Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
International Journal of Oncology
Join Editorial Board Propose a Special Issue
Print ISSN: 1019-6439 Online ISSN: 1791-2423
Journal Cover
January-2019 Volume 54 Issue 1

Full Size Image

Cover Legend PDF

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
January-2019 Volume 54 Issue 1

Full Size Image

Cover Legend PDF

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

HIF-1α contributes to tube malformation of human lymphatic endothelial cells by upregulating VEGFR-3

Corrigendum in: /10.3892/ijo.2022.5403
  • Authors:
    • Tao Han
    • Jun Yan
    • Haini Chen
    • Yi Ji
    • Jianbing Chen
    • Jie Cui
    • Weimin Shen
    • Jijun Zou
  • View Affiliations / Copyright

    Affiliations: Department of Burns and Plastic Surgery, Children's Hospital of Nanjing Medical University, Nanjing, Jiangsu 210008, P.R. China
    Copyright: © Han et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 139-151
    |
    Published online on: November 5, 2018
       https://doi.org/10.3892/ijo.2018.4623
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Hypoxia‑inducible factor‑1α (HIF‑1α) is upregulated in various tumors and associated with lymphangiogenesis and angiogenesis during tumor development and metastasis. However, the role of HIF‑1α in cystic lymphatic malformations (cLM) remains unclear. In the present study, expression of HIF‑1α and vascular endothelial growth factor receptor 3 (VEGFR‑3) was evaluated in 20 pairs of cLM specimens from patients who accepted curative surgery at Children's Hospital of Nanjing Medical University (Nanjing, China). Additionally, a stable HIF‑1α‑overexpressing human lymphatic endothelial cell (HLEC) line was established. Overexpression and silencing of HIF‑1α were used to investigate the biological role in colony formation, migration and lymphatic tube formation. HIF‑1α and VEGFR‑3 were upregulated in cLM specimens compared with adjacent normal tissues. In addition, HIF‑1α effectively induced HLEC colony formation and migration. Furthermore, lymphatic malformation of HLECs was promoted in vitro by overexpression of HIF‑1α. HIF‑1α overexpression upregulated VEGFR‑3 during lymphangiogenesis. Additionally, expression of lymphatic endothelial markers prospero homeobox protein 1 and lymphatic vessel endothelial hyaluronan receptor 1 increased significantly during lymphatic tube malformation. The presented data demonstrated that HIF‑1α overexpression in HLECs promoted colony formation, migration and tube malformation via upregulation of VEGFR‑3. These findings may assist in the development of HIF‑1α‑targeted cLM therapeutics in the future.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

Figure 7

Figure 8

View References

1 

Wassef M, Blei F, Adams D, Alomari A, Baselga E, Berenstein A, Burrows P, Frieden IJ, Garzon MC, Lopez-Gutierrez JC, et al ISSVA Board and Scientific Committee: Vascular anomalies classification: Recommendations from the International Society for the study of vascular anomalies. Pediatrics. 136:e203–e214. 2015. View Article : Google Scholar : PubMed/NCBI

2 

Florez-Vargas A, Vargas SO, Debelenko LV, Perez-Atayde AR, Archibald T, Kozakewich HP and Zurakowski D: Comparative analysis of D2-40 and LYVE-1 immunostaining in lymphatic malformations. Lymphology. 41:103–110. 2008.PubMed/NCBI

3 

Defnet AM, Bagrodia N, Hernandez SL, Gwilliam N and Kandel JJ: Pediatric lymphatic malformations: Evolving understanding and therapeutic options. Pediatr Surg Int. 32:425–433. 2016. View Article : Google Scholar : PubMed/NCBI

4 

Mulliken JB, Burrows PE and Fishman SJ: Mulliken and Young’s vascular anomalies: hemangiomas and malformations. 2nd edition. Oxford University Press; Oxford; 2013, View Article : Google Scholar

5 

Fonkalsrud EW: Lymphatic disorders. Pediatric surgery. Grosfeld JL: Mosby/Elsevier; Philadelphia, PA: pp. 2137–2146. 2006, View Article : Google Scholar

