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ZIC1 acts a tumor suppressor in breast cancer by targeting survivin

  • Authors:
    • Wei Han
    • Fang Cao
    • Xiao-Jiao Gao
    • Hua-Bing Wang
    • Fang Chen
    • Si-Jian Cai
    • Cong Zhang
    • Yong-Wei Hu
    • Jun Ma
    • Xing Gu
    • Hou-Zhong Ding
  • View Affiliations / Copyright

    Affiliations: Department of General Surgery, Kunshan First People's Hospital Affiliated to Jiangsu University, Kunshan, Jiangsu 215300, P.R. China, Department of Pathology, Kunshan First People's Hospital Affiliated to Jiangsu University, Kunshan, Jiangsu 215300, P.R. China, Department of General Surgery, Luan First People's Hospital, Luan, Anhui 237000, P.R. China, Business School, York St. John University, York YO31 7EX, UK, Department of Pharmacy, Kunshan Hospital of Traditional Chinese Medicine, Kunshan, Jiangsu 215300, P.R. China, Department of Urinary Surgery, Kunshan Hospital of Traditional Chinese Medicine, Kunshan, Jiangsu 215300, P.R. China, Department of Gynecology, Kunshan First People's Hospital Affiliated to Jiangsu University, Kunshan, Jiangsu 215300, P.R. China
    Copyright: © Han et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 937-948
    |
    Published online on: June 21, 2018
       https://doi.org/10.3892/ijo.2018.4450
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Abstract

In this study, we aimed to identify the tumor suppressive roles of zinc finger of the cerebellum 1 (ZIC1) in patients with malignant breast neoplasms and to examine the association between ZIC1 and survivin expression. For this purpose, 140 invasive breast cancer specimens, 1,075 RNA breast cancer samples from The Cancer Genome Atlas (TCGA), 6 human breast cancer cell lines and MCF-10A normal breast epithelial cells were selected in order to compare the expression level of ZIC1 with that of survivin via immunohistochemistry and western blot analysis. Subsequently, the MDA-MB-231 and SK-BR3 cells with a lower ZIC1 expression were transfected with rLV-Zic1-PGK-Puro lentivirus or rLV-ZsGreen-PGK‑Puro lentivirus in order to observe any alterations in cell proliferation and apoptosis through MTT assay, colony formation assay, mitochondrial membrane potential assay and flow cytometric analysis, and to analyze the modulation of molecular mechanisms by western blot analysis. In addition, xenograft mouse models were constructed to explore the role of ZIC1 in the growth of implanted tumors. The results revealed that ZIC1 negatively correlated with survivin in tumors and cells, and a higher ZIC1 RNA expression indicated a better overall survival in the 1,075 TCGA RNA breast cancer samples. In vitro, the overexpression of ZIC1 inhibited cell proliferation, reduced mitochondrial membrane potential and promoted the apoptosis of the MDA-MB-231 and SK-BR3 breast cancer cells by inactivating the Akt/mTOR/P70S6K pathway, suppressing survivin expression, modulating the cell cycle, releasing cytochrome c (Cyto-c) into the cytosol and activating caspase proteins. In vivo, an elevated ZIC1 expression suppressed the growth of implanted tumors and downregulated survivin expression in tumors. On the whole, the findings of this study demonstrate that ZIC1 plays a tumor suppressive role in breast cancer, by targeting surviving, significantly downregulating its expression.
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1 

Siegel RL, Miller KD and Jemal A: Cancer statistics, 2015. CA Cancer J Clin. 65:5–29. 2015. View Article : Google Scholar : PubMed/NCBI

2 

Ding L, Zhang Z, Xu Y and Zhang Y: Comparative study of Her-2, p53, Ki-67 expression and clinicopathological characteristics of breast cancer in a cohort of northern China female patients. Bioengineered. 8:383–392. 2017. View Article : Google Scholar : PubMed/NCBI

