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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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International Journal of Oncology

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Journal Cover
September-2018 Volume 53 Issue 3

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Journal Metrics

Impact Factor: 4.9

CiteScore: 8.9

CiteScore Rank: Q1: #66/415 Oncology

Source Normalized Impact per Paper (SNIP): 0.955

SCImago Journal Rank (SJR): 1226.0

Review

Overview of mitochondrial germline variants and mutations in human disease: Focus on breast cancer (Review)

Silvia Jiménez-Morales, Carlos J. Pérez-Amado, Elizabeth Langley, Alfredo Hidalgo-Miranda
Pages: 923-936
Published online on: 04 July 2018

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Article Open Access

ZIC1 acts a tumor suppressor in breast cancer by targeting survivin

Wei Han, Fang Cao, Xiao-Jiao Gao, Hua-Bing Wang, Fang Chen, Si-Jian Cai, Cong Zhang, Yong-Wei Hu, Jun Ma, Xing Gu, Hou-Zhong Ding
Pages: 937-948
Published online on: 21 June 2018

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Article Open Access

The enhanced antitumour response of pimozide combined with the IDO inhibitor L‑MT in melanoma

Huijie Jia, Wenjing Ren, Yuchen Feng, Tian Wei, Mengmeng Guo, Jing Guo, Jingjing Zhao, Xiangfeng Song, Mingyong Wang, Tiesuo Zhao, Hui Wang, Zhiwei Feng, Zhongwei Tian
Pages: 949-960
Published online on: 06 July 2018

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Article Open Access

KRAB zinc-finger protein 382 regulates epithelial-mesenchymal transition and functions as a tumor suppressor, but is silenced by CpG methylation in gastric cancer

Lijiao Pei, Xiaoqian He, Shuman Li, Ran Sun, Qin Xiang, Guosheng Ren, Tingxiu Xiang
Pages: 961-972
Published online on: 19 June 2018

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Article Open Access

NLRP3 in human glioma is correlated with increased WHO grade, and regulates cellular proliferation, apoptosis and metastasis via epithelial-mesenchymal transition and the PTEN/AKT signaling pathway

Xiao-Feng Yin, Qiong Zhang, Zhuo-Yu Chen, Hai-Fang Wang, Xin Li, Hong-Xia Wang, Hai-Xia Li, Chun-Min Kang, Shuai Chu, Kai-Fei Li, Yao Li, Yu-Rong Qiu
Pages: 973-986
Published online on: 12 July 2018

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Article Open Access

Epoxymicheliolide, a novelguaiane-type sesquiterpene lactone, inhibits NF‑κB/COX‑2 signaling pathways by targeting leucine 281 and leucine 25 in IKKβ in renal cell carcinoma

Jiabin Zhu, Jun Zhao, Zhenlong Yu, Sandeep Shrestha, Jing Song, Wenwen Liu, Wen Lan, Jinshan Xing, Shuang Liu, Chen Chen, Momo Cao, Xiuzhen Sun, Qi Wang, Xishuang Song
Pages: 987-1000
Published online on: 29 June 2018

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Article Open Access

Effects of a checkpoint kinase inhibitor, AZD7762, on tumor suppression and bone remodeling

Luqi Wang, Yue Wang, Andy Chen, Aydin Jalali, Shengzhi Liu, Yunxia Guo, Sungsoo Na, Harikrishna Nakshatri, Bai-Yan Li, Hiroki Yokota
Pages: 1001-1012
Published online on: 13 July 2018

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Article Open Access

Exosome-mediated transfer of lncRNA‑SNHG14 promotes trastuzumab chemoresistance in breast cancer Retraction in /10.3892/ijo.2022.5382

Huaying Dong, Wei Wang, Ru Chen, Yu Zhang, Kejian Zou, Mulin Ye, Xionghui He, Fan Zhang, Jing Han
Pages: 1013-1026
Published online on: 03 July 2018

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Article Open Access

Fordin: A novel type I ribosome inactivating protein from Vernicia fordii modulates multiple signaling cascades leading to anti-invasive and pro-apoptotic effects in cancer cells in vitro

