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Gene regulatory network construction identified NFYA as a diffuse subtype-specific prognostic factor in gastric cancer

  • Authors:
    • Bin Cao
    • Yu Zhao
    • Zheng Zhang
    • Hengcun Li
    • Jie Xing
    • Shuilong Guo
    • Xintao Qiu
    • Shutian Zhang
    • Li Min
    • Shengtao Zhu
  • View Affiliations / Copyright

    Affiliations: Department of Gastroenterology, Beijing Friendship Hospital, Capital Medical University, National Clinical Research Center for Digestive Disease, Beijing Digestive Disease Center, Beijing Key Laboratory for Precancerous Lesion of Digestive Disease, Beijing 100050, P.R. China, Department of Biomedical Informatics, Harvard School of Public Health, Boston, MA 02115, USA
    Copyright: © Cao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1857-1868
    |
    Published online on: August 9, 2018
       https://doi.org/10.3892/ijo.2018.4519
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Abstract

Lauren classification is a pathology-based gastric cancer (GC) subtyping system, which is widely used in the clinical treatment of patients with GC. However, genome-scale molecular characteristics to distinguish between diffuse (DF) and intestinal (IT) GC remain incompletely characterized, particularly at the transcriptional regulatory level. In the present study, gene regulatory networks were constructed using the Passing Attributes between Networks for Data Assimilation (PANDA) algorithm for DF, IT and mixed GC. The results indicated that >85% of transcription factor (TF)-target edges were shared among all three GC subtypes. In TF enrichment analysis, 13 TFs, including nuclear transcription factor Y subunit α (NFYA) and forkhead box L1, were activated in DF GC, whereas 8 TFs, including RELA proto-oncogene and T-cell leukemia homeobox 1 (TLX1), were activated in IT GC. Out of these identified TFs, NFYA [Hazard ratio (HR) (95% confidence interval, CI)=0.560 (0.349, 0.900), P=0.017] and sex determining region Y [HR (95% CI)=0.603 (0.375, 0.969), P=0.037] were identified as independent prognostic factors in DF GC, but not in IT GC, whereas TLX1 [HR (95% CI)=0.547 (0.321, 0.9325), P=0.027] was identified as an independent prognostic factor in IT GC, but not in DF GC. Verification at the cellular level was also performed; interference of NFYA expression using small interfering RNA in MGC803 cells (DF GC-derived cells) markedly inhibited cell growth and colony formation. Similar effects were also detected in SGC-7901 cells (IT GC-derived cells), but to a lesser extent. In conclusion, identified gene regulatory networks differed between distinct GC subtypes, in which the same TFs had different biological effects. Specifically, NFYA was identified as a DF subtype-specific independent prognostic factor in GC.
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1 

Torre LA, Bray F, Siegel RL, Ferlay J, Lortet-Tieulent J and Jemal A; Global cancer statistics: 2012.CA Cancer J Clin. 65:87–108. 2015. View Article : Google Scholar

2 

Chen W, Zheng R, Baade PD, Zhang S, Zeng H, Bray F, Jemal A, Yu XQ and He J; Cancer statistics in China: 2015.CA Cancer J Clin. 66:115–132. 2016. View Article : Google Scholar

3 

Wong SS, Kim KM, Ting JC, Yu K, Fu J, Liu S, Cristescu R, Nebozhyn M, Gong L, Yue YG, et al: Genomic landscape and genetic heterogeneity in gastric adenocarcinoma revealed by whole-genome sequencing. Nat Commun. 5:54772014. View Article : Google Scholar : PubMed/NCBI

4 

Lauren T: The two histological main types of gastric carcinoma, an attempt at a histoclinical classification. Acta Pathol Microbiol Scand. 64:191965. View Article : Google Scholar

5 

Hartgrink HH, Jansen EP, van Grieken NC and van de Velde CJ: Gastric cancer. Lancet. 374:477–490. 2009. View Article : Google Scholar : PubMed/NCBI

6 

He Z and Li B: Recent progress in genetic and epigenetic profile of diffuse gastric cancer. Cancer Transl Med. 1:80–93. 2015. View Article : Google Scholar

7 

Shah MA, Khanin R, Tang L, Janjigian YY, Klimstra DS, Gerdes H and Kelsen DP: Molecular classification of gastric cancer: A new paradigm. Clin Cancer Res. 17:2693–2701. 2011. View Article : Google Scholar : PubMed/NCBI

