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KIF14 promotes cell proliferation via activation of Akt and is directly targeted by miR-200c in colorectal cancer

  • Authors:
    • Zao-Zao Wang
    • Jie Yang
    • Bei-Hai Jiang
    • Jia-Bo Di
    • Pin Gao
    • Lin Peng
    • Xiang-Qian Su
  • View Affiliations / Copyright

    Affiliations: Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Gastrointestinal Surgery IV, Peking University Cancer Hospital and Institute, Beijing 100142, P.R. China
    Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1939-1952
    |
    Published online on: August 29, 2018
       https://doi.org/10.3892/ijo.2018.4546
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Abstract

As a mitotic kinesin, kinesin family member 14 (KIF14) has been reported to serve oncogenic roles in a variety of malignancies; however, its functional role and regulatory mechanisms in colorectal cancer (CRC) remain unclear. In the present study, KIF14 was observed to be markedly overexpressed in CRC, and this upregulation was associated with tumor size and marker of proliferation Ki-67 immunostaining scores. Gain- and loss-of-function experiments were applied to identify the function of KIF14 in CRC progression. In vitro and in vivo assays revealed that KIF14 promoted CRC cell proliferation and accelerated the cell cycle via activation of protein kinase B. In addition, the present study investigated the potential mechanisms underlying KIF14 overexpression in CRC. Bioinformatics analyses and validation experiments, including reverse transcription-quantitative polymerase chain reaction, western blotting and a Dual-Luciferase reporter assay, demonstrated that, in addition to genomic amplification and transcriptional activation, KIF14 was regulated by microRNA (miR)-200c at the post-transcriptional level. Rescue experiments further demonstrated that decreased miR-200c expression could facilitate KIF14 to exert its pro-proliferative role. The expression of miR-200c was negatively correlated with KIF14 in CRC specimens. Collectively, the findings of the present study demonstrated the oncogenic role of KIF14 in colorectal tumorigenesis, and also revealed a complexity of regulatory mechanisms mediating KIF14 overexpression, which may provide insight for developing novel treatments for patients with CRC.
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1 

Torre LA, Bray F, Siegel RL, Ferlay J, Lortet-Tieulent J and Jemal A: Global cancer statistics, 2012. CA Cancer J Clin. 65:87–108. 2015. View Article : Google Scholar : PubMed/NCBI

2 

Favoriti P, Carbone G, Greco M, Pirozzi F, Pirozzi RE and Corcione F: Worldwide burden of colorectal cancer: A review. Updates Surg. 68:7–11. 2016. View Article : Google Scholar : PubMed/NCBI

3 

Chen W, Zheng R, Zuo T, Zeng H, Zhang S and He J: National cancer incidence and mortality in China, 2012. Chin J Cancer Res. 28:1–11. 2016.PubMed/NCBI

4 

DeSantis CE, Lin CC, Mariotto AB, Siegel RL, Stein KD, Kramer JL, Alteri R, Robbins AS and Jemal A: Cancer treatment and survivorship statistics, 2014. CA Cancer J Clin. 64:252–271. 2014. View Article : Google Scholar : PubMed/NCBI

5 

Anaya DA, Becker NS and Abraham NS: Global graying, colorectal cancer and liver metastasis: New implications for surgical management. Crit Rev Oncol Hematol. 77:100–108. 2011. View Article : Google Scholar

6 

Stein U and Schlag PM: Clinical, biological, and molecular aspects of metastasis in colorectal cancer. Recent Results Cancer Res. 176:61–80. 2007. View Article : Google Scholar : PubMed/NCBI

7 

Cancer Genome Atlas, N; Cancer Genome and Atlas Network: Comprehensive molecular characterization of human colon and rectal cancer. Nature. 487:330–337. 2012. View Article : Google Scholar

8 

Uchi R, Takahashi Y, Niida A, Shimamura T, Hirata H, Sugimachi K, Sawada G, Iwaya T, Kurashige J, Shinden Y, et al: Integrated multiregional analysis proposing a new model of colorectal cancer evolution. PLoS Genet. 12:pp. e10057782016, View Article : Google Scholar : PubMed/NCBI

