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Expression and epigenetic regulatory mechanism of BNIP3 in clear cell renal cell carcinoma

  • Authors:
    • Yanxiang Shao
    • Zhenhua Liu
    • Jianbang Liu
    • Haizhou Wang
    • Long Huang
    • Tianhai Lin
    • Jiyan Liu
    • Qiang Wei
    • Hao Zeng
    • Gu He
    • Xiang Li
  • View Affiliations / Copyright

    Affiliations: Department of Urology, Institute of Urology, West China Hospital, West China Medical School, Sichuan University, Chengdu, Sichuan 610041, P.R. China, Department of Oncology, West China Hospital, West China Medical School, Sichuan University, Chengdu, Sichuan 610041, P.R. China, State Key Laboratory of Biotherapy, West China Hospital, West China Medical School, Sichuan University, Chengdu, Sichuan 610041, P.R. China
    Copyright: © Shao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 348-360
    |
    Published online on: October 24, 2018
       https://doi.org/10.3892/ijo.2018.4603
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Abstract

The majority of clear cell renal cell carcinomas (ccRCCs) are caused by an accumulation of hypoxia‑inducible factor (HIF) and the overexpression of downstream genes in response to the von Hippel‑Lindau (VHL) gene becoming inactivated. In the present study, our hypothesis was that BNIP3, a gene positioned downstream of HIF, would be expressed at a higher level in ccRCC; however, instead, lower levels of BNIP3 expression were identified in RCC tumor tissues compared with adjacent non‑tumor tissues. These changes were associated with lower levels of VHL, and higher levels of HIF and vascular endothelial growth factor. BNIP3 was also undetectable in three investigated RCC cell lines (786‑O, ACHN, A498) and GRC‑1‑1 cells. Methylation of the BNIP3 promoter was not detected, and neither did treatment with a methylation inhibitor cause cell proliferation. However, treatment with a histone deacetylation inhibitor, trichostatin A (TSA), inhibited cultured RCC cell proliferation, promoted apoptosis and restored BNIP3 expression. Furthermore, histone deacetylation of the BNIP3 promoter was identified in ACHN and 786‑O cells, and the acetylation status was restored following TSA treatment. Taken together, the results of the present study suggest that histone deacetylation, but not methylation, is most likely to cause BNIP3 inactivation in RCC. The data also indicated that restoration of BNIP3 expression by a histone deacetylation inhibitor led to growth inhibition and apoptotic promotion in RCC.
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1 

Subramanian VS, Stephenson AJ, Goldfarb DA, Fergany AF, Novick AC and Krishnamurthi V: Utility of preoperative renal artery embolization for management of renal tumors with inferior vena caval thrombi. Urology. 74:154–159. 2009. View Article : Google Scholar : PubMed/NCBI

2 

Clark PE: The role of VHL in clear-cell renal cell carcinoma and its relation to targeted therapy. Kidney Int. 76:939–945. 2009. View Article : Google Scholar : PubMed/NCBI

3 

Motzer RJ, Hutson TE, Tomczak P, Michaelson MD, Bukowski RM, Rixe O, Oudard S, Negrier S, Szczylik C, Kim ST, et al: Sunitinib versus interferon alfa in metastatic renal-cell carcinoma. N Engl J Med. 356:115–124. 2007. View Article : Google Scholar : PubMed/NCBI

4 

Bultitude MF: Campbell-Walsh Urology. 10th edition. BJU International; New York, NY: 2012

5 

Guo K, Searfoss G, Krolikowski D, Pagnoni M, Franks C, Clark K, Yu KT, Jaye M and Ivashchenko Y: Hypoxia induces the expression of the pro-apoptotic gene BNIP3. Cell Death Differ. 8:367–376. 2001. View Article : Google Scholar : PubMed/NCBI

6 

Gunaratnam L, Morley M, Franovic A, de Paulsen N, Mekhail K, Parolin DA, Nakamura E, Lorimer IA and Lee S: Hypoxia inducible factor activates the transforming growth factor-alpha/epidermal growth factor receptor growth stimulatory pathway in VHL(−/−) renal cell carcinoma cells. J Biol Chem. 278:44966–44974. 2003. View Article : Google Scholar : PubMed/NCBI

7 

Yasuda M, Theodorakis P, Subramanian T and Chinnadurai G: Adenovirus E1B-19K/BCL-2 interacting protein BNIP3 contains a BH3 domain and a mitochondrial targeting sequence. J Biol Chem. 273:12415–12421. 1998. View Article : Google Scholar : PubMed/NCBI

8 

Kothari S, Cizeau J, McMillan-Ward E, Israels SJ, Bailes M, Ens K, Kirshenbaum LA and Gibson SB: BNIP3 plays a role in hypoxic cell death in human epithelial cells that is inhibited by growth factors EGF and IGF. Oncogene. 22:4734–4744. 2003. View Article : Google Scholar : PubMed/NCBI

