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Article Open Access

Overexpression of SENP1 reduces the stemness capacity of osteosarcoma stem cells and increases their sensitivity to HSVtk/GCV

Corrigendum in: /10.3892/ijo.2019.4752
  • Authors:
    • Fengting Liu
    • Lili Li
    • Yanxia Li
    • Xiaofang Ma
    • Xiyun Bian
    • Xiaozhi Liu
    • Guowen Wang
    • Dianying Zhang
  • View Affiliations / Copyright

    Affiliations: Department of Bone and Soft Tissue Tumors, Tianjin Medical University Cancer Institute and Hospital, Tianjin 300060, P.R. China, Central Laboratory, The Fifth Central Hospital of Tianjin, Tianjin 300450, P.R. China, Department of Trauma and Orthopedics, Peking University People’s Hospital, Beijing 100044, P.R. China
    Copyright: © Liu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2010-2020
    |
    Published online on: August 23, 2018
       https://doi.org/10.3892/ijo.2018.4537
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Abstract

Osteosarcoma stem cells are able to escape treatment with conventional chemotherapeutic drugs, as the majority of them are in a quiescent state. Recent reports have suggested that small ubiquitin‑like modifiers (SUMOs) serve important roles in the maintenance of cancer stem cell stemness. Therefore, a potential strategy to increase the effectiveness of chemotherapeutic agents is to interfere with SUMO modification of proteins associated with the maintenance of stemness in osteosarcoma stem cells. The present study revealed a significant decrease in the expression of SUMO1 specific peptidase 1 (SENP1) in osteosarcoma tissues and osteosarcoma cell lines, and SENP1 expression was much lower in osteosarcoma stem cells than in non‑cancer stem cells. Further experiments indicated that the low levels of SENP1 were essential for maintenance of stemness in osteosarcoma stem cells. Overexpression of SENP1 resulted in a marked decrease in the maintenance of stemness, but only slightly induced apoptosis of osteosarcoma cells, which is crucial to reduce the side effects of drugs on normal precursor cells. Finally, SENP1 overexpression led to a significant increase in the sensitivity of osteosarcoma stem cells to the herpes simplex virus 1 thymidine kinase gene in combination with ganciclovir in vitro and in vivo. In conclusion, the present study described a novel method to increase the sensitivity of osteosarcoma stem cells to chemotherapeutic drugs. Notably, this approach may significantly reduce the required dose of conventional chemotherapeutic drugs and reduce side effects.
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Copy and paste a formatted citation
Spandidos Publications style
Liu F, Li L, Li Y, Ma X, Bian X, Liu X, Wang G and Zhang D: Overexpression of SENP1 reduces the stemness capacity of osteosarcoma stem cells and increases their sensitivity to HSVtk/GCV Corrigendum in /10.3892/ijo.2019.4752. Int J Oncol 53: 2010-2020, 2018.
APA
Liu, F., Li, L., Li, Y., Ma, X., Bian, X., Liu, X. ... Zhang, D. (2018). Overexpression of SENP1 reduces the stemness capacity of osteosarcoma stem cells and increases their sensitivity to HSVtk/GCV Corrigendum in /10.3892/ijo.2019.4752. International Journal of Oncology, 53, 2010-2020. https://doi.org/10.3892/ijo.2018.4537
MLA
Liu, F., Li, L., Li, Y., Ma, X., Bian, X., Liu, X., Wang, G., Zhang, D."Overexpression of SENP1 reduces the stemness capacity of osteosarcoma stem cells and increases their sensitivity to HSVtk/GCV Corrigendum in /10.3892/ijo.2019.4752". International Journal of Oncology 53.5 (2018): 2010-2020.
Chicago
Liu, F., Li, L., Li, Y., Ma, X., Bian, X., Liu, X., Wang, G., Zhang, D."Overexpression of SENP1 reduces the stemness capacity of osteosarcoma stem cells and increases their sensitivity to HSVtk/GCV Corrigendum in /10.3892/ijo.2019.4752". International Journal of Oncology 53, no. 5 (2018): 2010-2020. https://doi.org/10.3892/ijo.2018.4537
Copy and paste a formatted citation
x
Spandidos Publications style
Liu F, Li L, Li Y, Ma X, Bian X, Liu X, Wang G and Zhang D: Overexpression of SENP1 reduces the stemness capacity of osteosarcoma stem cells and increases their sensitivity to HSVtk/GCV Corrigendum in /10.3892/ijo.2019.4752. Int J Oncol 53: 2010-2020, 2018.
APA
Liu, F., Li, L., Li, Y., Ma, X., Bian, X., Liu, X. ... Zhang, D. (2018). Overexpression of SENP1 reduces the stemness capacity of osteosarcoma stem cells and increases their sensitivity to HSVtk/GCV Corrigendum in /10.3892/ijo.2019.4752. International Journal of Oncology, 53, 2010-2020. https://doi.org/10.3892/ijo.2018.4537
MLA
Liu, F., Li, L., Li, Y., Ma, X., Bian, X., Liu, X., Wang, G., Zhang, D."Overexpression of SENP1 reduces the stemness capacity of osteosarcoma stem cells and increases their sensitivity to HSVtk/GCV Corrigendum in /10.3892/ijo.2019.4752". International Journal of Oncology 53.5 (2018): 2010-2020.
Chicago
Liu, F., Li, L., Li, Y., Ma, X., Bian, X., Liu, X., Wang, G., Zhang, D."Overexpression of SENP1 reduces the stemness capacity of osteosarcoma stem cells and increases their sensitivity to HSVtk/GCV Corrigendum in /10.3892/ijo.2019.4752". International Journal of Oncology 53, no. 5 (2018): 2010-2020. https://doi.org/10.3892/ijo.2018.4537
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