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Article

Eya2 is critical for the E2A‑HLF‑mediated immortalization of mouse hematopoietic stem/progenitor cells

  • Authors:
    • Bishnu Devi Maharjan
    • Ryoichi Ono
    • Tetsuya Nosaka
  • View Affiliations / Copyright

    Affiliations: Department of Microbiology and Molecular Genetics, Mie University Graduate School of Medicine, Tsu 514‑8507, Japan
  • Pages: 981-990
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    Published online on: January 3, 2019
       https://doi.org/10.3892/ijo.2019.4673
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Abstract

The immunoglobulin enhancer‑binding factor/hepatic leukemia factor (E2A‑HLF) oncogenic fusion gene, generated by t(17;19)(q22;p13) translocation in childhood B‑cell acute lymphoblastic leukemia with a very poor prognosis, encodes a chimeric transcription factor in which the transactivation domains of E2A are fused to the DNA‑binding and dimerization domain of HLF. E2A‑HLF has been demonstrated to have an anti‑apoptotic effect. However, the molecular mechanism underlying E2A‑HLF‑mediated leukemogenesis remains unclear. The present study identified EYA transcriptional coactivator and phosphatase 2 (Eya2), the forced expression of which is known to immortalize mouse hematopoietic stem/progenitor cells (HSPCs), as a direct target molecule downstream of E2A‑HLF. E2A‑HLF‑immortalized mouse HSPCs expressed Eya2 at a high level in the aberrant self‑renewal program. Chromatin immunoprecipitation‑quantitative polymerase chain reaction and a reporter assay revealed that E2A‑HLF enhanced the Eya2 expression by binding to the promoter region containing the E2A‑HLF‑binding consensus sequence. Eya2 knockdown in E2A‑HLF‑immortalized cells resulted in reduced colony‑forming efficiency. These results suggest a critical role of Eya2 in E2A‑HLF‑mediated leukemogenesis.
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1 

Pui CH, Gajjar AJ, Kane JR, Qaddoumi IA and Pappo AS: Challenging issues in pediatric oncology. Nat Rev Clin Oncol. 8:540–549. 2011. View Article : Google Scholar : PubMed/NCBI

2 

Inaba T, Roberts WM, Shapiro LH, Jolly KW, Raimondi SC, Smith SD and Look AT: Fusion of the leucine zipper gene HLF to the E2A gene in human acute B-lineage leukemia. Science. 257:531–534. 1992. View Article : Google Scholar : PubMed/NCBI

3 

Hunger SP, Ohyashiki K, Toyama K and Cleary ML: Hlf, a novel hepatic bZIP protein, shows altered DNA-binding properties following fusion to E2A in t(17;19) acute lymphoblastic leukemia. Genes Dev. 6:1608–1620. 1992. View Article : Google Scholar : PubMed/NCBI

4 

Raimondi SC, Privitera E, Williams DL, Look AT, Behm F, Rivera GK, Crist WM and Pui CH: New recurring chromosomal translocations in childhood acute lymphoblastic leukemia. Blood. 77:2016–2022. 1991.PubMed/NCBI

5 

Inukai T, Hirose K, Inaba T, Kurosawa H, Hama A, Inada H, Chin M, Nagatoshi Y, Ohtsuka Y, Oda M, et al: Hypercalcemia in childhood acute lymphoblastic leukemia: Frequent implication of parathyroid hormone-related peptide and E2A-HLF from translocation 17;19. Leukemia. 21:288–296. 2007. View Article : Google Scholar

6 

Greenbaum S and Zhuang Y: Identification of E2A target genes in B lymphocyte development by using a gene tagging-based chromatin immunoprecipitation system. Proc Natl Acad Sci USA. 99:15030–15035. 2002. View Article : Google Scholar : PubMed/NCBI

7 

Massari ME and Murre C: Helix-loop-helix proteins: Regulators of transcription in eucaryotic organisms. Mol Cell Biol. 20:429–440. 2000. View Article : Google Scholar

8 

Quong MW, Romanow WJ and Murre C: E protein function in lymphocyte development. Annu Rev Immunol. 20:301–322. 2002. View Article : Google Scholar : PubMed/NCBI

9 

Hunger SP, Li S, Fall MZ, Naumovski L and Cleary ML: The proto-oncogene HLF and the related basic leucine zipper protein TEF display highly similar DNA-binding and transcriptional regulatory properties. Blood. 87:4607–4617. 1996.PubMed/NCBI

10 

Hunger SP, Brown R and Cleary ML: DNA-binding and transcriptional regulatory properties of hepatic leukemia factor (HLF) and the t(17;19) acute lymphoblastic leukemia chimera E2A-HLF. Mol Cell Biol. 14:5986–5996. 1994. View Article : Google Scholar : PubMed/NCBI

