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Sphingosine kinase 1 promotes the metastasis of colorectal cancer by inducing the epithelial‑mesenchymal transition mediated by the FAK/AKT/MMPs axis

  • Authors:
    • Shi‑Quan Liu
    • Chun‑Yan Xu
    • Wen‑Hong Wu
    • Zhen‑Hua Fu
    • Si‑Wei He
    • Meng‑Bin Qin
    • Jie‑An Huang
  • View Affiliations / Copyright

    Affiliations: Department of Gastroenterology, The Second Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi 530007, P.R. China
    Copyright: © Liu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 41-52
    |
    Published online on: October 25, 2018
       https://doi.org/10.3892/ijo.2018.4607
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Abstract

It was demonstrated that Sphingosine kinase 1 (SphK1) promotes tumor progression and confers the malignancy phenotype of colorectal cancer by activating the focal adhesion kinase (FAK) pathway. However, further clarification is required to determine if SphK1 promotes the metastasis of colorectal cancer by inducing epithelial‑mesenchymal transition (EMT), and its mechanisms have not been fully elucidated. Immunohistochemistry staining was used to detect protein expression in normal colonic mucosa tissues and colorectal cancer tissues. Cells were transfected to overexpress SphK1, downregulate SphK1 or downregulate FAK. An MTT assay was used to detect the drug toxicity to cells. Transwell and wound healing assays were used to detect cell migration ability. Reverse transcription‑polymerase chain reaction and western blot analysis were used to detect the expression of mRNA and protein, respectively. Scanning electron microscopy was used to observe the microvilli and pseudopodia of the cells. The analysis of protein expression in 114 human colorectal cancer tissues demonstrated that the expressions of SphK1, FAK, phosphorylated (p)‑FAK, E‑cadherin and vimentin were associated with the metastasis of colorectal cancer. Furthermore, the patients with colorectal cancer with SphK1‑positive cancer demonstrated poorer prognosis compared with SphK1‑negative cancer. FAK knockdown and SphK1 knockdown of human colon cancer RKO cells inhibited the EMT and migrational potency, along with the expression of p‑FAK, p‑protein kinase B (AKT) and matrix metalloproteinase (MMP)2/9. In contrast, SphK1 overexpression promoted EMT, migrational potency, and the expression of p‑FAK, p‑AKT and MMP2/9 in HT29 cells. Additionally, the EMT and migrational potency of SphK1‑overexpressing HT29 cells was suppressed by a FAK inhibitor, and the expression of p‑FAK, p‑AKT and MMP2/9 was suppressed by blocking the FAK pathway. In conclusion, SphK1 promoted the migration and metastasis of colon cancer by inducing EMT mediated by the FAK/AKT/MMPs axis.
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View References

1 

Jie D, Zhongmin Z, Guoqing L, Sheng L, Yi Z, Jing W and Liang Z: Positive expression of LSD1 and negative expression of E-cadherin correlate with metastasis and poor prognosis of colon cancer. Dig Dis Sci. 58:1581–1589. 2013. View Article : Google Scholar : PubMed/NCBI

2 

Li J, Wu H, Li W, Yin L, Guo S, Xu X, Ouyang Y, Zhao Z, Liu S, Tian Y, et al: Downregulated miR-506 expression facilitates pancreatic cancer progression and chemoresistance via SPHK1/Akt/NF-KB signaling. Oncogene. 35:5501–5514. 2016. View Article : Google Scholar : PubMed/NCBI

3 

Long J, Xie Y, Yin J, Lu W and Fang S: SphK1 promotes tumor cell migration and invasion in colorectal cancer. Tumour Biol. 37:6831–6836. 2016. View Article : Google Scholar

4 

Zheng XD, Zhang Y, Qi XW, Wang MH, Sun P, Zhang Y and Jiang J: Role of Sphk1 in the malignant transformation of breast epithelial cells and breast cancer progression. Indian J Cancer. 51:524–529. 2014. View Article : Google Scholar : PubMed/NCBI

5 

Su YJ, Huang JA, Liu SQ, Huang JX, Zhong YY, Tang GD and Jiang HX: The expression and clinical significance of SphK1 and nuclear factor-KB p65 in human colon carcinoma. Zhonghua Nei Ke Za Zhi. 51:220–224. 2012.PubMed/NCBI

6 

Liu SQ, Su YJ, Qin MB, Mao YB, Huang JA and Tang GD: Sphingosine kinase1 promotes tumor progression and confers malignancy phenotypes of colon cancer by regulating the focal adhesion kinase pathway and adhesion molecules. Int J Oncol. 42:617–626. 2013. View Article : Google Scholar