8 

Fléjou JF: WHO Classification of digestive tumors: The fourth edition. Ann Pathol. 31(Suppl 5): pp. S27–S31. 2011, (In French). View Article : Google Scholar

9 

Palli D, Bianchi S, Cipriani F, Duca P, Amorosi A, Avellini C, Russo A, Saragoni A, Todde P and Valdes E: Reproducibility of histologic classification of gastric cancer. Br J Cancer. 63:765–768. 1991. View Article : Google Scholar : PubMed/NCBI

10 

Jinawath N, Furukawa Y, Hasegawa S, Li M, Tsunoda T, Satoh S, Yamaguchi T, Imamura H, Inoue M, Shiozaki H, et al: Comparison of gene-expression profiles between diffuse- and intestinal-type gastric cancers using a genome-wide cDNA microarray. Oncogene. 23:6830–6844. 2004. View Article : Google Scholar : PubMed/NCBI

11 

Lee YS, Cho YS, Lee GK, Lee S, Kim YW, Jho S, Kim HM, Hong SH, Hwang JA, Kim SY, et al: Genomic profile analysis of diffuse-type gastric cancers. Genome Biol. 15:R552014. View Article : Google Scholar : PubMed/NCBI

12 

Tanabe S, Aoyagi K, Yokozaki H and Sasaki H: Gene expression signatures for identifying diffuse-type gastric cancer associated with epithelial-mesenchymal transition. Int J Oncol. 44:1955–1970. 2014. View Article : Google Scholar : PubMed/NCBI

13 

Förster S, Gretschel S, Jöns T, Yashiro M and Kemmner W: THBS4, a novel stromal molecule of diffuse-type gastric adenocarcinomas, identified by transcriptome-wide expression profiling. Mod Pathol. 24:1390–1403. 2011. View Article : Google Scholar : PubMed/NCBI

14 

Kim B, Bang S, Lee S, Kim S, Jung Y, Lee C, Choi K, Lee SG, Lee K, Lee Y, et al: Expression profiling and subtype-specific expression of stomach cancer. Cancer Res. 63:8248–8255. 2003.PubMed/NCBI

15 

Yoon C, Cho SJ, Aksoy BA, Park DJ, Schultz N, Ryeom S and Yoon SS: Chemotherapy resistance in diffuse type gastric adenocarcinoma is mediated by RhoA activation in cancer stem-like cells. Clin Cancer Res. 22:971–983. 2016. View Article : Google Scholar :

16 

Min L, Zhao Y, Zhu S, Qiu X, Cheng R, Xing J, Shao L, Guo S and Zhang S: Integrated analysis identifies molecular signatures and specific prognostic factors for different gastric cancer subtypes. Transl Oncol. 10:99–107. 2017. View Article : Google Scholar :

17 

Ritchie MD, Holzinger ER, Li R, Pendergrass SA and Kim D: Methods of integrating data to uncover genotype-phenotype interactions. Nat Rev Genet. 16:85–97. 2015. View Article : Google Scholar : PubMed/NCBI

18 

Vaquerizas JM, Kummerfeld SK, Teichmann SA and Luscombe NM: A census of human transcription factors: Function, expression and evolution. Nat Rev Genet. 10:252–263. 2009. View Article : Google Scholar : PubMed/NCBI

19 

Buckingham M and Rigby PW: Gene regulatory networks and transcriptional mechanisms that control myogenesis. Dev Cell. 28:225–238. 2014. View Article : Google Scholar : PubMed/NCBI

20 

Banks CA, Lee ZT, Boanca G, Lakshminarasimhan M, Groppe BD, Wen Z, Hattem GL, Seidel CW, Florens L and Washburn MP: Controlling for gene expression changes in transcription factor protein networks. Mol Cell Proteomics. 13:1510–1522. 2014. View Article : Google Scholar : PubMed/NCBI

21 

Glass K, Huttenhower C, Quackenbush J and Yuan GC: Passing messages between biological networks to refine predicted interactions. PLoS One. 8:pp. e648322013, View Article : Google Scholar : PubMed/NCBI

22 

Lao T, Glass K, Qiu W, Polverino F, Gupta K, Morrow J, Mancini JD, Vuong L, Perrella MA, Hersh CP, et al: Haploinsufficiency of Hedgehog interacting protein causes increased emphysema induced by cigarette smoke through network rewiring. Genome Med. 7:122015. View Article : Google Scholar : PubMed/NCBI