11 

Fischer U, Forster M, Rinaldi A, Risch T, Sungalee S, Warnatz HJ, Bornhauser B, Gombert M, Kratsch C, Stütz AM, et al: Genomics and drug profiling of fatal TCF3-HLF-positive acute lymphoblastic leukemia identifies recurrent mutation patterns and therapeutic options. Nat Genet. 47:1020–1029. 2015. View Article : Google Scholar : PubMed/NCBI

12 

Yoshihara T, Inaba T, Shapiro LH, Kato JY and Look AT: E2A-HLF-mediated cell transformation requires both the trans-activation domains of E2A and the leucine zipper dimerization domain of HLF. Mol Cell Biol. 15:3247–3255. 1995. View Article : Google Scholar : PubMed/NCBI

13 

Inaba T, Inukai T, Yoshihara T, Seyschab H, Ashmun RA, Canman CE, Laken SJ, Kastan MB and Look AT: Reversal of apoptosis by the leukaemia-associated E2A-HLF chimaeric transcription factor. Nature. 382:541–544. 1996. View Article : Google Scholar : PubMed/NCBI

14 

Duque-Afonso J, Smith KS and Cleary ML: Conditional expression of E2A-HLF induces B-cell precursor death and myeloproliferative-like disease in knock-in mice. PLoS One. 10:e01432162015. View Article : Google Scholar : PubMed/NCBI

15 

Honda H, Inaba T, Suzuki T, Oda H, Ebihara Y, Tsuiji K, Nakahata T, Ishikawa T, Yazaki Y and Hirai H: Expression of E2A-HLF chimeric protein induced T-cell apoptosis, B-cell maturation arrest, and development of acute lymphoblastic leukemia. Blood. 93:2780–2790. 1999.PubMed/NCBI

16 

Smith KS, Rhee JW, Naumovski L and Cleary ML: Disrupted differentiation and oncogenic transformation of lymphoid progenitors in E2A-HLF transgenic mice. Mol Cell Biol. 19:4443–4451. 1999. View Article : Google Scholar : PubMed/NCBI

17 

Hirose K, Inukai T, Kikuchi J, Furukawa Y, Ikawa T, Kawamoto H, Oram SH, Göttgens B, Kiyokawa N, Miyagawa Y, et al: Aberrant induction of LMO2 by the E2A-HLF chimeric transcription factor and its implication in leukemogenesis of B-precursor ALL with t(17;19). Blood. 116:962–970. 2010. View Article : Google Scholar : PubMed/NCBI

18 

de Boer J, Yeung J, Ellu J, Ramanujachar R, Bornhauser B, Solarska O, Hubank M, Williams O and Brady HJ: The E2A-HLF oncogenic fusion protein acts through Lmo2 and Bcl-2 to immortalize hematopoietic progenitors. Leukemia. 25:321–330. 2011. View Article : Google Scholar

19 

Inukai T, Inoue A, Kurosawa H, Goi K, Shinjyo T, Ozawa K, Mao M, Inaba T and Look AT: SLUG, a ces-1-related zinc finger transcription factor gene with antiapoptotic activity, is a downstream target of the E2A-HLF oncoprotein. Mol Cell. 4:343–352. 1999. View Article : Google Scholar : PubMed/NCBI

20 

Yeung J, O'Sullivan E, Hubank M and Brady HJ: E4BP4 expression is regulated by the t(17;19)-associated oncoprotein E2A-HLF in pro-B cells. Br J Haematol. 125:560–567. 2004. View Article : Google Scholar : PubMed/NCBI

21 

Dang J, Inukai T, Kurosawa H, Goi K, Inaba T, Lenny NT, Downing JR, Stifani S and Look AT: The E2A-HLF oncoprotein activates Groucho-related genes and suppresses Runx1. Mol Cell Biol. 21:5935–5945. 2001. View Article : Google Scholar : PubMed/NCBI

22 

Kurosawa H, Goi K, Inukai T, Inaba T, Chang KS, Shinjyo T, Rakestraw KM, Naeve CW and Look AT: Two candidate downstream target genes for E2A-HLF. Blood. 93:321–332. 1999.