Weili Lu, Yingji Mao, Xue Chen, Jun Ni, Rui Zhang, Yuting Wang, Jun Wang, Lifang Wu
Pages: 1027-1042
Published online on: 04 July 2018

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Article Open Access

NT21MP negatively regulates paclitaxel-resistant cells by targeting miR‑155‑3p and miR‑155-5p via the CXCR4 pathway in breast cancer

Yueyue Wang, Lei Yan, Lingyu Zhang, Henan Xu, Tiantian Chen, Yu Li, Haifeng Wang, Sulian Chen, Wenrui Wang, Changjie Chen, Qingling Yang
Pages: 1043-1054
Published online on: 09 July 2018

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Article Open Access

ABT737 reverses cisplatin resistance by targeting glucose metabolism of human ovarian cancer cells

Yunjie Xu, Weinan Gao, Yong Zhang, Shanshan Wu, Yanan Liu, Xinyue Deng, Lili Xie, Jiayan Yang, Huimei Yu, Jing Su, Liankun Sun
Pages: 1055-1068
Published online on: 09 July 2018

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Article Open Access

LRIG2 promotes the proliferation and cell cycle progression of glioblastoma cells in vitro and in vivo through enhancing PDGFRβ signaling Corrigendum in /10.3892/ijo.2019.4769 Corrigendum in /10.3892/ijo.2022.5305

Qungen Xiao, Minhai Dong, Fangling Cheng, Feng Mao, Weifeng Zong, Kang Wu, Heping Wang, Ruifan Xie, Baofeng Wang, Ting Lei, Dongsheng Guo
Pages: 1069-1082
Published online on: 16 July 2018

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Article Open Access

Identifying autophagy gene-associated module biomarkers through construction and analysis of an autophagy-mediated ceRNA‑ceRNA interaction network in colorectal cancer

Kun Qian, Huiying Huang, Jing Jiang, Dahua Xu, Shengnan Guo, Ying Cui, Hao Wang, Liqiang Wang, Kongning Li
Pages: 1083-1093
Published online on: 18 June 2018

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Article Open Access

lncRNA-ATB functions as a competing endogenous RNA to promote YAP1 by sponging miR-590-5p in malignant melanoma

Kuanhou Mou, Bo Liu, Meiling Ding, Xin Mu, Dan Han, Yan Zhou, Li-Juan Wang
Pages: 1094-1104
Published online on: 25 June 2018

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Article Open Access

Liposomal paclitaxel induces fewer hematopoietic and cardiovascular complications than bioequivalent doses of Taxol

Shih-Ting Huang, Yi‑Ping Wang, Yen-Hui Chen, Chin-Tarng Lin, Wen-Shan Li, Han-Chung Wu
Pages: 1105-1117
Published online on: 21 June 2018

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Article Open Access

Loss of profilin 2 contributes to enhanced epithelial-mesenchymal transition and metastasis of colorectal cancer

Hui Zhang, Weiqiang Yang, Jinlong Yan, Kaiping Zhou, Boshun Wan, Peidong Shi, Yueyu Chen, Songbing He, Dechun Li
Pages: 1118-1128
Published online on: 09 July 2018

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Article Open Access

Single-walled carbon nanohorn aggregates promotes mitochondrial dysfunction-induced apoptosis in hepatoblastoma cells by targeting SIRT3

Bowei Li, Xiaoxun Chen, Wenbin Yang, Jingliang He, Ke He, Zhenglin Xia, Jinqian Zhang, Guoan Xiang
Pages: 1129-1137
Published online on: 28 June 2018

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Article Open Access

High COX-2 expression contributes to a poor prognosis through the inhibition of chemotherapy-induced senescence in nasopharyngeal carcinoma

