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Article

β‑glucan, a dectin‑1 ligand, promotes macrophage M1 polarization via NF‑κB/autophagy pathway

  • Authors:
    • Xiuying Li
    • Hongli Luo
    • Yun Ye
    • Xuan Chen
    • Yuhong Zou
    • Jie Duan
    • Dong Xiang
  • View Affiliations / Copyright

    Affiliations: Department of Pharmacy, Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan 646000, P.R. China, Department of Gastrointestinal Surgery, Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan 646000, P.R. China
  • Pages: 271-282
    |
    Published online on: November 9, 2018
       https://doi.org/10.3892/ijo.2018.4630
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Abstract

Pro‑inflammatory (M1) macrophages have key roles in atherogenesis. As β‑glucan has been demonstrated to exert pro‑inflammatory effects, the present study examined whether β‑glucan exerts atherogenic effects via converting macrophages into M1 phenotype. The results from reverse transcription‑quantitative polymerase chain reaction, flow cytometry, western blotting and transmission electron microscope indicated that M1 macrophage markers inducible nitric oxide synthase and cluster of differentiation 80 were upregulated, dectin‑1 (a receptor for β‑glucan) expression and nuclear factor (NF)‑κB nuclear translocation were promoted, and autophagy level was inhibited following β‑glucan treatment of macrophages. Additionally, dectin‑1 small interfering RNA (siRNA), autophagy inducer rapamycin and NF‑κB inhibitor SN50 reversed the effects of β‑glucan on autophagy level and macrophage M1 polarization, suggesting that dectin‑1 and NF‑κB are upstream of autophagy in β‑glucan‑induced macrophage M1 polarization. Notably, simultaneous treatment with dectin‑1 siRNA and SN50 exhibited similar effects on β‑glucan‑reduced autophagy compared with dectin‑1 siRNA treatment alone. These findings demonstrate that dectin‑1 may mediate β‑glucan‑reduced autophagy through NF‑κB in macrophages. Accordingly, results from hematoxylin and eosin staining, western blotting and immunofluorescence staining demonstrated that β‑glucan accelerated the progress of atherosclerosis in apolipoprotein E‑deficient mice and modulated expression of dectin‑1, beclin‑1 and light chain 3II/I in aortas similarly to that observed in macrophages. These results indicate that dectin‑1 activation by β‑glucan exerts atherogenic effects via converting macrophages into M1 phenotype in an NF‑κB‑autophagy‑dependent pathway.
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1 

Fernández-Velasco M, González-Ramos S and Boscá L: Involvement of monocytes/macrophages as key factors in the development and progression of cardiovascular diseases. Biochem J. 458:187–193. 2014. View Article : Google Scholar : PubMed/NCBI

2 

Tabas I and Bornfeldt KE: Macrophage Phenotype and Function in Different Stages of Atherosclerosis. Circ Res. 118:653–667. 2016. View Article : Google Scholar : PubMed/NCBI

3 

Xu R, Li C, Wu Y, Shen L, Ma J, Qian J and Ge J: Role of KCa3.1 Channels in Macrophage Polarization and Its Relevance in Atherosclerotic Plaque Instability. Arterioscler Thromb Vasc Biol. 37:226–236. 2017. View Article : Google Scholar : PubMed/NCBI

4 

Fang S, Xu Y, Zhang Y, Tian J, Li J, Li Z, He Z, Chai R, Liu F, Zhang T, et al: Irgm1 promotes M1 but not M2 macrophage polarization in atherosclerosis pathogenesis and development. Atherosclerosis. 251:282–290. 2016. View Article : Google Scholar : PubMed/NCBI

5 

Colin S, Chinetti-Gbaguidi G and Staels B: Macrophage phenotypes in atherosclerosis. Immunol Rev. 262:153–166. 2014. View Article : Google Scholar : PubMed/NCBI

6 

McAlpine CS, Huang A, Emdin A, Banko NS, Beriault DR, Shi Y and Werstuck GH: Deletion of myeloid GSK3α attenuates atherosclerosis and promotes an M2 macrophage phenotype. Arterioscler Thromb Vasc Biol. 35:1113–1122. 2015. View Article : Google Scholar : PubMed/NCBI