23 

Yamasaki N, Miyazaki K, Nagamachi A, Koller R, Oda H, Miyazaki M, Sasaki T, Honda ZI, Wolff L, Inaba T, et al: Identification of Zfp521/ZNF521 as a cooperative gene for E2A-HLF to develop acute B-lineage leukemia. Oncogene. 29:1963–1975. 2010. View Article : Google Scholar : PubMed/NCBI

24 

Okuya M, Kurosawa H, Kikuchi J, Furukawa Y, Matsui H, Aki D, Matsunaga T, Inukai T, Goto H, Altura RA, et al: Up-regulation of survivin by the E2A-HLF chimera is indispensable for the survival of t(17;19)-positive leukemia cells. J Biol Chem. 285:1850–1860. 2010. View Article : Google Scholar :

25 

Zhang X, Inukai T, Hirose K, Akahane K, Kuroda I, Honna-Oshiro H, Kagami K, Goi K, Nakamura K, Kobayashi M, et al: Oncogenic fusion E2A-HLF sensitizes t(17;19)-positive acute lymphoblastic leukemia to TRAIL-mediated apoptosis by upregulating the expression of death receptors. Leukemia. 26:2483–2493. 2012. View Article : Google Scholar : PubMed/NCBI

26 

Bonini NM, Leiserson WM and Benzer S: The eyes absent gene: Genetic control of cell survival and differentiation in the developing Drosophila eye. Cell. 72:379–395. 1993. View Article : Google Scholar : PubMed/NCBI

27 

Bonini NM, Leiserson WM and Benzer S: Multiple roles of the eyes absent gene in Drosophila. Dev Biol. 196:42–57. 1998. View Article : Google Scholar : PubMed/NCBI

28 

Tadjuidje E and Hegde RS: The Eyes Absent proteins in development and disease. Cell Mol Life Sci. 70:1897–1913. 2013. View Article : Google Scholar :

29 

Zimmerman JE, Bui QT, Steingrímsson E, Nagle DL, Fu W, Genin A, Spinner NB, Copeland NG, Jenkins NA, Bucan M, et al: Cloning and characterization of two vertebrate homologs of the Drosophila eyes absent gene. Genome Res. 7:128–141. 1997. View Article : Google Scholar : PubMed/NCBI

30 

Zhang L, Yang N, Huang J, Buckanovich RJ, Liang S, Barchetti A, Vezzani C, O'Brien-Jenkins A, Wang J, Ward MR, et al: Transcriptional coactivator Drosophila eyes absent homologue 2 is up-regulated in epithelial ovarian cancer and promotes tumor growth. Cancer Res. 65:925–932. 2005.PubMed/NCBI

31 

Farabaugh SM, Micalizzi DS, Jedlicka P, Zhao R and Ford HL: Eya2 is required to mediate the pro-metastatic functions of Six1 via the induction of TGF-β signaling, epithelial-mesenchymal transition, and cancer stem cell properties. Oncogene. 31:552–562. 2012. View Article : Google Scholar

32 

Wen Z, Liang C, Pan Q and Wang Y: Eya2 overexpression promotes the invasion of human astrocytoma through the regulation of ERK/MMP9 signaling. Int J Mol Med. 40:1315–1322. 2017. View Article : Google Scholar : PubMed/NCBI

33 

Vincent A, Hong SM, Hu C, Omura N, Young A, Kim H, Yu J, Knight S, Ayars M, Griffith M, et al: Epigenetic silencing of EYA2 in pancreatic adenocarcinomas promotes tumor growth. Oncotarget. 5:2575–2587. 2014. View Article : Google Scholar : PubMed/NCBI

34 

Forsberg EC, Prohaska SS, Katzman S, Heffner GC, Stuart JM and Weissman IL: Differential expression of novel potential regulators in hematopoietic stem cells. PLoS Genet. 1:e282005. View Article : Google Scholar : PubMed/NCBI

35 

Ono R, Masuya M, Ishii S, Katayama N and Nosaka T: Eya2, a Target Activated by Plzf, Is Critical for PLZF-RARA-Induced Leukemogenesis. Mol Cell Biol. 37:e00585–e16. 2017. View Article : Google Scholar :

36 

Ono R, Masuya M, Nakajima H, Enomoto Y, Miyata E, Nakamura A, Ishii S, Suzuki K, Shibata-Minoshima F, Katayama N, et al: Plzf drives MLL-fusion-mediated leuke-mogenesis specifically in long-term hematopoietic stem cells. Blood. 122:1271–1283. 2013. View Article : Google Scholar : PubMed/NCBI

37 

Kitamura T, Koshino Y, Shibata F, Oki T, Nakajima H, Nosaka T and Kumagai H: Retrovirus-mediated gene transfer and expression cloning: Powerful tools in functional genomics. Exp Hematol. 31:1007–1014. 2003. View Article : Google Scholar : PubMed/NCBI

38 

Hunger SP, Galili N, Carroll AJ, Crist WM, Link MP and Cleary ML: The t(1;19)(q23;p13) results in consistent fusion of E2A and PBX1 coding sequences in acute lymphoblastic leukemias. Blood. 77:687–693. 1991.PubMed/NCBI

39 

LeBrun DP: E2A basic helix-loop-helix transcription factors in human leukemia. Front Biosci. 8:s206–s222. 2003. View Article : Google Scholar : PubMed/NCBI