7 

Cai G, Wu D, Wang Z, Xu Z, Wong KB, Ng CF, Chan FL and Yu S: Collapsin response mediator protein-1 (CRMP1) acts as an invasion and metastasis suppressor of prostate cancer via its suppression of epithelial-mesenchymal transition and remodeling of actin cytoskeleton organization. Oncogene. 36:546–558. 2017. View Article : Google Scholar

8 

Leonel C, Borin TF, de Carvalho Ferreira L, Moschetta MG, Bajgelman MC, Viloria-Petit AM and de Campos Zuccari DA: Inhibition of epithelial-mesenchymal transition and metastasis by combined TGFbeta knockdown and metformin treatment in a canine mammary cancer xenograft model. J Mammary Gland Biol Neoplasia. 22:27–41. 2017. View Article : Google Scholar : PubMed/NCBI

9 

Singla M, Kumar A, Bal A, Sarkar S and Bhattacharyya S: Epithelial to mesenchymal transition induces stem cell like phenotype in renal cell carcinoma cells. Cancer Cell Int. 18:572018. View Article : Google Scholar : PubMed/NCBI

10 

Liu CC, Cai DL, Sun F, Wu ZH, Yue B, Zhao SL, Wu XS, Zhang M, Zhu XW, Peng ZH, et al: fermt1 mediates epithelial-mesenchymal transition to promote colon cancer metastasis via modulation of β-catenin transcriptional activity. Oncogene. 36:1779–1792. 2017. View Article : Google Scholar

11 

Harner-Foreman N, Vadakekolathu J, Laversin SA, Mathieu MG, Reeder S, Pockley AG, Rees RC and Boocock DJ: A novel spontaneous model of epithelial-mesenchymal transition (EMT) using a primary prostate cancer derived cell line demonstrating distinct stem-like characteristics. Sci Rep. 7:406332017. View Article : Google Scholar : PubMed/NCBI

12 

Chiu LY, Hsin IL, Yang TY, Sung WW, Chi JY, Chang JT, Ko JL and Sheu GT: The ERK-ZEB1 pathway mediates epithelial-mesenchymal transition in pemetrexed resistant lung cancer cells with suppression by vinca alkaloids. Oncogene. 36:242–253. 2017. View Article : Google Scholar

13 

Yang Y, Zhang J, Yan Y, Cai H, Li M, Sun K, Wang J, Liu X, Wang J and Duan X: Low expression of Rap1GAP is associated with epithelial-mesenchymal transition (EMT) and poor prognosis in gastric cancer. Oncotarget. 8:8057–8068. 2017.

14 

Lv QL, Chen SH, Zhang X, Sun B, Hu L, Qu Q, Huang YT, Wang GH, Liu YL, Zhang YY, et al: Upregulation of long noncoding RNA zinc finger antisense 1 enhances epithelial-mesenchymal transition in vitro and predicts poor prognosis in glioma. Tumour Biol. 39:10104283176950222017. View Article : Google Scholar : PubMed/NCBI

15 

Ling HH, Kuo CC, Lin BX, Huang YH and Lin CW: Elevation of YAP promotes the epithelial-mesenchymal transition and tumor aggressiveness in colorectal cancer. Exp Cell Res. 350:218–225. 2017. View Article : Google Scholar

16 

Taliaferro-Smith L, Oberlick E, Liu T, McGlothen T, Alcaide T, Tobin R, Donnelly S, Commander R, Kline E, Nagaraju GP, et al: FAK activation is required for IGFIR-mediated regulation of EMT, migration, and invasion in mesenchymal triple negative breast cancer cells. Oncotarget. 6:4757–4772. 2015. View Article : Google Scholar : PubMed/NCBI

17 

Huang L, Huang Z, Fan Y, He L, Ye M, Shi K, Ji B, Huang J, Wang Y and Li Q: FOXC1 promotes proliferation and epithelial-mesenchymal transition in cervical carcinoma through the PI3K-AKT signal pathway. Am J Transl Res. 9:1297–1306. 2017.PubMed/NCBI

18 

Xu H, Li M, Zhou Y, Wang F, Li X, Wang L and Fan Q: S100A4 participates in epithelial-mesenchymal transition in breast cancer via targeting MMP2. Tumour Biol. 37:2925–2932. 2016. View Article : Google Scholar

19 

Asuthkar S, Nalla AK, Gondi CS, Dinh DH, Gujrati M, Mohanam S and Rao JS: Gadd45a sensitizes medulloblastoma cells to irradiation and suppresses MMP-9-mediated EMT. Neuro-oncol. 13:1059–1073. 2011. View Article : Google Scholar : PubMed/NCBI

20 

Baquero P, Jiménez-Mora E, Santos A, Lasa M and Chiloeches A: TGFβ induces epithelial-mesenchymal transition of thyroid cancer cells by both the BRAF/MEK/ERK and Src/FAK pathways. Mol Carcinog. 55:1639–1654. 2016. View Article : Google Scholar

