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Curcumin inhibits cell proliferation and motility via suppression of TROP2 in bladder cancer cells

  • Authors:
    • Lianhua Zhang
    • Guoliang Yang
    • Ruiyun Zhang
    • Liang Dong
    • Haige Chen
    • Juanjie Bo
    • Wei Xue
    • Yiran Huang
  • View Affiliations / Copyright

    Affiliations: Department of Urology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, P.R. China
    Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 515-526
    |
    Published online on: May 30, 2018
       https://doi.org/10.3892/ijo.2018.4423
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Abstract

Bladder cancer (BC) has become a serious health prob­lem and represents the second most commonly diagnosed urological tumor. Curcumin is a principal active natural component of turmeric and has long been used in Asia as a traditional herbal medicine. Curcumin suppresses cell growth in various types of cancer, including BC, by regulating numerous molecular signaling pathways. The human trophoblast cell surface antigen 2 (Trop2) belongs to the tumor-associated calcium signal transducer gene family. Trop2 has been described as a cancer driver and is deregulated in various types of cancer. However, whether Trop2 is involved in curcumin-induced BC cell inhibition remains to be elucidated. The present study hypothesized that Trop2 may be a promising target of curcumin in BC cells. It was found that Trop2 was closely involved in curcumin-induced cell proliferation suppression, mobility inhibition, apoptosis, and cell cycle arrest in BC cells. Curcumin decreased the expression of Trop2 and its downstream target cyclin E1, and increased the level of p27. The overexpression of Trop2 enhanced the oncogenic activity of BC cells, whereas downregulation of the expression of Trop2 suppressed cell proliferation and mobility, increased apoptosis, and sensitized BC cells to curcumin treatment. Therefore, Trop2 may be a promising target of curcumin in BC cells and the inhibition of Trop2 may be an important method for the therapeutic management of patients with BC.
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Copy and paste a formatted citation
Spandidos Publications style
Zhang L, Yang G, Zhang R, Dong L, Chen H, Bo J, Xue W and Huang Y: Curcumin inhibits cell proliferation and motility via suppression of TROP2 in bladder cancer cells. Int J Oncol 53: 515-526, 2018.
APA
Zhang, L., Yang, G., Zhang, R., Dong, L., Chen, H., Bo, J. ... Huang, Y. (2018). Curcumin inhibits cell proliferation and motility via suppression of TROP2 in bladder cancer cells. International Journal of Oncology, 53, 515-526. https://doi.org/10.3892/ijo.2018.4423
MLA
Zhang, L., Yang, G., Zhang, R., Dong, L., Chen, H., Bo, J., Xue , W., Huang, Y."Curcumin inhibits cell proliferation and motility via suppression of TROP2 in bladder cancer cells". International Journal of Oncology 53.2 (2018): 515-526.
Chicago
Zhang, L., Yang, G., Zhang, R., Dong, L., Chen, H., Bo, J., Xue , W., Huang, Y."Curcumin inhibits cell proliferation and motility via suppression of TROP2 in bladder cancer cells". International Journal of Oncology 53, no. 2 (2018): 515-526. https://doi.org/10.3892/ijo.2018.4423
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang L, Yang G, Zhang R, Dong L, Chen H, Bo J, Xue W and Huang Y: Curcumin inhibits cell proliferation and motility via suppression of TROP2 in bladder cancer cells. Int J Oncol 53: 515-526, 2018.
APA
Zhang, L., Yang, G., Zhang, R., Dong, L., Chen, H., Bo, J. ... Huang, Y. (2018). Curcumin inhibits cell proliferation and motility via suppression of TROP2 in bladder cancer cells. International Journal of Oncology, 53, 515-526. https://doi.org/10.3892/ijo.2018.4423
MLA
Zhang, L., Yang, G., Zhang, R., Dong, L., Chen, H., Bo, J., Xue , W., Huang, Y."Curcumin inhibits cell proliferation and motility via suppression of TROP2 in bladder cancer cells". International Journal of Oncology 53.2 (2018): 515-526.
Chicago
Zhang, L., Yang, G., Zhang, R., Dong, L., Chen, H., Bo, J., Xue , W., Huang, Y."Curcumin inhibits cell proliferation and motility via suppression of TROP2 in bladder cancer cells". International Journal of Oncology 53, no. 2 (2018): 515-526. https://doi.org/10.3892/ijo.2018.4423
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