23 

Glass K, Quackenbush J, Spentzos D, Haibe-Kains B and Yuan GC: A network model for angiogenesis in ovarian cancer. BMC Bioinformatics. 16:1152015. View Article : Google Scholar : PubMed/NCBI

24 

Min L, Zhang C, Qu L, Huang J, Jiang L, Liu J, Pinello L, Yuan GC and Shou C: Gene regulatory pattern analysis reveals essential role of core transcriptional factors’ activation in triple- negative breast cancer. Oncotarget. 8:21938–21953. 2017. View Article : Google Scholar : PubMed/NCBI

25 

Cristescu R, Lee J, Nebozhyn M, Kim K-M, Ting JC, Wong SS, Liu J, Yue YG, Wang J, Yu K, et al: Molecular analysis of gastric cancer identifies subtypes associated with distinct clinical outcomes. Nat Med. 21:449–456. 2015. View Article : Google Scholar : PubMed/NCBI

26 

Irizarry RA, Hobbs B, Collin F, Beazer-Barclay YD, Antonellis KJ, Scherf U and Speed TP: Exploration, normalization, and summaries of high density oligonucleotide array probe level data. Biostatistics. 4:249–264. 2003. View Article : Google Scholar : PubMed/NCBI

27 

Workman C, Jensen LJ, Jarmer H, Berka R, Gautier L, et al: A new non-linear normalization method for reducing variability in DNA microarray experiments. Genome Biol: Aug. 30:pp. 2002Epub ahead of print.

28 

Li C and Wong WH: Model-based analysis of oligonucleotide arrays: Expression index computation and outlier detection. Proc Natl Acad Sci USA. 98:31–36. 2001. View Article : Google Scholar : PubMed/NCBI

29 

Wu C, Macleod I and Su AI: BioGPS and MyGene.info: Organizing online, gene-centric information. Nucleic Acids Res. 41:D561–D565. 2013. View Article : Google Scholar :

30 

Mathelier A, Fornes O, Arenillas DJ, Chen CY, Denay G, Lee J, Shi W, Shyr C, Tan G, Worsley-Hunt R, et al: JASPAR 2016: A major expansion and update of the open-access database of transcription factor binding profiles. Nucleic Acids Res. 44:D110–D115. 2016. View Article : Google Scholar :

31 

Zhao Y, Min L, Xu C, Shao L, Guo S, Cheng R, Xing J, Zhu S and Zhang S: Construction of disease-specific transcriptional regulatory networks identifies co-activation of four gene in esophageal squamous cell carcinoma. Oncol Rep. 38:411–417. 2017. View Article : Google Scholar : PubMed/NCBI

32 

Ravasi T, Suzuki H, Cannistraci CV, Katayama S, Bajic VB, Tan K, Akalin A, Schmeier S, Kanamori-Katayama M, Bertin N, et al: An atlas of combinatorial transcriptional regulation in mouse and man. Cell. 140:744–752. 2010. View Article : Google Scholar : PubMed/NCBI

33 

Ernst J, Beg QK, Kay KA, Balázsi G, Oltvai ZN and Bar-Joseph Z: A semi-supervised method for predicting transcription factor- gene interactions in Escherichia coli. PLoS Comput Biol. 4:pp. e10000442008, View Article : Google Scholar

34 

Lemmens K, Dhollander T, De Bie T, Monsieurs P, Engelen K, Smets B, Winderickx J, De Moor B and Marchal K: Inferring transcriptional modules from ChIP-chip, motif and microarray data. Genome Biol. 7:R372006. View Article : Google Scholar : PubMed/NCBI

35 

Faith JJ, Hayete B, Thaden JT, Mogno I, Wierzbowski J, Cottarel G, Kasif S, Collins JJ and Gardner TS: Large-scale mapping and validation of Escherichia coli transcriptional regulation from a compendium of expression profiles. PLoS Biol. 5:e82007. View Article : Google Scholar : PubMed/NCBI

36 

Altay G and Emmert-Streib F: Structural influence of gene networks on their inference: Analysis of C3NET. Biol Direct. 6:312011. View Article : Google Scholar : PubMed/NCBI

37 

Benatti P, Chiaramonte ML, Lorenzo M, Hartley JA, Hochhauser D, Gnesutta N, Mantovani R, Imbriano C and Dolfini D: NF-Y activates genes of metabolic pathways altered in cancer cells. Oncotarget. 7:1633–1650. 2016. View Article : Google Scholar :