Chen Shi, Yongjun Guan, Liang Zeng, Guizhu Liu, Yinghong Zhu, He Xu, Yichen Lu, Jiabin Liu, Jiaojiao Guo, Xiangling Feng, Xinying Zhao, Weihong Jiang, Guancheng Li, Guiyuan Li, Yun Dai, Fengyan Jin, Wei Li, Wen Zhou
Pages: 1138-1148
Published online on: 29 June 2018

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Article Open Access

Effect of ABT-888 on the apoptosis, motility and invasiveness of BRAFi-resistant melanoma cells

Federica Fratangelo, Rosa Camerlingo, Maria Vincenza Carriero, Giuseppe Pirozzi, Giuseppe Palmieri, Giusy Gentilcore, Concetta Ragone, Michele Minopoli, Paolo Antonio Ascierto, Maria Letizia Motti
Pages: 1149-1159
Published online on: 27 June 2018

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Article Open Access

Rhaponticin decreases the metastatic and angiogenic abilities of cancer cells via suppression of the HIF‑1α pathway

Aeyung Kim, Jin Yeul Ma
Pages: 1160-1170
Published online on: 11 July 2018

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Article

Psoriasin overexpression confers drug resistance to cisplatin by activating ERK in gastric cancer

Liting Li, Yuxin Cui, Lin Ye, Zehang Zhao, Wen G. Jiang, Jiafu Ji
Pages: 1171-1182
Published online on: 26 June 2018

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Article

Silencing GOLPH3 gene expression reverses resistance to cisplatin in HT29 colon cancer cells via multiple signaling pathways

Zhi-Ping Zhou, Lin-Pei Wang, Zhong-Shi Hong, Cheng-Zhi Qiu, Ming-Zhen Wang, Zhi-Xiong Chen, Long-Feng Tang, Wai-Shi Yu, Chun-Xiao Wang
Pages: 1183-1192
Published online on: 05 July 2018

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Article

Modulation of the tumor microenvironment by intratumoral administration of IMO-2125, a novel TLR9 agonist, for cancer immunotherapy

Daqing Wang, Wayne Jiang, Fugang Zhu, Xianzhi Mao, Sudhir Agrawal
Pages: 1193-1203
Published online on: 27 June 2018

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Article

MicroRNA-494 acts as a tumor suppressor in pancreatic cancer, inhibiting epithelial-mesenchymal transition, migration and invasion by binding to SDC1

Ying Yang, Xiong Tao, Chun-Bo Li, Chang-Miao Wang
Pages: 1204-1214
Published online on: 19 June 2018

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Article

Tumor suppressor LKB1 inhibits the progression of gallbladder carcinoma and predicts the prognosis of patients with this malignancy

Ming-Tai Hu, Jing-Han Wang, Yong Yu, Chen Liu, Bin Li, Qing-Bao Cheng, Xiao-Qing Jiang
Pages: 1215-1226
Published online on: 02 July 2018

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Article

Long non‑coding RNA 00152 functions as a competing endogenous RNA to regulate NRP1 expression by sponging with miRNA‑206 in colorectal cancer

Zhuan-Peng Chen, Jian-Chang Wei, Qiang Wang, Ping Yang, Wang-Lin Li, Feng He, Hua‑Cui Chen, He Hu, Jun-Bin Zhong, Jie Cao
Pages: 1227-1236
Published online on: 22 June 2018

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Article

Identification of cisplatin sensitizers through high-throughput combinatorial screening

Yichen Sun, Weiye Jiang, Wenhua Lu, Ming Song, Kaiyan Liu, Ping Chen, Allison Chang, Jianhua Ling, Paul J. Chiao, Yumin Hu, Peng Huang
Pages: 1237-1246
Published online on: 19 June 2018

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Article

Decreased expression of miR‑490‑3p in colorectal cancer predicts poor prognosis and promotes cell proliferation and invasion by targeting RAB14

Bo Wang, Mujun Yin, Cheng Cheng, Hongpeng Jiang, Kewei Jiang, Zhanlong Shen, Yingjiang Ye, Shan Wang
Pages: 1247-1256
Published online on: 19 June 2018

