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Article

Silencing Ubc9 expression suppresses osteosarcoma tumorigenesis and enhances chemosensitivity to HSV-TK/GCV by regulating connexin 43 SUMOylation

  • Authors:
    • Dianying Zhang
    • Kai Yu
    • Zhong Yang
    • Yanxia Li
    • Xiaofang Ma
    • Xiyun Bian
    • Fengting Liu
    • Lili Li
    • Xiaozhi Liu
    • Wenhan Wu
  • View Affiliations / Copyright

    Affiliations: Department of Trauma and Orthopedics, Beijing University People's Hospital, Beijing 100044, P.R. China, Department of Orthopedics, The Fifth Central Hospital of Tianjin, Tianjin 300450, P.R. China, Central Laboratory, The Fifth Central Hospital of Tianjin, Tianjin 300450, P.R. China, Department of Bone and Soft Tissue Tumors, Tianjin Medical University Cancer Institute and Hospital, Tianjin 300060, P.R. China, Department of General Surgery, Beijing University First Hospital, Beijing 100034, P.R. China
  • Pages: 1323-1331
    |
    Published online on: June 21, 2018
       https://doi.org/10.3892/ijo.2018.4448
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Abstract

The ability of herpes simplex virus thymidine kinase/ganciclovir (HSV-TK/GCV) systems to kill tumor cells is partially dependent on the integrity of gap junction intercellular communication (GJIC) of targeted tumor cells. Recent studies have suggested that connexin 43 (Cx43), which serves a role in gap junction-mediated intercellular communication, is regulated by small ubiquitin-like modifiers (SUMOs). However, the roles of these post-translational modifications remain to be elucidated. The present study demonstrated overexpression of SUMO‑conjugating enzyme Ubc9 (Ubc9) protein in osteosarcoma. Silencing Ubc9 by siRNA inhibited osteosarcoma cell proliferation and migration, and significantly increased the sensitivity of cells to HSV-TK/GCV systems both in vitro and in vivo. Further experimentation demonstrated that silencing Ubc9 induced decoupling of SUMO1 from Cx43, generating increased free Cx43 levels, which is important for reconstructing GJIC and recovering cellular functions. In conclusion, the present study revealed a novel method for the effective restoration of GJIC in osteosarcoma cells, which may increase their sensitivity to conventional chemotherapy.
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1 

Akoluk A, Barazani Y, Slova D, Shah S and Tareen B: Carcinosarcoma of the bladder: Case report and review of the literature. Can Urol Assoc J. 5:E69–E73. 2011. View Article : Google Scholar : PubMed/NCBI

2 

Ottaviani G and Jaffe N: The epidemiology of osteosarcoma. Cancer Treat Res. 152:3–13. 2009. View Article : Google Scholar

3 

Gu X, Ding J, Zhang Z, Li Q, Zhuang X and Chen X: Polymeric nanocarriers for drug delivery in osteosarcoma treatment. Curr Pharm Des. 21:5187–5197. 2015. View Article : Google Scholar : PubMed/NCBI

4 

Grote HJ, Braun M, Kalinski T, Pomjanski N, Back W, Bleyl U, Böcking A and Roessner A: Spontaneous malignant transformation of conventional giant cell tumor. Skeletal Radiol. 33:169–175. 2004. View Article : Google Scholar : PubMed/NCBI

5 

Bennani S, Louahlia S, Aboutaieb R, el Mrini M and S: Carcinosarcoma of the bladder. Apropos of two cases J Urol (Paris). 100:210–216. 1994.In French.

6 

Chiu KC, Lin MC, Liang YC and Chen CY: Renal carcinosarcoma: Case report and review of literature. Ren Fail. 30:1034–1039. 2008. View Article : Google Scholar : PubMed/NCBI

7 

Nishisho T, Sakai T, Tezuka F, Higashino K, Takao S, Takata Y, Miyagi R, Toki S, Abe M, Yamashita K, et al: Delayed diagnosis of primary bone and soft tissue tumors initially treated as degenerative spinal disorders. J Med Invest. 63:274–277. 2016. View Article : Google Scholar : PubMed/NCBI

8 

Yi BR, Choi KJ, Kim SU and Choi KC: Therapeutic potential of stem cells expressing suicide genes that selectively target human breast cancer cells: Evidence that they exert tumoricidal effects via tumor tropism (review). Int J Oncol. 41:798–804. 2012. View Article : Google Scholar : PubMed/NCBI

