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From chemotherapy to biological therapy: A review of novel concepts to reduce the side effects of systemic cancer treatment (Review)

  • Authors:
    • Volker Schirrmacher
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    Affiliations: Immunological and Oncological Center Cologne (IOZK), D-50674 Cologne, Germany
    Copyright: © Schirrmacher et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 407-419
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    Published online on: December 10, 2018
       https://doi.org/10.3892/ijo.2018.4661
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Abstract

The side effects of systemic chemotherapy used to treat cancer are often severe. For decades, oncologists have focused on treating the tumor, which may result in damage to the tumor‑bearing host and its immune system. Recently, much attention has been paid to the immune system of patients and its activation via biological therapies. Biological therapies, including immunotherapy and oncolytic virus (OV) therapy, are often more physiological and well tolerated. The present review elucidated how these therapies work and why these therapies may be better tolerated: i) In contrast to chemotherapy, immunotherapies induce a memory function of the adaptive immunity system; ii) immunotherapies aim to specifically activate the immune system against cancer; side effects are low due to immune tolerance mechanisms, which maintain the integrity of the body in the presence of B and T lymphocytes with their antigen‑receptor specificities and; iii) the type I interferon response, which is evoked by OVs, is an ancient innate immune defense system. Biological and physiological therapies, which support the immune system, may therefore benefit cancer treatment. The present review focused on immunotherapy, with the aim of reducing side effects and increasing long‑lasting efficacy in cancer therapy.
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Copy and paste a formatted citation
Spandidos Publications style
Schirrmacher V: From chemotherapy to biological therapy: A review of novel concepts to reduce the side effects of systemic cancer treatment (Review). Int J Oncol 54: 407-419, 2019.
APA
Schirrmacher, V. (2019). From chemotherapy to biological therapy: A review of novel concepts to reduce the side effects of systemic cancer treatment (Review). International Journal of Oncology, 54, 407-419. https://doi.org/10.3892/ijo.2018.4661
MLA
Schirrmacher, V."From chemotherapy to biological therapy: A review of novel concepts to reduce the side effects of systemic cancer treatment (Review)". International Journal of Oncology 54.2 (2019): 407-419.
Chicago
Schirrmacher, V."From chemotherapy to biological therapy: A review of novel concepts to reduce the side effects of systemic cancer treatment (Review)". International Journal of Oncology 54, no. 2 (2019): 407-419. https://doi.org/10.3892/ijo.2018.4661
Copy and paste a formatted citation
x
Spandidos Publications style
Schirrmacher V: From chemotherapy to biological therapy: A review of novel concepts to reduce the side effects of systemic cancer treatment (Review). Int J Oncol 54: 407-419, 2019.
APA
Schirrmacher, V. (2019). From chemotherapy to biological therapy: A review of novel concepts to reduce the side effects of systemic cancer treatment (Review). International Journal of Oncology, 54, 407-419. https://doi.org/10.3892/ijo.2018.4661
MLA
Schirrmacher, V."From chemotherapy to biological therapy: A review of novel concepts to reduce the side effects of systemic cancer treatment (Review)". International Journal of Oncology 54.2 (2019): 407-419.
Chicago
Schirrmacher, V."From chemotherapy to biological therapy: A review of novel concepts to reduce the side effects of systemic cancer treatment (Review)". International Journal of Oncology 54, no. 2 (2019): 407-419. https://doi.org/10.3892/ijo.2018.4661
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