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Article Open Access

High PLK4 expression promotes tumor progression and induces epithelial‑mesenchymal transition by regulating the Wnt/β‑catenin signaling pathway in colorectal cancer

Corrigendum in: /10.3892/ijo.2021.5213
Corrigendum in: /10.3892/ijo.2021.5291
  • Authors:
    • Zhibin Liao
    • Hongwei Zhang
    • Pan Fan
    • Qibo Huang
    • Keshuai Dong
    • Yongqiang Qi
    • Jia Song
    • Lin Chen
    • Huifang Liang
    • Xiaoping Chen
    • Zhanguo Zhang
    • Bixiang Zhang
  • View Affiliations / Copyright

    Affiliations: Hepatic Surgery Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, P.R. China, Department of Clinical Medicine, Medical College of Wuhan University of Science and Technology, Wuhan, Hubei 430081, P.R. China
    Copyright: © Liao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 479-490
    |
    Published online on: December 10, 2018
       https://doi.org/10.3892/ijo.2018.4659
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Abstract

Polo‑like kinase 4 (PLK4) has been identified as an oncogene, which is overexpressed in various types of human cancer; however, its role in colorectal cancer (CRC) development remains unknown. The present study demonstrated that PLK4 protein expression was upregulated in CRC tissues compared with in normal tissues through western blotting. In addition, immunohistochemical analysis of 39 CRC specimens further demonstrated that PLK4 protein expression was upregulated in 64.1% (25/39) of samples. Increased PLK4 expression was closely associated with enhanced tumor size (P=0.031), lymph node metastasis (P=0.016) and TNM stage (P=0.001). Subsequently, cell viability, wound scratch, migration and invasion assays were conducted in vitro, and nude mice CRC xenograft models were generated. The results demonstrated that knockdown of PLK4 in CRC cells resulted in significant decreases in cell viability and proliferation, and decreased the protein expression levels of N‑cadherin and snail, which are biomarkers of epithelial‑mesenchymal transition. Furthermore, PLK4 knockdown inactivated the Wnt/β‑catenin pathway in CRC cells in vitro and in vivo, and suppressed the growth of xenograft tumors in nude mice. In conclusion, these results suggested that PLK4 may promote the carcinogenesis and metastasis of CRC, thus indicating that PLK4 may be considered a molecular target for CRC treatment.
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Copy and paste a formatted citation
Spandidos Publications style
Liao Z, Zhang H, Fan P, Huang Q, Dong K, Qi Y, Song J, Chen L, Liang H, Chen X, Chen X, et al: High PLK4 expression promotes tumor progression and induces epithelial‑mesenchymal transition by regulating the Wnt/β‑catenin signaling pathway in colorectal cancer Corrigendum in /10.3892/ijo.2021.5213 Corrigendum in /10.3892/ijo.2021.5291. Int J Oncol 54: 479-490, 2019.
APA
Liao, Z., Zhang, H., Fan, P., Huang, Q., Dong, K., Qi, Y. ... Zhang, B. (2019). High PLK4 expression promotes tumor progression and induces epithelial‑mesenchymal transition by regulating the Wnt/β‑catenin signaling pathway in colorectal cancer Corrigendum in /10.3892/ijo.2021.5213 Corrigendum in /10.3892/ijo.2021.5291. International Journal of Oncology, 54, 479-490. https://doi.org/10.3892/ijo.2018.4659
MLA
Liao, Z., Zhang, H., Fan, P., Huang, Q., Dong, K., Qi, Y., Song, J., Chen, L., Liang, H., Chen, X., Zhang, Z., Zhang, B."High PLK4 expression promotes tumor progression and induces epithelial‑mesenchymal transition by regulating the Wnt/β‑catenin signaling pathway in colorectal cancer Corrigendum in /10.3892/ijo.2021.5213 Corrigendum in /10.3892/ijo.2021.5291". International Journal of Oncology 54.2 (2019): 479-490.
Chicago
Liao, Z., Zhang, H., Fan, P., Huang, Q., Dong, K., Qi, Y., Song, J., Chen, L., Liang, H., Chen, X., Zhang, Z., Zhang, B."High PLK4 expression promotes tumor progression and induces epithelial‑mesenchymal transition by regulating the Wnt/β‑catenin signaling pathway in colorectal cancer Corrigendum in /10.3892/ijo.2021.5213 Corrigendum in /10.3892/ijo.2021.5291". International Journal of Oncology 54, no. 2 (2019): 479-490. https://doi.org/10.3892/ijo.2018.4659
Copy and paste a formatted citation
x
Spandidos Publications style
Liao Z, Zhang H, Fan P, Huang Q, Dong K, Qi Y, Song J, Chen L, Liang H, Chen X, Chen X, et al: High PLK4 expression promotes tumor progression and induces epithelial‑mesenchymal transition by regulating the Wnt/β‑catenin signaling pathway in colorectal cancer Corrigendum in /10.3892/ijo.2021.5213 Corrigendum in /10.3892/ijo.2021.5291. Int J Oncol 54: 479-490, 2019.
APA
Liao, Z., Zhang, H., Fan, P., Huang, Q., Dong, K., Qi, Y. ... Zhang, B. (2019). High PLK4 expression promotes tumor progression and induces epithelial‑mesenchymal transition by regulating the Wnt/β‑catenin signaling pathway in colorectal cancer Corrigendum in /10.3892/ijo.2021.5213 Corrigendum in /10.3892/ijo.2021.5291. International Journal of Oncology, 54, 479-490. https://doi.org/10.3892/ijo.2018.4659
MLA
Liao, Z., Zhang, H., Fan, P., Huang, Q., Dong, K., Qi, Y., Song, J., Chen, L., Liang, H., Chen, X., Zhang, Z., Zhang, B."High PLK4 expression promotes tumor progression and induces epithelial‑mesenchymal transition by regulating the Wnt/β‑catenin signaling pathway in colorectal cancer Corrigendum in /10.3892/ijo.2021.5213 Corrigendum in /10.3892/ijo.2021.5291". International Journal of Oncology 54.2 (2019): 479-490.
Chicago
Liao, Z., Zhang, H., Fan, P., Huang, Q., Dong, K., Qi, Y., Song, J., Chen, L., Liang, H., Chen, X., Zhang, Z., Zhang, B."High PLK4 expression promotes tumor progression and induces epithelial‑mesenchymal transition by regulating the Wnt/β‑catenin signaling pathway in colorectal cancer Corrigendum in /10.3892/ijo.2021.5213 Corrigendum in /10.3892/ijo.2021.5291". International Journal of Oncology 54, no. 2 (2019): 479-490. https://doi.org/10.3892/ijo.2018.4659
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