9 

Hirokawa N, Noda Y, Tanaka Y and Niwa S: Kinesin superfamily motor proteins and intracellular transport. Nat Rev Mol Cell Biol. 10:682–696. 2009. View Article : Google Scholar : PubMed/NCBI

10 

Miki H, Setou M, Kaneshiro K and Hirokawa N: All kinesin superfamily protein, KIF, genes in mouse and human. Proc Natl Acad Sci USA. 98:7004–7011. 2001. View Article : Google Scholar : PubMed/NCBI

11 

Hirokawa N and Tanaka Y: Kinesin superfamily proteins (KIFs): Various functions and their relevance for important phenomena in life and diseases. Exp Cell Res. 334:16–25. 2015. View Article : Google Scholar : PubMed/NCBI

12 

Lawrence CJ, Dawe RK, Christie KR, Cleveland DW, Dawson SC, Endow SA, Goldstein LS, Goodson HV, Hirokawa N, Howard J, et al: A standardized kinesin nomenclature. J Cell Biol. 167:19–22. 2004. View Article : Google Scholar : PubMed/NCBI

13 

Nakagawa T, Tanaka Y, Matsuoka E, Kondo S, Okada Y, Noda Y, Kanai Y and Hirokawa N: Identification and classification of 16 new kinesin superfamily (KIF) proteins in mouse genome. Proc Natl Acad Sci USA. 94:9654–9659. 1997. View Article : Google Scholar : PubMed/NCBI

14 

Bassi ZI, Audusseau M, Riparbelli MG, Callaini G and D’Avino PP: Citron kinase controls a molecular network required for midbody formation in cytokinesis. Proc Natl Acad Sci USA. 110:9782–9787. 2013. View Article : Google Scholar : PubMed/NCBI

15 

Arora K, Talje L, Asenjo AB, Andersen P, Atchia K, Joshi M, Sosa H, Allingham JS and Kwok BH: KIF14 binds tightly to microtubules and adopts a rigor-like conformation. J Mol Biol. 426:2997–3015. 2014. View Article : Google Scholar : PubMed/NCBI

16 

Gruneberg U, Neef R, Li X, Chan EH, Chalamalasetty RB, Nigg EA and Barr FA: KIF14 and citron kinase act together to promote efficient cytokinesis. J Cell Biol. 172:363–372. 2006. View Article : Google Scholar : PubMed/NCBI

17 

Watanabe S, De Zan T, Ishizaki T and Narumiya S: Citron kinase mediates transition from constriction to abscission through its coiled-coil domain. J Cell Sci. 126:1773–1784. 2013. View Article : Google Scholar : PubMed/NCBI

18 

Molina I, Baars S, Brill JA, Hales KG, Fuller MT and Ripoll P: A chromatin-associated kinesin-related protein required for normal mitotic chromosome segregation in Drosophila. J Cell Biol. 139:1361–1371. 1997. View Article : Google Scholar

19 

Carleton M, Mao M, Biery M, Warrener P, Kim S, Buser C, Marshall CG, Fernandes C, Annis J and Linsley PS: RNA interference-mediated silencing of mitotic kinesin KIF14 disrupts cell cycle progression and induces cytokinesis failure. Mol Cell Biol. 26:3853–3863. 2006. View Article : Google Scholar : PubMed/NCBI

20 

Zhu C, Zhao J, Bibikova M, Leverson JD, Bossy-Wetzel E, Fan JB, Abraham RT and Jiang W: Functional analysis of human microtubule-based motor proteins, the kinesins and dyneins, in mitosis/cytokinesis using RNA interference. Mol Biol Cell. 16:3187–3199. 2005. View Article : Google Scholar : PubMed/NCBI

21 

Moawia A, Shaheen R, Rasool S, Waseem SS, Ewida N, Budde B, Kawalia A, Motameny S, Khan K, Fatima A, et al: Mutations of KIF14 cause primary microcephaly by impairing cytokinesis. Ann Neurol. 82:562–577. 2017. View Article : Google Scholar : PubMed/NCBI