9 

Wildner O: In situ use of suicide genes for therapy of brain tumours. Ann Med. 31:421–429. 1999. View Article : Google Scholar

10 

van Dillen IJ, Mulder NH, Vaalburg W, de Vries EF and Hospers GA: Influence of the bystander effect on HSV-tk/GCV gene therapy. A review Curr Gene Ther. 2:307–322. 2002. View Article : Google Scholar

11 

Määttä AM, Samaranayake H, Pikkarainen J, Wirth T and Ylä-Herttuala S: Adenovirus mediated herpes simplex virus-thymidine kinase/ganciclovir gene therapy for resectable malignant glioma. Curr Gene Ther. 9:356–367. 2009. View Article : Google Scholar : PubMed/NCBI

12 

Czyż J, Szpak K and Madeja Z: The role of connexins in prostate cancer promotion and progression. Nat Rev Urol. 9:274–282. 2012. View Article : Google Scholar

13 

El-Sabban ME, Abi-Mosleh LF and Talhouk RS: Developmental regulation of gap junctions and their role in mammary epithelial cell differentiation. J Mammary Gland Biol Neoplasia. 8:463–473. 2003. View Article : Google Scholar

14 

Abbaci M, Barberi-Heyob M, Blondel W, Guillemin F and Didelon J: Advantages and limitations of commonly used methods to assay the molecular permeability of gap junctional intercellular communication. Biotechniques. 45:33–52. 56–62. 2008. View Article : Google Scholar : PubMed/NCBI

15 

Aasen T: Connexins: Junctional and non-junctional modulators of proliferation. Cell Tissue Res. 360:685–699. 2015. View Article : Google Scholar

16 

Ehrlich HP: A snapshot of direct cell-cell communications in wound healing and scarring. Adv Wound Care (New Rochelle). 2:113–121. 2013. View Article : Google Scholar

17 

Falk MM, Fong JT, Kells RM, O'Laughlin MC, Kowal TJ and Thévenin AF: Degradation of endocytosed gap junctions by autophagosomal and endo-/lysosomal pathways: A perspective. J Membr Biol. 245:465–476. 2012. View Article : Google Scholar : PubMed/NCBI

18 

Jiang JX, Siller-Jackson AJ and Burra S: Roles of gap junctions and hemichannels in bone cell functions and in signal transmission of mechanical stress. Front Biosci. 12:1450–1462. 2007. View Article : Google Scholar :

19 

Klaunig JE: Alterations in intercellular communication during the stage of promotion. Proc Soc Exp Biol Med. 198:688–692. 1991. View Article : Google Scholar : PubMed/NCBI

20 

Barry J and Lock RB: Small ubiquitin-related modifier-1: Wrestling with protein regulation. Int J Biochem Cell Biol. 43:37–40. 2011. View Article : Google Scholar

21 

Morris JR: SUMO in the mammalian response to DNA damage. Biochem Soc Trans. 38:92–97. 2010. View Article : Google Scholar : PubMed/NCBI

22 

Hoeller D and Dikic I: Targeting the ubiquitin system in cancer therapy. Nature. 458:438–444. 2009. View Article : Google Scholar : PubMed/NCBI

23 

Moschos SJ and Mo YY: Role of SUMO/Ubc9 in DNA damage repair and tumorigenesis. J Mol Histol. 37:309–319. 2006. View Article : Google Scholar : PubMed/NCBI

24 

Praefcke GJ, Hofmann K and Dohmen RJ: SUMO playing tag with ubiquitin. Trends Biochem Sci. 37:23–31. 2012. View Article : Google Scholar

25 

Princz A and Tavernarakis N: The role of SUMOylation in ageing and senescent decline. Mech Ageing Dev. 162:85–90. 2017. View Article : Google Scholar : PubMed/NCBI

26 

Kjenseth A, Fykerud TA, Sirnes S, Bruun J, Yohannes Z, Kolberg M, Omori Y, Rivedal E and Leithe E: The gap junction channel protein connexin 43 is covalently modified and regulated by SUMOylation. J Biol Chem. 287:15851–15861. 2012. View Article : Google Scholar : PubMed/NCBI