3 

Parsa Y, Mirmalek SA, Kani FE, Aidun A, Salimi-Tabatabaee SA, Yadollah-Damavandi S, Jangholi E, Parsa T and Shahverdi E: A review of the clinical implications of breast cancer biology. Electron Physician. 8:2416–2424. 2016. View Article : Google Scholar : PubMed/NCBI

4 

Ali RG, Bellchambers HM and Arkell RM: Zinc fingers of the cerebellum (Zic): Transcription factors and co-factors. Int J Biochem Cell Biol. 44:2065–2068. 2012. View Article : Google Scholar : PubMed/NCBI

5 

Sankar S, Yellajoshyula D, Zhang B, Teets B, Rockweiler N and Kroll KL: Gene regulatory networks in neural cell fate acquisition from genome-wide chromatin association of Geminin and Zic1. Sci Rep. 6:374122016. View Article : Google Scholar : PubMed/NCBI

6 

Zhong J, Chen S, Xue M, Du Q, Cai J, Jin H, Si J and Wang L: ZIC1 modulates cell-cycle distributions and cell migration through regulation of sonic hedgehog, PI(3)K and MAPK signaling pathways in gastric cancer. BMC Cancer. 12:2902012. View Article : Google Scholar : PubMed/NCBI

7 

Gan L, Chen S, Zhong J, Wang X, Lam EK, Liu X, Zhang J, Zhou T, Yu J, Si J, et al: ZIC1 is downregulated through promoter hypermethylation, and functions as a tumor suppressor gene in colorectal cancer. PLoS One. 6:e169162011. View Article : Google Scholar : PubMed/NCBI

8 

Qiang W, Zhao Y, Yang Q, Liu W, Guan H, Lv S, Ji M, Shi B and Hou P: ZIC1 is a putative tumor suppressor in thyroid cancer by modulating major signaling pathways and transcription factor FOXO3a. J Clin Endocrinol Metab. 99:E1163–E1172. 2014. View Article : Google Scholar : PubMed/NCBI

9 

Wang YY, Jiang JX, Ma H, Han J, Sun ZY, Liu ZM and Xu ZG: Role of ZIC1 methylation in hepatocellular carcinoma and its clinical significance. Tumour Biol. 35:7429–7433. 2014. View Article : Google Scholar : PubMed/NCBI

10 

Ma G, Dai W, Sang A, Yang X and Li Q: Roles of ZIC family genes in human gastric cancer. Int J Mol Med. 38:259–266. 2016. View Article : Google Scholar : PubMed/NCBI

11 

Nakakido M, Tamura K, Chung S, Ueda K, Fujii R, Kiyotani K and Nakamura Y: Phosphatidylinositol glycan anchor biosynthesis, class X containing complex promotes cancer cell proliferation through suppression of EHD2 and ZIC1, putative tumor suppressors. Int J Oncol. 49:868–876. 2016. View Article : Google Scholar : PubMed/NCBI

12 

Tamm I, Wang Y, Sausville E, Scudiero DA, Vigna N, Oltersdorf T and Reed JC: IAP-family protein survivin inhibits caspase activity and apoptosis induced by Fas (CD95), Bax, caspases, and anticancer drugs. Cancer Res. 58:5315–5320. 1998.PubMed/NCBI

13 

Colnaghi R, Connell CM, Barrett RM and Wheatley SP: Separating the anti-apoptotic and mitotic roles of survivin. J Biol Chem. 281:33450–33456. 2006. View Article : Google Scholar : PubMed/NCBI

14 

Hamy AS, Bieche I, Lehmann-Che J, Scott V, Bertheau P, Guinebretière JM, Matthieu MC, Sigal-Zafrani B, Tembo O, Marty M, et al: BIRC5 (survivin): A pejorative prognostic marker in stage II/III breast cancer with no response to neoadjuvant chemotherapy. Breast Cancer Res Treat. 159:499–511. 2016. View Article : Google Scholar : PubMed/NCBI

