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International Journal of Oncology
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International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

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Article

Promoted delivery of salinomycin sodium to lung cancer cells by dual targeting PLGA hybrid nanoparticles

  • Authors:
    • Jie Zhou
    • Jin Sun
    • Huaiwen Chen
    • Qing Peng
  • View Affiliations / Copyright

    Affiliations: Department of Pulmonary Medicine, Minhang Hospital, Zhongshan Hospital, Fudan University, Shanghai 201199, P.R. China, Department of Pharmacy, The Naval Medical University, Shanghai 200433, P.R. China, Center of Clinical and Translational Medicine, Shanghai Changhai Hospital, The Naval Medical University, Shanghai 200433, P.R. China
  • Pages: 1289-1300
    |
    Published online on: July 6, 2018
       https://doi.org/10.3892/ijo.2018.4474
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Abstract

As the leading cause of cancer-associated mortality worldwide, lung cancer is often associated with therapy failure and decreases in survival; these factors are often attributed to lung cancer-initiating cells (CICs). In addition, sufficient evidence has suggested that simultaneous targeting of CICs, together with cancer cells, is critical for the achievement of preferable therapeutic efficacy, due to the spontaneous conversion between CICs and cancer cells. Salinomycin sodium (SS) is an antibacterial therapeutic agent that exerts potent activity against CICs in various types of cancer, including lung cancer. The present study generated SS lipid-polymer hybrid nanoparticles (NPs) with cluster of differentiation (CD)133 and epidermal growth factor receptor (EGFR) antibodies (CD133/EGFR SS NPs) for the simultaneous treatment of lung CICs and cancer cells. The activity of CD133/EGFR SS NPs was analyzed using cytotoxicity and tumorsphere formation assays, flow cytometry, and an in vivo anticancer assay in mice bearing lung cancer xenografts. The results revealed that CD133/EGFR SS NPs effectively promoted SS delivery to lung CICs and cancer cells, achieving superior therapeutic effects compared with non-targeted NPs or NPs with a single antibody. Furthermore, CD133/EGFR SS NPs exhibited the best efficacy in inhibiting tumor growth compared with the control agents in lung cancer-bearing mice. In conclusion, CD133/EGFR SS NPs may be capable of efficiently targeting and treating lung CICs together with cancer cells, and may represent an effective treatment for lung cancer.
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Copy and paste a formatted citation
Spandidos Publications style
Zhou J, Sun J, Chen H and Peng Q: Promoted delivery of salinomycin sodium to lung cancer cells by dual targeting PLGA hybrid nanoparticles. Int J Oncol 53: 1289-1300, 2018.
APA
Zhou, J., Sun, J., Chen, H., & Peng, Q. (2018). Promoted delivery of salinomycin sodium to lung cancer cells by dual targeting PLGA hybrid nanoparticles. International Journal of Oncology, 53, 1289-1300. https://doi.org/10.3892/ijo.2018.4474
MLA
Zhou, J., Sun, J., Chen, H., Peng, Q."Promoted delivery of salinomycin sodium to lung cancer cells by dual targeting PLGA hybrid nanoparticles". International Journal of Oncology 53.3 (2018): 1289-1300.
Chicago
Zhou, J., Sun, J., Chen, H., Peng, Q."Promoted delivery of salinomycin sodium to lung cancer cells by dual targeting PLGA hybrid nanoparticles". International Journal of Oncology 53, no. 3 (2018): 1289-1300. https://doi.org/10.3892/ijo.2018.4474
Copy and paste a formatted citation
x
Spandidos Publications style
Zhou J, Sun J, Chen H and Peng Q: Promoted delivery of salinomycin sodium to lung cancer cells by dual targeting PLGA hybrid nanoparticles. Int J Oncol 53: 1289-1300, 2018.
APA
Zhou, J., Sun, J., Chen, H., & Peng, Q. (2018). Promoted delivery of salinomycin sodium to lung cancer cells by dual targeting PLGA hybrid nanoparticles. International Journal of Oncology, 53, 1289-1300. https://doi.org/10.3892/ijo.2018.4474
MLA
Zhou, J., Sun, J., Chen, H., Peng, Q."Promoted delivery of salinomycin sodium to lung cancer cells by dual targeting PLGA hybrid nanoparticles". International Journal of Oncology 53.3 (2018): 1289-1300.
Chicago
Zhou, J., Sun, J., Chen, H., Peng, Q."Promoted delivery of salinomycin sodium to lung cancer cells by dual targeting PLGA hybrid nanoparticles". International Journal of Oncology 53, no. 3 (2018): 1289-1300. https://doi.org/10.3892/ijo.2018.4474
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