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Article

ERp57‑small interfering RNA silencing can enhance the sensitivity of drug‑resistant human ovarian cancer cells to paclitaxel

  • Authors:
    • Shuo Li
    • Xiaoyun Zhao
    • Shijie Chang
    • Yanqiu Li
    • Min Guo
    • Yifu Guan
  • View Affiliations / Copyright

    Affiliations: Department of Biochemistry and Molecular Biology, China Medical University, Shenyang, Liaoning 110122, P.R. China, Department of Microbiology and Cell Biology, Shenyang Pharmaceutical University, Shenyang, Liaoning 110016, P.R. China, Department of Biomedical Engineering, China Medical University, Shenyang, Liaoning 110122, P.R. China
  • Pages: 249-260
    |
    Published online on: November 7, 2018
       https://doi.org/10.3892/ijo.2018.4628
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Abstract

ERp57 has been identified to be associated with the chemoresistance of human ovarian cancer. However, its biological roles in the chemoresistance phenotype remain unclear. In the present study, the association of ERp57 with paclitaxel‑resistant cellular behavior was investigated and the sensitivity enhancement of chemoresistant human ovarian cancer cells to paclitaxel was examined using ERp57‑small interfering (si)RNA silencing. Cell viability, cell proliferation, cell apoptosis and cell migration were detected using an MTT assay, clonogenic assay, flow cytometry analysis and transwell assay. Furthermore, mRNA expression levels of ERp57 and protein expression levels of ERp57, STAT3, phosphorylated STAT3, PCNA, nucelolin, TUBB3, P-gp, vimentin, Bcl-2, Bax, Bcl-xl, p53, MMP1, MMP2 and MMP9 of paclitaxel-sensitive human SKOV3 ovarian cancer cells were compared with paclitaxel-resistant counterpart SKOV3/tax using the real-time PCR and western blot analysis. ERp57 was highly expressed in the paclitaxel‑resistant SKOV3/tax cells, and experimental results concluded that the paclitaxel‑resistance phenotype was due primarily to the activation of the STAT3 signaling pathway. ERp57 overexpression by lentiviral particle infection decreased the sensitivity of SKOV3 cells to paclitaxel. Furthermore, ERp57‑siRNA silencing restored paclitaxel sensitivity of SKOV3/tax cells. Notably, the IC50 value of ERp57‑siRNA silenced SKOV3/tax cells was reduced to the original level and colony survival was significantly decreased in comparison with that of SKOV3/tax cells. Additionally, co‑treatment of ERp57‑siRNA silencing and paclitaxel could inhibit the STAT3 signaling pathway and downregulate the expression levels of downstream proteins. Notably, ERp57‑siRNA and 100 nM paclitaxel co‑treatment downregulated Bcl‑2, Bcl‑xl, MMP2, MMP9, TUBB3 and P‑gp expression levels and upregulated the expression of Bax protein. Furthermore, co‑treatment promoted change of the isoform of p53 to p53/p47. Bioinformatics analyses supported the experimental observations that ERp57 was associated with drug resistance in ovarian cancer. The present study implies that ERp57 is a potential therapeutic target for the treatment of paclitaxel‑resistant human ovarian cancer.
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View References

1 

Gloss BS and Samimi G: Epigenetic biomarkers in epithelial ovarian cancer. Cancer Lett. 342:257–263. 2014. View Article : Google Scholar

2 

Sundar S, Wu J, Hillaby K, Yap J and Lilford R: A systematic review evaluating the relationship between progression free survival and post progression survival in advanced ovarian cancer. Gynecol Oncol. 125:493–499. 2012. View Article : Google Scholar

3 

Ziebarth AJ, Landen CN Jr and Alvarez RD: Molecular/genetic therapies in ovarian cancer: Future opportunities and challenges. Clin Obstet Gynecol. 55:156–172. 2012. View Article : Google Scholar : PubMed/NCBI

4 

Kipps E, Tan DS and Kaye SB: Meeting the challenge of ascites in ovarian cancer: New avenues for therapy and research. Nat Rev Cancer. 13:273–282. 2013. View Article : Google Scholar : PubMed/NCBI

5 

Ford JM, Bruggemann EP, Pastan I, Gottesman MM and Hait WN: Cellular and biochemical characterization of thioxanthenes for reversal of multidrug resistance in human and murine cell lines. Cancer Res. 50:1748–1756. 1990.PubMed/NCBI