6 

Sun ZJ, Zhang L, Zhang WF, Liu B, Li ZB and Zhao YF: A possible hypoxia-induced endothelial proliferation in the pathogenesis of epithelioid hemangioma. Med Hypotheses. 67:1133–1135. 2006. View Article : Google Scholar : PubMed/NCBI

7 

North PE, Waner M, Mizeracki A and Mihm MC Jr: GLUT1: A newly discovered immunohistochemical marker for juvenile hemangiomas. Hum Pathol. 31:11–22. 2000. View Article : Google Scholar : PubMed/NCBI

8 

Revencu N, Boon LM, Mendola A, Cordisco MR, Dubois J, Clapuyt P, Hammer F, Amor DJ, Irvine AD, Baselga E, et al: RASA1 mutations and associated phenotypes in 68 families with capillary malformation-arteriovenous malformation. Hum Mutat. 34:1632–1641. 2013. View Article : Google Scholar : PubMed/NCBI

9 

Liao D and Johnson RS: Hypoxia: A key regulator of angiogenesis in cancer. Cancer Metastasis Rev. 26:281–290. 2007. View Article : Google Scholar : PubMed/NCBI

10 

Fulda S and Debatin KM: HIF-1-regulated glucose metabolism: A key to apoptosis resistance? Cell Cycle. 6:790–792. 2007. View Article : Google Scholar : PubMed/NCBI

11 

Simon F, Bockhorn M, Praha C, Baba HA, Broelsch CE, Frilling A and Weber F: Deregulation of HIF1-alpha and hypoxia-regulated pathways in hepatocellular carcinoma and corresponding non-malignant liver tissue - influence of a modulated host stroma on the prognosis of HCC. Langenbecks Arch Surg. 395:395–405. 2010. View Article : Google Scholar : PubMed/NCBI

12 

Tao J, Li T, Li K, Xiong J, Yang Z, Wu H and Wang C: Effect of HIF-1alpha on VEGF-C induced lymphangiogenesis and lymph nodes metastases of pancreatic cancer. J Huazhong Univ Sci Technolog Med Sci. 26:562–564. 2006. View Article : Google Scholar

13 

Katsuta M, Miyashita M, Makino H, Nomura T, Shinji S, Yamashita K, Tajiri T, Kudo M, Ishiwata T and Naito Z: Correlation of hypoxia inducible factor-1alpha with lymphatic metastasis via vascular endothelial growth factor-C in human esophageal cancer. Exp Mol Pathol. 78:123–130. 2005. View Article : Google Scholar : PubMed/NCBI

14 

Secker GA and Harvey NL: VEGFR signaling during lymphatic vascular development: From progenitor cells to functional vessels. Dev Dyn. 244:323–331. 2015. View Article : Google Scholar

15 

Tammela T, Saaristo A, Lohela M, Morisada T, Tornberg J, Norrmén C, Oike Y, Pajusola K, Thurston G, Suda T, et al: Angiopoietin-1 promotes lymphatic sprouting and hyperplasia. Blood. 105:4642–4648. 2005. View Article : Google Scholar : PubMed/NCBI

16 

Liang X, Yang D, Hu J, Hao X, Gao J and Mao Z: Hypoxia inducible factor-alpha expression correlates with vascular endothelial growth factor-C expression and lymphangiogenesis/angiogenesis in oral squamous cell carcinoma. Anticancer Res. 28(3A): 1659–1666. 2008.PubMed/NCBI

17 

Mizukami Y, Li J, Zhang X, Zimmer MA, Iliopoulos O and Chung DC: Hypoxia-inducible factor-1-independent regulation of vascular endothelial growth factor by hypoxia in colon cancer. Cancer Res. 64:1765–1772. 2004. View Article : Google Scholar : PubMed/NCBI