38 

Murakami S, Ninomiya W, Sakamoto E, Shibata T, Akiyama H and Tashiro F: SRY and OCT4 are required for the acquisition of cancer stem cell-like properties and are potential differentiation therapy targets. Stem Cells. 33:2652–2663. 2015. View Article : Google Scholar : PubMed/NCBI

39 

Asuthkar S, Gogineni VR, Rao JS and Velpula KK: Nuclear translocation of Hand-1 acts as a molecular switch to regulate vascular radiosensitivity in medulloblastoma tumors: The protein uPAR is a cytoplasmic sequestration factor for Hand-1. Mol Cancer Ther. 13:1309–1322. 2014. View Article : Google Scholar : PubMed/NCBI

40 

Wang G, Cheng Z, Liu F, Zhang H, Li J and Li F: CREB is a key negative regulator of carbonic anhydrase IX (CA9) in gastric cancer. Cell Signal. 27:1369–1379. 2015. View Article : Google Scholar

41 

Dadi S, Le Noir S, Payet-Bornet D, Lhermitte L, Zacarias- Cabeza J, Bergeron J, Villarèse P, Vachez E, Dik WA, Millien C, et al: TLX homeodomain oncogenes mediate T cell maturation arrest in T-ALL via interaction with ETS1 and suppression of TCRα gene expression. Cancer Cell. 21:563–576. 2012. View Article : Google Scholar : PubMed/NCBI

42 

Zheng L, Pu J, Jiang G, Weng M, He J, Mei H, Hou X and Tong Q: Abnormal expression of early growth response 1 in gastric cancer: Association with tumor invasion, metastasis and heparanase transcription. Pathol Int. 60:268–277. 2010. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Cao B, Zhao Y, Zhang Z, Li H, Xing J, Guo S, Qiu X, Zhang S, Min L, Zhu S, Zhu S, et al: Gene regulatory network construction identified NFYA as a diffuse subtype-specific prognostic factor in gastric cancer. Int J Oncol 53: 1857-1868, 2018.
APA
Cao, B., Zhao, Y., Zhang, Z., Li, H., Xing, J., Guo, S. ... Zhu, S. (2018). Gene regulatory network construction identified NFYA as a diffuse subtype-specific prognostic factor in gastric cancer. International Journal of Oncology, 53, 1857-1868. https://doi.org/10.3892/ijo.2018.4519
MLA
Cao, B., Zhao, Y., Zhang, Z., Li, H., Xing, J., Guo, S., Qiu, X., Zhang, S., Min, L., Zhu, S."Gene regulatory network construction identified NFYA as a diffuse subtype-specific prognostic factor in gastric cancer". International Journal of Oncology 53.5 (2018): 1857-1868.
Chicago
Cao, B., Zhao, Y., Zhang, Z., Li, H., Xing, J., Guo, S., Qiu, X., Zhang, S., Min, L., Zhu, S."Gene regulatory network construction identified NFYA as a diffuse subtype-specific prognostic factor in gastric cancer". International Journal of Oncology 53, no. 5 (2018): 1857-1868. https://doi.org/10.3892/ijo.2018.4519
Copy and paste a formatted citation
x
Spandidos Publications style
Cao B, Zhao Y, Zhang Z, Li H, Xing J, Guo S, Qiu X, Zhang S, Min L, Zhu S, Zhu S, et al: Gene regulatory network construction identified NFYA as a diffuse subtype-specific prognostic factor in gastric cancer. Int J Oncol 53: 1857-1868, 2018.
APA
Cao, B., Zhao, Y., Zhang, Z., Li, H., Xing, J., Guo, S. ... Zhu, S. (2018). Gene regulatory network construction identified NFYA as a diffuse subtype-specific prognostic factor in gastric cancer. International Journal of Oncology, 53, 1857-1868. https://doi.org/10.3892/ijo.2018.4519
MLA
Cao, B., Zhao, Y., Zhang, Z., Li, H., Xing, J., Guo, S., Qiu, X., Zhang, S., Min, L., Zhu, S."Gene regulatory network construction identified NFYA as a diffuse subtype-specific prognostic factor in gastric cancer". International Journal of Oncology 53.5 (2018): 1857-1868.
Chicago
Cao, B., Zhao, Y., Zhang, Z., Li, H., Xing, J., Guo, S., Qiu, X., Zhang, S., Min, L., Zhu, S."Gene regulatory network construction identified NFYA as a diffuse subtype-specific prognostic factor in gastric cancer". International Journal of Oncology 53, no. 5 (2018): 1857-1868. https://doi.org/10.3892/ijo.2018.4519
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