15 

Véquaud E, Desplanques G, Jézéquel P, Juin P and Barillé-Nion S: Survivin contributes to DNA repair by homologous recombination in breast cancer cells. Breast Cancer Res Treat. 155:53–63. 2016. View Article : Google Scholar :

16 

Wilson JM, Kunnimalaiyaan S, Kunnimalaiyaan M and Gamblin TC: Inhibition of the AKT pathway in cholangiocarcinoma by MK2206 reduces cellular viability via induction of apoptosis. Cancer Cell Int. 15:132015. View Article : Google Scholar : PubMed/NCBI

17 

Jin Q, Feng L, Behrens C, Bekele BN, Wistuba II, Hong WK and Lee HY: Implication of AMP-activated protein kinase and Akt-regulated survivin in lung cancer chemopreventive activities of deguelin. Cancer Res. 67:11630–11639. 2007. View Article : Google Scholar : PubMed/NCBI

18 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar

19 

Li Q, Liu J, Meng X, Pang R and Li J: MicroRNA-454 may function as an oncogene via targeting AKT in triple negative breast cancer. J Biol Res (Thessalon). 24:102017. View Article : Google Scholar

20 

Sauer SJ, Tarpley M, Shah I, Save AV, Lyerly HK, Patierno SR, Williams KP and Devi GR: Bisphenol A activates EGFR and ERK promoting proliferation, tumor spheroid formation and resistance to EGFR pathway inhibition in estrogen receptor-negative inflammatory breast cancer cells. Carcinogenesis. 38:252–260. 2017. View Article : Google Scholar : PubMed/NCBI

21 

Du G, Cao D and Meng L: miR-21 inhibitor suppresses cell proliferation and colony formation through regulating the PTEN/AKT pathway and improves paclitaxel sensitivity in cervical cancer cells. Mol Med Rep. 15:2713–2719. 2017. View Article : Google Scholar : PubMed/NCBI

22 

Ding JH, Yuan LY and Chen GA: Aspirin enhances the cytotoxic activity of bortezomib against myeloma cells via suppression of Bcl-2, survivin and phosphorylation of AKT. Oncol Lett. 13:647–654. 2017. View Article : Google Scholar : PubMed/NCBI

23 

Wu ZH, Lin C, Liu MM, Zhang J, Tao ZH and Hu XC: Src inhibition can synergize with gemcitabine and reverse resistance in triple negative breast cancer cells via the AKT/c-Jun pathway. PLoS One. 11:e01692302016. View Article : Google Scholar : PubMed/NCBI

24 

Khan Z, Khan AA, Yadav H, Prasad GBKS and Bisen PS: Survivin, a molecular target for therapeutic interventions in squamous cell carcinoma. Cell Mol Biol Lett. 22:82017. View Article : Google Scholar : PubMed/NCBI

25 

Kawakami H, Tomita M, Matsuda T, Ohta T, Tanaka Y, Fujii M, Hatano M, Tokuhisa T and Mori N: Transcriptional activation of survivin through the NF-kappaB pathway by human T-cell leukemia virus type I tax. Int J Cancer. 115:967–974. 2005. View Article : Google Scholar : PubMed/NCBI

26 

Lens SM, Vader G and Medema RH: The case for survivin as mitotic regulator. Curr Opin Cell Biol. 18:616–622. 2006. View Article : Google Scholar : PubMed/NCBI

27 

Liu W, Zhu F, Jiang Y, Sun D, Yang B and Yan H: siRNA targeting survivin inhibits the growth and enhances the chemosensitivity of hepatocellular carcinoma cells. Oncol Rep. 29:1183–1188. 2013. View Article : Google Scholar

28 

Brill E, Gobble R, Angeles C, Lagos-Quintana M, Crago A, Laxa B, Decarolis P, Zhang L, Antonescu C, Socci ND, et al: ZIC1 overexpression is oncogenic in liposarcoma. Cancer Res. 70:6891–6901. 2010. View Article : Google Scholar : PubMed/NCBI