9 

Höckel M and Vaupel P: Tumor hypoxia: Definitions and current clinical, biologic, and molecular aspects. J Natl Cancer Inst. 93:266–276. 2001. View Article : Google Scholar : PubMed/NCBI

10 

Vaupel P, Kelleher DK and Höckel M: Oxygen status of malignant tumors: Pathogenesis of hypoxia and significance for tumor therapy. Semin Oncol. 28(Suppl 8): 29–35. 2001. View Article : Google Scholar : PubMed/NCBI

11 

Matak D, Brodaczewska KK, Lipiec M, Szymanski Ł, Szczylik C and Czarnecka AM: Colony, hanging drop, and methylcellulose three dimensional hypoxic growth optimization of renal cell carcinoma cell lines. Cytotechnology. 69:565–578. 2017. View Article : Google Scholar : PubMed/NCBI

12 

Parks SK, Cormerais Y and Pouysségur J: Hypoxia and cellular metabolism in tumour pathophysiology. J Physiol. 595:2439–2450. 2017. View Article : Google Scholar : PubMed/NCBI

13 

Luo L, Xiong ZB, Zeng H, Chen N, Chen XQ, Zhang P and Li X: Expression of BNIP3 and its correlations to HIF-1alpha and VEGF in clear cell renal cell carcinoma. Sichuan Da Xue Xue Bao Yi Xue Ban. 43:79–82. 2012.In Chinese. PubMed/NCBI

14 

Ding Y, Yu L, Li M, Liu L and Zhong H: Establishment and biological characteristics of human renal granular cell carcinoma cell line (GRC-1). Chin J Urol. 16:3–6. 1995.In Chinese.

15 

Jiang Z, Liu X, Chang K, Liu X and Xiong J: Allyl isothiocyanate inhibits the proliferation of renal carcinoma cell line GRC-1 by inducing an imbalance between Bcl2 and Bax. Med Sci Monit. 22:4283–4288. 2016. View Article : Google Scholar : PubMed/NCBI

16 

Sun X, Lou L, Zhong K and Wan L: MicroRNA-451 regulates chemoresistance in renal cell carcinoma by targeting ATF-2 gene. Exp Biol Med (Maywood). Jan 1–2017.Epub ahead of print. View Article : Google Scholar

17 

Okami J, Simeone DM and Logsdon CD: Silencing of the hypoxia-inducible cell death protein BNIP3 in pancreatic cancer. Cancer Res. 64:5338–5346. 2004. View Article : Google Scholar : PubMed/NCBI

18 

Bacon AL, Fox S, Turley H and Harris AL: Selective silencing of the hypoxia-inducible factor 1 target gene BNIP3 by histone deacetylation and methylation in colorectal cancer. Oncogene. 26:132–141. 2007. View Article : Google Scholar

19 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(−Delta Delta C(T)) Method. Methods. 25:402–408. 2001. View Article : Google Scholar

20 

Murai M, Toyota M, Suzuki H, Satoh A, Sasaki Y, Akino K, Ueno M, Takahashi F, Kusano M, Mita H, et al: Aberrant methylation and silencing of the BNIP3 gene in colorectal and gastric cancer. Clin Cancer Res. 11:1021–1027. 2005.PubMed/NCBI

21 

Chinnadurai G, Vijayalingam S and Gibson SB: BNIP3 subfamily BH3-only proteins: Mitochondrial stress sensors in normal and pathological functions. Oncogene. 27(Suppl 1): S114–S127. 2008. View Article : Google Scholar

22 

Ryter SW, Mizumura K and Choi AM: The impact of autophagy on cell death modalities. Int J Cell Biol. 2014.502676:2014.

23 

Jing K and Lim K: Why is autophagy important in human diseases? Exp Mol Med. 44:69–72. 2012. View Article : Google Scholar : PubMed/NCBI

24 

Gump JM and Thorburn A: Autophagy and apoptosis: What is the connection? Trends Cell Biol. 21:387–392. 2011. View Article : Google Scholar : PubMed/NCBI

25 

Su M, Mei Y and Sinha S: Role of the Crosstalk between Autophagy and Apoptosis in Cancer. J Oncol. 2013.102735:2013.