27 

Liu Z, Jiang Z, Huang J, Huang S, Li Y, Yu S, Yu S and Liu X: miR-7 inhibits glioblastoma growth by simultaneously interfering with the PI3K/ATK and Raf/MEK/ERK pathways. Int J Oncol. 44:1571–1580. 2014. View Article : Google Scholar : PubMed/NCBI

28 

Chai L, Kang X-J, Sun Z-Z, Zeng MF, Yu SR, Ding Y, Liang JQ, Li TT and Zhao J: MiR-497-5p, miR-195-5p and miR-455-3p function as tumor suppressors by targeting hTERT in melanoma A375 cells. Cancer Manag Res. 10:989–1003. 2018. View Article : Google Scholar : PubMed/NCBI

29 

Liu X, Li G, Su Z, Jiang Z, Chen L, Wang J, Yu S and Liu Z: Poly(amido amine) is an ideal carrier of miR-7 for enhancing gene silencing effects on the EGFR pathway in U251 glioma cells. Oncol Rep. 29:1387–1394. 2013. View Article : Google Scholar : PubMed/NCBI

30 

Jiang Z, Zhang L, Zhang L, Wang S, Zheng M, Li Y and Liu X: Enhancement of B-cell translocation gene-2 inhibits proliferation and metastasis of colon cancer cells]. Zhonghua Zhong Liu Za Zhi. 37:330–335. 2015.In Chinese. PubMed/NCBI

31 

Li XD, Chang B, Chen B, Liu ZY, Liu DX, Wang JS, Hou GQ, Huang DY and Du SX: Panax notoginseng saponins potentiate osteogenesis of bone marrow stromal cells by modulating gap junction intercellular communication activities. Cell Physiol Biochem. 26:1081–1092. 2010. View Article : Google Scholar

32 

Liu D and Liu A: Administration of vitamin E prevents thymocyte apoptosis in murine sarcoma S180 tumor bearing mice. Cell Mol Biol (Noisy-le-grand). 58(Suppl): OL1671–OL1679. 2012.

33 

Wasik U and Filipek A: The CacyBP/SIP protein is sumoylated in neuroblastoma NB2a cells. Neurochem Res. 38:2427–2432. 2013. View Article : Google Scholar : PubMed/NCBI

34 

Zhu S, Sachdeva M, Wu F, Lu Z and Mo YY: Ubc9 promotes breast cell invasion and metastasis in a sumoylation-independent manner. Oncogene. 29:1763–1772. 2010. View Article : Google Scholar :

35 

Galanty Y, Belotserkovskaya R, Coates J, Polo S, Miller KM and Jackson SP: Mammalian SUMO E3-ligases PIAS1 and PIAS4 promote responses to DNA double-strand breaks. Nature. 462:935–939. 2009. View Article : Google Scholar : PubMed/NCBI

36 

Matt S and Hofmann TG: The DNA damage-induced cell death response: A roadmap to kill cancer cells. Cell Mol Life Sci. 73:2829–2850. 2016. View Article : Google Scholar : PubMed/NCBI

37 

Hong SS, Lee H and Kim KW: HIF-1alpha: A valid therapeutic target for tumor therapy. Cancer Res Treat. 36:343–353. 2004. View Article : Google Scholar : PubMed/NCBI

38 

Garbuz DG: Regulation of heat shock gene expression in response to stress. Mol Biol (Mosk). 51:400–417. 2017.In Russian. View Article : Google Scholar

39 

Rape M: Ubiquitylation at the crossroads of development and disease. Nat Rev Mol Cell Biol. 19:59–70. 2018. View Article : Google Scholar

40 

Perry JA, Kiezun A, Tonzi P, Van Allen EM, Carter SL, Baca SC, Cowley GS, Bhatt AS, Rheinbay E, Pedamallu CS, et al: Complementary genomic approaches highlight the PI3K/mTOR pathway as a common vulnerability in osteosarcoma. Proc Natl Acad Sci USA. 111:E5564–E5573. 2014. View Article : Google Scholar : PubMed/NCBI

41 

Zhang J, Yu XH, Yan YG, Wang C and Wang WJ: PI3K/Akt signaling in osteosarcoma. Clin Chim Acta. 444:182–192. 2015. View Article : Google Scholar : PubMed/NCBI

42 

Graziano AC, Cardile V, Avola R, Vicario N, Parenti C, Salvatorelli L, Magro G and Parenti R: Wilms' tumor gene 1 silencing inhibits proliferation of human osteosarcoma MG-63 cell line by cell cycle arrest and apoptosis activation. Oncotarget. 8:13917–13931. 2017. View Article : Google Scholar : PubMed/NCBI