6 

Ranganathan S, Benetatos CA, Colarusso PJ, Dexter DW and Hudes GR: Altered beta-tubulin isotype expression in paclitaxel-resistant human prostate carcinoma cells. Br J Cancer. 77:562–566. 1998. View Article : Google Scholar : PubMed/NCBI

7 

Hari M, Loganzo F, Annable T, Tan X, Musto S, Morilla DB, Nettles JH, Snyder JP and Greenberger LM: Paclitaxel-resistant cells have a mutation in the paclitaxel-binding region of beta-tubulin (Asp26Glu) and less stable microtubules. Mol Cancer Ther. 5:270–278. 2006. View Article : Google Scholar : PubMed/NCBI

8 

Haass NK, Beaumont KA, Hill DS, Anfosso A, Mrass P, Munoz MA, Kinjyo I and Weninger W: Real-time cell cycle imaging during melanoma growth, invasion, and drug response. Pigment Cell Melanoma Res. 27:764–776. 2014. View Article : Google Scholar : PubMed/NCBI

9 

Kapse-Mistry S, Govender T, Srivastava R and Yergeri M: Nanodrug delivery in reversing multidrug resistance in cancer cells. Front Pharmacol. 5:1592014.PubMed/NCBI

10 

Bordelon JR and Grichnik JM: TGF-β may control the switch between tumorigenic growth and ‘stem cell/mesenchymal’ potentially drug-resistant states. Dermatol Ther (Heidelb). 28:177–178. 2015. View Article : Google Scholar

11 

Bernardini M, Lee CH, Beheshti B, Prasad M, Albert M, Marrano P, Begley H, Shaw P, Covens A, Murphy J, et al: High-resolution mapping of genomic imbalance and identification of gene expression profiles associated with differential chemotherapy response in serous epithelial ovarian cancer. Neoplasia. 7:603–613. 2005. View Article : Google Scholar : PubMed/NCBI

12 

Cicchillitti L, Di Michele M, Urbani A, Ferlini C, Donat MB, Scambia G and Rotilio D: Comparative proteomic analysis of paclitaxel sensitive A2780 epithelial ovarian cancer cell line and its resistant counterpart A2780TC1 by 2D-DIGE: The role of ERp57. J Proteome Res. 8:1902–1912. 2009. View Article : Google Scholar : PubMed/NCBI

13 

Duan Z, Feller AJ, Penson RT, Chabner BA and Seiden MV: Discovery of differentially expressed genes associated with paclitaxel resistance using cDNA array technology: Analysis of interleukin (IL) 6, IL-8, and monocyte chemotactic protein 1 in the paclitaxel-resistant phenotype. Clin Cancer Res. 5:3445–3453. 1999.PubMed/NCBI

14 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods. 25:402–408. 2001. View Article : Google Scholar

15 

Szklarczyk D, Morris JH, Cook H, Kuhn M, Wyder S, Simonovic M, Santos A, Doncheva NT, Roth A, Bork P, et al: The STRING database in 2017: Quality-controlled protein-protein association networks, made broadly accessible. Nucleic Acids Res. 45D:D362–D368. 2017. View Article : Google Scholar

16 

Zuberi K, Franz M, Rodriguez H, Montojo J, Lopes CT, Bader GD and Morris Q: GeneMANIA prediction server 2013 update. Nucleic Acids Res. 41W:W115–W22. 2013. View Article : Google Scholar

17 

de Leeuw N, Dijkhuizen T, Hehir-Kwa JY, Carter NP, Feuk L, Firth HV, Kuhn RM, Ledbetter DH, Martin CL, van Ravenswaaij-Arts CM, et al: Diagnostic interpretation of array data using public databases and internet sources. Hum Mutat. 33:930–940. 2012. View Article : Google Scholar : PubMed/NCBI

18 

Huang W, Sherman BT and Lempicki RA: Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nat Protoc. 4:44–57. 2009. View Article : Google Scholar

19 

Vikhanskaya F, Erba E, D’Incalci M and Broggini M: Introduction of wild-type p53 in a human ovarian cancer cell line not expressing endogenous p53. Nucleic Acids Res. 22:1012–1017. 1994. View Article : Google Scholar : PubMed/NCBI

20 

Alaseem A, Alhazzani K, Dondapati P, Alobid S, Bishayee A and Rathinavelu A: Matrix Metalloproteinases: A challenging paradigm of cancer management. Semin Cancer Biol. Nov 16–2017.Epub ahead of print. View Article : Google Scholar : PubMed/NCBI