26 

Mariño G, Niso-Santano M, Baehrecke EH and Kroemer G: Self-consumption: The interplay of autophagy and apoptosis. Nat Rev Mol Cell Biol. 15:81–94. 2014. View Article : Google Scholar : PubMed/NCBI

27 

Azad MB and Gibson SB: Role of BNIP3 in proliferation and hypoxia-induced autophagy: Implications for personalized cancer therapies. Ann N Y Acad Sci. 1210:8–16. 2010. View Article : Google Scholar : PubMed/NCBI

28 

Burton TR and Gibson SB: The role of Bcl-2 family member BNIP3 in cell death and disease: NIPping at the heels of cell death. Cell Death Differ. 16:515–523. 2009. View Article : Google Scholar : PubMed/NCBI

29 

Giatromanolaki A, Koukourakis MI, Gatter KC, Harris AL and Sivridis E: BNIP3 expression in endometrial cancer relates to active hypoxia inducible factor 1alpha pathway and prognosis. J Clin Pathol. 61:217–220. 2008. View Article : Google Scholar

30 

Giatromanolaki A, Koukourakis MI, Sowter HM, Sivridis E, Gibson S, Gatter KC and Harris AL: BNIP3 expression is linked with hypoxia-regulated protein expression and with poor prognosis in non small cell lung cancer. Clin Cancer Res. 10:5566–5571. 2004. View Article : Google Scholar : PubMed/NCBI

31 

Lukashova-v Zangen I, Kneitz S, Monoranu CM, Rutkowski S, Hinkes B, Vince GH, Huang B and Roggendorf W: Ependymoma gene expression profiles associated with histological subtype, proliferation, and patient survival. Acta Neuropathol. 113:325–337. 2007. View Article : Google Scholar : PubMed/NCBI

32 

Erkan M, Kleeff J, Esposito I, Giese T, Ketterer K, Büchler MW, Giese NA and Friess H: Loss of BNIP3 expression is a late event in pancreatic cancer contributing to chemoresistance and worsened prognosis. Oncogene. 24:4421–4432. 2005. View Article : Google Scholar : PubMed/NCBI

33 

Tang H, Liu YJ, Liu M and Li X: Establishment and gene analysis of an oxaliplatin-resistant colon cancer cell line THC8307/L-OHP. Anticancer Drugs. 18:633–639. 2007. View Article : Google Scholar : PubMed/NCBI

34 

de Angelis PM, Fjell B, Kravik KL, Haug T, Tunheim SH, Reichelt W, Beigi M, Clausen OP, Galteland E and Stokke T: Molecular characterizations of derivatives of HCT116 colorectal cancer cells that are resistant to the chemotherapeutic agent 5-fluorouracil. Int J Oncol. 24:1279–1288. 2004.PubMed/NCBI

35 

Jacobsen J, Grankvist K, Rasmuson T, Bergh A, Landberg G and Ljungberg B: Expression of vascular endothelial growth factor protein in human renal cell carcinoma. BJU Int. 93:297–302. 2004. View Article : Google Scholar : PubMed/NCBI

36 

Gardiner-Garden M and Frommer M: CpG islands in vertebrate genomes. J Mol Biol. 196:261–282. 1987. View Article : Google Scholar : PubMed/NCBI

37 

Bird AP: CpG-rich islands and the function of DNA methylation. Nature. 321:209–213. 1986. View Article : Google Scholar : PubMed/NCBI

38 

Graff JR, Herman JG, Myöhänen S, Baylin SB and Vertino PM: Mapping patterns of CpG island methylation in normal and neoplastic cells implicates both upstream and downstream regions in de novo methylation. J Biol Chem. 272:22322–22329. 1997. View Article : Google Scholar : PubMed/NCBI

39 

Herman JG, Umar A, Polyak K, Graff JR, Ahuja N, Issa JP, Markowitz S, Willson JK, Hamilton SR, Kinzler KW, et al: Incidence and functional consequences of hMLH1 promoter hypermethylation in colorectal carcinoma. Proc Natl Acad Sci USA. 95:6870–6875. 1998. View Article : Google Scholar : PubMed/NCBI

40 

Murai M, Toyota M, Satoh A, Suzuki H, Akino K, Mita H, Sasaki Y, Ishida T, Shen L, Garcia-Manero G, et al: Aberrant DNA methylation associated with silencing BNIP3 gene expression in haematopoietic tumours. Br J Cancer. 92:1165–1172. 2005. View Article : Google Scholar : PubMed/NCBI

41 

Cleven AHG, Spiertz A, Wouters B, van Engeland M and De Bruine A: Stromal expression of RIF 2A correlates with BNIP3 promoter hypermethylation and overall patient survival in colorectal carcinomas. Cell Oncol. 29:1272007.