22 

Makrythanasis P, Maroofian R, Stray-Pedersen A, Musaev D, Zaki MS, Mahmoud IG, Selim L, Elbadawy A, Jhangiani SN, Coban Akdemir ZH, et al: Biallelic variants in KIF14 cause intellectual disability with microcephaly. Eur J Hum Genet. 26:330–339. 2018. View Article : Google Scholar : PubMed/NCBI

23 

Huang W, Wang J, Zhang D, Chen W, Hou L, Wu X and Lu Y: Inhibition of KIF14 suppresses tumor cell growth and promotes apoptosis in human glioblastoma. Cell Physiol Biochem. 37:1659–1670. 2015. View Article : Google Scholar : PubMed/NCBI

24 

Corson TW, Zhu CQ, Lau SK, Shepherd FA, Tsao MS and Gallie BL: KIF14 messenger RNA expression is independently prognostic for outcome in lung cancer. Clin Cancer Res. 13:3229–3234. 2007. View Article : Google Scholar : PubMed/NCBI

25 

Xu H, Choe C, Shin SH, Park SW, Kim HS, Jung SH, Yim SH, Kim TM and Chung YJ: Silencing of KIF14 interferes with cell cycle progression and cytokinesis by blocking the p27(Kip1) ubiquitination pathway in hepatocellular carcinoma. Exp Mol Med. 46:pp. e972014, View Article : Google Scholar : PubMed/NCBI

26 

Abiatari I, DeOliveira T, Kerkadze V, Schwager C, Esposito I, Giese NA, Huber P, Bergman F, Abdollahi A, Friess H, et al: Consensus transcriptome signature of perineural invasion in pancreatic carcinoma. Mol Cancer Ther. 8:1494–1504. 2009. View Article : Google Scholar : PubMed/NCBI

27 

Singel SM, Cornelius C, Zaganjor E, Batten K, Sarode VR, Buckley DL, Peng Y, John GB, Li HC, Sadeghi N, et al: KIF14 promotes AKT phosphorylation and contributes to chemoresistance in triple-negative breast cancer. Neoplasia. 16:pp. 247–256. pp. 256.e2422014, https://doi.org/10.1016/j.neo.2014.03.008. 10.1016/j.neo.2014.03.008.

28 

Corson TW and Gallie BL: KIF14 mRNA expression is a predictor of grade and outcome in breast cancer. Int J Cancer. 119:1088–1094. 2006. View Article : Google Scholar : PubMed/NCBI

29 

Singel SM, Cornelius C, Batten K, Fasciani G, Wright WE, Lum L and Shay JW: A targeted RNAi screen of the breast cancer genome identifies KIF14 and TLN1 as genes that modulate docetaxel chemosensitivity in triple-negative breast cancer. Clin Cancer Res. 19:2061–2070. 2013. View Article : Google Scholar : PubMed/NCBI

30 

Thériault BL, Cybulska P, Shaw PA, Gallie BL and Bernardini MQ: The role of KIF14 in patient-derived primary cultures of high-grade serous ovarian cancer cells. J Ovarian Res. 7:1232014. View Article : Google Scholar : PubMed/NCBI

31 

Thériault BL, Pajovic S, Bernardini MQ, Shaw PA and Gallie BL: Kinesin family member 14: An independent prognostic marker and potential therapeutic target for ovarian cancer. Int J Cancer. 130:1844–1854. 2012. View Article : Google Scholar

32 

Corson TW, Huang A, Tsao MS and Gallie BL: KIF14 is a candidate oncogene in the 1q minimal region of genomic gain in multiple cancers. Oncogene. 24:4741–4753. 2005. View Article : Google Scholar : PubMed/NCBI

33 

Kumar S, Nag A and Mandal CC: A Comprehensive Review on miR-200c, a promising cancer biomarker with therapeutic potential. Curr Drug Targets. 16:1381–1403. 2015. View Article : Google Scholar : PubMed/NCBI

34 

Mutlu M, Raza U, Saatci Ö, Eyüpoğlu E, Yurdusev E and Şahin Ö: miR-200c: A versatile watchdog in cancer progression, EMT, and drug resistance. J Mol Med (Berl). 94:629–644. 2016. View Article : Google Scholar

35 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods. 25:402–408. 2001. View Article : Google Scholar

