YL, DeLay M, Jahangiri A, Molinaro AM,
Rose SD, Carbonell WS and Aghi MK: Hypoxia-induced autophagy
promotes tumor cell survival and adaptation to antiangiogenic
treatment in glioblastoma. Cancer Res. 72:1773–1783. 2012.
View Article : Google Scholar : PubMed/NCBI
|
|
39
|
Bellot G, Garcia-Medina R, Gounon P,
Chiche J, Roux D, Pouysségur J and Mazure NM: Hypoxia-induced
autophagy is mediated through hypoxia-inducible factor induction of
BNIP3 and BNIP3L via their BH3 domains. Mol Cell Biol.
29:2570–2581. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
40
|
Huang HY, Wang WC, Lin PY, Huang CP, Chen
CY and Chen YK: The roles of autophagy and hypoxia in human
inflammatory periapical lesions. Int Endod J. 51(Suppl 2):
e125–e145. 2018. View Article : Google Scholar
|
|
41
|
Kim J, Kundu M, Viollet B and Guan KL:
AMPK and mTOR regulate autophagy through direct phosphorylation of
Ulk1. Nat Cell Biol. 13:132–141. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
42
|
Jin Y, Bai Y, Ni H, Qiang L, Ye L, Shan Y
and Zhou M: Activation of autophagy through calcium-dependent
AMPK/mTOR and PKCθ pathway causes activation of rat hepatic
stellate cells under hypoxic stress. FEBS Lett. 590:672–682. 2016.
View Article : Google Scholar : PubMed/NCBI
|
|
43
|
Liu H, Qiu H, Xiao Q and Le W: Chronic
hypoxia-induced autophagy aggravates the neuropathology of
Alzheimer's disease through AMPK-mTOR signaling in the
APPSwe/PS1dE9 mouse model. J Alzheimers Dis. 48:1019–1032. 2015.
View Article : Google Scholar : PubMed/NCBI
|
|
44
|
Fang Y, Tan J and Zhang Q: Signaling
pathways and mechanisms of hypoxia-induced autophagy in the animal
cells. Cell Biol Int. 39:891–898. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
45
|
Pike LR, Singleton DC, Buffa F, Abramczyk
O, Phadwal K, Li JL, Simon AK, Murray JT and Harris AL:
Transcriptional up-regulation of ULK1 by ATF4 contributes to cancer
cell survival. Biochem J. 449:389–400. 2013. View Article : Google Scholar
|
|
46
|
Rzymski T, Milani M, Pike L, Buffa F,
Mellor HR, Winchester L, Pires I, Hammond E, Ragoussis I and Harris
AL: Regulation of autophagy by ATF4 in response to severe hypoxia.
Oncogene. 29:4424–4435. 2010. View Article : Google Scholar : PubMed/NCBI
|