42 

Abe T, Toyota M, Suzuki H, Murai M, Akino K, Ueno M, Nojima M, Yawata A, Miyakawa H, Suga T, et al: Upregulation of BNIP3 by 5-aza-2′-deoxycytidine sensitizes pancreatic cancer cells to hypoxia-mediated cell death. J Gastroenterol. 40:504–510. 2005. View Article : Google Scholar : PubMed/NCBI

43 

Eckschlager T, Plch J, Stiborova M and Hrabeta J: Histone Deacetylase Inhibitors as Anticancer Drugs. Int J Mol Sci. 18:pii: E1414. 2017. View Article : Google Scholar : PubMed/NCBI

44 

Park KC, Heo JH, Jeon JY, Choi HJ, Jo AR, Kim SW, Kwon HJ, Hong SJ and Han KS: The novel histone deacetylase inhibitor, N-hydroxy-7-(2-naphthylthio) hepatonomide, exhibits potent antitumor activity due to cytochrome-c-release-mediated apoptosis in renal cell carcinoma cells. BMC Cancer. 15:192015. View Article : Google Scholar : PubMed/NCBI

45 

Park WH, Jung CW, Park JO, Kim K, Kim WS, Im YH, Lee MH, Kang WK and Park K: Trichostatin inhibits the growth of ACHN renal cell carcinoma cells via cell cycle arrest in association with p27, or apoptosis. Int J Oncol. 22:1129–1134. 2003.PubMed/NCBI

46 

Nagata Y and Todokoro K: Requirement of activation of JNK and p38 for environmental stress-induced erythroid differentiation and apoptosis and of inhibition of ERK for apoptosis. Blood. 94:853–863. 1999.PubMed/NCBI

47 

Yang Q, Wang Y, Pan X, Ye J, Gan S, Qu F, Chen L, Chu C, Gao Y and Cui X: Frizzled 8 promotes the cell proliferation and metastasis of renal cell carcinoma. Oncotarget. 8:78989–79002. 2017.PubMed/NCBI

48 

Santos N, Wenger JB, Havre P, Liu Y, Dagan R, Imanirad I, Ivey AM, Zlotecki RA, Algood CB, Gilbert SM, et al: Combination therapy for renal cell cancer: What are possible options? Oncology. 81:220–229. 2011. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Shao Y, Liu Z, Liu J, Wang H, Huang L, Lin T, Liu J, Wei Q, Zeng H, He G, He G, et al: Expression and epigenetic regulatory mechanism of BNIP3 in clear cell renal cell carcinoma. Int J Oncol 54: 348-360, 2019.
APA
Shao, Y., Liu, Z., Liu, J., Wang, H., Huang, L., Lin, T. ... Li, X. (2019). Expression and epigenetic regulatory mechanism of BNIP3 in clear cell renal cell carcinoma. International Journal of Oncology, 54, 348-360. https://doi.org/10.3892/ijo.2018.4603
MLA
Shao, Y., Liu, Z., Liu, J., Wang, H., Huang, L., Lin, T., Liu, J., Wei, Q., Zeng, H., He, G., Li, X."Expression and epigenetic regulatory mechanism of BNIP3 in clear cell renal cell carcinoma". International Journal of Oncology 54.1 (2019): 348-360.
Chicago
Shao, Y., Liu, Z., Liu, J., Wang, H., Huang, L., Lin, T., Liu, J., Wei, Q., Zeng, H., He, G., Li, X."Expression and epigenetic regulatory mechanism of BNIP3 in clear cell renal cell carcinoma". International Journal of Oncology 54, no. 1 (2019): 348-360. https://doi.org/10.3892/ijo.2018.4603
Copy and paste a formatted citation
x
Spandidos Publications style
Shao Y, Liu Z, Liu J, Wang H, Huang L, Lin T, Liu J, Wei Q, Zeng H, He G, He G, et al: Expression and epigenetic regulatory mechanism of BNIP3 in clear cell renal cell carcinoma. Int J Oncol 54: 348-360, 2019.
APA
Shao, Y., Liu, Z., Liu, J., Wang, H., Huang, L., Lin, T. ... Li, X. (2019). Expression and epigenetic regulatory mechanism of BNIP3 in clear cell renal cell carcinoma. International Journal of Oncology, 54, 348-360. https://doi.org/10.3892/ijo.2018.4603
MLA
Shao, Y., Liu, Z., Liu, J., Wang, H., Huang, L., Lin, T., Liu, J., Wei, Q., Zeng, H., He, G., Li, X."Expression and epigenetic regulatory mechanism of BNIP3 in clear cell renal cell carcinoma". International Journal of Oncology 54.1 (2019): 348-360.
Chicago
Shao, Y., Liu, Z., Liu, J., Wang, H., Huang, L., Lin, T., Liu, J., Wei, Q., Zeng, H., He, G., Li, X."Expression and epigenetic regulatory mechanism of BNIP3 in clear cell renal cell carcinoma". International Journal of Oncology 54, no. 1 (2019): 348-360. https://doi.org/10.3892/ijo.2018.4603
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