29 

Rodríguez-Rodero S, Fernández AF, Fernández-Morera JL, Castro-Santos P, Bayon GF, Ferrero C, Urdinguio RG, Gonzalez-Marquez R, Suarez C, Fernández-Vega I, et al: DNA methylation signatures identify biologically distinct thyroid cancer subtypes. J Clin Endocrinol Metab. 98:2811–2821. 2013. View Article : Google Scholar : PubMed/NCBI

30 

Verlaat W, Snijders PJ, Novianti PW, Wilting SM, De Strooper LM, Trooskens G, Vandersmissen J, Van Criekinge W, Wisman GB, Meijer CJ, et al: Genome-wide DNA methylation profiling reveals methylation markers associated with 3q gain for detection of cervical pre-cancer and cancer. Clin Cancer Res. 23:3813–3822. 2017. View Article : Google Scholar : PubMed/NCBI

31 

Du L, Qian X, Dai C, Wang L, Huang D, Wang S and Shen X: Screening the molecular targets of ovarian cancer based on bioinformatics analysis. Tumori. 101:384–389. 2015. View Article : Google Scholar : PubMed/NCBI

32 

Fang F, Munck J, Tang J, Taverna P, Wang Y, Miller DF, Pilrose J, Choy G, Azab M, Pawelczak KS, et al: The novel, small-molecule DNA methylation inhibitor SGI-110 as an ovarian cancer chemo-sensitizer. Clin Cancer Res. 20:6504–6516. 2014. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Han W, Cao F, Gao X, Wang H, Chen F, Cai S, Zhang C, Hu Y, Ma J, Gu X, Gu X, et al: ZIC1 acts a tumor suppressor in breast cancer by targeting survivin. Int J Oncol 53: 937-948, 2018.
APA
Han, W., Cao, F., Gao, X., Wang, H., Chen, F., Cai, S. ... Ding, H. (2018). ZIC1 acts a tumor suppressor in breast cancer by targeting survivin. International Journal of Oncology, 53, 937-948. https://doi.org/10.3892/ijo.2018.4450
MLA
Han, W., Cao, F., Gao, X., Wang, H., Chen, F., Cai, S., Zhang, C., Hu, Y., Ma, J., Gu, X., Ding, H."ZIC1 acts a tumor suppressor in breast cancer by targeting survivin". International Journal of Oncology 53.3 (2018): 937-948.
Chicago
Han, W., Cao, F., Gao, X., Wang, H., Chen, F., Cai, S., Zhang, C., Hu, Y., Ma, J., Gu, X., Ding, H."ZIC1 acts a tumor suppressor in breast cancer by targeting survivin". International Journal of Oncology 53, no. 3 (2018): 937-948. https://doi.org/10.3892/ijo.2018.4450
Copy and paste a formatted citation
x
Spandidos Publications style
Han W, Cao F, Gao X, Wang H, Chen F, Cai S, Zhang C, Hu Y, Ma J, Gu X, Gu X, et al: ZIC1 acts a tumor suppressor in breast cancer by targeting survivin. Int J Oncol 53: 937-948, 2018.
APA
Han, W., Cao, F., Gao, X., Wang, H., Chen, F., Cai, S. ... Ding, H. (2018). ZIC1 acts a tumor suppressor in breast cancer by targeting survivin. International Journal of Oncology, 53, 937-948. https://doi.org/10.3892/ijo.2018.4450
MLA
Han, W., Cao, F., Gao, X., Wang, H., Chen, F., Cai, S., Zhang, C., Hu, Y., Ma, J., Gu, X., Ding, H."ZIC1 acts a tumor suppressor in breast cancer by targeting survivin". International Journal of Oncology 53.3 (2018): 937-948.
Chicago
Han, W., Cao, F., Gao, X., Wang, H., Chen, F., Cai, S., Zhang, C., Hu, Y., Ma, J., Gu, X., Ding, H."ZIC1 acts a tumor suppressor in breast cancer by targeting survivin". International Journal of Oncology 53, no. 3 (2018): 937-948. https://doi.org/10.3892/ijo.2018.4450
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