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Article

The antioxidant, aged garlic extract, exerts cytotoxic effects on wild-type and multidrug-resistant human cancer cells by altering mitochondrial permeability

Shinji Ohkubo, Lisa Dalla Via, Silvia Grancara, Yuta Kanamori, Aída Nelly García-Argáez, Gianluca Canettieri, Paolo Arcari, Antonio Toninello, Enzo Agostinelli
Pages: 1257-1268
Published online on: 22 June 2018

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Article

Tristetraprolin activation by resveratrol inhibits the proliferation and metastasis of colorectal cancer cells

Se-Ra Lee, Hua Jin, Won-Tae Kim, Won-Jung Kim, Sung Zoo Kim, Sun-Hee Leem, Soo Mi Kim
Pages: 1269-1278
Published online on: 25 June 2018

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Article

Polyphyllin I inhibits invasion and epithelial-mesenchymal transition via CIP2A/PP2A/ERK signaling in prostate cancer

Xuewen Liu, Zhiting Sun, Jikun Deng, Jun Liu, Kaihuai Ma, Yuan Si, Te Zhang, Tingting Feng, Ying Liu, Yan Tan
Pages: 1279-1288
Published online on: 29 June 2018

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Article

Promoted delivery of salinomycin sodium to lung cancer cells by dual targeting PLGA hybrid nanoparticles

Jie Zhou, Jin Sun, Huaiwen Chen, Qing Peng
Pages: 1289-1300
Published online on: 06 July 2018

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Article

BECN1-knockout impairs tumor growth, migration and invasion by suppressing the cell cycle and partially suppressing the epithelial-mesenchymal transition of human triple-negative breast cancer cells

Cheng-Lin Wu, Shi‑Meng Zhang, Li Lin, Shan-Shan Gao, Kai-Fei Fu, Xiao-Dan Liu, Yan Liu, Li-Jun Zhou, Ping-Kun Zhou
Pages: 1301-1312
Published online on: 05 July 2018

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Article

Prolonged survival of patients with colorectal cancer is associated with a higher regucalcin gene expression: Overexpression of regucalcin suppresses the growth of human colorectal carcinoma cells in vitro

Masayoshi Yamaguchi, Satoru Osuka, Tomiyasu Murata
Pages: 1313-1322
Published online on: 28 June 2018

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Article

Silencing Ubc9 expression suppresses osteosarcoma tumorigenesis and enhances chemosensitivity to HSV-TK/GCV by regulating connexin 43 SUMOylation

Dianying Zhang, Kai Yu, Zhong Yang, Yanxia Li, Xiaofang Ma, Xiyun Bian, Fengting Liu, Lili Li, Xiaozhi Liu, Wenhan Wu
Pages: 1323-1331
Published online on: 21 June 2018

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Article

MicroRNA-381 reduces inflammation and infiltration of macrophages in polymyositis via downregulating HMGB1

Yutao Liu, Yuan Gao, Jing Yang, Changhe Shi, Yanlin Wang, Yuming Xu
Pages: 1332-1342
Published online on: 29 June 2018

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Article

Curcumin attenuates resistance to irinotecan via induction of apoptosis of cancer stem cells in chemoresistant colon cancer cells

Pengfei Su, Yong Yang, Guoxin Wang, Xiaowu Chen, Yongle Ju
Pages: 1343-1353
Published online on: 29 June 2018

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Article

Biological effects of BMP7 on small-cell lung cancer cells and its bone metastasis Corrigendum in /10.3892/ijo.2025.5757

Weiwei Shen, Hailin Pang, Bo Xin, Lian Duan, Lili Liu, Helong Zhang
Pages: 1354-1362
Published online on: 04 July 2018

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Article

Active fraction of clove induces apoptosis via PI3K/Akt/mTOR-mediated autophagy in human colorectal cancer HCT-116 cells

Minghua Liu, Ge Zhao, Dan Zhang, Weixiao An, Honglin Lai, Xiaofang Li, Shousong Cao, Xiukun Lin
Pages: 1363-1373
Published online on: 02 July 2018