21 

Yang J, Hou Y, Zhou M, Wen S, Zhou J, Xu L, Tang X, Du YE, Hu P and Liu M: Twist induces epithelial-mesenchymal transition and cell motility in breast cancer via ITGB1-FAK/ILK signaling axis and its associated downstream network. Int J Biochem Cell Biol. 71:62–71. 2016. View Article : Google Scholar

22 

Xue X, Wang X, Liu Y, Teng G, Wang Y, Zang X, Wang K, Zhang J, Xu Y, Wang J, et al: SchA-p85-FAK complex dictates isoform-specific activation of Akt2 and subsequent PCBPl-mediated post-transcriptional regulation of TGFβ-mediated epithelial to mesenchymal transition in human lung cancer cell line A549. Tumour Biol. 35:7853–7859. 2014. View Article : Google Scholar : PubMed/NCBI

23 

Lv C, Yang S, Chen X and Zhu X: MicroRNA-21 promotes bone mesenchymal stem cells migration in vitro by activating PI3K/Akt/MMPs pathway. J Clin Neurosci. 46:156–162. 2017. View Article : Google Scholar : PubMed/NCBI

24 

Qin M and Liu S, Li A, Xu C, Tan L, Huang J and Liu S: NIK- and IKKβ-binding protein promotes colon cancer metastasis by activating the classical NF-KB pathway and MMPs. Tumour Biol. 37:5979–5990. 2016. View Article : Google Scholar

25 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(−Delta Delta C(T)) Method. Methods. 25:402–408. 2001. View Article : Google Scholar

26 

Xu CY, Liu SQ, Qin MB, Zhuge CF, Qin L, Qin N, Lai MY and Huang JA: SphK1 modulates cell migration and EMT-related marker expression by regulating the expression of p-FAK in colorectal cancer cells. Int J Mol Med. 39:1277–1284. 2017. View Article : Google Scholar : PubMed/NCBI

27 

Li S, Zhou Y, Zheng X, Wu X, Liang Y, Wang S and Zhang Y: Sphk1 promotes breast epithelial cell proliferation via NF-K B-p65-mediated cyclin D1 expression. Oncotarget. 7:80579–80585. 2016.PubMed/NCBI

28 

Yeung KT and Yang J: Epithelial-mesenchymal transition in tumor metastasis. Mol Oncol. 11:28–39. 2017. View Article : Google Scholar : PubMed/NCBI

29 

Gu K, Li MM, Shen J, Liu F, Cao JY, Jin S and Yu Y: Interleukin-17-induced EMT promotes lung cancer cell migration and invasion via NF-KB/ZEB1 signal pathway. Am J Cancer Res. 5:1169–1179. 2015.

30 

Dai S, Zhang J, Huang S, Lou B, Fang B, Ye T, Huang X, Chen B and Zhou M: HNRNPA2B1 regulates the epithelial-mesenchymal transition in pancreatic cancer cells through the ERK/snail signalling pathway. Cancer Cell Int. 17(12): 2017

31 

Park J and Schwarzbauer JE: Mammary epithelial cell interactions with fibronectin stimulate epithelial-mesenchymal transition. Oncogene. 33:1649–1657. 2014. View Article : Google Scholar :

32 

Kokkinos MI, Wafai R, Wong MK, Newgreen DF, Thompson EW and Waltham M: Vimentin and epithelial-mesenchymal transition in human breast cancer–observations in vitro and in vivo. Cells Tissues Organs. 185:191–203. 2007. View Article : Google Scholar

33 

Kessler BE, Sharma V, Zhou Q, Jing X, Pike LA, Kerege AA, Sams SB and Schweppe RE: FAK expression, not kinase activity, is a key mediator of thyroid tumorigenesis and protumorigenic processes. Mol Cancer Res. 14:869–882. 2016. View Article : Google Scholar : PubMed/NCBI

34 

Lee BY, Timpson P, Horvath LG and Daly RJ: FAK signaling in human cancer as a target for therapeutics. Pharmacol Ther. 146:132–149. 2015. View Article : Google Scholar

35 

Zhu L, Wang Z, Lin Y, Chen Z, Liu H, Chen Y, Wang N and Song X: Sphingosine kinase 1 enhances the invasion and migration of non-small cell lung cancer cells via the AKT pathway. Oncol Rep. 33:1257–1263. 2015. View Article : Google Scholar

36 

Bugide S, Gonugunta VK, Penugurti V, Malisetty VL, Vadlamudi RK and Manavathi B: HPIP promotes epithelial-mesenchymal transition and cisplatin resistance in ovarian cancer cells through PI3K/AKT pathway activation. Cell Oncol (Dordr). 40:133–144. 2017. View Article : Google Scholar