7 

Peled M and Fisher EA: Dynamic aspects of macrophage polarization during atherosclerosis progression and regression. Front Immunol. 5:5792014. View Article : Google Scholar : PubMed/NCBI

8 

Sergin I, Evans TD, Zhang X, Bhattacharya S, Stokes CJ, Song E, Ali S, Dehestani B, Holloway KB, Micevych PS, et al: Exploiting macrophage autophagy-lysosomal biogenesis as a therapy for atherosclerosis. Nat Commun. 8:157502017. View Article : Google Scholar : PubMed/NCBI

9 

Masuyama A, Mita T, Azuma K, Osonoi Y, Nakajima K, Goto H, Nishida Y, Miyatsuka T, Mitsumata M and Watada H: Defective autophagy in vascular smooth muscle cells enhances athero-sclerotic plaque instability. Biochem Biophys Res Commun. Oct 11–2018.Epub ahead of print. View Article : Google Scholar

10 

Wang C, Xu W, Liang M, Huang D and Huang K: CTRP13 inhibits atherosclerosis via autophagy-lysosome-dependent degradation of CD36. FASEB J. Sep 17;2018Epub ahead of print.

11 

Liao X, Sluimer JC, Wang Y, Subramanian M, Brown K, Pattison JS, Robbins J, Martinez J and Tabas I: Macrophage autophagy plays a protective role in advanced atherosclerosis. Cell Metab. 15:545–553. 2012. View Article : Google Scholar : PubMed/NCBI

12 

Dai S, Wang B, Li W, Wang L, Song X, Guo C, Li Y, Liu F, Zhu F, Wang Q, et al: Systemic application of 3-methyladenine markedly inhibited atherosclerotic lesion in ApoE-/- mice by modulating autophagy, foam cell formation and immune-negative molecules. Cell Death Dis. 7:e24982016. View Article : Google Scholar

13 

Kou JY, Li Y, Zhong ZY, Jiang YQ, Li XS, Han XB, Liu ZN, Tian Y and Yang LM: Berberine-sonodynamic therapy induces autophagy and lipid unloading in macrophage. Cell Death Dis. 8:e25582017. View Article : Google Scholar : PubMed/NCBI

14 

Martinet W, De Bie M, Schrijvers DM, De Meyer GR, Herman AG and Kockx MM: 7-ketocholesterol induces protein ubiquitination, myelin figure formation, and light chain 3 processing in vascular smooth muscle cells. Arterioscler Thromb Vasc Biol. 24:2296–2301. 2004. View Article : Google Scholar : PubMed/NCBI

15 

Martinet W and De Meyer GR: Autophagy in atherosclerosis: A cell survival and death phenomenon with therapeutic potential. Circ Res. 104:304–317. 2009. View Article : Google Scholar : PubMed/NCBI

16 

Wang T, Zhang L, Hu J, Duan Y, Zhang M, Lin J, Man W, Pan X, Jiang Z, Zhang G, et al: Mst1 participates in the atherosclerosis progression through macrophage autophagy inhibition and macrophage apoptosis enhancement. J Mol Cell Cardiol. 98:108–116. 2016. View Article : Google Scholar : PubMed/NCBI

17 

Chan GC, Chan WK and Sze DM: The effects of beta-glucan on human immune and cancer cells. J Hematol Oncol. 2:252009. View Article : Google Scholar : PubMed/NCBI

18 

Li X, Wang J, Wang W, Liu C, Sun S, Gu J, Wang X, Boraschi D, Huang Y and Qu D: Immunomodulatory activity of a novel, synthetic beta-glucan (β-glu6) in murine macrophages and human peripheral blood mononuclear cells. PLoS One. 8:e803992013. View Article : Google Scholar

19 

Karumuthil-Melethil S, Gudi R, Johnson BM, Perez N and Vasu C: Fungal β-glucan, a Dectin-1 ligand, promotes protection from type 1 diabetes by inducing regulatory innate immune response. J Immunol. 193:3308–3321. 2014. View Article : Google Scholar : PubMed/NCBI

20 

Xu J, Liu D, Yin Q and Guo L: Tetrandrine suppresses β glucan induced macrophage activation via inhibiting NF κB, ERK and STAT3 signaling pathways. Mol Med Rep. 13:5177–5184. 2016. View Article : Google Scholar : PubMed/NCBI

21 

Brown GD and Gordon S: Immune recognition. A new receptor for beta-glucans Nature. 413:36–37. 2001.

