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Review

Full-length osteopontin and its splice variants as modulators of chemoresistance and radioresistance (Review)

  • Authors:
    • Etel R.P. Gimba
    • Mariana C.M. Brum
    • Gabriela Nestal De Moraes
  • View Affiliations / Copyright

    Affiliations: Program of Cellular and Molecular Oncobiology, National Cancer Institute, Rio de Janeiro 20231-050, Brazil, Cellular and Molecular Hemato-Oncology Laboratory, Molecular Hemato-Oncology Program, National Cancer Institute, Rio de Janeiro 20230-130, Brazil
  • Pages: 420-430
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    Published online on: December 6, 2018
       https://doi.org/10.3892/ijo.2018.4656
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Abstract

Osteopontin (OPN) is a matricellular phosphoglycoprotein overexpressed in several tumor types and can activate several aspects of cancer progression in solid and non‑solid tumors. In the present review, the roles of OPN in mediating resistance to chemotherapy and radiotherapy and their main associated signaling pathways were summarized and discussed. Furthermore, it was detailed how OPN expression may be able to modulate resistance to these therapies by controlling epithelial cell plasticity, stemness potential and cell survival. Based on these data, the use of OPN and associated signaling was then proposed as potential molecular targets in order to sensitize resistant cells to main current therapeutic approaches. Finally, based on experimental evidence obtained by our group, the importance of investigating the specific roles OPN splicing isoforms have and how their properties may specifically control resistance to therapy was highlighted. These data elucidate a better understanding of how total OPN and their splicing isoforms, as well as their associated signaling, may contribute to main aspects of chemoresistance and radioresistance, such as those controlling cell survival, apoptosis, autophagy, stemness, epithelial cell plasticity and associated cell receptors.
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Copy and paste a formatted citation
Spandidos Publications style
Gimba ER, Brum MC and Nestal De Moraes G: Full-length osteopontin and its splice variants as modulators of chemoresistance and radioresistance (Review). Int J Oncol 54: 420-430, 2019.
APA
Gimba, E.R., Brum, M.C., & Nestal De Moraes, G. (2019). Full-length osteopontin and its splice variants as modulators of chemoresistance and radioresistance (Review). International Journal of Oncology, 54, 420-430. https://doi.org/10.3892/ijo.2018.4656
MLA
Gimba, E. R., Brum, M. C., Nestal De Moraes, G."Full-length osteopontin and its splice variants as modulators of chemoresistance and radioresistance (Review)". International Journal of Oncology 54.2 (2019): 420-430.
Chicago
Gimba, E. R., Brum, M. C., Nestal De Moraes, G."Full-length osteopontin and its splice variants as modulators of chemoresistance and radioresistance (Review)". International Journal of Oncology 54, no. 2 (2019): 420-430. https://doi.org/10.3892/ijo.2018.4656
Copy and paste a formatted citation
x
Spandidos Publications style
Gimba ER, Brum MC and Nestal De Moraes G: Full-length osteopontin and its splice variants as modulators of chemoresistance and radioresistance (Review). Int J Oncol 54: 420-430, 2019.
APA
Gimba, E.R., Brum, M.C., & Nestal De Moraes, G. (2019). Full-length osteopontin and its splice variants as modulators of chemoresistance and radioresistance (Review). International Journal of Oncology, 54, 420-430. https://doi.org/10.3892/ijo.2018.4656
MLA
Gimba, E. R., Brum, M. C., Nestal De Moraes, G."Full-length osteopontin and its splice variants as modulators of chemoresistance and radioresistance (Review)". International Journal of Oncology 54.2 (2019): 420-430.
Chicago
Gimba, E. R., Brum, M. C., Nestal De Moraes, G."Full-length osteopontin and its splice variants as modulators of chemoresistance and radioresistance (Review)". International Journal of Oncology 54, no. 2 (2019): 420-430. https://doi.org/10.3892/ijo.2018.4656
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