18 

Boussat S, Eddahibi S, Coste A, Fataccioli V, Gouge M, Housset B, Adnot S and Maitre B: Expression and regulation of vascular endothelial growth factor in human pulmonary epithelial cells. Am J Physiol Lung Cell Mol Physiol. 279:L371–L378. 2000. View Article : Google Scholar : PubMed/NCBI

19 

Shen W, Weiping S, Cui J, Chen J and Zou J: Management of cystic lymphangioma in the head and neck region: Endoscopic cautery and postoperative intratumoral negative pressure. J Craniofac Surg. 21:1884–1886. 2010. View Article : Google Scholar : PubMed/NCBI

20 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(−Delta Delta C(T)) Method. Methods. 25:402–408. 2001. View Article : Google Scholar

21 

Perkins JA: New frontiers in our understanding of lymphatic malformations of the head and neck: Natural history and basic research. Otolaryngol Clin North Am. 51:147–158. 2018. View Article : Google Scholar

22 

Ji RC: Hypoxia and lymphangiogenesis in tumor microenvironment and metastasis. Cancer Lett. 346:6–16. 2014. View Article : Google Scholar

23 

Chen S, Zhang M, Xing L, Wang Y, Xiao Y and Wu Y: HIF-1α contributes to proliferation and invasiveness of neuroblastoma cells via SHH signaling. PLoS One. 10:e01211152015. View Article : Google Scholar

24 

Stoeltzing O, McCarty MF, Wey JS, Fan F, Liu W, Belcheva A, Bucana CD, Semenza GL and Ellis LM: Role of hypoxia-inducible factor 1alpha in gastric cancer cell growth, angiogenesis, and vessel maturation. J Natl Cancer Inst. 96:946–956. 2004. View Article : Google Scholar : PubMed/NCBI

25 

Nam SY, Ko YS, Jung J, Yoon J, Kim YH, Choi YJ, Park JW, Chang MS, Kim WH and Lee BL: A hypoxia-dependent upregulation of hypoxia-inducible factor-1 by nuclear factor-κB promotes gastric tumour growth and angiogenesis. Br J Cancer. 104:166–174. 2011. View Article : Google Scholar

26 

Kimura S, Kitadai Y, Tanaka S, Kuwai T, Hihara J, Yoshida K, Toge T and Chayama K: Expression of hypoxia-inducible factor (HIF)-1alpha is associated with vascular endothelial growth factor expression and tumour angiogenesis in human oesophageal squamous cell carcinoma. Eur J Cancer. 40:1904–1912. 2004. View Article : Google Scholar : PubMed/NCBI

27 

Schoppmann SF, Fenzl A, Schindl M, Bachleitner-Hofmann T, Nagy K, Gnant M, Horvat R, Jakesz R and Birner P: Hypoxia inducible factor-1alpha correlates with VEGF-C expression and lymphangiogenesis in breast cancer. Breast Cancer Res Treat. 99:135–141. 2006. View Article : Google Scholar : PubMed/NCBI

28 

Zhu H and Zhang S: Hypoxia inducible factor-1α/vascular endothelial growth factor signaling activation correlates with response to radiotherapy and its inhibition reduces hypoxia-induced angiogenesis in lung cancer. J Cell Biochem. 119:7707–7718. 2018. View Article : Google Scholar : PubMed/NCBI

29 

Morfoisse F, Kuchnio A, Frainay C, Gomez-Brouchet A, Delisle MB, Marzi S, Helfer AC, Hantelys F, Pujol F, Guillermet-Guibert J, et al: Hypoxia induces VEGF-C expression in metastatic tumor cells via a HIF-1α-independent translation-mediated mechanism. Cell Reports. 6:155–167. 2014. View Article : Google Scholar

30 

Kuwai T, Kitadai Y, Tanaka S, Onogawa S, Matsutani N, Kaio E, Ito M and Chayama K: Expression of hypoxia-inducible factor-1alpha is associated with tumor vascularization in human colorectal carcinoma. Int J Cancer. 105:176–181. 2003. View Article : Google Scholar : PubMed/NCBI