22 

Brown GD, Taylor PR, Reid DM, Willment JA, Williams DL, Martinez-Pomares L, Wong SY and Gordon S: Dectin-1 is a major beta-glucan receptor on macrophages. J Exp Med. 196:407–412. 2002. View Article : Google Scholar : PubMed/NCBI

23 

Taylor PR, Tsoni SV, Willment JA, Dennehy KM, Rosas M, Findon H, Haynes K, Steele C, Botto M, Gordon S, et al: Dectin-1 is required for beta-glucan recognition and control of fungal infection. Nat Immunol. 8:31–38. 2007. View Article : Google Scholar

24 

Brown GD, Herre J, Williams DL, Willment JA, Marshall AS and Gordon S: Dectin-1 mediates the biological effects of beta-glucans. J Exp Med. 197:1119–1124. 2003. View Article : Google Scholar : PubMed/NCBI

25 

Steele C, Marrero L, Swain S, Harmsen AG, Zheng M, Brown GD, Gordon S, Shellito JE and Kolls JK: Alveolar macrophage-mediated killing of Pneumocystis carinii fsp muris involves molecular recognition by the Dectin-1 beta-glucan receptor. J Exp Med. 198:1677–1688. 2003. View Article : Google Scholar : PubMed/NCBI

26 

Gantner BN, Simmons RM, Canavera SJ, Akira S and Underhill DM: Collaborative induction of inflammatory responses by dectin-1 and Toll-like receptor 2. J Exp Med. 197:1107–1117. 2003. View Article : Google Scholar : PubMed/NCBI

27 

Goodridge HS, Wolf AJ and Underhill DM: Beta-glucan recognition by the innate immune system. Immunol Rev. 230:38–50. 2009. View Article : Google Scholar : PubMed/NCBI

28 

Liu M, Luo F, Ding C, Albeituni S, Hu X, Ma Y, Cai Y, McNally L, Sanders MA, Jain D, et al: Dectin-1 activation by a natural product β-glucan converts immunosuppressive macrophages into an M1-like phenotype. J Immunol. 195:5055–5065. 2015. View Article : Google Scholar : PubMed/NCBI

29 

Tam JM, Mansour MK, Khan NS, Seward M, Puranam S, Tanne A, Sokolovska A, Becker CE, Acharya M, Baird MA, et al: Dectin-1-dependent LC3 recruitment to phagosomes enhances fungicidal activity in macrophages. J Infect Dis. 210:1844–1854. 2014. View Article : Google Scholar : PubMed/NCBI

30 

Öhman T, Teirilä L, Lahesmaa-Korpinen AM, Cypryk W, Veckman V, Saijo S, Wolff H, Hautaniemi S, Nyman TA and Matikainen S: Dectin-1 pathway activates robust autophagy-dependent unconventional protein secretion in human macrophages. J Immunol. 192:5952–5962. 2014. View Article : Google Scholar : PubMed/NCBI

31 

Li X, Zhou Y, Yu C, Yang H, Zhang C, Ye Y and Xiao S: Paeonol suppresses lipid accumulation in macrophages via upregulation of the ATP binding cassette transporter A1 and downregulation of the cluster of differentiation 36. Int J Oncol. 46:764–774. 2015. View Article : Google Scholar

32 

Jang CW, Shibata Y, Starmer J, Yee D and Magnuson T: Histone H3.3 maintains genome integrity during mammalian development. Genes Dev. 29:1377–1392. 2015. View Article : Google Scholar : PubMed/NCBI

33 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar

34 

Deng X, Zhang J, Liu Y, Chen L and Yu C: TNF-α regulates the proteolytic degradation of ST6Gal-1 and endothelial cell-cell junctions through upregulating expression of BACE1. Sci Rep. 7:402562017. View Article : Google Scholar