37 

Fu QF, Liu Y, Fan Y, Hua SN, Qu HY, Dong SW, Li RL, Zhao MY, Zhen Y, Yu XL, et al: Alpha-enolase promotes cell glycolysis, growth, migration, and invasion in non-small cell lung cancer through FAK-mediated PI3K/AKT pathway. J Hematol Oncol. 8:222015. View Article : Google Scholar : PubMed/NCBI

38 

Yang Y, Qiu S, Qian L, Tian Y, Chen Y, Bi L and Chen W: OCF can repress tumor metastasis by inhibiting epithelial-mesenchymal transition involved in PTEN/PI3K/AKT pathway in lung cancer cells. PLoS One. 12:e01740212017. View Article : Google Scholar : PubMed/NCBI

39 

Liu SQ, Huang JA, Qin MB, Su YJ, Lai MY, Jiang HX and Tang GD: Sphingosine kinase 1 enhances colon cancer cell proliferation and invasion by upregulating the production of MMP-2/9 and uPA via MAPK pathways. Int J Colorectal Dis. 27:1569–1578. 2012. View Article : Google Scholar : PubMed/NCBI

40 

Su Y, Gao L, Teng L, Wang Y, Cui J, Peng S and Fu S: Id1 enhances human ovarian cancer endothelial progenitor cell angiogenesis via PI3K/Akt and NF-kB/MMP-2 signaling pathways. J Transl Med. 11:1322013. View Article : Google Scholar

41 

Yuan H, Yang P, Zhou D, Gao W, Qiu Z, Fang F, Ding S and Xiao W: Knockdown of sphingosine kinase 1 inhibits the migration and invasion of human rheumatoid arthritis fibroblast-like synoviocytes by downregulating the PI3K/AKT activation and MMP-2/9 production in vitro. Mol Biol Rep. 41:5157–5165. 2014. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Liu SQ, Xu CY, Wu WH, Fu ZH, He SW, Qin MB and Huang JA: Sphingosine kinase 1 promotes the metastasis of colorectal cancer by inducing the epithelial‑mesenchymal transition mediated by the FAK/AKT/MMPs axis. Int J Oncol 54: 41-52, 2019.
APA
Liu, S., Xu, C., Wu, W., Fu, Z., He, S., Qin, M., & Huang, J. (2019). Sphingosine kinase 1 promotes the metastasis of colorectal cancer by inducing the epithelial‑mesenchymal transition mediated by the FAK/AKT/MMPs axis. International Journal of Oncology, 54, 41-52. https://doi.org/10.3892/ijo.2018.4607
MLA
Liu, S., Xu, C., Wu, W., Fu, Z., He, S., Qin, M., Huang, J."Sphingosine kinase 1 promotes the metastasis of colorectal cancer by inducing the epithelial‑mesenchymal transition mediated by the FAK/AKT/MMPs axis". International Journal of Oncology 54.1 (2019): 41-52.
Chicago
Liu, S., Xu, C., Wu, W., Fu, Z., He, S., Qin, M., Huang, J."Sphingosine kinase 1 promotes the metastasis of colorectal cancer by inducing the epithelial‑mesenchymal transition mediated by the FAK/AKT/MMPs axis". International Journal of Oncology 54, no. 1 (2019): 41-52. https://doi.org/10.3892/ijo.2018.4607
Copy and paste a formatted citation
x
Spandidos Publications style
Liu SQ, Xu CY, Wu WH, Fu ZH, He SW, Qin MB and Huang JA: Sphingosine kinase 1 promotes the metastasis of colorectal cancer by inducing the epithelial‑mesenchymal transition mediated by the FAK/AKT/MMPs axis. Int J Oncol 54: 41-52, 2019.
APA
Liu, S., Xu, C., Wu, W., Fu, Z., He, S., Qin, M., & Huang, J. (2019). Sphingosine kinase 1 promotes the metastasis of colorectal cancer by inducing the epithelial‑mesenchymal transition mediated by the FAK/AKT/MMPs axis. International Journal of Oncology, 54, 41-52. https://doi.org/10.3892/ijo.2018.4607
MLA
Liu, S., Xu, C., Wu, W., Fu, Z., He, S., Qin, M., Huang, J."Sphingosine kinase 1 promotes the metastasis of colorectal cancer by inducing the epithelial‑mesenchymal transition mediated by the FAK/AKT/MMPs axis". International Journal of Oncology 54.1 (2019): 41-52.
Chicago
Liu, S., Xu, C., Wu, W., Fu, Z., He, S., Qin, M., Huang, J."Sphingosine kinase 1 promotes the metastasis of colorectal cancer by inducing the epithelial‑mesenchymal transition mediated by the FAK/AKT/MMPs axis". International Journal of Oncology 54, no. 1 (2019): 41-52. https://doi.org/10.3892/ijo.2018.4607
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