40 

Inukai T, Inaba T, Ikushima S and Look AT: The AD1 and AD2 transactivation domains of E2A are essential for the antiapoptotic activity of the chimeric oncoprotein E2A-HLF. Mol Cell Biol. 18:6035–6043. 1998. View Article : Google Scholar : PubMed/NCBI

41 

Morita S, Kojima T and Kitamura T: Plat-E: An efficient and stable system for transient packaging of retroviruses. Gene Ther. 7:1063–1066. 2000. View Article : Google Scholar : PubMed/NCBI

42 

Ono R, Nakajima H, Ozaki K, Kumagai H, Kawashima T, Taki T, Kitamura T, Hayashi Y and Nosaka T: Dimerization of MLL fusion proteins and FLT3 activation synergize to induce multiple-lineage leukemogenesis. J Clin Invest. 115:919–929. 2005. View Article : Google Scholar : PubMed/NCBI

43 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2−ΔΔCT method. Methods. 25:402–408. 2001. View Article : Google Scholar

44 

Nosaka T, Morita S, Kitamura H, Nakajima H, Shibata F, Morikawa Y, Kataoka Y, Ebihara Y, Kawashima T, Itoh T, et al: Mammalian twisted gastrulation is essential for skeleto-lymphogenesis. Mol Cell Biol. 23:2969–2980. 2003. View Article : Google Scholar : PubMed/NCBI

45 

Nosaka T, Kawashima T, Misawa K, Ikuta K, Mui AL and Kitamura T: STAT5 as a molecular regulator of proliferation, differentiation and apoptosis in hematopoietic cells. EMBO J. 18:4754–4765. 1999. View Article : Google Scholar : PubMed/NCBI

46 

ENCODE Project Consortium: An integrated encyclopedia of DNA elements in the human genome. Nature. 489:57–74. 2012. View Article : Google Scholar : PubMed/NCBI

47 

Smith KS, Rhee JW and Cleary ML: Transformation of bone marrow B-cell progenitors by E2a-Hlf requires coexpression of Bcl-2. Mol Cell Biol. 22:7678–7687. 2002. View Article : Google Scholar : PubMed/NCBI

48 

Grifone R, Demignon J, Giordani J, Niro C, Souil E, Bertin F, Laclef C, Xu PX and Maire P: Eya1 and Eya2 proteins are required for hypaxial somitic myogenesis in the mouse embryo. Dev Biol. 302:602–616. 2007. View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Maharjan BD, Ono R and Nosaka T: Eya2 is critical for the E2A‑HLF‑mediated immortalization of mouse hematopoietic stem/progenitor cells. Int J Oncol 54: 981-990, 2019.
APA
Maharjan, B.D., Ono, R., & Nosaka, T. (2019). Eya2 is critical for the E2A‑HLF‑mediated immortalization of mouse hematopoietic stem/progenitor cells. International Journal of Oncology, 54, 981-990. https://doi.org/10.3892/ijo.2019.4673
MLA
Maharjan, B. D., Ono, R., Nosaka, T."Eya2 is critical for the E2A‑HLF‑mediated immortalization of mouse hematopoietic stem/progenitor cells". International Journal of Oncology 54.3 (2019): 981-990.
Chicago
Maharjan, B. D., Ono, R., Nosaka, T."Eya2 is critical for the E2A‑HLF‑mediated immortalization of mouse hematopoietic stem/progenitor cells". International Journal of Oncology 54, no. 3 (2019): 981-990. https://doi.org/10.3892/ijo.2019.4673
Copy and paste a formatted citation
x
Spandidos Publications style
Maharjan BD, Ono R and Nosaka T: Eya2 is critical for the E2A‑HLF‑mediated immortalization of mouse hematopoietic stem/progenitor cells. Int J Oncol 54: 981-990, 2019.
APA
Maharjan, B.D., Ono, R., & Nosaka, T. (2019). Eya2 is critical for the E2A‑HLF‑mediated immortalization of mouse hematopoietic stem/progenitor cells. International Journal of Oncology, 54, 981-990. https://doi.org/10.3892/ijo.2019.4673
MLA
Maharjan, B. D., Ono, R., Nosaka, T."Eya2 is critical for the E2A‑HLF‑mediated immortalization of mouse hematopoietic stem/progenitor cells". International Journal of Oncology 54.3 (2019): 981-990.
Chicago
Maharjan, B. D., Ono, R., Nosaka, T."Eya2 is critical for the E2A‑HLF‑mediated immortalization of mouse hematopoietic stem/progenitor cells". International Journal of Oncology 54, no. 3 (2019): 981-990. https://doi.org/10.3892/ijo.2019.4673
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