36 

Shin G, Kang TW, Yang S, Baek SJ, Jeong YS and Kim SY: GENT: Gene expression database of normal and tumor tissues. Cancer Inform. 10:149–157. 2011. View Article : Google Scholar : PubMed/NCBI

37 

Rhodes DR, Yu J, Shanker K, Deshpande N, Varambally R, Ghosh D, Barrette T, Pandey A and Chinnaiyan AM: ONCOMINE: A cancer microarray database and integrated data-mining platform. Neoplasia. 6:1–6. 2004. View Article : Google Scholar : PubMed/NCBI

38 

Subramanian A, Tamayo P, Mootha VK, Mukherjee S, Ebert BL, Gillette MA, Paulovich A, Pomeroy SL, Golub TR, Lander ES, et al: Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles. Proc Natl Acad Sci USA. 102:15545–15550. 2005. View Article : Google Scholar : PubMed/NCBI

39 

Mootha VK, Lindgren CM, Eriksson KF, Subramanian A, Sihag S, Lehar J, Puigserver P, Carlsson E, Ridderstråle M, Laurila E, et al: PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes. Nat Genet. 34:267–273. 2003. View Article : Google Scholar : PubMed/NCBI

40 

Cerami E, Gao J, Dogrusoz U, Gross BE, Sumer SO, Aksoy BA, Jacobsen A, Byrne CJ, Heuer ML, Larsson E, et al: The cBio cancer genomics portal: An open platform for exploring multi- dimensional cancer genomics data. Cancer Discov. 2:401–404. 2012. View Article : Google Scholar : PubMed/NCBI

41 

Mermel CH, Schumacher SE, Hill B, Meyerson ML, Beroukhim R and Getz G: GISTIC2.0 facilitates sensitive and confident localization of the targets of focal somatic copy-number alteration in human cancers. Genome Biol. 12:R412011. View Article : Google Scholar : PubMed/NCBI

42 

Betel D, Wilson M, Gabow A, Marks DS and Sander C: The http://microRNA.orgurisimplemicroRNA.org resource: Targets and expression. Nucleic Acids Res. 36:Database. pp. D149–D153. 2008, View Article : Google Scholar

43 

Lewis BP, Burge CB and Bartel DP: Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets. Cell. 120:15–20. 2005. View Article : Google Scholar : PubMed/NCBI

44 

Li LT, Jiang G, Chen Q and Zheng JN: Ki67 is a promising molecular target in the diagnosis of cancer (Review). Mol Med Rep. 11:1566–1572. 2015. View Article : Google Scholar

45 

Liu P, Begley M, Michowski W, Inuzuka H, Ginzberg M, Gao D, Tsou P, Gan W, Papa A, Kim BM, et al: Cell-cycle-regulated activation of Akt kinase by phosphorylation at its carboxyl terminus. Nature. 508:541–545. 2014. View Article : Google Scholar : PubMed/NCBI

46 

Liang J and Slingerland JM: Multiple roles of the PI3K/PKB (Akt) pathway in cell cycle progression. Cell Cycle. 2:339–345. 2003. View Article : Google Scholar : PubMed/NCBI

47 

Thériault BL, Basavarajappa HD, Lim H, Pajovic S, Gallie BL and Corson TW: Transcriptional and epigenetic regulation of KIF14 overexpression in ovarian cancer. PLoS One. 9:pp. e915402014, View Article : Google Scholar : PubMed/NCBI

48 

O’Brien SJ, Carter JV, Burton JF, Oxford BG, Schmidt MN, Hallion JC and Galandiuk S: The role of the miR-200 family in epithelial-mesenchymal transition in colorectal cancer: A systematic review. Int J Cancer. 142:2501–2511. 2018. View Article : Google Scholar

49 

Tian Y, Pan Q, Shang Y, Zhu R, Ye J, Liu Y, Zhong X, Li S, He Y, Chen L, et al: MicroRNA-200 (miR-200) cluster regulation by achaete scute-like 2 (Ascl2): Impact on the epithelial- mesenchymal transition in colon cancer cells. J Biol Chem. 289:36101–36115. 2014. View Article : Google Scholar : PubMed/NCBI