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Article

Long non-coding RNA SNHG12promotes the proliferation and migration of glioma cells by binding to HuR

Wei Lei, Zhi-Long Wang, He-Jun Feng, Xiang-Dan Lin, Chuang-Zhong Li, Di Fan
Pages: 1374-1384
Published online on: 11 July 2018

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Journal Cover
January-2026 Volume 68 Issue 1

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Journal Metrics

Impact Factor: 4.9

CiteScore: 8.9

CiteScore Rank: Q1: #66/415 Oncology

Source Normalized Impact per Paper (SNIP): 0.955

SCImago Journal Rank (SJR): 1226.0

Article Open Access

c‑Myc‑regulated RPLP0 via the ROS‑mediated JAK2/STAT3 positive feedback loop facilitates hepatocellular carcinoma malignancy progression

Yanqiu Meng, Lebin Yuan, Gangrui Meng, Hongxiang Huang, Xianbin Huang, Xinping Xu, Xiaodong Peng
Article Number: 13
Published online on: 27 November 2025

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Review Open Access

Obesity, chronic breast inflammation and carcinogenesis: Molecular pathways and clinical implications (Review)

Fangying Li, Zhenhua Gao
Article Number: 12
Published online on: 27 November 2025

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Review Open Access

The tumor microenvironment in lung cancer: Heterogeneity, therapeutic resistance and emerging treatment strategies (Review)

Li Liu, Li Yang, Hongmin Li, Tianlu Shang, Lihan Liu
Article Number: 11
Published online on: 26 November 2025

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Article Open Access

Discovery of the late autophagy inhibitor FZU‑0045‑053 and its anti‑breast cancer and immunomodulatory effects

Jinlan Luo, Yi Yang, Lulu Cheng, Fangting Cheng, Huangwenlong Zhuang, Shanshan Chen, Panpan Qiao, Yinbin Liang, Li Chen, Yang Sun, Haijun Chen, Qinying Liu
Article Number: 10
Published online on: 26 November 2025

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Correction Open Access

[Corrigendum] RIPK4/PEBP1 axis promotes pancreatic cancer cell migration and invasion by activating RAF1/MEK/ERK signaling

Zi-Hao Qi, Hua-Xiang Xu, Shi-Rong Zhang, Jin-Zhi Xu, Shuo Li, He-Li Gao, Wei Jin, Wen-Quan Wang, Chun-Tao Wu, Quan-Xing Ni, Xian-Jun Yu, Liang Liu
Article Number: 9
Published online on: 24 November 2025

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Article Open Access

Ephrin‑B2 promotes gastric cancer growth by inhibiting apoptosis and regulating the cell cycle via the Wnt/β‑catenin signaling pathway

Ding Ding, Xiaoshan Wang, Ran Xuan, Rui Li, Yalu Zhang, Zhengguang Wang
Article Number: 8
Published online on: 18 November 2025

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Expression of Concern Open Access

[Expression of Concern] Gene therapy for human colorectal cancer cell lines with recombinant adenovirus 5 based on loss of the insulin‑like growth factor 2 imprinting

Huiling Sun, Yuqin Pan, Bangshun He, Qiwen Deng, Rui Li, Yeqiong Xu, Jie Chen, Tianyi Gao, Houqun Ying, Feng Wang, Xian Liu, Shukui Wang
Article Number: 7
Published online on: 18 November 2025

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Review Open Access

Ferroptosis in biliary tract cancer: Molecular mechanisms and therapeutic applications (Review)

Ruiqi Zou, Yushi Dai, Siqi Yang, Haijie Hu, Fuyu Li, Fei Liu
Article Number: 6
Published online on: 14 November 2025

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Expression of Concern Open Access

[Expression of Concern] Radiosensitization of esophageal carcinoma cells by knockdown of RNF2 expression

Xing-Xiao Yang, Ming Ma, Mei-Xiang Sang, Xue-Xiao Wang, Heng Song, Zhi-Kun Liu, Shu-Chai Zhu
Article Number: 5
Published online on: 10 November 2025

