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Article

The Wnt modulator ICG‑001 mediates the inhibition of nasopharyngeal carcinoma cell migration in vitro via the miR‑150/CD44 axis

  • Authors:
    • Lai‑Sheung Chan
    • On‑Ying Man
    • Hoi‑Hin Kwok
    • Luo Chen
    • King‑Chi Chan
    • Hong‑Lok Lung
    • Roger Kai‑Cheong Ngan
    • Ricky Ngok‑Shun Wong
    • Kwok‑Wai Lo
    • Anne Wing‑Mui Lee
    • George Sai‑Wah Tsao
    • Michael Kahn
    • Maria Li Lung
    • Nai‑Ki Mak
  • View Affiliations / Copyright

    Affiliations: Department of Biology, Hong Kong Baptist University, Hong Kong, P.R. China, Center for Nasopharyngeal Carcinoma Research, University of Hong Kong, Hong Kong, P.R. China, Department of Anatomical and Cellular Pathology, State Key Laboratory of Translational Oncology, The Chinese University of Hong Kong, Hong Kong, P.R. China, Department of Molecular Medicine, Beckman Research Institute at City of Hope, Duarte, CA 91010, USA
  • Pages: 1010-1020
    |
    Published online on: December 12, 2018
       https://doi.org/10.3892/ijo.2018.4664
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Abstract

The Wnt signaling pathway is known to serve an important role in the control of cell migration. The present study analyzed the mechanisms underlying the in vitro modulation of the migration of nasopharyngeal carcinoma (NPC) cells by the CREB‑binding protein/catenin antagonist and Wnt modulator ICG‑001. The results revealed that ICG‑001‑mediated inhibition of tumor cell migration involved downregulated mRNA and protein expression of the Wnt target gene cluster of differentiation (CD)44. It was also demonstrated that ICG‑001 downregulated the expression of CD44, and this effect was accompanied by restored expression of microRNA (miRNA)‑150 in various NPC cell lines. Using a CD44 3'‑untranslated region luciferase reporter assay, miR‑150 was confirmed to be a novel CD44‑targeting miRNA, which could directly target CD44 and subsequently regulate the migration of NPC cells. The present study provides further insight into the inhibition of tumor cell migration through the modulation of miRNA expression by the Wnt modulator ICG‑001.
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Copy and paste a formatted citation
Spandidos Publications style
Chan LS, Man OY, Kwok HH, Chen L, Chan KC, Lung HL, Ngan RC, Wong RS, Lo KW, Lee AM, Lee AM, et al: The Wnt modulator ICG‑001 mediates the inhibition of nasopharyngeal carcinoma cell migration in vitro via the miR‑150/CD44 axis. Int J Oncol 54: 1010-1020, 2019.
APA
Chan, L., Man, O., Kwok, H., Chen, L., Chan, K., Lung, H. ... Mak, N. (2019). The Wnt modulator ICG‑001 mediates the inhibition of nasopharyngeal carcinoma cell migration in vitro via the miR‑150/CD44 axis. International Journal of Oncology, 54, 1010-1020. https://doi.org/10.3892/ijo.2018.4664
MLA
Chan, L., Man, O., Kwok, H., Chen, L., Chan, K., Lung, H., Ngan, R., Wong, R., Lo, K., Lee, A., Tsao, G., Kahn, M., Lung, M., Mak, N."The Wnt modulator ICG‑001 mediates the inhibition of nasopharyngeal carcinoma cell migration in vitro via the miR‑150/CD44 axis". International Journal of Oncology 54.3 (2019): 1010-1020.
Chicago
Chan, L., Man, O., Kwok, H., Chen, L., Chan, K., Lung, H., Ngan, R., Wong, R., Lo, K., Lee, A., Tsao, G., Kahn, M., Lung, M., Mak, N."The Wnt modulator ICG‑001 mediates the inhibition of nasopharyngeal carcinoma cell migration in vitro via the miR‑150/CD44 axis". International Journal of Oncology 54, no. 3 (2019): 1010-1020. https://doi.org/10.3892/ijo.2018.4664
Copy and paste a formatted citation
x
Spandidos Publications style
Chan LS, Man OY, Kwok HH, Chen L, Chan KC, Lung HL, Ngan RC, Wong RS, Lo KW, Lee AM, Lee AM, et al: The Wnt modulator ICG‑001 mediates the inhibition of nasopharyngeal carcinoma cell migration in vitro via the miR‑150/CD44 axis. Int J Oncol 54: 1010-1020, 2019.
APA
Chan, L., Man, O., Kwok, H., Chen, L., Chan, K., Lung, H. ... Mak, N. (2019). The Wnt modulator ICG‑001 mediates the inhibition of nasopharyngeal carcinoma cell migration in vitro via the miR‑150/CD44 axis. International Journal of Oncology, 54, 1010-1020. https://doi.org/10.3892/ijo.2018.4664
MLA
Chan, L., Man, O., Kwok, H., Chen, L., Chan, K., Lung, H., Ngan, R., Wong, R., Lo, K., Lee, A., Tsao, G., Kahn, M., Lung, M., Mak, N."The Wnt modulator ICG‑001 mediates the inhibition of nasopharyngeal carcinoma cell migration in vitro via the miR‑150/CD44 axis". International Journal of Oncology 54.3 (2019): 1010-1020.
Chicago
Chan, L., Man, O., Kwok, H., Chen, L., Chan, K., Lung, H., Ngan, R., Wong, R., Lo, K., Lee, A., Tsao, G., Kahn, M., Lung, M., Mak, N."The Wnt modulator ICG‑001 mediates the inhibition of nasopharyngeal carcinoma cell migration in vitro via the miR‑150/CD44 axis". International Journal of Oncology 54, no. 3 (2019): 1010-1020. https://doi.org/10.3892/ijo.2018.4664
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