43 

Xia W, Tian H, Cai X, Kong H, Fu W, Xing W, Wang Y, Zou M, Hu Y and Xu D: Inhibition of SUMO-specific protease 1 induces apoptosis of astroglioma cells by regulating NF-κB/Akt pathways. Gene. 595:175–179. 2016. View Article : Google Scholar : PubMed/NCBI

44 

de la Cruz-Herrera CF, Campagna M, Lang V, del Carmen González-Santamaría J, Marcos-Villar L, Rodríguez MS, Vidal A, Collado M and Rivas C: SUMOylation regulates AKT1 activity. Oncogene. 34:1442–1450. 2015. View Article : Google Scholar

45 

Lin CH, Liu SY and Lee EH: SUMO modification of Akt regulates global SUMOylation and substrate SUMOylation specificity through Akt phosphorylation of Ubc9 and SUMO1. Oncogene. 35:595–607. 2016. View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Zhang D, Yu K, Yang Z, Li Y, Ma X, Bian X, Liu F, Li L, Liu X, Wu W, Wu W, et al: Silencing Ubc9 expression suppresses osteosarcoma tumorigenesis and enhances chemosensitivity to HSV-TK/GCV by regulating connexin 43 SUMOylation. Int J Oncol 53: 1323-1331, 2018.
APA
Zhang, D., Yu, K., Yang, Z., Li, Y., Ma, X., Bian, X. ... Wu, W. (2018). Silencing Ubc9 expression suppresses osteosarcoma tumorigenesis and enhances chemosensitivity to HSV-TK/GCV by regulating connexin 43 SUMOylation. International Journal of Oncology, 53, 1323-1331. https://doi.org/10.3892/ijo.2018.4448
MLA
Zhang, D., Yu, K., Yang, Z., Li, Y., Ma, X., Bian, X., Liu, F., Li, L., Liu, X., Wu, W."Silencing Ubc9 expression suppresses osteosarcoma tumorigenesis and enhances chemosensitivity to HSV-TK/GCV by regulating connexin 43 SUMOylation". International Journal of Oncology 53.3 (2018): 1323-1331.
Chicago
Zhang, D., Yu, K., Yang, Z., Li, Y., Ma, X., Bian, X., Liu, F., Li, L., Liu, X., Wu, W."Silencing Ubc9 expression suppresses osteosarcoma tumorigenesis and enhances chemosensitivity to HSV-TK/GCV by regulating connexin 43 SUMOylation". International Journal of Oncology 53, no. 3 (2018): 1323-1331. https://doi.org/10.3892/ijo.2018.4448
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang D, Yu K, Yang Z, Li Y, Ma X, Bian X, Liu F, Li L, Liu X, Wu W, Wu W, et al: Silencing Ubc9 expression suppresses osteosarcoma tumorigenesis and enhances chemosensitivity to HSV-TK/GCV by regulating connexin 43 SUMOylation. Int J Oncol 53: 1323-1331, 2018.
APA
Zhang, D., Yu, K., Yang, Z., Li, Y., Ma, X., Bian, X. ... Wu, W. (2018). Silencing Ubc9 expression suppresses osteosarcoma tumorigenesis and enhances chemosensitivity to HSV-TK/GCV by regulating connexin 43 SUMOylation. International Journal of Oncology, 53, 1323-1331. https://doi.org/10.3892/ijo.2018.4448
MLA
Zhang, D., Yu, K., Yang, Z., Li, Y., Ma, X., Bian, X., Liu, F., Li, L., Liu, X., Wu, W."Silencing Ubc9 expression suppresses osteosarcoma tumorigenesis and enhances chemosensitivity to HSV-TK/GCV by regulating connexin 43 SUMOylation". International Journal of Oncology 53.3 (2018): 1323-1331.
Chicago
Zhang, D., Yu, K., Yang, Z., Li, Y., Ma, X., Bian, X., Liu, F., Li, L., Liu, X., Wu, W."Silencing Ubc9 expression suppresses osteosarcoma tumorigenesis and enhances chemosensitivity to HSV-TK/GCV by regulating connexin 43 SUMOylation". International Journal of Oncology 53, no. 3 (2018): 1323-1331. https://doi.org/10.3892/ijo.2018.4448
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