50 

Lu YX, Yuan L, Xue XL, Zhou M, Liu Y, Zhang C, Li JP, Zheng L, Hong M and Li XN: Regulation of colorectal carcinoma stemness, growth, and metastasis by an miR-200c-Sox2-negative feedback loop mechanism. Clin Cancer Res. 20:2631–2642. 2014. View Article : Google Scholar : PubMed/NCBI

51 

Toiyama Y, Hur K, Tanaka K, Inoue Y, Kusunoki M, Boland CR and Goel A: Serum miR-200c is a novel prognostic and metastasis-predictive biomarker in patients with colorectal cancer. Ann Surg. 259:735–743. 2014. View Article : Google Scholar :

52 

Wang M, Zhang P, Li Y, Liu G, Zhou B, Zhan L, Zhou Z and Sun X: The quantitative analysis by stem-loop real-time PCR revealed the microRNA-34a, microRNA-155 and microRNA- 200c overexpression in human colorectal cancer. Med Oncol. 29:3113–3118. 2012. View Article : Google Scholar : PubMed/NCBI

53 

Hur K, Toiyama Y, Takahashi M, Balaguer F, Nagasaka T, Koike J, Hemmi H, Koi M, Boland CR and Goel A: MicroRNA-200c modulates epithelial-to-mesenchymal transition (EMT) in human colorectal cancer metastasis. Gut. 62:1315–1326. 2013. View Article : Google Scholar :

54 

Pan Q, Meng L, Ye J, Wei X, Shang Y, Tian Y, He Y, Peng Z, Chen L, Chen W, et al: Transcriptional repression of miR-200 family members by Nanog in colon cancer cells induces epithelial-mesenchymal transition (EMT). Cancer Lett. 392:26–38. 2017. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Wang Z, Yang J, Jiang B, Di J, Gao P, Peng L and Su X: KIF14 promotes cell proliferation via activation of Akt and is directly targeted by miR-200c in colorectal cancer. Int J Oncol 53: 1939-1952, 2018.
APA
Wang, Z., Yang, J., Jiang, B., Di, J., Gao, P., Peng, L., & Su, X. (2018). KIF14 promotes cell proliferation via activation of Akt and is directly targeted by miR-200c in colorectal cancer. International Journal of Oncology, 53, 1939-1952. https://doi.org/10.3892/ijo.2018.4546
MLA
Wang, Z., Yang, J., Jiang, B., Di, J., Gao, P., Peng, L., Su, X."KIF14 promotes cell proliferation via activation of Akt and is directly targeted by miR-200c in colorectal cancer". International Journal of Oncology 53.5 (2018): 1939-1952.
Chicago
Wang, Z., Yang, J., Jiang, B., Di, J., Gao, P., Peng, L., Su, X."KIF14 promotes cell proliferation via activation of Akt and is directly targeted by miR-200c in colorectal cancer". International Journal of Oncology 53, no. 5 (2018): 1939-1952. https://doi.org/10.3892/ijo.2018.4546
Copy and paste a formatted citation
x
Spandidos Publications style
Wang Z, Yang J, Jiang B, Di J, Gao P, Peng L and Su X: KIF14 promotes cell proliferation via activation of Akt and is directly targeted by miR-200c in colorectal cancer. Int J Oncol 53: 1939-1952, 2018.
APA
Wang, Z., Yang, J., Jiang, B., Di, J., Gao, P., Peng, L., & Su, X. (2018). KIF14 promotes cell proliferation via activation of Akt and is directly targeted by miR-200c in colorectal cancer. International Journal of Oncology, 53, 1939-1952. https://doi.org/10.3892/ijo.2018.4546
MLA
Wang, Z., Yang, J., Jiang, B., Di, J., Gao, P., Peng, L., Su, X."KIF14 promotes cell proliferation via activation of Akt and is directly targeted by miR-200c in colorectal cancer". International Journal of Oncology 53.5 (2018): 1939-1952.
Chicago
Wang, Z., Yang, J., Jiang, B., Di, J., Gao, P., Peng, L., Su, X."KIF14 promotes cell proliferation via activation of Akt and is directly targeted by miR-200c in colorectal cancer". International Journal of Oncology 53, no. 5 (2018): 1939-1952. https://doi.org/10.3892/ijo.2018.4546
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