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Article Open Access

Downregulation of CD147 induces malignant melanoma cell apoptosis via the regulation of IGFBP2 expression

Corrigendum in: /10.3892/ijo.2023.5591
  • Authors:
    • Shuang Zhao
    • Lisha Wu
    • Yehong Kuang
    • Juan Su
    • Zhongling Luo
    • Yan Wang
    • Jinmao Li
    • Jianglin Zhang
    • Wangqing Chen
    • Fangfang Li
    • Yijing He
    • Juan Tao
    • Jianda Zhou
    • Xiaowei Xu
    • Cong Peng
    • Xiang Chen
  • View Affiliations / Copyright

    Affiliations: Department of Dermatology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, P.R. China, Institute of Medical Sciences, Xiangya Hospital, Central South University, Changsha, Hunan 410008, P.R. China, Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing, Jiangsu 210042, Department of Dermatology, Affiliated Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, P.R. China, Department of Plastic Surgery of The Third Xiangya Hospital, Central South University, Changsha, Hunan 410013, P.R. China, Department of Dermatology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Copyright: © Zhao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2397-2408
    |
    Published online on: October 1, 2018
       https://doi.org/10.3892/ijo.2018.4579
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Abstract

Cluster of differentiation (CD)147, as a transmembrane glycoprotein, is highly expressed in a variety of tumors. Accumulating evidence has demonstrated that CD147 serves critical roles in tumor cell death and survival; however, the underlying mechanism requires further investigation. In the present study, it was revealed that CD147 knockdown significantly increased melanoma cell apoptosis. In addition, downregulation of CD147 reversed the malignant phenotype of melanoma, as demonstrated by the induction of tumor cell apoptosis in a xenograft mouse model. In addition, a human apoptosis antibody array was performed and 9 differentially expressed apoptosis-related proteins associated with CD147 were identified, including insulin-like growth factor-binding protein 2 (IGFBP2). Additionally, CD147 knockdown was observed to significantly decreased IGFBP2 expression at the mRNA and protein levels in melanoma cells. Providing that IGFBP2 is a downstream molecule in the phosphatase and tensin homolog (PTEN)/phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT) signaling pathway, the effects of CD147 on this particular pathway were investigated. Interestingly, the expression of phosphorylated (p)-AKT and p‑mechanistic target of rapamycin was attenuated, whereas PTEN was markedly upregulated in CD147-underexpressing melanoma cells. Furthermore, application of a PI3K‑specific inhibitor also decreased IGFBP2 expression. Importantly, IGFBP2 was highly expressed in clinical tissues of melanoma compared with the control group, and its expression exhibited a positive association with CD147. The present study revealed that CD147 served a critical role in mediating the apoptosis of melanoma cells via IGFBP2 and the PTEN/PI3K/AKT signaling pathway. IGFBP2 and CD147 were observed to be overexpressed in clinical melanoma tissues; IGFBP2 was shown to be positively associated with CD147 expression, suggesting that CD147 may be considered as a potential therapeutic target for chemotherapy or prevention for in melanoma.
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Copy and paste a formatted citation
Spandidos Publications style
Zhao S, Wu L, Kuang Y, Su J, Luo Z, Wang Y, Li J, Zhang J, Chen W, Li F, Li F, et al: Downregulation of CD147 induces malignant melanoma cell apoptosis via the regulation of IGFBP2 expression Corrigendum in /10.3892/ijo.2023.5591. Int J Oncol 53: 2397-2408, 2018.
APA
Zhao, S., Wu, L., Kuang, Y., Su, J., Luo, Z., Wang, Y. ... Chen, X. (2018). Downregulation of CD147 induces malignant melanoma cell apoptosis via the regulation of IGFBP2 expression Corrigendum in /10.3892/ijo.2023.5591. International Journal of Oncology, 53, 2397-2408. https://doi.org/10.3892/ijo.2018.4579
MLA
Zhao, S., Wu, L., Kuang, Y., Su, J., Luo, Z., Wang, Y., Li, J., Zhang, J., Chen, W., Li, F., He, Y., Tao, J., Zhou, J., Xu, X., Peng, C., Chen, X."Downregulation of CD147 induces malignant melanoma cell apoptosis via the regulation of IGFBP2 expression Corrigendum in /10.3892/ijo.2023.5591". International Journal of Oncology 53.6 (2018): 2397-2408.
Chicago
Zhao, S., Wu, L., Kuang, Y., Su, J., Luo, Z., Wang, Y., Li, J., Zhang, J., Chen, W., Li, F., He, Y., Tao, J., Zhou, J., Xu, X., Peng, C., Chen, X."Downregulation of CD147 induces malignant melanoma cell apoptosis via the regulation of IGFBP2 expression Corrigendum in /10.3892/ijo.2023.5591". International Journal of Oncology 53, no. 6 (2018): 2397-2408. https://doi.org/10.3892/ijo.2018.4579
Copy and paste a formatted citation
x
Spandidos Publications style
Zhao S, Wu L, Kuang Y, Su J, Luo Z, Wang Y, Li J, Zhang J, Chen W, Li F, Li F, et al: Downregulation of CD147 induces malignant melanoma cell apoptosis via the regulation of IGFBP2 expression Corrigendum in /10.3892/ijo.2023.5591. Int J Oncol 53: 2397-2408, 2018.
APA
Zhao, S., Wu, L., Kuang, Y., Su, J., Luo, Z., Wang, Y. ... Chen, X. (2018). Downregulation of CD147 induces malignant melanoma cell apoptosis via the regulation of IGFBP2 expression Corrigendum in /10.3892/ijo.2023.5591. International Journal of Oncology, 53, 2397-2408. https://doi.org/10.3892/ijo.2018.4579
MLA
Zhao, S., Wu, L., Kuang, Y., Su, J., Luo, Z., Wang, Y., Li, J., Zhang, J., Chen, W., Li, F., He, Y., Tao, J., Zhou, J., Xu, X., Peng, C., Chen, X."Downregulation of CD147 induces malignant melanoma cell apoptosis via the regulation of IGFBP2 expression Corrigendum in /10.3892/ijo.2023.5591". International Journal of Oncology 53.6 (2018): 2397-2408.
Chicago
Zhao, S., Wu, L., Kuang, Y., Su, J., Luo, Z., Wang, Y., Li, J., Zhang, J., Chen, W., Li, F., He, Y., Tao, J., Zhou, J., Xu, X., Peng, C., Chen, X."Downregulation of CD147 induces malignant melanoma cell apoptosis via the regulation of IGFBP2 expression Corrigendum in /10.3892/ijo.2023.5591". International Journal of Oncology 53, no. 6 (2018): 2397-2408. https://doi.org/10.3892/ijo.2018.4579
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