31 

Koshikawa N, Iyozumi A, Gassmann M and Takenaga K: Constitutive upregulation of hypoxia-inducible factor-1alpha mRNA occurring in highly metastatic lung carcinoma cells leads to vascular endothelial growth factor overexpression upon hypoxic exposure. Oncogene. 22:6717–6724. 2003. View Article : Google Scholar : PubMed/NCBI

32 

Simiantonaki N, Jayasinghe C, Michel-Schmidt R, Peters K, Hermanns MI and Kirkpatrick CJ: Hypoxia-induced epithelial VEGF-C/VEGFR-3 upregulation in carcinoma cell lines. Int J Oncol. 32:585–592. 2008.PubMed/NCBI

33 

Okada K, Osaki M, Araki K, Ishiguro K, Ito H and Ohgi S: Expression of hypoxia-inducible factor (HIF-1alpha), VEGF-C and VEGF-D in non-invasive and invasive breast ductal carcinomas. Anticancer Res. 25:3003–3009. 2005.PubMed/NCBI

34 

Liu ZY, Qiu HO, Yuan XJ, Ni YY, Sun JJ, Jing W and Fan YZ: Suppression of lymphangiogenesis in human lymphatic endothelial cells by simultaneously blocking VEGF-C and VEGF-D/VEGFR-3 with norcantharidin. Int J Oncol. 41:1762–1772. 2012. View Article : Google Scholar : PubMed/NCBI

35 

Su JL, Yen CJ, Chen PS, Chuang SE, Hong CC, Kuo IH, Chen HY, Hung MC and Kuo ML: The role of the VEGF-C/VEGFR-3 axis in cancer progression. Br J Cancer. 96:541–545. 2007. View Article : Google Scholar

36 

Teng X, Li D and Johns RA: Hypoxia up-regulates mouse vascular endothelial growth factor D promoter activity in rat pulmonary microvascular smooth-muscle cells. Chest. 121(Suppl): 82S–83S. 2002. View Article : Google Scholar : PubMed/NCBI

37 

O TM and Lou MS: Zinc effect on human lymphatic malformation cells in vitro. Int J Pediatr Otorhinolaryngol. 80:33–38. 2016. View Article : Google Scholar : PubMed/NCBI

38 

Boscolo E, Coma S, Luks VL, Greene AK, Klagsbrun M, Warman ML and Bischoff J: AKT hyper-phosphorylation associated with PI3K mutations in lymphatic endothelial cells from a patient with lymphatic malformation. Angiogenesis. 18:151–162. 2015. View Article : Google Scholar :

39 

Semenza GL: HIF-1 mediates metabolic responses to intra-tumoral hypoxia and oncogenic mutations. J Clin Invest. 123:3664–3671. 2013. View Article : Google Scholar : PubMed/NCBI

40 

Hong SS, Lee H and Kim KW: HIF-1alpha: A valid therapeutic target for tumor therapy. Cancer Res Treat. 36:343–353. 2004. View Article : Google Scholar : PubMed/NCBI

41 

Oliveira SL, Trujillo CA, Negraes PD and Ulrich H: Effects of ATP and NGF on Proliferation and Migration of Neural Precursor Cells. Neurochem Res. 40:1849–1857. 2015. View Article : Google Scholar : PubMed/NCBI

42 

Chen JB, Liu WJ, Che H, Liu J, Sun HY and Li GR: Adenosine-5′-triphosphate up-regulates proliferation of human cardiac fibroblasts. Br J Pharmacol. 166:1140–1150. 2012. View Article : Google Scholar : PubMed/NCBI

43 

Song X, Rui C, Meng L, Zhang R, Shen R, Ding H, Li J, Li J and Long W: Long non-coding RNA RPAIN regulates the invasion and apoptosis of trophoblast cell lines via complement protein C1q. Oncotarget. 8:7637–7646. 2017.