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Review Open Access

Targeting ferroptosis in Helicobacter pylori‑associated gastric cancer development: From molecular mechanisms to application prospects (Review)

Chen-Yi Wang, Meng-Hui Wang, Chuan Xie
Article Number: 4
Published online on: 05 November 2025

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Expression of Concern Open Access

[Expression of Concern] Leptin promotes breast cancer cell migration and invasion via IL‑18 expression and secretion

Kuangfa Li, Lan Wei, Yunxiu Huang, Yang Wu, Min Su, Xueli Pang, Nian Wang, Feihu Ji, Changli Zhong, Tingmei Chen
Article Number: 3
Published online on: 04 November 2025

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Review Open Access

Cancer immunotherapy strategies based on transition‑metal medical materials: Still a long way to go (Review)

Zhefei Du, Zhenyu Cao, Chao Fang, Daihan Xie, Lixin Xie, Chunxia Su, Yu Huo
Article Number: 2
Published online on: 04 November 2025

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Expression of Concern Open Access

[Expression of Concern] Regulation of NADPH oxidase (Nox2) by lipid rafts in breast carcinoma cells

Rama Rao Malla, Hari Raghu, Jasti S. Rao
Article Number: 1
Published online on: 23 October 2025

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Journal Cover
February-2026 Volume 68 Issue 2

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Journal Metrics

Impact Factor: 4.9

CiteScore: 8.9

CiteScore Rank: Q1: #66/415 Oncology

Source Normalized Impact per Paper (SNIP): 0.955

SCImago Journal Rank (SJR): 1226.0

Retraction Open Access

[Retracted] Cdc42 expression in cervical cancer and its effects on cervical tumor invasion and migration

Hongnan Ye, Youyi Zhang, Li Geng, Zijian Li
Article Number: 20
Published online on: 05 December 2025

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Article Open Access

Regulation and reversal of paclitaxel resistance via the STAT1‑mediated apoptotic pathway in ovarian cancer

Fanchen Wang, Xiaolin Xu, Bin Guan, Xin Li, Jia Yuan, Wencai Guan, Junyu Chen, Jingyi Fang, Qi Lu, Guoxiong Xu
Article Number: 19
Published online on: 05 December 2025

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Review

Cancer stem cell heterogeneity‑inspired therapeutics for enhancing tumor treatment outcomes (Review)

Hanning Xu, Qunchao Si, Yongyao Song, Shengping Sun, Xianghong Wei, Hui Long, Xiaomei Wang
Article Number: 18
Published online on: 04 December 2025

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Review Open Access

Roles of interleukins in spasmolytic polypeptide‑expressing metaplasia (Review)

Jiale Ma, Tiancheng Zhan, Xinyuan Zhang, Wang Gao, Shuangmei Zhao, Huizhen Li
Article Number: 17
Published online on: 03 December 2025

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Expression of Concern Open Access

[Expression of Concern] MUC1 is a downstream target of STAT3 and regulates lung cancer cell survival and invasion

Jingchun Gao, Matthew J. Mcconnell, Bin Yu, Jiannong Li, Justin M. Balko, Esther P. Black, Joseph O. Johnson, Mark C. Lloyd, Soner Altiok, Eric B. Haura
Article Number: 16
Published online on: 03 December 2025

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Review Open Access

Emerging biomarkers in prostate cancer diagnosis and treatment: Insights into genetic, RNA and metabolic markers (Review)

Yuanshe Huang, Jingxin Mao, Xiaobing Li
Article Number: 15
Published online on: 03 December 2025

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Retraction Open Access

[Retracted] GDC‑0152 attenuates the malignant progression of osteosarcoma promoted by ANGPTL2 via PI3K/AKT but not p38MAPK signaling pathway

Lin Yang, Taipengfei Shu, Yingjian Liang, Wenguang Gu, Chunlei Wang, Xuanhe Song, Changdong Fan, Wenbo Wang
Article Number: 14
Published online on: 01 December 2025

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