35 

Wang Y, Li Y, Li H, Song H, Zhai N, Lou L, Wang F, Zhang K, Bao W, Jin X, et al: Brucella Dysregulates Monocytes and Inhibits Macrophage Polarization through LC3-Dependent Autophagy. Front Immunol. 8:6912017. View Article : Google Scholar :

36 

Zhang Y, Morgan MJ, Chen K, Choksi S and Liu ZG: Induction of autophagy is essential for monocyte-macrophage differentiation. Blood. 119:2895–2905. 2012. View Article : Google Scholar : PubMed/NCBI

37 

Vannucci L, Krizan J, Sima P, Stakheev D, Caja F, Rajsiglova L, Horak V and Saieh M: Immunostimulatory properties and antitumor activities of glucans (Review). Int J Oncol. 43:357–364. 2013. View Article : Google Scholar : PubMed/NCBI

38 

Chang CF, Liao KC and Chen CH: 2-Phenylnaphthalene Derivatives Inhibit Lipopolysaccharide-Induced Pro-Inflammatory Mediators by Downregulating of MAPK/NF-κB Pathways in RAW 264.7 Macrophage Cells. PLoS One. 12:e01689452017. View Article : Google Scholar

39 

Chian CF, Chiang CH, Chuang CH, Liu SL and Tsai CL: SN50, a Cell-Permeable Inhibitor of Nuclear Factor-κB, Attenuates Ventilator-Induced Lung Injury in an Isolated and Perfused Rat Lung Model. Shock. 46:194–201. 2016. View Article : Google Scholar : PubMed/NCBI

40 

Kanarek N and Ben-Neriah Y: Regulation of NF-κB by ubiquitination and degradation of the IκBs. Immunol Rev. 246:77–94. 2012. View Article : Google Scholar : PubMed/NCBI

41 

Hou X, Xiao H, Zhang Y, Zeng X, Huang M, Chen X, Birnbaumer L and Liao Y: Transient receptor potential channel 6 knockdown prevents apoptosis of renal tubular epithelial cells upon oxidative stress via autophagy activation. Cell Death Dis. 9:10152018. View Article : Google Scholar : PubMed/NCBI

42 

Kirbis S, Breskvar UD, Sabovic M, Zupan I and Sinkovic A: Inflammation markers in patients with coronary artery disease - comparison of intracoronary and systemic levels. Wien Klin Wochenschr. 122(Suppl 2): 31–34. 2010. View Article : Google Scholar

43 

Jetten N, Verbruggen S, Gijbels MJ, Post MJ, De Winther MP and Donners MM: Anti-inflammatory M2, but not pro-inflammatory M1 macrophages promote angiogenesis in vivo. Angiogenesis. 17:109–118. 2014. View Article : Google Scholar

44 

Lee CG, Homer RJ, Zhu Z, Lanone S, Wang X, Koteliansky V, Shipley JM, Gotwals P, Noble P, Chen Q, et al: Interleukin-13 induces tissue fibrosis by selectively stimulating and activating transforming growth factor beta(1). J Exp Med. 194:809–821. 2001. View Article : Google Scholar : PubMed/NCBI

45 

Sierra-Filardi E, Vega MA, Sánchez-Mateos P, Corbí AL and Puig-Kröger A: Heme Oxygenase-1 expression in M-CSF-polarized M2 macrophages contributes to LPS-induced IL-10 release. Immunobiology. 215:788–795. 2010. View Article : Google Scholar : PubMed/NCBI

46 

Harris J: Autophagy and cytokines. Cytokine. 56:140–144. 2011. View Article : Google Scholar : PubMed/NCBI

47 

Moore KJ and Tabas I: Macrophages in the pathogenesis of atherosclerosis. Cell. 145:341–355. 2011. View Article : Google Scholar : PubMed/NCBI

48 

Murray PJ and Wynn TA: Protective and pathogenic functions of macrophage subsets. Nat Rev Immunol. 11:723–737. 2011. View Article : Google Scholar : PubMed/NCBI