44 

Xia H, Li Y and Lv X: MicroRNA-107 inhibits tumor growth and metastasis by targeting the BDNF-mediated PI3K/AKT pathway in human non-small lung cancer. Int J Oncol. 49:1325–1333. 2016. View Article : Google Scholar : PubMed/NCBI

45 

Xie F, Huang Q, Liu CH, Lin XS, Liu Z, Liu LL, Huang DW and Zhou HC: MiR-1271 negatively regulates AKT/MTOR signaling and promotes apoptosis via targeting PDK1 in pancreatic cancer. Eur Rev Med Pharmacol Sci. 22:678–686. 2018.PubMed/NCBI

46 

Wang J, Yang S, Ge W, Wang Y, Han C and Li M: MiR-613 suppressed the laryngeal squamous cell carcinoma progression through regulating PDK1. J Cell Biochem. 119:5118–5125. 2018. View Article : Google Scholar

47 

Dai J, Wang J, Yang L, Xiao Y and Ruan Q: miR-125a regulates angiogenesis of gastric cancer by targeting vascular endothelial growth factor A. Int J Oncol. 47:1801–1810. 2015. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Han T, Yan J, Chen H, Ji Y, Chen J, Cui J, Shen W and Zou J: HIF-1α contributes to tube malformation of human lymphatic endothelial cells by upregulating VEGFR-3 Corrigendum in /10.3892/ijo.2022.5403. Int J Oncol 54: 139-151, 2019.
APA
Han, T., Yan, J., Chen, H., Ji, Y., Chen, J., Cui, J. ... Zou, J. (2019). HIF-1α contributes to tube malformation of human lymphatic endothelial cells by upregulating VEGFR-3 Corrigendum in /10.3892/ijo.2022.5403. International Journal of Oncology, 54, 139-151. https://doi.org/10.3892/ijo.2018.4623
MLA
Han, T., Yan, J., Chen, H., Ji, Y., Chen, J., Cui, J., Shen, W., Zou, J."HIF-1α contributes to tube malformation of human lymphatic endothelial cells by upregulating VEGFR-3 Corrigendum in /10.3892/ijo.2022.5403". International Journal of Oncology 54.1 (2019): 139-151.
Chicago
Han, T., Yan, J., Chen, H., Ji, Y., Chen, J., Cui, J., Shen, W., Zou, J."HIF-1α contributes to tube malformation of human lymphatic endothelial cells by upregulating VEGFR-3 Corrigendum in /10.3892/ijo.2022.5403". International Journal of Oncology 54, no. 1 (2019): 139-151. https://doi.org/10.3892/ijo.2018.4623
Copy and paste a formatted citation
x
Spandidos Publications style
Han T, Yan J, Chen H, Ji Y, Chen J, Cui J, Shen W and Zou J: HIF-1α contributes to tube malformation of human lymphatic endothelial cells by upregulating VEGFR-3 Corrigendum in /10.3892/ijo.2022.5403. Int J Oncol 54: 139-151, 2019.
APA
Han, T., Yan, J., Chen, H., Ji, Y., Chen, J., Cui, J. ... Zou, J. (2019). HIF-1α contributes to tube malformation of human lymphatic endothelial cells by upregulating VEGFR-3 Corrigendum in /10.3892/ijo.2022.5403. International Journal of Oncology, 54, 139-151. https://doi.org/10.3892/ijo.2018.4623
MLA
Han, T., Yan, J., Chen, H., Ji, Y., Chen, J., Cui, J., Shen, W., Zou, J."HIF-1α contributes to tube malformation of human lymphatic endothelial cells by upregulating VEGFR-3 Corrigendum in /10.3892/ijo.2022.5403". International Journal of Oncology 54.1 (2019): 139-151.
Chicago
Han, T., Yan, J., Chen, H., Ji, Y., Chen, J., Cui, J., Shen, W., Zou, J."HIF-1α contributes to tube malformation of human lymphatic endothelial cells by upregulating VEGFR-3 Corrigendum in /10.3892/ijo.2022.5403". International Journal of Oncology 54, no. 1 (2019): 139-151. https://doi.org/10.3892/ijo.2018.4623
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team