21 

Cicchillitti L, Della Corte A, Di Michele M, Donati MB, Rotilio D and Scambia G: Characterisation of a multimeric protein complex associated with ERp57 within the nucleus in paclitaxel-sensitive and -resistant epithelial ovarian cancer cells: The involvement of specific conformational states of beta-actin. Int J Oncol. 37:445–454. 2010. View Article : Google Scholar : PubMed/NCBI

22 

Haufroid V: Genetic polymorphisms of ATP-binding cassette transporters ABCB1 and ABCC2 and their impact on drug disposition. Curr Drug Targets. 12:631–646. 2011. View Article : Google Scholar

23 

Kwak JO, Lee SH, Lee GS, Kim MS, Ahn YG, Lee JH, Kim SW, Kim KH and Lee MG: Selective inhibition of MDR1 (ABCB1) by HM30181 increases oral bioavailability and therapeutic efficacy of paclitaxel. Eur J Pharmacol. 627:92–98. 2010. View Article : Google Scholar

24 

Calastretti A, Gatti G, Quaresmini C and Bevilacqua A: Down-modulation of Bcl-2 sensitizes PTEN-mutated prostate cancer cells to starvation and taxanes. Prostate. 74:1411–1422. 2014. View Article : Google Scholar : PubMed/NCBI

25 

Luo Y, Tong L, Meng H, Zhu W, Guo L, Wei T and Zhang J: MiR-335 regulates the chemo-radioresistance of small cell lung cancer cells by targeting PARP-1. Gene. 600:9–15. 2017. View Article : Google Scholar

26 

Friedrich K, Wieder T, Von Haefen C, Radetzki S, Jänicke R, Schulze-Osthoff K, Dörken B and Daniel PT: Overexpression of caspase-3 restores sensitivity for drug-induced apoptosis in breast cancer cell lines with acquired drug resistance. Oncogene. 20:2749–2760. 2001. View Article : Google Scholar : PubMed/NCBI

27 

Turano C, Gaucci E, Grillo C and Chichiarelli S: ERp57/GRP58: A protein with multiple functions. Cell Mol Biol Lett. 16:539–563. 2011. View Article : Google Scholar : PubMed/NCBI

28 

Khanal RC and Nemere I: The ERp57/GRp58/1,25D3-MARRS receptor: Multiple functional roles in diverse cell systems. Curr Med Chem. 14:1087–1093. 2007. View Article : Google Scholar : PubMed/NCBI

29 

Vigneron N, Peaper DR, Leonhardt RM and Cresswell P: Functional significance of tapasin membrane association and disulfide linkage to ERp57 in MHC class I presentation. Eur J Immunol. 39:2371–2376. 2009. View Article : Google Scholar : PubMed/NCBI

30 

Chapman DC and Williams DB: ER quality control in the biogenesis of MHC class I molecules. Semin Cell Dev Biol. 21:512–519. 2010. View Article : Google Scholar : PubMed/NCBI

31 

Frenkel Z, Shenkman M, Kondratyev M and Lederkremer GZ: Separate roles and different routing of calnexin and ERp57 in endoplasmic reticulum quality control revealed by interactions with asialoglycoprotein receptor chains. Mol Biol Cell. 15:2133–2142. 2004. View Article : Google Scholar : PubMed/NCBI

32 

Celli CM and Jaiswal AK: Role of GRP58 in mitomycin C-induced DNA cross-linking. Cancer Res. 63:6016–6025. 2003.PubMed/NCBI

33 

He Y, Shao F, Pi W, Shi C, Chen Y, Gong D, Wang B, Cao Z and Tang K: Largescale transcriptomics analysis suggests over-expression of BGH3, MMP9 and PDIA3 in oral squamous vell carcinoma. PLoS One. 11:e01465302016. View Article : Google Scholar

34 

Lovat PE, Corazzari M, Armstrong JL, Martin S, Pagliarini V, Hill D, Brown AM, Piacentini M, Birch-Machin MA and Redfern CP: Increasing melanoma cell death using inhibitors of protein disulfide isomerases to abrogate survival responses to endoplasmic reticulum stress. Cancer Res. 68:5363–5369. 2008. View Article : Google Scholar : PubMed/NCBI

35 

Corazzari M, Lovat PE, Armstrong JL, Fimia GM, Hill DS, Birch-Machin M, Redfern CP and Piacentini M: Targeting homeostatic mechanisms of endoplasmic reticulum stress to increase susceptibility of cancer cells to fenretinide-induced apoptosis: The role of stress proteins ERdj5 and ERp57. Br J Cancer. 96:1062–1071. 2007. View Article : Google Scholar : PubMed/NCBI