49 

Zhang Y and Ren J: Epigenetics and obesity cardiomyopathy: From pathophysiology to prevention and management. Pharmacol Ther. 161:52–66. 2016. View Article : Google Scholar : PubMed/NCBI

50 

Zhang Y, Xu X and Ren J: MTOR overactivation and interrupted autophagy flux in obese hearts: A dicey assembly? Autophagy. 9:939–941. 2013. View Article : Google Scholar : PubMed/NCBI

51 

Razani B, Feng C, Coleman T, Emanuel R, Wen H, Hwang S, Ting JP, Virgin HW, Kastan MB and Semenkovich CF: Autophagy links inflammasomes to atherosclerotic progression. Cell Metab. 15:534–544. 2012. View Article : Google Scholar : PubMed/NCBI

52 

Verheye S, Martinet W, Kockx MM, Knaapen MW, Salu K, Timmermans JP, Ellis JT, Kilpatrick DL and De Meyer GR: Selective clearance of macrophages in atherosclerotic plaques by autophagy. J Am Coll Cardiol. 49:706–715. 2007. View Article : Google Scholar : PubMed/NCBI

53 

Baldwin AS: Regulation of cell death and autophagy by IKK and NF-κB: Critical mechanisms in immune function and cancer. Immunol Rev. 246:327–345. 2012. View Article : Google Scholar : PubMed/NCBI

54 

Lim MK, Ku SK, Choi JS and Kim JW: Effect of polycan, a β-glucan originating from Aureobasidium, on a high-fat diet-induced hyperlipemic hamster model. Exp Ther Med. 9:1369–1378. 2015. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Li X, Luo H, Ye Y, Chen X, Zou Y, Duan J and Xiang D: β‑glucan, a dectin‑1 ligand, promotes macrophage M1 polarization via NF‑κB/autophagy pathway. Int J Oncol 54: 271-282, 2019.
APA
Li, X., Luo, H., Ye, Y., Chen, X., Zou, Y., Duan, J., & Xiang, D. (2019). β‑glucan, a dectin‑1 ligand, promotes macrophage M1 polarization via NF‑κB/autophagy pathway. International Journal of Oncology, 54, 271-282. https://doi.org/10.3892/ijo.2018.4630
MLA
Li, X., Luo, H., Ye, Y., Chen, X., Zou, Y., Duan, J., Xiang, D."β‑glucan, a dectin‑1 ligand, promotes macrophage M1 polarization via NF‑κB/autophagy pathway". International Journal of Oncology 54.1 (2019): 271-282.
Chicago
Li, X., Luo, H., Ye, Y., Chen, X., Zou, Y., Duan, J., Xiang, D."β‑glucan, a dectin‑1 ligand, promotes macrophage M1 polarization via NF‑κB/autophagy pathway". International Journal of Oncology 54, no. 1 (2019): 271-282. https://doi.org/10.3892/ijo.2018.4630
Copy and paste a formatted citation
x
Spandidos Publications style
Li X, Luo H, Ye Y, Chen X, Zou Y, Duan J and Xiang D: β‑glucan, a dectin‑1 ligand, promotes macrophage M1 polarization via NF‑κB/autophagy pathway. Int J Oncol 54: 271-282, 2019.
APA
Li, X., Luo, H., Ye, Y., Chen, X., Zou, Y., Duan, J., & Xiang, D. (2019). β‑glucan, a dectin‑1 ligand, promotes macrophage M1 polarization via NF‑κB/autophagy pathway. International Journal of Oncology, 54, 271-282. https://doi.org/10.3892/ijo.2018.4630
MLA
Li, X., Luo, H., Ye, Y., Chen, X., Zou, Y., Duan, J., Xiang, D."β‑glucan, a dectin‑1 ligand, promotes macrophage M1 polarization via NF‑κB/autophagy pathway". International Journal of Oncology 54.1 (2019): 271-282.
Chicago
Li, X., Luo, H., Ye, Y., Chen, X., Zou, Y., Duan, J., Xiang, D."β‑glucan, a dectin‑1 ligand, promotes macrophage M1 polarization via NF‑κB/autophagy pathway". International Journal of Oncology 54, no. 1 (2019): 271-282. https://doi.org/10.3892/ijo.2018.4630
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