36 

Choe MH, Min JW, Jeon HB, Cho DH, Oh JS, Lee HG, Hwang SG, An S, Han YH and Kim JS: ERp57 modulates STAT3 activity in radioresistant laryngeal cancer cells and serves as a prognostic marker for laryngeal cancer. Oncotarget. 6:2654–2666. 2015. View Article : Google Scholar : PubMed/NCBI

37 

Bourougaa K, Naski N, Boularan C, Mlynarczyk C, Candeias MM, Marullo S and Fåhraeus R: Endoplasmic reticulum stress induces G2 cell-cycle arrest via mRNA translation of the p53 isoform p53/47. Mol Cell. 38:78–88. 2010. View Article : Google Scholar : PubMed/NCBI

38 

Candeias MM, Powell DJ, Roubalova E, Apcher S, Bourougaa K, Vojtesek B, Bruzzoni-Giovanelli H and Fåhraeus R: Expression of p53 and p53/47 are controlled by alternative mechanisms of messenger RNA translation initiation. Oncogene. 25:6936–6947. 2006. View Article : Google Scholar : PubMed/NCBI

39 

Carpenter RL and Lo HW: STAT3 target genes relevant to human cancers. Cancers (Basel). 6:897–925. 2014. View Article : Google Scholar

40 

Guo GG, Patel K, Kumar V, Shah M, Fried VA, Etlinger JD and Sehgal PB: Association of the chaperone glucose-regulated protein 58 (GRP58/ER-60/ERp57) with Stat3 in cytosol and plasma membrane complexes. J Interferon Cytokine Res. 22:555–563. 2002. View Article : Google Scholar : PubMed/NCBI

41 

Chichiarelli S, Gaucci E, Ferraro A, Grillo C, Altieri F, Cocchiola R, Arcangeli V, Turano C and Eufemi M: Role of ERp57 in the signaling and transcriptional activity of STAT3 in a melanoma cell line. Arch Biochem Biophys. 494:178–183. 2010. View Article : Google Scholar

42 

Eufemi M, Coppari S, Altieri F, Grillo C, Ferraro A and Turano C: ERp57 is present in STAT3-DNA complexes. Biochem Biophys Res Commun. 323:1306–1312. 2004. View Article : Google Scholar : PubMed/NCBI

43 

Gu F, Ma Y, Zhang Z, Zhao J, Kobayashi H, Zhang L and Fu L: Expression of Stat3 and Notch1 is associated with cisplatin resistance in head and neck squamous cell carcinoma. Oncol Rep. 23:671–676. 2010.PubMed/NCBI

44 

Zhu H, Chen X, Chen B, Chen B, Fan J, Song W, Xie Z, Jiang D, Li Q, Zhou M, et al: Activating transcription factor 4 mediates a multidrug resistance phenotype of esophageal squamous cell carcinoma cells through transactivation of STAT3 expression. Cancer Lett. 354:142–152. 2014. View Article : Google Scholar : PubMed/NCBI

45 

Ryu K, Susa M, Choy E, Yang C, Hornicek FJ, Mankin HJ and Duan Z: Oleanane triterpenoid CDDO-Me induces apoptosis in multidrug resistant osteosarcoma cells through inhibition of Stat3 pathway. BMC Cancer. 10:1872010. View Article : Google Scholar : PubMed/NCBI

46 

Gariboldi MB, Ravizza R, Molteni R, Osella D, Gabano E and Monti E: Inhibition of Stat3 increases doxorubicin sensitivity in a human metastatic breast cancer cell line. Cancer Lett. 258:181–188. 2007. View Article : Google Scholar : PubMed/NCBI

47 

Selvendiran K, Bratasz A, Kuppusamy ML, Tazi MF, Rivera BK and Kuppusamy P: Hypoxia induces chemoresistance in ovarian cancer cells by activation of signal transducer and activator of transcription 3. Int J Cancer. 125:2198–2204. 2009. View Article : Google Scholar : PubMed/NCBI

48 

Zhang F, Wang Z, Fan Y, Xu Q, Ji W, Tian R and Niu R: Elevated STAT3 signaling-mediated upregulation of MMP-2/9 confers enhanced invasion ability in multidrug-resistant breast cancer cells. Int J Mol Sci. 16:24772–24790. 2015. View Article : Google Scholar : PubMed/NCBI

49 

Yang JM, Xu Z, Wu H, Zhu H, Wu X and Hait WN: Overexpression of extracellular matrix metalloproteinase inducer in multidrug resistant cancer cells. Mol Cancer Res. 1:420–427. 2003.PubMed/NCBI

50 

Colone M, Calcabrini A, Toccacieli L, Bozzuto G, Stringaro A, Gentile M, Cianfriglia M, Ciervo A, Caraglia M, Budillon A, et al: The multidrug transporter P-glycoprotein: A mediator of melanoma invasion? J Invest Dermatol. 128:957–971. 2008. View Article : Google Scholar

51 

Hikawa T, Mori T, Abe T and Hori S: The ability in adhesion and invasion of drug-resistant human glioma cells. Journal of experimental and clinical cancer research CR (East Lansing Mich). 19:357–362. 2000.

52 

Işeri OD, Kars MD, Arpaci F and Gündüz U: Gene expression analysis of drug-resistant MCF-7 cells: Implications for relation to extracellular matrix proteins. Cancer Chemother Pharmacol. 65:447–455. 2010. View Article : Google Scholar

53 

Santana-Codina N, Carretero R, Sanz-Pamplona R, Cabrera T, Guney E, Oliva B, Clezardin P, Olarte OE, Loza-Alvarez P, Méndez-Lucas A, et al: A transcriptome-proteome integrated network identifies endoplasmic reticulum thiol oxidoreductase (ERp57) as a hub that mediates bone metastasis. Mol Cell Proteomics. 12:2111–2125. 2013. View Article : Google Scholar : PubMed/NCBI

54 

Xu D, Perez RE, Rezaiekhaligh MH, Bourdi M and Truog WE: Knockdown of ERp57 increases BiP/GRP78 induction and protects against hyperoxia and tunicamycin-induced apoptosis. Am J Physiol Lung Cell Mol Physiol. 297:L44–L51. 2009. View Article : Google Scholar : PubMed/NCBI

55 

Zhao G, Lu H and Li C: Proapoptotic activities of protein disulfide isomerase (PDI) and PDIA3 protein, a role of the Bcl-2 protein Bak. J Biol Chem. 290:8949–8963. 2015. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Li S, Zhao X, Chang S, Li Y, Guo M and Guan Y: ERp57‑small interfering RNA silencing can enhance the sensitivity of drug‑resistant human ovarian cancer cells to paclitaxel. Int J Oncol 54: 249-260, 2019.
APA
Li, S., Zhao, X., Chang, S., Li, Y., Guo, M., & Guan, Y. (2019). ERp57‑small interfering RNA silencing can enhance the sensitivity of drug‑resistant human ovarian cancer cells to paclitaxel. International Journal of Oncology, 54, 249-260. https://doi.org/10.3892/ijo.2018.4628
MLA
Li, S., Zhao, X., Chang, S., Li, Y., Guo, M., Guan, Y."ERp57‑small interfering RNA silencing can enhance the sensitivity of drug‑resistant human ovarian cancer cells to paclitaxel". International Journal of Oncology 54.1 (2019): 249-260.
Chicago
Li, S., Zhao, X., Chang, S., Li, Y., Guo, M., Guan, Y."ERp57‑small interfering RNA silencing can enhance the sensitivity of drug‑resistant human ovarian cancer cells to paclitaxel". International Journal of Oncology 54, no. 1 (2019): 249-260. https://doi.org/10.3892/ijo.2018.4628
Copy and paste a formatted citation
x
Spandidos Publications style
Li S, Zhao X, Chang S, Li Y, Guo M and Guan Y: ERp57‑small interfering RNA silencing can enhance the sensitivity of drug‑resistant human ovarian cancer cells to paclitaxel. Int J Oncol 54: 249-260, 2019.
APA
Li, S., Zhao, X., Chang, S., Li, Y., Guo, M., & Guan, Y. (2019). ERp57‑small interfering RNA silencing can enhance the sensitivity of drug‑resistant human ovarian cancer cells to paclitaxel. International Journal of Oncology, 54, 249-260. https://doi.org/10.3892/ijo.2018.4628
MLA
Li, S., Zhao, X., Chang, S., Li, Y., Guo, M., Guan, Y."ERp57‑small interfering RNA silencing can enhance the sensitivity of drug‑resistant human ovarian cancer cells to paclitaxel". International Journal of Oncology 54.1 (2019): 249-260.
Chicago
Li, S., Zhao, X., Chang, S., Li, Y., Guo, M., Guan, Y."ERp57‑small interfering RNA silencing can enhance the sensitivity of drug‑resistant human ovarian cancer cells to paclitaxel". International Journal of Oncology 54, no. 1 (2019): 249-260. https://doi.org/10.3892/ijo.2018.4628
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